Application and functional characterization of POVACOAT, a hydrophilic co-polymer poly(vinyl alcohol/acrylic acid/methyl methacrylate) as a hot-melt extrusion carrier

References

• Kerns EH. High throughput physicochemical profiling for drug discovery. J Pharm Sci 2001;90:1838–58
   PubMed Web of Science ®Google Scholar
• Repka MA, Shah S, Lu J, et al. Melt extrusion: process to product. Expert Opin Drug Deliv 2012;9:105–25
   PubMed Web of Science ®Google Scholar
• Singh A, Worku ZA, van den Mooter G. Oral formulation strategies to improve solubility of poorly water-soluble drugs. Expert Opin Drug Deliv 2011;8:1361–78
   PubMed Web of Science ®Google Scholar
• Srinarong P, de Waard H, Frijlink HW, Hinrichs WL. Improved dissolution behavior of lipophilic drugs by solid dispersions: the production process as starting point for formulation considerations. Expert Opin Drug Deliv 2011;8:1121–40
   PubMed Web of Science ®Google Scholar
• Fahr A, Liu X. Drug delivery strategies for poorly water-soluble drugs. Expert Opin Drug Deliv 2007;4:403–16
   PubMed Web of Science ®Google Scholar
• Coppens KA, Hall MJ, Mitchell SA, Read MD. Hypromellose, ethylcellulose, and polyethylene oxide use in hot melt extrusion. Pharm Technol 2006;30:60–71
   Google Scholar
• Fujii T, Noami M, Tomita K, Furuya Y. PVA copolymer: the new coating agent. Pharm Technol Eur 2008;20:32–9
   Google Scholar
• Uramatsu S, Shinike H, Kida A, et al. Application of poly(vinylalcohol/acrylic acid/methyl methacrylate) (PVA copolymer) as a solid dispersion matrix. 1st Asian Pharmaceutical Science and Technology Symposium ABSTRACT BOOK; 2007:280--2
   Google Scholar
• Zhipeng C, Jiabi Z, Hongxuan C, et al. Distribution of liposomal bifendate in liver following intravenous injection in mice. J Drug Target 2010;18:627–36
   PubMed Web of Science ®Google Scholar
• Moon JH, Chun IK. Enhanced dissolution and permeation of biphenyl dimethyl dicarboxylate using solid dispersions. J Korean Pharm Sci 1999;29:227–34
   Google Scholar
• Jia F, Lishuang X, Renchao G, et al. Evaluation of polymer carriers with regard to the bioavailability enhancement of bifendate solid dispersions prepared by hot-melt extrusion. Drug Dev Ind Pharm 2012;38:735–43
   PubMed Web of Science ®Google Scholar
• Chi SC, Yeom DI, Kim SC, Park ES. A polymeric micellar carrier for the solubilization of biphenyl dimethyl dicarboxylate. Arch Pharm Res 2003;26:173–81
   PubMed Web of Science ®Google Scholar
• Kim CK, Cho YJ, Gao ZG. Preparation and evaluation of biphenyl dimethyl dicarboxylate microemulsions for oral delivery. J Control Release 2001;70:149–55
   PubMed Web of Science ®Google Scholar
• Aburahma MH, Abdelbary GA. Novel diphenyl dimethyl bicarboxylate provesicular powders with enhanced hepatocurative activity: preparation, optimization, in vitro/in vivo evaluation. Int J Pharm 2012; 422:139–50
   PubMed Web of Science ®Google Scholar
• Higuchi T, Connors KA. Phase-solubility techniques. Adv Anal Chem Instrum 1965;4:117–212
   Google Scholar
• Jijun F, Lili Z, Tingting G, et al. Stable nimodipine tablets with high bioavailability containing NM-SD prepared by hot-melt extrusion. Powder Technol 2010;204:214–21
   Web of Science ®Google Scholar
• Andrews GP, AbuDiak OA, Jones DS. Physicochemical characterization of hot melt extruded bicalutamide-polyvinylpyrrolidone solid dispersions. J Pharm Sci 2010;99:1322–35
   PubMed Web of Science ®Google Scholar
• Abu-Diak OA, Jones DS, Andrews GP. An investigation into the dissolution properties of celecoxib melt extrudates: understanding the role of polymer type and concentration in stabilizing supersaturated drug concentrations. Mol Pharm 2011;8:1362–71
   PubMed Web of Science ®Google Scholar
• Aggarwal AK, Singh S. Physicochemical characterization and dissolution study of solid dispersions of diacerein with polyethylene glycol 6000. Drug Dev Ind Pharm 2011;37:1181–91
   PubMed Web of Science ®Google Scholar
• Ahuja N, Katare OP, Singh B. Studies on dissolution enhancement and mathematical modeling of drug release of a poorly water-soluble drug using water-soluble carriers. Eur J Pharm Biopharm 2007;65:26–38
   PubMed Web of Science ®Google Scholar
• Maulvi FA, Dalwadi SJ, Thakkar VT, et al. Improvement of dissolution rate of aceclofenac by solid dispersion technique. Powder Technol 2011;207:47–54
   Web of Science ®Google Scholar
• Mehanna MM, Motawaa AM, Samaha MW. In sight into tadalafil – block copolymer binary solid dispersion: mechanistic investigation of dissolution enhancement. Int J Pharm 2010;402:78–88
   PubMed Web of Science ®Google Scholar
• Vasconcelos T, Sarmento B, Costa P. Solid dispersions as strategy to improve oral bioavailability of poor water soluble drugs. Drug Discovery Today 2007;12:1068–75
   PubMed Web of Science ®Google Scholar
• Brouwers J, Brewster ME, Augustijns P. Supersaturating drug delivery systems: the answer to solubility-limited oral bioavailability? J Pharm Sci 2009;98:2549–72
   PubMed Web of Science ®Google Scholar
• Tajarobi F, Larsson A, Matic H, Abrahmsen-Alami S. The influence of crystallization inhibition of HPMC and HPMCAS on model substance dissolution and release in swellable matrix tablets. Eur J Pharm Biopharm 2011;78:125–33
   PubMed Web of Science ®Google Scholar
• Janssens S, Nagels S, Armas HN, et al. Formulation and characterization of ternary solid dispersions made up of Itraconazole and two excipients, TPGS 1000 and PVPVA 64, that were selected based on a supersaturation screening study. Eur J Pharm Biopharm 2008;69:158–66
   PubMed Web of Science ®Google Scholar
• Tanno F, Nishiyama Y, Kokubo H, Obara S. Evaluation of hypromellose acetate succinate (HPMCAS) as a carrier in solid dispersions. Drug Dev Ind Pharm 2004;30:9–17
   PubMed Web of Science ®Google Scholar
• Konno H, Handa T, Alonzo DE, Taylor LS. Effect of polymer type on the dissolution profile of amorphous solid dispersions containing felodipine. Eur J Pharm Biopharm 2008;70:493–9
   PubMed Web of Science ®Google Scholar
• Lindfors L, Forssén S, Westergren J, Olsson U. Nucleation and crystal growth in supersaturated solutions of a model drug. J Colloid Interface Sci 2008;325:404–13
   PubMed Web of Science ®Google Scholar
• DiNunzio JC, Brough C, Miller DA, et al. Fusion processing of itraconazole solid dispersions by kinetisol dispersing: a comparative study to hot melt extrusion. J Pharm Sci 2010;99:1239–53
   PubMed Web of Science ®Google Scholar
• Alonzo DE, Gao Y, Zhou D, et al. Dissolution and precipitation behavior of amorphous solid dispersions. J Pharm Sci 2011;100:3316–31
   PubMed Web of Science ®Google Scholar
• Kanaujia P, Lau G, Ng WK, et al. Nanoparticle formation and growth during in vitro dissolution of ketoconazole solid dispersion. J Pharm Sci 2011;100:2876–85
   PubMed Web of Science ®Google Scholar
• Craig DQM. The mechanisms of drug release from solid dispersions in water-soluble polymers. Int J Pharm 2002;231:131–44
   PubMed Web of Science ®Google Scholar
• Albers J, Alles R, Matthée K, et al. Mechanism of drug release from polymethacrylate-based extrudates and milled strands prepared by hot-melt extrusion. Eur J Pharm Biopharm 2009;71:387–94
   PubMed Web of Science ®Google Scholar