In vitro models to estimate drug penetration through the compromised stratum corneum barrier

References

• Menon GK, Cleary GW, Lane ME. The structure and function of the stratum corneum. Int J Pharm 2012;435:3–9.
   PubMed Web of Science ®Google Scholar
• Jepps OG, Dancik Y, Anissimov YG, Roberts MS. Modeling the human skin barrier–towards a better understanding of dermal absorption. Adv Drug Deliv Rev 2013;65:152–68.
   PubMed Web of Science ®Google Scholar
• Kristl J, Teskac K, Grabnar PA. Current view on nanosized solid lipid carriers for drug delivery to the skin. J Biomed Nanotechnol 2010;6:529–42.
   PubMed Web of Science ®Google Scholar
• Bouwstra JA, Honeywell-Nguyen PL, Gooris GS, Ponec M. Structure of the skin barrier and its modulation by vesicular formulations. Prog Lipid Res 2003;42:1–36.
   PubMed Web of Science ®Google Scholar
• Palac Z, Hurler J, Skalko-Basnet N, et al. Elastic liposomes-in-vehicle formulations destined for skin therapy: the synergy between type of liposomes and vehicle. Drug Dev Ind Pharm 2015;41:1274–53.
   PubMed Web of Science ®Google Scholar
• Rehman K, ZM H. Recent advances in gel technologies for topical and transdermal drug delivery. Drug Dev Ind Pharm 2014;40:433–40.
   PubMed Web of Science ®Google Scholar
• OECD. Guideline for testing of chemicals, No 428: skin absorption: in vitro methods. Paris: Organisation for Economic Cooperation and Developmente; 2003.
   Google Scholar
• OECD. Guidance document for the conduct of skin absorption studies, OECD series on testing and assessment, number 28. Paris: Organisation for Economical Cooperation and Development; 2004.
   Google Scholar
• Mohammed D, Matts PJ, Hadgraft J, Lane ME. Variation of stratum corneum biophysical and molecular properties with anatomic site. AAPS J 2012;14:806–12.
   PubMed Web of Science ®Google Scholar
• van Smeden J, Janssens M, Boiten WA, et al. Intercellular skin barrier lipid composition and organization in Netherton syndrome patients. J Invest Dermatol 2014;134:1238–45.
   PubMed Web of Science ®Google Scholar
• Bouwstra JA, Ponec M. The skin barrier in healthy and diseased state. Biochim Biophys Acta 2006;1758:2080–95.
   PubMed Web of Science ®Google Scholar
• Janssens M, van Smeden J, Gooris GS, et al. Increase in short-chain ceramides correlates with an altered lipid organization and decreased barrier function in atopic eczema patients. J Lipid Res 2012;53:2755–66.
   PubMed Web of Science ®Google Scholar
• Gattu S, Maibach HI. Enhanced absorption through damaged skin: an overview of the in vitro human model. Skin Pharmacol Physiol 2010;23:171–6.
   PubMed Web of Science ®Google Scholar
• Flaten GE, Palac Z, Engesland A, et al. In vitro skin models as a tool in optimization of drug formulation. Eur J Pharm Sci 2015;75:10–24.
   PubMed Web of Science ®Google Scholar
• Oliveira G, Hadgraft J, Lane ME. The role of vehicle interactions on permeation of an active through model membranes and human skin. Int J Cosmet Sci 2012;34:536–45.
   PubMed Web of Science ®Google Scholar
• Sinko B, Kokosi J, Avdeef A, Takacs-Novak K. A PAMPA study of the permeability-enhancing effect of new ceramide analogues. Chem Biodivers 2009;6:1867–74.
   PubMed Web of Science ®Google Scholar
• Sinko B, Garrigues TM, Balogh GT, et al. Skin-PAMPA: a new method for fast prediction of skin penetration. Eur J Pharm Sci 2012;45:698–707.
   PubMed Web of Science ®Google Scholar
• Netzlaff F, Lehr CM, Wertz PW, Schaefer UF. The human epidermis models EpiSkin, SkinEthic and EpiDerm: an evaluation of morphology and their suitability for testing phototoxicity, irritancy, corrosivity, and substance transport. Eur J Pharm Biopharm 2005;60:167–78.
   PubMed Web of Science ®Google Scholar
• Schafer-Korting M, Bock U, Diembeck W, et al. The use of reconstructed human epidermis for skin absorption testing: results of the validation study. Altern Lab Anim 2008;36:161–87.
   PubMed Web of Science ®Google Scholar
• Caussin J, Gooris GS, Janssens M, Bouwstra JA. Lipid organization in human and porcine stratum corneum differs widely, while lipid mixtures with porcine ceramides model human stratum corneum lipid organization very closely. Biochim Biophys Acta 2008;1778:1472–82.
   PubMed Web of Science ®Google Scholar
• Klang V, Schwarz JC, Lenobel B, et al. In vitro vs. in vivo tape stripping: validation of the porcine ear model and penetration assessment of novel sucrose stearate emulsions. Eur J Pharm Biopharm 2012;80:604–14.
   PubMed Web of Science ®Google Scholar
• Engesland A, Skar M, Hansen T, et al. New applications of phospholipid vesicle-based permeation assay: permeation model mimicking skin barrier. J Pharm Sci 2013;102:1588–600.
   PubMed Web of Science ®Google Scholar
• Engesland A, Skalko-Basnet N, Flaten GE. PVPA and EpiSkin® in assessment of drug therapies destined for skin administration. J Pharm Sci 2015;104:1119–27.
   PubMed Web of Science ®Google Scholar
• Flaten GE, Dhanikula AB, Luthman K, Brandl M. Drug permeability across a phospholipid vesicle based barrier: a novel approach for studying passive diffusion. Eur J Pharm Sci 2006;27:80–90.
   PubMed Web of Science ®Google Scholar
• Kanzer J, Tho I, Flaten GE, et al. In-vitro permeability screening of melt extrudate formulations containing poorly water-soluble drug compounds using the phospholipid vesicle-based barrier. J Pharm Pharmacol 2010;62:1591–8.
   PubMed Web of Science ®Google Scholar
• Hansen T, Ausbacher D, Flaten GE, et al. Synthesis of cationic antimicrobial beta(2,2)-amino acid derivatives with potential for oral administration. J Med Chem 2011;54:858–68.
   PubMed Web of Science ®Google Scholar
• Naderkhani E, Erber A, Skalko-Basnet N, Flaten GE. Improved permeability of acyclovir: optimization of mucoadhesive liposomes using the phospholipid vesicle-based permeation assay. J Pharm Sci 2014;103:661–8.
   PubMed Web of Science ®Google Scholar
• Abraham W, Downing DT. Preparation of model membranes for skin permeability studies using stratum corneum lipids. J Invest Dermatol 1989;93:809–13.
   PubMed Web of Science ®Google Scholar
• Bouwstra J. Structure of stratum corneum lipid layers and interactions with lipid liposomes. Cosmetic science and technology series, New York: Marcel Dekker lnc. 2002;24:37–73.
   Google Scholar
• Schmieder S, Patel P, Krishnamurthy K. Research techniques made simple: drug delivery techniques, Part 1: concepts in transepidermal penetration and absorption. J Invest Dermatol 2015;135:1–5.
   PubMed Web of Science ®Google Scholar
• Elzainy AA, Gu X, Simons FE, Simons KJ. Hydroxyzine- and cetirizine-loaded liposomes: effect of duration of thin film hydration, freeze-thawing, and changing buffer pH on encapsulation and stability. Drug Dev Ind Pharm 2005;31:281–91.
   PubMed Web of Science ®Google Scholar
• Flaten GE, Skar ML, Luthman K, Brandl M. Drug permeability across a phospholipid vesicle-based barrier: 3. Characterization of drug-membrane interactions and the effect of agitation on the barrier integrity and on the permeability. Eur J Pharm Sci 2007;30:324–32.
   PubMed Web of Science ®Google Scholar
• Flaten GE, Bunjes H, Luthman K, Brandl M. Drug permeability across a phospholipid vesicle-based barrier: 2. Eur J Pharm Sci 2006;28:336–43.
   PubMed Web of Science ®Google Scholar
• Jacobi U, Kaiser M, Toll R, et al. Porcine ear skin: an in vitro model for human skin. Skin Res Technol 2007;13:19–24.
   PubMed Web of Science ®Google Scholar
• Bronaugh RL, Stewart RF. Methods for in vitro percutaneous absorption studies IV: the flow-through diffusion cell. J Pharm Sci 1985;74:64–7.
   PubMed Web of Science ®Google Scholar
• Nielsen JB, Nielsen F, Sorensen JA. Defense against dermal exposures is only skin deep: significantly increased penetration through slightly damaged skin. Arch Dermatol Res 2007;299:423–31.
   PubMed Web of Science ®Google Scholar
• Rubio L, Alonso C, Lopez O, et al. Barrier function of intact and impaired skin: percutaneous penetration of caffeine and salicylic acid. Int J Dermatol 2011;50:881–9.
   PubMed Web of Science ®Google Scholar
• Palac Z, Engesland A, Flaten GE, et al. Liposomes for (trans)dermal drug delivery: the skin-PVPA as a novel in vitro stratum corneum model in formulation development. J Liposome Res 2014;24:313–22.
   PubMed Web of Science ®Google Scholar
• Lian G, Chen L, Han L. An evaluation of mathematical models for predicting skin permeability. J Pharm Sci 2008;97:584–98.
   PubMed Web of Science ®Google Scholar
• Avdeef A. Absorption and Drug Development; Solubility, Permeability and Charge State. 1. ed. New Jersey: Wiley-Interscience; 2003: 116–246.
   Google Scholar
• Benoit RL, Frenchette M. Protonation of hypoxanthine, guanine, xanthine, and caffeine. Can J Chem 1985;63:3053–6.
   Web of Science ®Google Scholar
• Chiang A, Tudela E, Maibach HI. Percutaneous absorption in diseased skin: an overview. J Appl Toxicol 2012;32:537–63.
   PubMed Web of Science ®Google Scholar
• Petitot F, Moreels AM, Paquet F. Evolution of the percutaneous penetration and distribution of uranyl nitrate as a function of skin-barrier integrity: an in vitro assessment. Drug Chem Toxicol 2010;33:316–24.
   PubMed Web of Science ®Google Scholar
• Petitot F, Frelon S, Moreels AM, et al. Incorporation and distribution of uranium in rats after a contamination on intact or wounded skin. Health Phys 2007;92:464–74.
   PubMed Web of Science ®Google Scholar
• Zhu C, Jiang L, Chen TM, Hwang KK. A comparative study of artificial membrane permeability assay for high throughput profiling of drug absorption potential. Eur J Med Chem 2002;37:399–407.
   PubMed Web of Science ®Google Scholar
• Sugano K, Takata N, Machida M, et al. Prediction of passive intestinal absorption using bio-mimetic artificial membrane permeation assay and the paracellular pathway model. Int J Pharm 2002;241:241–51.
   PubMed Web of Science ®Google Scholar
• Nokhodchi A, Sharabiani K, Rashidi MR, Ghafourian T. The effect of terpene concentrations on the skin penetration of diclofenac sodium. Int J Pharm 2007;335:97–105.
   PubMed Web of Science ®Google Scholar
• Chuasuwan B, Binjesoh V, Polli JE, et al. Biowaiver monographs for immediate release solid oral dosage forms: diclofenac sodium and diclofenac potassium. J Pharm Sci 2009;98:1206–19.
   PubMed Web of Science ®Google Scholar
• Alelyunas YW, Pelosi-Kilby L, Turcotte P, et al. A high throughput dried DMSO LogD lipophilicity measurement based on 96-well shake-flask and atmospheric pressure photoionization mass spectrometry detection. J Chromatogr a 2010;1217:1950–5.
   PubMed Web of Science ®Google Scholar
• Wishart DS, Knox C, Guo AC, et al. DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res 2008;36:D901–6.
   PubMed Web of Science ®Google Scholar
• Akomeah FK, Martin GP, Muddle AG, Brown MB. Effect of abrasion induced by a rotating brush on the skin permeation of solutes with varying physicochemical properties. Eur J Pharm Biopharm 2008;68:724–34.
   PubMed Web of Science ®Google Scholar
• Tsai JC, Sheu HM, Hung PL, Cheng CL. Effect of barrier disruption by acetone treatment on the permeability of compounds with various lipophilicities: implications for the permeability of compromised skin. J Pharm Sci 2001;90:1242–54.
   PubMed Web of Science ®Google Scholar
• Rubio L, Alonso C, Lopez O, et al. Barrier function of intact and impaired skin: percutaneous penetration of caffeine and salicylic acid. Int J Dermatol 2011;50:881–9.
   PubMed Web of Science ®Google Scholar
• Takahashi K, Sakano H, Yoshida M, et al. Characterization of the influence of polyol fatty acid esters on the permeation of diclofenac through rat skin. J Control Release 2001;73:351–8.
   PubMed Web of Science ®Google Scholar
• Sintov AC, Botner S. Transdermal drug delivery using microemulsion and aqueous systems: influence of skin storage conditions on the in vitro permeability of diclofenac from aqueous vehicle systems. Int J Pharm 2006;311:55–62.
   PubMed Web of Science ®Google Scholar