References
- Pinto JF. Site-specific drug delivery systems within the gastro-intestinal tract: from the mouth to the colon. Int J Pharm 2010;395:44–52.
- Isha C, Nimrata S, Rana AC, Surbihi G. Oral sustained release drug delivery system: an overview. Int Res J Pharm 2012;3:57–62.
- Pezzini BR, Silva MAS, Ferraz HG. Formas farmacêuticas de liberação prolongada: Sistemas monolíticos e multiparticulados. Braz J Pharm Sci 2007;43:491–502.
- Reis AS-MJF, Pedreiro AU, Cavalcanti LN. Phosphated crosslinked pectin as a potential excipient for specific drug delivery: preparation and physicochemical characterization. Polymer Int 2010;59:127–35.
- Torchilin VP. Drug targeting. Eur J Pharm Sci 2000;11:S81–91.
- Philip AK, Philip B. Colon targeted drug delivery systems: a review on primary and novel approaches. Oman Med J 2010;25:79–87.
- Friend DR. Colon-specific drug delivery. Adv Drug Deliv Rev 1991;7:149–99.
- Sinha VR, Kumria R. Polysaccharides in colon-specific drug delivery. Int J Pharm 2001;224:19–38.
- Carbinatto FM, De Castro AD, Cury BSF, et al. Physical properties of pectin–high amylose starch mixtures cross-linked with sodium trimetaphosphate. Int J Pharm 2012;423:281–8.
- Meneguin AB, Cury BS, Evangelista RC. Films from resistant starch-pectin dispersions intended for colonic drug delivery. Carbohydr Polym 2014;99:140–9.
- Osmałek T, Froelich A, Tasarek S. Application of gellan gum in pharmacy and medicine. Int J Pharm 2014;466:328–40.
- Prezotti FG, Meneguin AB, Evangelista RC, Cury BS. Preparation and characterization of free films of high amylose/pectin mixtures cross-linked with sodium trimetaphosphate. Drug Dev Ind Pharm 2012;38:1354–9.
- Orlu M, Cevher E, Araman A. Design and evaluation of colon specific drug delivery system containing flurbiprofen microsponges. Int J Pharm 2006;318:103–17.
- Cury BS, Castro AD, Klein SI, Evangelista RC. Modeling a system of phosphated cross-linked high amylose for controlled drug release. Part 2: physical parameters, cross-linking degrees and drug delivery relationships. Int J Pharm 2009;371:8–15.
- Bhadouriya P, Kumar M, Pathak K. Formulation and in vitro evaluation of prolonged release floating microspheres of atenolol using multicompartment dissolution apparatus. Drug Dev Ind Pharm 2013;39:1663–71.
- Patil SB, Sawant KK. Chitosan microspheres as a delivery system for nasal insufflation. Colloids Surf B Biointerfaces 2011;84:384–9.
- Vasir JK, Tambwekar K, Garg S. Bioadhesive microspheres as a controlled drug delivery system. Int J Pharm 2003;255:13–32.
- Kumari S, Bhandari A, Sharma PK. Solvent evaporation as a imposing method for microencapsulation – a review. J Drug Discov Therap 2014;2:13–20.
- Maestrelli F, Zerrouk N, Cirri M, et al. Microspheres for colonic delivery of ketoprofen- hidroxypropyl-b-cyclodextrin complex. Eur J Pharm Sci 2008;34:1–11.
- Schmidt C, Bodmeier R. A multiparticulate drug-delivery system based on pellets incorporated into congealable polyethylene glycol carrier materials. Int J Pharm 2001;216:9–16.
- Jyothi NV, Prasanna PM, Sakarkar SN, et al. Microencapsulation techniques, factors influencing encapsulation efficiency. J Microencapsul 2010;27:187–97.
- Agnihotri SA, Jawalkar SS, Aminabhavi TM. Controlled release of cephalexin through gellan gum beads: effect of formulation parameters on entrapment efficiency, size, and drug release. Eur J Pharm Biopharm 2006;63:249–61.
- Maiti S, Ranjita S, Mandola R, et al. Al+ 3 ion cross-linked and acetalated gellan hydrogel network beads for prolonged release of glipizide. Carbohydr Polym 2011;85:164–72.
- Racoviţă Ş, Vasiliu S, Popa M, Luca C. Polysaccharides based on micro and nanoparticles obtained by ionic gelation and their applications as drug delivery systems. Drug Deliv Syst 2009;54:709–18.
- Morris ER, Nishinari K, Rinaudo M. Gelation of gellan – a review. Food Hydrocoll 2012;28:373–411.
- Picone CS, Cunha RL. Chitosan-gellan electrostatic complexes: influence of preparation conditions and surfactant presence. Carbohydr Polym 2013;94:695–703.
- Shu XZ, Zhu KJ. Controlled drug release properties of ionically cross-linked chitosan beads: the influence of anion structure. Int J Pharm 2002;233:217–25.
- López OV, García MA, Zaritzky NE. Film forming capacity of chemically modified corn starches. Carbohydr Polym 2008;73:573–81.
- Narkar M, Sher P, Pawar A. Stomach-specific controlled release gellan beads of acid-soluble drug prepared by ionotropic gelation method. AAPS PharmSciTech 2010;11:267–77.
- Cao SL, Ren XW, Zhang QZ, et al. In situ gel based on gellan gum as new carrier for nasal administration of mometasone furoate. Int J Pharm 2009;365:109–15.
- Tayel SA, El-Nabarawi MA, Tadros MI, Abd-Elsalam WH. Promising ion-sensitive in situ ocular nanoemulsion gels of terbinafine hydrochloride: design, in vitro characterization and in vivo estimation of the ocular irritation and drug pharmacokinetics in the aqueous humor of rabbits. Int J Pharm 2013;443:293–305.
- Emeje MO, Franklin-Ude PI, Ofoefule SI. Evaluation of the fluid uptake kinetics and drug release from gellan gum tablets containing metronidazole. Int J Biol Macromol 2010;47:158–63.
- Reddy T, Tammishetti S. Gastric resistant microbeads of metal ion cross-linked carboxymethyl guar gum for oral drug delivery. J Microencapsul 2002;19:311–18.
- Nokhodchi A, Tailor A. In situ cross-linking of sodium alginate with calcium and aluminum ions to sustain the release of theophylline from polymeric matrices. Farmaco 2004;59:999–1004.
- Mundargi RC, Patil SA, Agnihotri SA, Aminabhavi TM. Development of polysaccharide-based colon targeted drug delivery systems for the treatment of amoebiasis. Drug Dev Ind Pharm 2007;33:255–64.
- Prezotti FG, Cury BS, Evangelista RC. Mucoadhesive beads of gellan gum/pectin intended to controlled delivery of drugs. Carbohydr Polym 2014;113:286–95.
- Gohel MC, Amin AF. Formulation optimization of controlled release diclofenac sodium microspheres using factorial design. J Control Release 1998;51:115–22.
- Nila MV, Sudhir MR, Cinu TA, et al. Floating microspheres of carvedilol as gastro retentive drug delivery system: 3(2) full factorial design and in vitro evaluation. Drug Deliv 2014;21:110–17.
- Dhawan S, Singla AK, Sinha VR. Evaluation of mucoadhesive properties of chitosan microspheres prepared by different methods. AAPS PharmSciTech 2004;5:e67.
- Peterson GL. A simplification of the protein assay method of Lowry et al. which is more generally applicable. Anal Biochem 1977;83:346–56.
- Rao KVR, Buri P. A novel in situ method to test polymers and coated microparticles for bioadhesion. Int J Pharm 1989;52:265–70.
- Seifert DB, Phillips JA. Production of small, monodispersed alginate beads for cell imobilization. Biotechnol Prog 1997;13:562–8.
- Chan ES, Lee BB, Ravindra P, Poncelet D. Prediction models for shape and size Ca-alginate macrobeads produced through extrusion-dripping method. J Colloid Interface Sci 2009;338:63–72.
- Cellesi F, Tirelli N, Hubbell JA. Towards a fully-synthetic substitute of alginate: development of a new process using thermal gelation and chemical cross-linking. Biomaterials 2004;25:5115–24.
- Kaity S, Isaac J, Ghosh A. Interpenetrating polymer network of locust bean gum-poly (vinyl alcohol) for controlled release drug delivery. Carbohydr Polym 2013;94:456–67.
- Nayak AK, Das B, Maji R. Calcium alginate/gum Arabic beads containing glibenclamide: development and in vitro characterization. Int J Biol Macromol 2012;51:1070–8.
- Mi FL, Sung HW, Shyu SS, et al. Synthesis and characterization of biodegradable TPP/genipin co-crosslinked chitosan gel beads. Polymer 2003;44:6521–30.
- Colombo P, Bettini R, Santi P, Peppas NA. Swellable matrices for controlled drug delivery: gel-layer behaviour, mechanisms and optimal performance. Pharm Sci Technol Today 2000;3:198–204.
- Khare AR, Peppas NA. Swelling/deswelling of anionic copolymer gels. Biomaterials 1995;16:559–67.
- Singh B, Bala R, Chauhan N. In vitro release dynamics of model drugs from psyllium and acrylic acid based hydrogels for the use in colon specific drug delivery. J Mater Sci Mater Med 2008;19:2771–80.
- Simonoska Crcarevska M, Glavas Dodov M, Goracinova K. Chitosan coated Ca-alginate microparticles loaded with budesonide for delivery to the inflamed colonic mucosa. Eur J Pharm Biopharm 2008;68:565–78.
- Mulhbacher J, Ispas-Szabo P, Mateescu MA. Cross-linked high amylose starch derivatives for drug release. II. Swelling properties and mechanistic study. Int J Pharm 2004;278:231–8.
- Shi L, Caldwell KD. Mucin adsorption to hydrophobic surfaces. J Colloid Interface Sci 2000;224:372–81.
- Asane GS, Nirmal SA, Rasal KB, et al. Polymers for mucoadhesive drug delivery system: a current status. Drug Dev Ind Pharm 2008;34:1246–66.
- Gamboa JM, Leong KW. In vitro and in vivo models for the study of oral delivery of nanoparticles. Adv Drug Deliv Rev 2013;65:800–10.
- Peppas NA, Sahlin JJ. Hydrogels as mucoadhesive and bioadhesive materials: a review. Biomaterials 1996;17:1553–61.
- Carvalho FC, Bruschi ML, Evangelista RC, Gremião MPD. Mucoadhesive drug delivery systems. Braz J Pharm Sci 2010;46:1–17.
- Varum FJ, Veiga F, Sousa JS, Basit AW. An investigation into the role of mucus thickness on mucoadhesion in the gastrointestinal tract of pig. Eur J Pharm Sci 2010;40:335–41.
- Sriamornsak P, Wattanakorn N, Takeuchi H. Study on the mucoadhesion mechanism of pectin by atomic force microscopy and mucin-particle method. Carbohydr Polym 2010;79:54–9.
- Joergensen L, Klösgen B, Simonsen AC, et al. New insights into the mucoadhesion of pectins by AFM roughness parameters in combination with SPR. Int J Pharm 2011;411:162–8.
- Adams E, De Maesschalck R, De Spiegeleer B, et al. Evaluation of dissolution profiles using principal component analysis. Int J Pharm 2001;212:41–53.
- Papadopoulou V, Kosmidis K, Vlachou M, Macheras P. On the use of the Weibull function for the discernment of drug release mechanisms. Int J Pharm 2006;309:44–50.