3
Views
13
CrossRef citations to date
0
Altmetric
Original Article

Controversies in Treatment of Small Cell Carcinoma of the Lung

&
Pages 367-387 | Published online: 11 Jun 2009

References

  • Fox W., Scadding J G. Medical Research Council comparative trial of surgery and radiotherapy for primary treatment of small-celled or oat-celled carcinoma of bronchus: Ten-year-follow-up. Lancet 1973; 2: 63–65
  • Salazar O M, Creech R H. “The state of the art” toward defining the role of radiation therapy in the management of small cell bronchogenic carcinoma. Int J Rad Oncol Biol Phys 1980; 6: 1103–1107
  • Matthews M J, Kanhouwa S, Pickren J, et al. Frequency of residual and metastatic tumors in patients undergoing curative surgical resection for lung cancer. Cancer Chemother Rep 1973; 4: 63–67
  • Greco F A, Richardson R L, Snell J D, et al. Small cell lung cancer: Complete remission and improved survival. Am J Med 1979; 66: 625–630
  • Comis R. Small cell carcinoma of the lung. Cancer Treat Rev 1982; 9: 237–258
  • Morstyn G, Ihde D C, Lichter A S, et al. Small cell lung cancer 1973–1983: Early progress and recent obstacles. Int J Rad Oncol Biol Phys 1984; 10: 515–539
  • Ihde D. Current status of therapy for small cell carcinoma of the lung. Cancer 1984; 54: 2722–2728
  • Aisner J, Alberto P, Bitran J, et al. Role of chemotherapy in small cell lung cancer: A consensus report of the International Assocation for the Study of Lung Cancer Workshop. Cancer Treat Rep 1983; 67: 37–43
  • Spremulli E N, Dexter D L. Human tumor cell heterogeneity and metastasis. J Clin Oncol 1983; 8: 496–509
  • Curt G., Carney D, Cowan R, et al. Unstable methotrexate resistance in human small cell carcinoma associated with double minute chromosomes. N Engl J Med 1983; 308: 199–202
  • Goldie J H, Coldman A J. A mathematical model for relating the drug sensitivity of tumors to their spontaneous mutation rate. Cancer Treat Rep 1979; 63: 1727–1733
  • Goldie J H, Coldman A J, Gudauskas G A. Rationale for the use of alternating non-cross-resistant chemotherapy. Cancer Treat Rep 1982; 66: 439–449
  • Alberto P, Berchtold W, Sonntag R, et al. Chemotherapy of small cell carcinoma of the lung: Comparison of cyclic alternative combinations with simultaneous combinations of four and seven agents. Eur J Cancer Clin Oncol 1981; 17: 1027–1033
  • Osterlind K., Sorenson S, Hansen H, et al. Treatment of advanced small cell carcinoma of the lung: Continuous versus alternating combination chemotherapy. Cancer Res 1983; 43: 6085–6089
  • Havemann K., Harms V., Gropp C, et al. Randomized trial comparing sequential combination chemotherapy (A) with cyclic alternating chemotherapy (B) in small cell lung cancer (SCCL). Proc Am Soc Clin Onc 1984; 3: 232
  • Ettinger D, Lagakos S. Phase III study of CCNU, cyclophosphamide, adriamycin, vincristine and VP-16 in small-cell carcinoma of the lung. Cancer 1982; 49: 1544–1554
  • Daniels J R, Chak L Y, Bl Sikic, et al. Chemotherapy of small-cell carcinoma of the lung: A randomized comparison of alternating and sequential combination chemotherapy programs. J Clin Oncol 1984; 2: 1192–1199
  • Krauss S, Lowenbraun S, Bartolucci A, et al. Alternating non-cross resistant drug combinations in the treatment of small-cell carcinoma of the lung. Cancer Clin Trials 1981; 4: 147–153
  • Aisner J, Whitacre M, Van Echo D A, et al. Combination chemotherapy for small cell carcinoma of the lung: Continuous versus alternating non-cross-resistant combinations. Cancer Treat Rep 1982; 66: 221–230
  • Broder L., Selawry O, Charyulu K, et al. A controlled clinical trial testing two potentially non-cross resistant chemotherapeutic regimens in small-cell carcinoma of the lung. Chest 1981; 79: 327–335
  • Lininger T, Fleming T, Eagen R. Evaluation of alternating chemotherapy and sites and extent of disease in extensive small cell lung cancer. Cancer 1981; 48: 2147–2153
  • Elliot J, Osterlind K, Hansen H. Cyclic alternating “non-cross resistant” chemotherapy in the management of small cell anaplastic carcinoma of the lung. Cancer Treat Rev 1985, in press
  • Cohen M H, Broder L E, Fossieck B E, et al. Combination chemotherapy with vincristine, adriamycin and procarbazine in previously treated patients with small cell carcinoma. Cancer Treat Rep 1977; 61: 485–487
  • Aroney R, Bell D, Chan W, et al. Alternating non-cross-resistant combination of chemotherapy for small cell anaplastic carcinoma of the lung. Cancer 1982; 49: 2449–2454
  • Dillman R, Taetle R, Seagren S, et al. Extensive disease small cell carcinoma of the lung: trial of non-cross-resistant chemotherapy and consolidation radiotherapy. Cancer 1982; 49: 2003–2008
  • Mehta C, Vogl S. Cycling non-cross resistant combination chemotherapy (CT) for small cell lung cancer (SCLC) in remission (R)-50% prolongation of remission duration without prolongation of survival and with enhanced toxicity. Proc Am Soc Clin One 1981; 1: 152
  • Arnold A M, Williams C J, Mead G M, et al. Combination chemotherapy using high or low dose methotrexate for small cell carcinoma of the lung-a randomized trial. Med Oncol Tumor Pharmacother 1984; 1: 9–14
  • Sierocki J S, Hilaris B S, Hopfan S, et al. Cis-dichlorodiamineplatinum (II) and VP-16–213: An active induction regimen for small cell carcinoma of the lung. Cancer Treat Rep 1979; 63: 1593–1597
  • Einhorn L, Williams S, Loehrer P. Platinum (P) + VP-16 chemotherapy for refractory small cell lung cancer (RSCLC). Proc Am Assoc Cancer Res 1984; 25: 174
  • Evans W, Osoba D, Feld R, et al. Etoposide (VP-16) and cisplatin: an effective treatment for relapse in small cell lung cancer. J Clin Oncol 1985; 3: 36–71
  • Kessinger A, Foley J F, Lemon M H. Can maximum benefit be achieved with lower dosages and less toxicity in the chemo-therapeutic management of small cell lung cancer?. Proc Am Soc Clin One 1983; 2: 186
  • Einhorn L, Bond W H, Hornback W, et al. Long term results in combined modality treatment of small cell lung cancer. Sem Oncol 1978; 5: 309–313
  • Livingston R B, Greenstreet R L. Reinduction prolongs survival in complete responders (CR) with small cell lung cancer. Proc Am Soc Clin Oncol 1982; 1: 151
  • Abeloff M D, Ettinger D S, Order S E, et al. Intensive induction chemotherapy in 54 patients with small cell carcinoma of the lung. Cancer Treat Rep 1981; 65: 639–646
  • Smith I., Sappino A, Bondy P, et al. Long-term survival five years or more after combination chemotherapy and radiotherapy for small cell lung carcinoma. Eur J Cancer Clin Oncol 1981; 11: 1249–1253
  • Souhami R, Harper P, Ling D, et al. Higher dose cyclophosphamide with autologous marrow transplantation on initial treatment of small cell carcinoma of the bronchus. Cancer Chemother Pharm 1982; 8: 31–34
  • Feld R, Evans W K, DeBoer G, et al. Combined modality induction therapy without maintenance chemotherapy for small cell carcinoma of the lung. J Clin Oncol 1984; 2: 294–304
  • Vogl S E, Mehta C. High-dose cyclophosphamide in the induction chemotherapy of small cell lung cancer-minor improvements in the rate of remission and in survival. III World Conf Lung Cancer, Japan, 1982; 168, Abstracts
  • Hande K, Oldham R, Fer M, et al. Randomized study of high-dose versus low-dose methotrexate in the treatment of extensive small cell lung cancer. Am J Med 1982; 73: 413–419
  • Johnson D H, Wolff S N, Porter L L, et al. Combination high-dose (HD) VP-16–213 (E) cyclophosphamide (C) chemotherapy (CT) without bone marrow transplantation (BMT) for extensive stage small cell lung cancer (SCLC). Proc Am Soc Clin Oncol 1984; 3: 215
  • Brower M, Ihde D C, Johnston-Early A. Treatment of extensive stage small cell bronchogenic carcinoma: Effects of variation in intensity of induction chemotherapy. Am J Med 1983; 75: 993–1000
  • Thomas E D, Buckner C D, Clift R, et al. Marrow transplantation for acute nonlymphoblastic leukemia in first remission. N Engl J Med 1979; 301: 597–599
  • Ihde D C, Lichter A S, Deisseroth A B, et al. Late intensive combined modality therapy with autologous bone marrow infusion in extensive stage small cell lung cancer. Proc. 13th International Congress of Chemotherapy, Egermann, Vienna, 1983; 281/5–281/8
  • Klastersky J, Nicaise C, Longeval E, et al. Cisplatin, adriamycin and etoposide (CAV) for remission induction of small-cell bronchogenic carcinoma. Evaluation of efficacy and toxicity and pilot study of a “late intensification” with autologous bone-marrow rescue. Cancer 1982; 50: 652–658
  • Stewart P, Buckner C D, Thomas E D., et al. Intensive chemo-radiotherapy with autologous marrow transplantation for small cell carcinoma of the lung. Cancer Treat Rep 1983; 67: 1055–1059
  • Combleet M, Gregor A, Allan S, et al. High dose melphalan as consolidation therapy for good prognosis patients with small cell carcinoma of bronchus (SCCB). Proc Am Soc Clin Oncol 1984; 3: 210
  • Rosen S, Mulshine J, Cuttitta F, et al. Analysis of human small cell lung cancer differentiation antigens using a panel of rat monoclonal antibodies. Cancer Res 1984; 44: 2052–2061
  • Spitzer G, Farha P, Dicke K, et al. High dose intensification with autologous bone marrow transplantation (ABMT) in limited small cell bronchogenic carcinoma (SCBC). Proc Am Soc Clin Oncol 1984; 3: 221
  • Perez C A, Einhorn L., Oldham R K, et al. Randomized trial of radiotherapy to the thorax in limited small-cell carcinoma of the lung treated with multiagent chemotherapy and elective brain irradiation: A preliminary report. J Clin Oncol 1984; 2: 1200–1208
  • Shank B, Natale R B, Hilaris B S, et al. Treatment of small cell carcinoma of lung with combined high dose mediastinal irradiation, whole brain prophylaxis and chemotherapy. Int J Rad Oncol Biol Phys 1981; 7: 469–475
  • Scher H, Chapman R, Shank B, et al. Combination chemotherapy (CT) and radiotherapy (RT) with and without thymosin (T) in small cell lung cancer (SCLC). III World Conf Lung Cancer, Japan, 1982; 155, Abstracts
  • Goodman G E, Miller T P, Manning M M, et al. Treatment of small cell lung cancer with VP-16, vincristine, doxorubicin (Adriamycin). cyclophosphamide (EVAC), and high-dose chest radiotherapy. J Clin Oncol 1983; 1: 483–488
  • Feld R. Complications in the treatment of small cell carcinoma of the lung. Cancer Treat Rep 1981; 8: 5–25
  • Markman M, Pavy M, Abeloff M. Acute leukemia following intensive therapy for small-cell carcinoma of the lung. Cancer 1982; 50: 672–675
  • Johnson B E, Ihde D C, Lichter A S, et al. Five to 10 year follow-up of small cell lung cancer (SCLC) patients disease free at 30 months: Chronic toxicities and late relapses. Proc Am Soc Clin One 1984; 3: 218
  • Byhardt R W, Cox J D, Holoye P Y, et al. The role of consolidation irradiation in combined modality therapy of small cell carcinoma of the lung. lnt J Rad Oncol Biol Phys 1982; 8: 1271–1276
  • Thatcher N, Hunter R, Jegarajah S, et al. Eleven-week course of sequential methotrexate, thoracic irradiation and moderate-dose cyclophosphamide for “limited” stage small cell bronchogenic carcinoma. A study from the Manchester Lung Tumour Group. Lancet 1982; 1: 1040–1042
  • Johnson R, Brereton H, Kent C. Total therapy for small cell carcinoma of the lung. Ann Thor Surg 1978; 25: 510–515
  • Woods R L, Levi J A. Chemotherapy for small ceil lung cancer (SCLC): a randomized study of maintenance therapy with cyclophosphamide, adriamycin and vincristine (CAV) after remission induction with cis-platinum (cis-DDP), VP-16–213 and radiotherapy. Proc Am Soc Clin Oncol 1984; 3: 214
  • Lenhard R, Woo K, Abeloff M. Predictive value of regression rates following chemotherapy of small cell carcinoma of the lung. Cancer Res 1983; 43: 3013–3017
  • Carney D N, Broder L, Edelstein M, et al. Experimental studies of the biology of human small cell lung cancer. Cancer Treat Rep 1983; 67: 27–36
  • Carney D N, Mitchell J B, Kinsella T J. In vitro radiation and chemotherapy sensitivity of established cell lines of human small cell lung cancer and its large cell morphological variants. Cancer Res 1983; 43: 2806–2811
  • Whang-Peng J, Kao-Shan C, Lee E, et al. Specific chromosome defect associated with human small cell lung cancer: Deletion 3p (14–23). Science 1982; 215: 191–192
  • Eagen R T, Carr D T, Frytak S, et al. VP-16–213 versus poly-chemotherapy in patients with advanced small cell lung cancer. Cancer Treat Rep 1976; 60: 949–951
  • Harper P C, Dally M B, Geddes D M, et al. Epipodophyllotoxin (VP16–213) in small cell carcinoma of the bronchus resistant to initial combination chemotherapy. Cancer Chemother Pharmacol 1982; 7: 179–180
  • Antman K, Pomfret E, Karp G, et al. Phase II trial of etoposide in previously treated patients with small cell carcinoma of the lung. Cancer Treat Rep 1984; 68: 1413–1414
  • Issell B F, Einhorn L H, Comis R L, et al. Multicenter phase II trial of etoposide in refractory small cell lung cancer. Cancer Treat Rep 1985; 69: 127–128
  • Natale R, Gralla R, Wittes R. Phase II trial of vindesine in patients with small cell lung carcinoma. Cancer Treat Rep 1981; 65: 129–131
  • Chang A Y, Witte R S, Tormey D C, et al. Evaluation of vindesine in patients with refractory small cell lung cancer. Cancer Treat Rep 1984; 68: 1407–1408
  • Osterlind K, Dombernowsky P, Sorenson P, et al. Vindesine in the treatment of small cell anaplastic bronchogenic carcinoma. Cancer Treat Rep 1981; 65: 145–148
  • Smith I E, Harland S J, Robinson B A, et al. Carboplatin: A very active new cisplatin analog in the treatment of small cell lung cancer. Cancer Treat Rep 1985; 69: 43–46
  • Madajewicz S, Takita H, Creaven P, et al. Phase II study of iproplatin (IPP) in small cell carcinoma of the lung (SCCL). Proc Am Soc Clin One 1984; 3: 225
  • Cohen E, Gralla R, Kris M, et al. Phase II studies in small cell lung cancer (SCLC); an analysis of 97 trials. Proc Am Soc Clin Oncol 1985; 4: 190
  • Jackson D V, ZeKan P J, Caldwell R D, et al. VP-16–213 in combination chemotherapy with chest irradiation for small-cell-lung cancer: A randomized trial of the Piedmont Oncology Association. J Clin Oncol 1984; 2: 1343–1351
  • Nugent J L, Bunn P A, Matthews M J, et al. CNS metastases in small cell bronchogenic carcinoma: Increasing frequency and changing pattern with lengthening survival. Cancer 1979; 44: 1885–1893
  • Doyle T J. Brain metastasis in the natural history of small-cell lung cancer 1972–1979. Cancer 1982; 50: 752–754
  • Ihde D C, Makuch R W, Carney D N, et al. Prognostic implications of stage of disease and sites of metastases in patients with small cell carcinoma of the lung treated with intensive combination chemotherapy. Am Rev Resp Dis 1981; 123: 500–507
  • Bunn P A, Nugent J L, Matthews M J. Central nervous system metastases in small cell bronchogenic carcinoma. Sem Oncol 1978; 5: 314–322
  • Komaki R, Cox J D, Whitson W. Risk of brain metastasis from small cell carcinoma of the lung related to length of survival and prophylactic irradiation. Cancer Treat Rep 1981; 65: 811–814
  • Jackson D V, Richards F, Cooper R, et al. Prophylactic cranial irradiation in small cell carcinoma of the lung. JAMA 1977; 237: 2730–2733
  • Seydel H G, Crrech R, Pagano M, et al. Combined modality treatment of regional small cell undifferentiated carcinoma of the lung: A cooperative study of the RTOG and ECOG. Int J Rad Oncol Biol Phys 1983; 9: 1135–1141
  • Beiler D D, Kane R C, Bernath A M, et al. Low dose elective brain irradiation in small cell carcinoma of the lung. Int J Rad Oncol Biol Phys 1979; 5: 941–945
  • Maurer L H, Tulloh M, Weiss R B, et al. A randomized combined modality trial in small cell carcinoma of the lung: Comparison of combination chemotherapy-radiation therapy versus cyclophosphamide-radiation therapy effects of maintenance chemotherapy and prophylactic whole brain irradiation. Cancer 1980; 45: 30–39
  • Cox J D, Petrovich Z, Paig C, et al. Prophylactic cranial irradiation with inoperable carcinoma of the lung: Preliminary report of a cooperative trial. Cancer 1978; 42: 1135–1140
  • Hirsch F R, Hansen H H, Paulson O B, . Development of brain metastases in small-cell anaplastic carcinoma of the lung. CNS Complications of Malignant Disease, J MA White-House, H EM Kay, et al. Macmillan, New York 1979; 175–184
  • Rosen S T, Makuch R W, Lichter A S, et al. Role of prophylactic cranial irradiation in prevention of central nervous system metastases in small cell lung cancer: Potential benefit restricted to patients with complete response. Am J Med 1983; 74: 615–624
  • Aroney R S, Aisner J, Wesley M N, et al. Value of prophylactic cranial irradiation given at complete remission in small cell lung carcinoma. Cancer Treat Rep 1983; 67: 675–682
  • Ellison N, Bernath A, Kane R, et al. Disturbing problems of success: Clinical status of long-term survivors of small cell lung cancer (SCLC). Proc Am Soc Clin Oncol 1982; 1: 149
  • Walker R, Lazar R M, Gralla R, et al. Neuropsychological abnormalities in long term survivors of small cell lung cancer receiving prophylactic cranial irradiation. Am Soc Clin One 1985, Submitted to
  • Licciardello J, Bromer R, Karp D, et al. Delayed neurotoxicity (DN) after prophylactic cranial irradiation (PCXRT) or mediastinal irradiation with chemotherapy for patients with small cell lung cancer. Proc Am Soc Clin One 1983; 2: 189
  • Scher H, Hilaris B, Wittes R. Long term follow-up of combined modality therapy in small cell carcinoma (SCLC) of the lung. Proc Am Soc Clin One 1983; 2: 199
  • Livingston R B, Stephens R L, Bonnet J D, et al. Long-term survival and toxicity in small cell lung cancer: A Southwest Oncology Group study. Am J Med 1984; 77: 415–417
  • Looper J D, Einhorn L H, Garcia S A, et al. Severe neurologic problems following successful therapy for small cell lung cancer (SCLC). Proc Am Soc Clin One 1984; 3: 231
  • Lee J S, Lee Y Y, Umsawasdi T, et al. Neurotoxicity (NT) in long-term survivors (LTS) of small cell lung cancer (SCLC). Proc Am Soc Clin One 1984; 3: 220
  • Mira J G, Chen T, Livingston R B. Evaluation of prophylactic brain irradiation (PB1) vs. therapeutic irradiation (TBI) in disseminated small cell lung carcinoma (SCLC): A Southwest Oncology Group (SWOG) study. Int J Rad Oncol Biol Phys 1983; 9: 122
  • Catane R, Schwade J G, Yarr I, et al. Follow-up neurological evaluation in patients with small cell lung carcinoma treated with prophylactic cranial irradiation and chemotherapy. Int J Rad Oncol Biol Phys 1981; 7: 105–109
  • Rosenman J, Choi N C. Improved quality of life of patients with small-cell carcinoma of the lung elective irradiation of the brain. Int J Rad Oncol Biol Phys 1981; 8: 1041–1043
  • Crane J, Nelson M, Ihde D, et al. A comparison of computed tomography and radionuclide scanning for detection of brain metastases in small cell lung cancer. J Clin Oncol 1984; 2: 1017–1024
  • Byhardt R W, Cox J D. Is chest radiotherapy necessary in any or all patients with small cell carcinoma of the lung? Yes. Cancer Treat Rep 1983; 67: 209–215
  • Ochs J J, Tester W J, Cohen M H, et al. “Salvage” radiation therapy for intrathoracic small cell carcinoma of the lung progressing on combination chemotherapy. Cancer Treat Rep 1983; 67: 1123–1126
  • Looper J D, Hornback N B. The role of chest irradiation in limited small cell carcinoma of the lung treated with combination chemotherapy. Int J Rad Oncol Biol Phys 1984; 10: 1855–1860
  • Dombernowsky P, Hansen H H, Hansen M, et al. Treatment of small cell anaplastic bronchogenic carcinoma. Results from 2 randomized trials. II World Conf Lung Cancer. Copenhagen. Excerpta Medica, Amsterdam 1980; 149, Abstracts
  • Hansen H H, Dombernowsky P, Hansen H S, et al. Chemotherapy versus chemotherapy plus radiotherapy in regional small-cell carcinoma of the lung-a randomized trial. Proc Am Assoc Cancer Res 1979; 20: 277
  • Souhami R L, Geddes D M, Spiro S G, et al. Radiotherapy in small cell cancer of the lung treated with combination chemotherapy: A controlled trial. Br Med J 1984; 288: 1643–1646
  • Fox R M, Woods R L, Brodie G N, et al. A randomized study: Small cell anaplastic lung cancer treated by combination chemotherapy and adjuvant radiotherapy. Int J Rad Oncol Biol Phys 1980; 6: 1083–1085
  • Fox R M, Tattersall M HN, Woods R L. Radiation therapy as an adjuvant in small cell lung cancer treated by combination chemotherapy: A randomized study. Proc Am Soc Clin One 1981; 22: 502
  • Ihde D C, et al. Fourth Int Conf Adjuvant Ther Cancer. Reported in Clin Cancer Letter 1984; 7: 3
  • Lichter A S, Bunn P A, Ihde D C, et al. The role of radiation therapy in the treatment of small cell lung cancer. Nat Conf Rad Oncol, Am Cancer Soc, San Francisco, CA, 1984, Abstract
  • Bunn P., Cohen M, Lichter A, et al. Randomized trial of chemotherapy versus chemotherapy plus radiotherapy in limited stage small cell lung cancer (SCLC). Proc Am Soc Clin Oncol 1983; 2: 200
  • Perez C, Einhorn L, Oldham R K, et al. Value of radiation therapy to the thorax in limited small cell carcinoma of the lung treated with multiagent chemotherapy and elective brain irradiation. J Clin Oncol 1984; 2: 1200–1208
  • Perry M C, Eaton W L, Ware J, et al. Chemotherapy (CT) with or without radiation therapy (RT) in limited small cell cancer of the lung (SCCL). Proc Am Soc Clin Oncol 1984; 3: 230
  • Morgan D AL. Radiotherapy in small cell cancer of the lung. Letter, Br Med J 1984; 289: 189–190
  • Choi C H, Carey R W. Small cell anaplastic carcinoma of the lung: Reappraisal of current management. Cancer 1976; 37: 2651–2657
  • Cox J D, Byhardt R W, Wilson J F, et al. Dose-time relationships and the local control of small cell carcinoma of the lung. Radiology 1978; 128: 205–207
  • Eaton W L, Maurer H, Glicksman A, et al. The relationship of infield recurrences to prescribed tumor dose in small cell carcinoma of the lung. Int J Rad Oncol Biol Phys 1981; 7: 1223
  • Bleehen N M, Bunn P A, Cox J D, et al. Role of radiation therapy in small cell anaplastic carcinoma of the lung. Cancer Treat Rep 1983; 67: 11–19
  • Goodman G E, Manning M R, Ketchel S, . Improved survival in small cell lung cancer treated with combination (EVAC) and high dose adjuvant radiotherapy (XRT). Adjuvant Therapy of Cancer III, S Salmon, S Jones, et al. Grune and Stratton, New York 1981
  • Shank B, Scher H, Hilaris B, et al. Increased survival with high dose multifield radiotherapy and intensive chemotherapy in limited small cell carcinoma of lung. Int J Rad Oncol Biol Phys 1983; 9: 122–123
  • Martini N. Surgery. Commentary-treatment of small cell undifferentiated carcinoma of the lung: Update of recent results, R B Weiss, J D Minna, E Glatstein, et al, 1980; 64: 539–548, Cancer Treat Rep
  • Foster J M, Prager R L, Hainsworth J D, et al. Limited-stage small-cell carcinoma (SCC): Prospective evaluation regarding the feasibility of adjuvant surgery. Proc Am Soc Clin One 1983; 2: 196
  • Hande K R, DesPrez R M. Current perspectives in small cell lung cancer. Chest 1984; 85: 669–677
  • Higgins G A, Shields T W, Keehn R J. The solitary pulmonary nodule: ten-year followup of Veterans Administration-Armed Forces cooperative study. Arch Surg 1975; 110: 570–575
  • Shields T W, Higgins G A, Matthews M J, et al. Surgical resection in the management of small cell carcinoma of the lung. J Thorac Cardiovasc Surg 1982; 84: 481–488
  • Shore D F, Paneth M. Survival after resection of small cell carcinoma of the bronchus. Thorax 1980; 35: 819–822
  • Meyer J A, Comis R L, Ginsberg S J, et al. Phase II trial of extended indications for resection in small cell carcinoma of the lung. J Thorac Cardiovasc Surg 1982; 83: 12–19
  • Comis R, Meyer J, Ginsberg S, et al. The impact of TNM stage on results with chemotherapy (CT) and adjuvant surgery (AS) in small cell lung cancer (SCLC). Proc Am Soc Clin Oncol 1984; 3: 226
  • Valdivieso M, McMurtrey M J, Farha P, et al. Prospective evaluation of adjuvant surgical resection (ASR) in small cell lung cancer (SCLC). Proc Am Soc Clin One 1984; 3: 220
  • Shepherd F A, Ginsberg R, Evans W K, et al. “Very limited” small cell lung cancer (SCLC) results of non-surgical treatment. Proc Am Soc Clin One 1984; 3: 223
  • Karrer K, Pridun N, Denck H. Small cell bronchial carcinoma radically operated adjuvant for polychemotherapy. II World Conf Lung Cancer. Abstracts. Copenhagen. Excerpta Medica, Amsterdam 1980; 155
  • Friess G, McCracken J, Clark G, et al. Improved long term survival associated with surgery in limited small cell cancer of the lung (SCCL). A Southwest Oncology Group (SWOG) study. Proc Am Soc Clin One 1984; 3: 219
  • Brambilla C, Grance C, Carpentier F, et al. Immunologic monitoring of patients with small cell anaplastic carcinoma who are treated with chemotherapy and radiotherapy. Int J Rad Oncol Biol Phys 1980; 6: 1057–1060
  • McCracken J D, Heilbrun L, White J, et al. Combination chemotherapy, radiotherapy, and BCG immunotherapy in extensive (metastatic) small cell carcinoma of the lung. Cancer 1980; 46: 2335–2340
  • McCracken J D, Chen T, White J, et al. Combination chemotherapy, radiotherapy, and BCG immunotherapy in limited small-cell carcinoma of the lung. Cancer 1982; 49: 2252–2258
  • Cohen M H, Chretien P B, Ihde D C, et al. Thymosin fraction V and intensive combination chemotherapy: Prolonging the survival of patients with small-cell lung cancer. JAMA 1979; 241: 1813–1815
  • Minna J. Recent advances of potential clinical importance in the biology of lung cancer. The Richard and Hinda Rosenthal Foundation Lecture. Proc Am Assoc Can Res 1984; 25: 393–394

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.