References
- Ceriani R, Thompson K, Peterson J A, et al. Surface differentiation antigens of human mammary epithelial cells carried on the human milk fat globule. Proc Natl Acad Sci (USA) 1977; 74: 582–586
- Freudenstein C, Kennan T W, Eigel W N, et al. Preparation and characterisation of the inner coat material associated with fat globule membranes from bovine and human milk. Exp Cell Res 1979; 118: 277–294
- Horisberger M, Rosset J, Vonlanthen M. Location of glycoproteins on milk fat globule membrane by scanning and transmission electron microscopy, using lectin labelled gold granules. Exp Cell Res 1977; 109: 361–369
- Glockner W, Newman R, Dahr W, et al. Alkali-labile oligosaccharides from glycoproteins of different erythrocyte and milk fat globule membranes. Biochem Biophys Acta 1976; 443: 402–413
- Hounsell E F, Feizi T. Gastro-intestinal mucins—structures and antigenicities of their carbohydrate chains in health and disease. Med Biol 1982; 60: 227–236
- Shimizu M, Yamauchi K. Isolation and characterisation of mucinlike glycoproteins in human milk fat globule membranes. J Biochem 1982; 91: 515–524
- Shimizu M, Yamauchi K, Miyauchi Y, et al. High Mr glycoprotein profiles in human milk serum and fat-globule membrane. Biochem J 1986; 233: 725–730
- Mather I H, Keenan T W. Studies on the structure of milk fat globule membranes. J Membr Biol 1975; 21: 65–85
- Imam A, Laurence D, Neville A. Isolation and characterisation of a major glycoprotein from milk-fat globule membrane of human breast milk. Biochem J 1981; 193: 47–54
- Patton S, Keenan T W. The milk fat globule membrane. Biochem Biophys Acts 1975; 415: 273–309
- Sasaki M, Peterson J A, Ceriani R L. Quantitation of human mammary epithelial antigens in cells cultured from normal and cancerous breast tissue. In Vitro 1981; 17: 150–158
- Franke W, Heid H, Grand C, et al. Antibodies to the major insoluble milk fat globule membrane-associated protein: specific location in apical regions of lactating epithelial cells. J Cell Biol 1981; 89: 485–494
- Imam A. Investigation of the asymmetric distribution of proteins in the human milk fat globule membranes. J Biochem 1986; 99: 143–152
- Heyderman E, Steele K, Ormerod M G. A new antigen on the epithelial membrane: Its immunoperoxidase localization in normal and neoplastic tissues. J Clin Pathol 1979; 32: 35–39
- Ormerod M G, Monaghan P, Easty D, et al. Asymmetrical distribution of epithelial membrane antigen on the plasma membrane of human breast lines in culture. Diag Histopathol 1981; 4: 89–93
- Sloane J P, Ormerod M G, Carter R L, et al. An immunocytochemical study of the distribution of epithelial membrane antigen in normal and disordered squamous epithelium. Diag Histopathol 1982; 5: 11–17
- Imam A, Drushella M, Taylor C, et al. Preferential expression of a Mr 155,000 milk fat globule membrane glycoprotein on luminal epithelium of lobules in human breast. Cancer Res 1986; 46: 6374–6379
- Peterson J A, Buehring G C, Taylor-Papadimitriou J. Expression of human mammary epithelial (HME) antigens in primary cultures of normal and abnormal breast tissue. Int J Cancer 1978; 22: 655–661
- Ceriani R, Taylor-Papadimitriou J, Peterson J A, et al. Characterisation of cells cultured from early lactating milks. In Vitro 1979; 15: 356–362
- Sasaki M, Peterson J A, Wara W M, et al. Human mammary epithelial antigens (HME-Ags) in the circulation of nude mice implanted with a breast tumour and non-breast tumours. Cancer 1981; 48: 2204–2210
- Sloane J P, Ormerod M G, Imrie S F, et al. The use of antiserum to epithelial membrane antigen in detecting micrometastases in histological sections. Br J Cancer 1980; 42: 392–398
- Dearnaley D P, Sloane J P, Ormerod M G, et al. Increased detection of mammary carcinoma cells in marrow smears using antisera to epithelial membrane antigens. Br J Cancer 1981; 44: 85–90
- Coleman D V, To A, Ormerod M G, et al. Immunoperoxidase staining in tumour marker distribution studies in cytologic specimens. Acta Cytologica 1981; 25: 205–206
- Ceriani R L, Sasaki M, Sussman H, et al. Circulating human epithelial antigens in breast cancer. Proc Natl Acad Sci (USA) 1982; 79: 5420–5424
- Taylor-Papadimitriou J, Peterson J, Arklie J, et al. Monoclonal antibodies to epithelium-specific components of the human milk fat globule membrane: production and reaction with cells in culture. Int J Cancer 1981; 28: 17–21
- Foster C, Edwards P A, Dinsdale E A, et al. Monoclonal antibodies to the human mammary gland. I. Distribution of determinants in non-neoplastic mammary and extra mammary tissues. Virchows Arch (Path Anat) 1982; 394: 279–293
- Ceriani R L, Peterson J A, Lee J Y, et al. Characterisation of cell surface antigens of human mammary epithelial cells with monoclonal antibodies prepared against human milk fat globule. Somatic Cell Gen 1983; 9: 415–427
- Hilkens J, Buijs F, Hilgers J, et al. Monoclonal antibodies against human milk fat globule membranes detecting differentiation antigens of the mammary gland and its tumours. Int J Cancer 1984; 34: 197–206
- Ashorn P, Krohn K. Characterization and partial purification of human milk fat globule membrane antigens by polyacrylamide gel electrophoresis and immunoblotting using monoclonal antibodies. Int J Cancer 1985; 35: 179–184
- Gooi H, Jones N, Hounsell E F, et al. Novel antigenic specificity involving the blood group antigen Lea in combination with oncodevelopmental antigen, SSEA-1 recognised by two monoclonal antibodies to human milk fat globule membranes. Biochem Biophys Res Comm 1985; 131: 543–550
- Johnson V, Mather I. Monoclonal antibodies prepared against PAS-1 butrophilin and Gp55 from guinea pig milk fat globule membrane bind specifically to the apical pole of secretory epithelial cell in lactating mammary tissue. Exp Cell Res 1985; 156: 144–158
- Jarasch E-D, Grand C, Bruder G, et al. Localization of xanthine oxidase in mammary gland epithelium and capillary endothelium. Cell 1981; 25: 67–82
- Burchell J, Durbin H, Taylor-Papadimitriou J. Complexity of expression of antigenic determinants recognised by monoclonal antibodies HMFG-1 and HMFG-2, in normal and malignant human mammary epithelial cells. J Immunol 1983; 131: 508–513
- McIlhinney R AJ, Patel S, Gore M. Monoclonal antibodies recognizing epitopes carried on both glycolipids and glycoproteins of the human milk fat globule membrane. Biochem J 1985; 227: 155–162
- Reid L, Clamp J R. Biochemical and histochemical nomenclature of mucins. Br Med Bull 1978; 34: 5–8
- Hill H D, Reynolds J A, Hill R L. Purification, composition, molecular weight and subunit structure of ovine submaxillary mucin. J Biol Chem 1977; 252: 3791–3798
- Clamp J R, Allen A, Gribbons R A, et al. Chemical aspects of mucus. Br Med Bull 1978; 34: 25–41
- Arklie J, Taylor-Papadimitriou J, Bodmer W, et al. Differentiation antigens expressed by epithelial cells in the lactating breast are also detectable in breast cancers. Int J Cancer 1981; 28: 23–29
- Bramwell M E, Bhavanandan V P, Wiseman G, et al. Structure and function of the Ca antigen. Br J Cancer 1983; 48: 177–183
- Papsidero L, Croghan G, O'Connell M J. Monoclonal antibodies (F36/22 and M7/105) to human breast carcinoma. Cancer Res 1983; 43: 1741–1747
- Magnani J, Steplewski Z, Korprowski H, et al. Identification of the gastro-intestinal and pancreatic cancer-associated antigen detected by monoclonal antibody 19-9 in the sera of patients as a mucin. Cancer Res 1983; 43: 5489–5492
- Lan M S, Finn O J, Femsten P D, et al. Isolation and properties of a human pancreatic adenocarcinoma-associated antigen, DU-PAN-2. Cancer Res 1985; 45: 305–310
- Sekine H, Ohno T, Kufe D. Purification and characterization of a high molecular weight glycoprotein detectable in human milk and breast carcinomas. J Immunol 1985; 135: 3610–3615
- Johnson V, Schlom J, Patterson A J, et al. Analysis of a human tumour-associated glycoprotein (TAG-72) identified by monoclonal antibody B72.3. Cancer Res 1986; 46: 850–857
- Price M, Edwards S, Owainati A, et al. Multiple epitopes on a human breast carcinoma associated antigen. Int J Cancer 1985; 36: 567–572
- Davis H M, Zurawski V R, Bast R C, et al. Characterisation of the CA125 antigen associated with human epithelial ovarian carcinoma. Cancer Res 1986; 46: 6143–6148
- Price M, Edwards S, Robins A, et al. Epitopes with diagnostic and prognostic significance co-expressed on a human breast carcinoma-associated antigen. Eur J Cancer Clin Oncol 1986; 22: 115–117
- Griffiths A B, Burchell J, Taylor-Papadimitriou J, et al. Immunological analysis of mucin molecules expressed by normal and malignant mammary epithelial cells. Int J Cancer 1987; 40: 319–327
- Abe M, Kufe D. Identification of a family of high molecular weight tumour-associated glycoproteins. J Immunol 1987; 139: 257–261
- Lan M, Bast R, Colnaghi M, et al. Co-expression of human cancer-associated epitopes on mucin molecules. Int J Cancer 1987; 39: 68–72
- Gooi M C, Uemura K, Edwards P AW, et al. Two mouse hybridoma antibodies against human milk fat globules recognise the I(Ma) antigenic determinant Gal β14G1cNAc β16. Carbohydrate Res 1983; 20: 293–298
- Burchell J, Gendler S, Taylor-Papadimitriou J, et al. Development and characterisation of breast cancer reactive monoclonal antibodies direct to the core protein of the human milk mucin. Cancer Res 1987; 47: 5476–5482
- Gendler S J, Burchell J M, Duhig T, et al. Cloning the cDNA coding for differentiation and tumour-associated mucin glycoproteins expressed by human mammary epithelium. Proc Natl Acad Sci (USA) 1987; 84: 6060–6064
- Greenwalt D, Johnson V, Kuhajda F, et al. Localization of a membrane glycoprotein in benign fibrocystic disease and infiltrating duct carcinomas of the human breast with the use of a monoclonal antibody to guinea pig milk fat globule membranes. Am J Pathol 1985; 118: 351–359
- Swallow D, Griffiths B, Bramwell M, et al. Detection of the urinary 'PUM' polymorphism by the tumour-binding monoclonal antibodies Ca1, Ca2, Ca3, HMFG-1 and HMFG-2. Dis Markers 1986; 4: 247–254
- Karlsson S, Swallow D, Griffiths B, et al. A genetic polymorphism of a human urinary mucin. Ann Hum Gen 1983; 47: 263–266
- Griffiths B, Gordon A, Burchell J, et al. The breast tumour-associated epithelial mucins and the peanut lectin binding urinary mucins are coded by a single highly polymorphic gene locus 'PUM'. Dis Markers 1988; 6: 185–194
- Foster C, Neville A M. Monoclonal antibodies to the human mammary gland: 111. Monoclonal antibody LICR-LON-M18 identifies impaired expression and excess sialylation of the 1(Ma) cell surface antigen by primary breast carcinoma cells. Hum Pathol 1984; 15: 82–86
- Newman R, Klein P, Rudland P. Binding of peanut lectin to breast epithelium, human carcinomas and a cultured rat mammary stem cell: Use of the lectin as a marker of mammary differentiation. J Natl Cancer Inst 1979; 63: 1339–1349
- Leathern A J, Brooks S A. Predictive value of lectin binding on breast cancer recurrence and survival. Lancet 1987; 1: 1054–1056
- Mort A J, Lamport D. Anhydrous hydrogen fluoride deglycosy-lates glycoproteins. Anal Biochem 1977; 82: 289–309
- Swallow D, Gendler S, Griffiths B, et al. The human tumour-associated epithelial mucins are coded by an expressed hypervariable gene locus PUM. Nature 1987; 327: 82–84
- Wesley A, Mantle M, Man D, et al. Neural and acidic species of human intestinal mucin. J Biol Chem 1985; 260: 7955–7959
- Boland C R, Roberts J, Liddiqui B, et al. Cancer-associated colonic mucin in cultured human tumour cells and athymic (nude) mouse xenografts. Cancer Res 1986; 46: 5724–5729
- Steck P, North S, Nicolson G. Purification and partial characterization of a tumour-metastasis-associated high Mr glycoprotein from rat 13762NF mammary adenocarcinoma cells. Biochem J 1987; 242: 779–787
- Swallow D, Gendler S, Griffiths B, et al. The hypervariable locus PUM, which codes for the tumour associated epithelial mucins, is located on chromosome 1, within the region 1q21-24. Ann Hum Genet 1987; 51: 289–294
- Kovacs G. Preferential involvement of chromosome 1q in a primary breast carcinoma. Cancer Genet Cytogen 1981; 3: 125–129
- Garter K, Abdulaziz Z, Cordulan J RF, et al. Use of monoclonal antibodies for the histopathological diagnosis of human malignancy. J Clin Pathol 1982; 35: 1253–1267
- Epenetos A, Canti G, Taylor-Papadimitriou J, et al. Use of two epithelium-specific monoclonal antibodies for diagnosis of malignancy in serous effusions. Lancet 1982; II: 1004–1006
- Osborn M, Weber K. Intermediate filaments: Cell-type specific markers in differentiation on malignancy. Cell 1983; 31: 303–306
- Wilkinson M, Howell A, Harris J, et al. The prognostic significance of two epithelial membrane antigens expressed by human mammary carcinomas. Int J Cancer 1984; 33: 299–304
- Kufe D, Inghirami G, Abe M, et al. Differential activity of a novel monoclonal antiody (DF3) with human malignant versus benign breast tumours. Hybridoma 1984; 3: 223–232
- Burchell J, Wang D, Taylor-Papadimitriou J. Detection of the tumour associated antigens recognised by the monoclonal antibodies HMFG-1 and 2 in serum from patients with breast cancer. Int J Cancer 1984; 34: 763–768
- Ward B, Cruickshank D. Circulating tumour-associated antigen detected by the monoclonal antibody HMFG-2 in human epithelial ovarian cancer. Int J Cancer 1987; 39: 30–33
- Hayes D F, Sekine H, Onhno T, et al. Detection of circulating plasma DF3 antigen levels in breast cancer patients. J Clin Invest 1985; 75: 1671–1678
- Hilkens J, Kroezen V, Bonfrer J M, et al. MAM-6 antigen, a new serum marker for breast cancer monitoring. Cancer Res 1986; 46: 2586–2587
- Klug T, Bast R, Niloff J, et al. Monoclonal antibody immunoradi-ometric assay for an antigenic determinant (CA125) associated with human epithelial ovarian carcinomas. Cancer Res 1984; 44: 1048–1053
- Rainsbury R M, Westwood J M, Coombes R C, et al. Location of metastatic breast carcinoma by a monoclonal antibody chelate labelled with Indium-111. Lancet 1983; II: 934–938
- Epenetos A, Britton K, Mather S, et al. Targeting of iodine-123-labelled tumour associated monoclonal antibodies to ovarian, breast and gastrointestinal tumours. Lancet 1982; II: 999–1005
- Granowska M, Shepherd J, Britton K, et al. Ovarian cancer: Diagnosis using I-123 monoclonal antibody in comparison with surgical findings. Nucl Med Comm 1984; 5: 485–499
- Pateisky N, Philip K, Sevelda P, et al. Radioimmunoscintigraphy using monoclonal antibodies before second-look surgery in patients suffering from ovarian cancer. Gynecol Obstet Invest 1987; 754: 1–5
- Epenetos A, Courtenay-Luck N, Hainan K, et al. Antibody-guided irradiation of malignant: Three cases illustrating a new method of treatment. Lancet 1984; II: 1441–1443