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LetterToEditor Article

Severe 5-Fluorouracil Toxicity in a Patient with Decreased Dihydropyrimidine Dehydrogenase Activity

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Pages 239-240 | Published online: 11 Jun 2009

References

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  • Wasternack C. Degradation of pyrimidines and pyrimidine analogs—Pathways and mutual influences. Pharmacol Ther 1980; 8: 629–651
  • Bonadonna G, Valagussa B S. Systemic therapy in resectable breast cancer. Hematol Clin North Am 1989; 3: 727–742
  • Tuchman M, Stoeckeler J S, Kiang D T. Familial pyrimidi-nemia and pyrimidinuria associated with severe flourouracil toxicity. N Engl J Med 1985; 313: 245–249
  • Diasio R B, Beavers T L, Carpenter J T. Familial deficiency of dihydropyrimidine dehydrogenase: Biochemical basis for familial pyrimidinemia and severe 5-fluorouracil-induced toxicity. J Clin Invest 1988; 81: 47–51
  • Harris B E, Carpenter J T, Diasio R B. Severe 5-fluorouracil toxicity secondary to dihydropyrimidine dehydrogenase deficiency: A potentially more common pharmacogenetic syndrome. Cancer 1991, in press

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