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Research Article

Powder flow in an automated uniaxial tester and an annular shear cell: a study of pharmaceutical excipients and analytical data comparison

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Pages 1476-1483 | Received 13 Apr 2012, Accepted 05 Sep 2012, Published online: 08 Oct 2012

References

  • Fassihi AR, Kanfer I. (1986). Effect of compressibility and powder flow properties on tablet weight variation. Drug Dev Ind Pharm, 12:1947–1966.
  • Tan SB, Newton JM.(1990). Powder flowability as an indication of capsule filling performance. Int J Pharm, 61:145–155.
  • Jones BE. (2001). The filling of two-piece hard capsules. Int J Pharm, 227:5–26.
  • Freeman T.(2010). The importance of powder characterization. Pharma Technol Eur, 22:21–26.
  • Yu LX. (2008). Pharmaceutical quality by design: product and process development, understanding, and control. Pharm Res, 25:781–791.
  • Juliano P, Barbosa-Cánovas GV. (2010). Food powders flowability characterization: theory, methods, and applications. Annu Rev Food Sci Technol, 1:211–239.
  • Hamad ML, Bowman K, Smith N, Sheng X, Morris KR. (2010). Multi-scale pharmaceutical process understanding: From particle to powder to dosage form. Chem Eng Sci, 65:5625–5638.
  • Jenike AW.(1964). Storage and flow of solids. Utah. Eng Exp Station Bull, 123:1–194.
  • Schmitt R, Feise H. (2004). Influence of tester geometry, speed and procedure on the results from ring shear tester. Part An Syst Charact, 21:403–410.
  • Schwedes J. (2003). Review on testers for measuring flow properties of bulk solids. Granular Matter, 5:1–43.
  • Schulze D. (2007). Powders and bulk solids – behavior, characterization, storage and flow. Berlin Heidelberg, New York: Springer, 163–198.
  • Lindberg NO, Pålsson M, Pihl AC, Freeman R, Freeman T, Zetzener H et al. (2004). Flowability measurements of pharmaceutical powder mixtures with poor flow using five different techniques. Drug Dev Ind Pharm, 30:785–791.
  • Enstad G. (1998). News on the development of the uniaxial tester. Postec Newslett, 16:17–18.
  • Polizzi M, Yuan X, Hancock, B. (2011). Direct measurement of the Unconfined Yield Strength of Moderately Compressed Pharmaceutical Powders. Annual Meeting AAPS, Washington, USA.
  • Parrella L, Barletta D, Boerefijn R, Poletto M. (2008). Comparison between a uniaxial compaction tester and a shear tester for the characterization of powder flowability. KONA Pow Par J, 26:178–189
  • Doelker E. (1994). Assessment of powder compaction. In: Chulia D, Deleuil M, Pourcelot Y, eds. Powder Technology and Pharmaceutical Processes. North Holland: Elsevier, 403–471.
  • Tripodi MA, Puri VM, Manbeck HB, Messing GL. (1995). Elastoplastic finite element model development and validation for low pressure uniaxial compaction of dry cohesive powders. Powder Technol, 85:241–251.
  • Saraber F, Enstad GG, Haaker G. (1991). Investigations on the anisotropic yield behaviour of a cohesive bulk solid. Powder Technol, 64:183–190.
  • Kaye BH. (1997). Characterization the flowability of a powder using the concept of fractal geometry and chaos theory. Part An Syst Charact, 14:53–66.
  • Li T, Park K. (1998). Fractal analysis of pharmaceutical particles by atomic force microscopy. Pharm Res, 15:1222–1232.
  • Nalluri VR, Kuentz M. (2010). Flowability characterisation of drug-excipient blends using a novel powder avalanching method. Eur J Pharm Biopharm, 74:388–396.
  • Shipway PH, Hutchings IM. (1993). Attrition of brittle spheres by fracture under compression and impact loading. Powder Technol, 76:23–30.

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