736
Views
34
CrossRef citations to date
0
Altmetric
Research Article

Effect of moisture content, temperature and exposure time on the physical stability of chitosan powder and tablets

, , &
Pages 730-742 | Received 07 Aug 2012, Accepted 01 Mar 2013, Published online: 18 Apr 2013

References

  • Vromans H, Lerk CF. Densification properties and compactibility of mixtures of pharmaceutical excipients with and without magnesium stearate. Int J Pharm 1988;46:183–92
  • Andrès C, Ndiaye A, Thomas C, et al. Influence of the parameters molecular structure and granularity on the compactibility of a powder. Drug Dev Ind Pharm 1995;21:1875–85
  • Mattsson S. Pharmaceutical binders and their function in directly compressed tablets. Acta Univ Ups 2000;238:1–64
  • Onishi H, Nagai T, Machida Y. Applications of chitin, chitosan and their derivatives to drug carriers for microparticulated or conjugated drug delivery systems. In: Goosen MFA, ed. Applications of chitin and chitosan. Basel: Technomic Publishing Company, Inc.; 1997:205–31
  • Felt O, Buri P, Gurny R. Chitosan: a unique polysaccharide for drug delivery. Drug Dev Ind Pharm 1998;24:979–93
  • Kotzé AF, Leuβen HL, Thanou M, et al. Chitosan and chitosan derivatives as absorption enhancers for peptide drugs across mucosal epithelia. In Mathiowitz E, Chickering DE, Lehr CM, eds. Bioadhesive drug delivery systems: fundaments, novel approaches and development. New York: Marcel Dekker; 1999:341–86
  • Paul W, Sharma CP. Chitosan, a drug carrier for the 21st centrury: a review. S.T.P. Pharmasci 2000;10:5–22
  • Perioli L, Ambrogi V, Pagano C, et al. FG90 chitosan as a new polymer for metronidazole mucoadhesive tablets for vaginal administration. Int J Pharm 2009;377:120–7
  • Mura P, Zerrouk N, Mennini N, et al. Development and characterization of naproxen – chitosan solid systems with improved drug dissolution properties. Eurp J Pharm Sci 2003;19:67–75
  • Win PP, Shin-Ya Y, Hong K, Kajiuchi T. Formulation and characterization of pH sensitive drug carrier based on phosphorylated chitosan. Carbohydrate Polymers 2003;53:305–10
  • Upadrashta SM, Katikaneni PR, Nuessle NO. Chitosan as a tablet binder. Drug Dev Ind Pharm 1992;18:1701–8
  • Knapczyk J. Excipient ability of chitosan for direct tableting. Int J Pharm 1993;89:1–7
  • Aspden TJ, Adler J, Davis SS, et al. Chitosan as a nasal delivery system: evaluation of the effect of chitosan on mucociliary clearance rate in the frog palate model. Int J Pharm 1995;122:69–78
  • Rege PR, Shukla DJ, Block LH. Chitinosans as tableting excipients for modified release delivery systems. Int J Pharm 1999;181:49–60
  • Bernkop-Schnürch A. Chitosan and its derivatives: potential excipients for peroral peptide delivery systems. Int J Pharm 2000;194:1–13
  • Leane MM, Nankervis R, Smith A, Illum ML. Use of the ninhydrin assay to measure the release of chitosan from oral solid dosage forms. Int J Pharm 2004;271:241–9
  • Nokhodchi A, Rubinstein MH, Larhrib H, Guyot JC. The effect of moisture content on the energies involved in the compaction of ibuprofen. Int J Pharm 1995;120:13–20
  • Marshall K, Rudnic EM. Tablet dosage forms. In: Banker GS, Rhodes T, eds. Modern pharmaceutics. 3rd ed. New York: Dekker; 1991;355–425
  • Garr JSM, Rubinstein MH. The influence of moisture content on the consolidation and compaction properties of paracetamol. Int J Pharm 1992;81:187–92
  • Malamataris S, Karidas T. Effect of particle size and sorbed moisture on the tensile strength of some tableted hydroxypropyl methylcellulose (HPMC) polymers. Int J Pharm 1994;104:115–23
  • Ahlneck C, Alderborn G. Moisture adsorption and tableting. I. Effect on volume reduction properties and tablet strength for some crystalline material. Int J Pharm 1989;54:131–41
  • Mir VG, Heinämäki J, Antikainen O, et al. Direct compression properties of chitin and chitosan. Eur J Pharm Biopharm, 2008;69:964–8
  • Bühler V. 2003. Kollidon®: polyvinylpyrrolidone for the pharmaceutical industry. 7th ed. Ludwigshafen: BASF
  • Lavertu M, Xia Z, Serreqi AN, et al. A validated 1H NMR method for the determination of the degree of deacetylation of chitosan. J Pharm Biomed Anal 2003;32:1149–58
  • Snyman D, Hamman JH, Kotze JS, et al. The relationship between the absolute molecular weight and the degree of quaternisation of N-trimethyl chitosan chloride. Carbohydrate Polym 2002;50:145–50
  • HMSO. British pharmacopoeia. London: HMSO; 2012:A239; A320; A341; A471--2
  • Young RJ, Lovell PA. Introduction to polymers. Kingstonon-Thames, UK: Nelson Thornes Ltd; 1991
  • Fell JT, Newton JM. The tensile strength of lactose tablets. J Pharm Pharmacol 1968;20:657–8
  • Ahuja A, Khar RK, Ali J. Mucoadhesive drug delivery systems. Drug Dev Ind Pharm, 1997;23:489–515
  • Tombs MP, Harding SE. An introduction to polysaccharide biotechnology. London, UK: Taylor & Francis; 1998
  • Şenel S, McClure SJ. Potential applications of chitosan in veterinary medicine. Adv Drug Deliv Rev 2004;56:1467–80
  • Tsaih ML, Chen RH. Effect of molecular weight and area on the conformation of chitosan molecules in dilute solutions. Int J Biol Macromol 1997;20:233–40
  • Morris GA, Castile J, Smith A, et al. Macromolecular conformation of chitosan in dilute solution: a new global hydrodynamic approach. Carbohydrate Polym 2009;76:616–21

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.