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Review Article

Neuropeptide-induced chemotaxis of eosinophils in pulmonary diseases

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Pages 429-439 | Published online: 08 Jul 2009

References

  • McDonald DM. The concept of neurogenic inflammation in the respiratory tract. Neuropeptides in respiratory medicine, MA Kaliner, PJ Barnes, GHH Kunkel, JN Baraniuk. Marcel Dekker, New York 1994; 321–50
  • Barnes PJ. Asthma as an axon reflex. Lancet 1986; 1: 242–5
  • Barnes P J, Baraniuk J N, Belvisi MG. Neuropeptides in the respiratory tract: part I. Am Rev Respir Dis 1991; 144: 1187–98
  • Barnes P J, Baraniuk J N, Belvisi MG. Neuropeptides in the respiratory tract: part 11. Am Rev Respir Dis 1991b; 144: 1391–9
  • Sertl K, Wiedermann C J, Kowalski M L, Hurtado S, Plutchok J, Linnoila I. Substance P: the relationship between receptor distribution in rat lung and the capacity of substance P to stimulate vascular permeability. Am Rev Respir Dis 1988; 138: 151–9
  • Lundgren J D, Wiedermann C J, Logun C, Plutchok J, Kaliner M, Sertl JH. Substance P receptor-mediated secretion of respiratory glycoconjugate from feline airways in vitro. Exp Lung Res 1989; 15: 17–29
  • Rosenfeld M G, Mermod J J, Amara S G, Swanson L W, Sawchenko P E, Rivier J. Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing. Nature 1983; 304: 129–35
  • Martling C R, Saria A, Fischer J A, Hokfelt T, Lundberg JM. Calcitonin gene-related peptide and the lung: neuronal coexistence with substance P, release by capsaicin and vasodilatory effect. Regul Pept 1988; 20: 125–39
  • Cadieux A, Monast N P, Pomerleau F, Fournier A, Lanoue C. Bronchoprotector properties of calcitonin gene-related peptide in guinea pig and human airways. Effect of pulmonary inflammation. Am J Respir Crit Care Med 1999; 159: 235–43
  • Ehrlich P. Über die spezifischen Granulationen des Blutes. Arch Anat Physiol Lpz 1879; 3: 571–9, (Physiol Abstr)
  • Haslett C. Granulocyte apoptosis and its role in the resolution and control of lung inflammation. Am J Respir Crit Care Med 1999; 160: S511
  • Kroegel C, Warner J A, Virchow J C, Matthys H. Pulmonary immune cells in health and disease: The eosinophil leukocyte (part II). Eur Resp J 1994; 7: 743–60
  • Clutterbuck E J, Hirst E M, Sanderson CJ. Human inter-leukin-5 (IL-5) regulates the production of eosinophils in human bone marrow cultures: comparison and interaction with IL-1, IL-3, IL-6 and GMCSF. Blood 1989; 73: 1504–12
  • Palframan R T, Collins P D, Williams T J, Rankin SM. Eotaxin induces a rapid release of eosinophils and their progenitors from the bone marrow. Blood 1998; 91: 2240–8
  • Steinbach K H, Schick P, Trepel F, Raffler H, Dohrmann J, Heilgeist G. Estimation of kinetic parameters of neutrophilic, eosinophilic, and basophilic granulocytes in human blood. Blut 1979; 39: 27–38
  • Giembycz M A, Lindsay MA. Pharmacology of the eosinophil. Pharmacol Rev 1999; 51: 213–339
  • Spry C JF. The natural history of eosinophils. Immunopharmacology of eosinophils, H Smith, RM Cook. Academic Press, London 1993; 1–9
  • Rytomaa T. Organ distribution and histochemical properties of eosinophil granulocytes in the rat. Acta Pathol Microbiol Scand 1969; 50: 12–8, (Suppl 140)
  • Lukacs N W, Strieter R M, Kunkel SL. Leukocyte infiltration in allergic airway inflammation. Am J Respir Cell Mol Biol 1995; 13: 1–6
  • Resnick M B, Weller PF. Mechanisms of eosinophil recruitment. Am J Respir Cell Mol Biol 1993; 8: 349–55
  • Weller PF. The immunology of eosinophils. N. Engl J Med 1991a; 324: 1110–8
  • Kita H, Sur S, Hunt L W, Edell E S, Weiler D A, Swanson M C. Cytokine production at the site of disease in chronic eosinophilic pneumonia. Am J Respir Crit Care Med 1996a; 153: 1437–41
  • Baggiolini M, Dahinden CA. CC chemokines in allergic inflammation. Immunol Today 1994; 15: 127–33
  • Kita H, Gleich GJ. Chemokines active on eosinophils: potential roles in allergic inflammation. J Exp Med 1996; 183: 2421–6
  • Shinkai A, Yoshisue H, Koike M, Shoji E, Nakagawa S, Saito A. A novel human CC chemokine, eotaxin-3, which is expressed in IL-4-stimulated vascular endothelial cells, exhibits potent activity toward eosinophils. J Immunol 1999; 163: 1602–10
  • Kumano K, Nakao A, Nakajima H, Hayashi F, Kurimoto M, Okamura H. Interleukin-18 enhances antigen-induced eosinophil recruitment into the mouse airways. Am J Respir Crit Care Med 1999; 160: 873–8
  • Ying S, Humbert M, Barkans J, Corrigan C J, Pfister R, Menz G. Expression of IL-4 and IL-5 mRNA and protein product by CD4+ and CD8+ T cells, eosinophils, and mast cells in bronchial biopsies collected from atopic and non-atopic (intrinsic) asthmatics. J Immunol 1997; 158: 3539–44
  • Stellato C, Collins P, Ponath P D, Soler D, Newman W, La Rosa G. Production of the novel CC chemokine MCP-4 by airway cells and comparison of its biological activity to other CC chemokines. J Clin Invest 1997; 99: 926–36
  • Marfaing-Koka A, Devergne O, Gorgone G, Portier A, Schall T J, Galanaud P. Regulation of the production of the RANTES chemokine by endothelial cells: synergistic induction by IFN-gamma plus TNF-alpha and inhibition by IL-4 and IL-13. J Immunol 1995; 154: 1870–8
  • Strieter R M, Chensue S W, Basha M A, Standiford T J, Lynch J P, Kunkel SL. Human alveolar macrophage gene expression of interleukin-8 by TNF, LPS, and IL-1. Am J Respir Cell Mol Biol 1990; 2: 321–6
  • Rolfe M W, Kunkel S L, Standiford T J, Chensue S W, Allen R M, Evanoff H L. Pulmonary fibroblast expression of interleukin-8: a model for alveolar macrophage-derived cytokine networking. Am J Respir Cell Mol Biol 1991; 5: 493–501
  • John M, Hirst S J, Jose P J, Robichaud A, Berkman N, Witt C. Human airway smooth muscle cells express and release RANTES in response to T helper 1 cytokines: regulation by T helper 2 cytokines and corticosteroids. J Immunol 1997; 158: 1841–7
  • Saunders M A, Mitchell J A, Sheldon P M, Yacoub M H, Barnes P J, Giembycz M A. Release of granulocyte-macrophage colony stimulating factor by human cultured airway smooth muscle cells: suppression of dexamethasone. Br J Pharmacol 1997; 120: 545–6
  • Ghaffar O, Hamid Q, Renzi P M, Allakhverdi Z, Molet S, Hogg J C. Constitutive and cytokine-stimulated expression of eotaxin by human airway smooth muscle cells. Am J Respir Crit Care Med 1999; 159: 1933–42
  • Teixeira M M, Williams T J, Hellewell PG. Mechanisms and pharmacological manipulation of eosinophil accumulation in vivo. Trends Pharmacol Sci 1995; 16: 418–23
  • Sriramarao P, Von Andrian U H, Butcher E C, Bourdon M A, Broide DH. L-selectin and very late antigen-4 integrin promote eosinophil rolling at physiological shear rates in vivo. J Immunol 1994; 153: 4238–46
  • Symon F A, Lawrence M B, Williamson M L, Walsh G M, Watson S R, Wardlaw AJ. Functional and structural characterization of the eosinophil P-selectin ligand. J Immunol 1996; 157: 1711–9
  • Kitayama J, Fuhlbrigge R C, Puri K D, Springer T, P- A. selectin, L-selectin, and alpha 4 integrin have distinct roles in eosinophil tethering and arrest on vascular endothelial cells under physiological flow conditions. J Immunol 1997; 159: 3929–39
  • Broide D H, Sullivan S, Gifford T, Sriramarao P. Inhibition of pulmonary eosinophilia in P-selectin-and ICAM-1-deficient mice. Am J Respir Cell Mol Biol 1998; 18: 218–25
  • Lamas A M, Mulroney C M, Schleimer RP. Studies on the adhesive interaction between purified human eosinophils and cultured vascular endothelial cells. J Immunol 1988; 140: 1500–5
  • Walsh G M, Hartnell A, Wardlaw A J, Kurihara K, Sanderson C J, Kay AB. IL-5 enhances the in vitro adhesion of human eosinophils, but not neutrophils, in a leucocyte integrin (CD11/18)-dependent manner. Immunology 1990; 71: 258–65
  • Walsh G M, Mermod J J, Hartnell A, Kay A B, Wardlaw AJ. Human eosinophil, but not neutrophil, adherence to IL-1-stimulated human umbilical vascular endothelial cells is alpha 4 beta 1 (very late antigen-4) dependent. J Immunol 1991; 146: 3419–23
  • Bochner B S, Luscinskas F W, Gimbrone MA, Jr, Newman W, Sterbinsky S A, Derse-Anthony C P. Adhesion of human basophils, eosinophils, and neutrophils to interleukin 1-activated human vascular endothelial cells: contributions of endothelial cell adhesion molecules. J Exp Med 1991; 173: 1553–7
  • Dobrina A, Menegazzi R, Carlos T M, Nardon E, Cramer R, Zacchi T. Mechanisms of eosinophil adherence to cultured vascular endothelial cells. Eosinophils bind to the cytokine-induced ligand vascular cell adhesion molecule-1 via the very late activation antigen-4 integrin receptor. J Clin Invest 1991; 88: 20–6
  • Kyan-Aung U, Haskard D O, Lee TH. Vascular cell adhesion molecule-1 and eosinophil adhesion to cultured human umbilical vein endothelial cells in vitro. Am J Respir Cell Mol Biol 1991; 5: 445–50
  • Kyan-Aung U, Haskard D O, Poston R N, Thornhill M H, Lee TH. Endothelial leukocyte adhesion molecule-1 and intercellular adhesion molecule-1 mediate the adhesion of eosinophils to endothelial cells in vitro and are expressed by endothelium in allergic cutaneous inflammation in vivo. J Immunol 1991b; 146: 521–8
  • Weller P F, Rand T H, Goelz S E, Chi-Rosso G, Lobb RR. Human eosinophil adherence to vascular endothelium mediated by binding to vascular cell adhesion molecule 1 and endothelial leukocyte adhesion molecule 1. Proc Natl Acad Sci USA 1991; 88: 7430–3
  • Nakajima H, Sano H, Nishimura T, Yoshida S, Iwamoto I. Role of vascular cell adhesion molecule l/very late activation antigen 4 and intercellular adhesion molecule Ulymphocyte function-associated antigen 1 interactions in antigen-induced eosinophil and T cell recruitment into the tissue. J Exp Med 1994; 179: 1145–54
  • Chin J E, Winterrowd G E, Hatfield C A, Brashler J R, Griffin R L, Vonderfecht S L. Involvement of intercellular adhesion molecule-1 in the antigen-induced infiltration of eosinophils and lymphocytes into the airways in a murine model of pulmonary inflammation. Am J Respir Cell Mol Bid 1998; 18: 158–67
  • Hansel T T, Braunstein J B, Walker C, Blaser K, Bruijnzeel P L, Virchow JC, Jr. Sputum eosinophils from asthmatics express ICAM-1 and HLA-DR. Clin Exp Immunol 1991; 86: 271–7
  • Kroegel C, Liu M C, Hubbard W C, Lichtenstein L M, Bochner BS. Blood and bronchoalveolar eosinophils in allergic subjects after segmental antigen challenge: surface phenotype, density heterogeneity, and prostanoid production. J Allergy Clin Immunol 1994; 93: 725–34
  • Mengelers H J, Maikoe T, Brinkman L, Hooibrink B, Lammers J W, Koenderman L. Immunophenotyping of eosinophils recovered from blood and BAL of allergic asthmatics. Am J Respir Crit Care Med 1994; 149: 345–51
  • Ohkawara Y, Yamauchi K, Maruyama N, Hoshi H, Ohno I, Honma M. In situ expression of the cell adhesion molecules in bronchial tissues from asthmatics with air flow limitation: in vivo evidence of VCAM-1NLA-4 interaction in selective eosinophil infiltration. Am J Respir Cell Mol Biol 1995; 12: 4–12
  • Kraneveld A D, Van Ark I, Van Der Linde H J, Fattah D, Nijkamp F P, Van Oosterhout AJ. Antibody to very late activation antigen 4 prevents interleukin-5-induced airway hyperresponsiveness and eosinophil infiltration in the airways of guinea pigs. J Allergy Clin Immunol 1997; 100: 242–50
  • Forssmann U, Uguccioni M, Loetscher P, Dahinden C A, Langen H, Thelen M. Eotaxin-2, a novel CC chemokine that is selective for the chemokine receptor CCR3, and acts like eotaxin on human eosinophil and basophil leukocytes. J Exp Med 1997; 185: 2171–6
  • Humbles A A, Conroy D M, Marleau S, Rankin S M, Palframan R T, Proudfoot A E. Kinetics of eotaxin generation and its relationship to eosinophil accumulation in allergic airways disease: analysis in a guinea pig model in vivo. J Exp Med 1997; 186: 601–12
  • Minshall E M, Cameron L, Lavigne F, Leung D Y, Hamilos D, Garcia-Zepada E A. Eotaxin mRNA and protein expression in chronic sinusitis and allergen-induced nasal responses in seasonal allergic rhinitis. Am J Respir Cell Mol Biol 1997; 17: 683–90
  • Ying S, Robinson D S, Meng Q, Rottman J, Kennedy R, Ringler D J. Enhanced expression of eotaxin and CCR3 mRNA and protein in atopic asthma. Association with airway hyperresponsiveness and predominant co-localization of eotaxin mRNA to bronchial epithelial and endothelial cells. Eur J Immunol 1997; 27: 3507–16
  • Kuna P, Alam R, Ruta U, Gorski P. RANTES induces nasal mucosal inflammation rich in eosinophils, basophils, and lymphocytes in vivo. Am J Respir Crit Care Med 1998; 157: 873–9
  • Venge J, Lampinen M, Hakansson L, Rak S, Venge P. Identification of IL-5 and RANTES as the major eosinophil chemoattractants in the asthmatic lung. J Allergy Clin Immunol 1996; 97: 1110–5
  • Dunzendorfer S, Meierhofer C, Wiedermann CJ. Signaling in neuropeptide-induced migration of human eosinophils. J Leukoc Biol 1998; 64: 828–34
  • Morita E, Schroder J M, Christophers E. Chemotactic responsiveness of eosinophils isolated from patients with inflammatory skin diseases. J Dermatol 1989; 16: 348–51
  • Morita E, Schroder J M, Christophers E. Differential sensitivities of purified human eosinophils and neutrophils to defined chemotaxins. Scand J Immunol 1989b; 29: 709–16
  • Bruijnzeel P L, Kuijper P H, Rihs S, Betz S, Warringa R A, Koenderman L. Eosinophil migration in atopic dermatitis. I: Increased migratory responses to N-formyl-methionyl-leucyl-phenylalanine, neutrophil-activating factor, platelet-activating factor, and platelet factor 4. J lnvest Dermatol 1993; 100: 137–42
  • Warringa R A, Mengelers H J, Raaijmakers J A, Bruijnzeel P L, Koenderman L. Upregulation of formyl-peptide and interleukin-8-induced eosinophil chemotaxis in patients with allergic asthma. J Allergy Clin Immunol 1993; 91: 1198–205
  • Elsner J, Dichmann S, Dobos G J, Kapp A. Actin polymerization in human eosinophils, unlike human neutrophils, depends on intracellular calcium mobilization. J Cell Physiol 1996; 167: 548–55
  • Wiedermann C J, Dunzendorfer S, Kahler C M, Reinisch N, Schratzberger P. Secretoneurin and neurogenic inflammation. Acta Pharmacol Sin 1999; 20: 789–94
  • Barnes PJ. Overview of neural mechanisms in asthma. Pulm Pharmacol 1995; 8: 151–9
  • Goetzl E J, Sreedharan SP. Mediators of communication and adaptation in the neuroendocrine and immune systems. FASEB J 1992; 6: 2646–52
  • Aliakbari J, Sreedharan S P, Turck C W, Goetzl EJ. Selective localization of vasoactive intestinal peptide and substance P in human eosinophils. Biochem Biophys Res Commun 1987; 148: 1440–5
  • Weinstock J V, Blum A, Walder J, Walder R. Eosinophils from granulomas in murine schistosomiasis mansoni produce substance P. J Immunol 1988; 141: 961–6
  • Weinstock J V, Blum AM. Tachykinin production in granulomas of murine schistosomiasis mansoni. J Immunol 1989; 142: 3256–61
  • Weinstock J V, Blum AM. Release of substance P by granuloma eosinophils in response to secretagogues in murine schistosomiasis mansoni. Cell Immunol 1990; 125: 380–5
  • Weinstock JV. Production of neuropeptides by inflammatory cells within the granulomas of murine schistosomiasis mansoni. Eur J Clin Invest 1991; 21: 145–53
  • Metwali A, Blum A M, Ferraris L, Klein J S, Fiocchi C, Weinstock JV. Eosinophils within the healthy or inflamed human intestine produce substance P and vasoactive intestinal peptide. J Neuroimmunol 1994; 52: 69–78
  • Elsner J, Hochstetter R, Kimmig D, Kapp A. Human eotaxin represents a potent activator of the respiratory burst of human eosinophils. Eur J Immunol 1996; 26: 1919–25
  • Kapp A, Zeck-Kapp G, Czech W, Schopf E. The chemokine RANTES is more than a chemoattractant: characterization of its effect on human eosinophil oxidative metabolism and morphology in comparison with IL-5 and GM-CSF. J Invest Dermatol 1994; 102: 906–14
  • Bach M K, Brashler J R, Petzold E N, Sanders ME. Superoxide production by human eosinophils can be inhibited in an agonist-selective manner. Agents Actions 1992; 35: 1–11
  • Schweizer R C, Van Kessel-Welmers B A, Warringa R A, Maikoe T, Raaijmakers J A, Lammers J W. Mechanisms involved in eosinophil migration. Platelet-activating-factor-induced chernotaxis and interleukin-5-induced chemokinesis are mediated by different signals. J Leukoc Biol 1996; 59: 347–56
  • Kaneko T, Alvarez R, Ueki I F, Nadel JA. Elevated intracellular cyclic AMP inhibits chemotaxis in human eosinophils. Cell Signal 1995; 7: 527–34
  • Alves A C, Pires A L, Cruz H N, Serra M F, Diaz B L, Cordeiro R S. Selective inhibition of phosphodiesterase type IV suppresses the chemotactic responsiveness of rat eosinophils in vitro. Eur J Pharmacol 1996; 312: 89–96
  • Numao T, Agrawal DK. Neuropeptides modulate human eosinophil chemotaxis. J Immunol 1992; 149: 3309–15
  • Wiedermann F J, Kahler C M, Reinisch N, Wiedermann CJ. Induction of normal human eosinophil migration in vitro by substance P. Acta Haematol 1993; 89: 213–5
  • Dunzendorfer S, Schratzberger P, Reinisch N, Kahler C M, Wiedermann CJ. Secretoneurin, a novel neuropeptide, is a potent chemoattractant for human eosinophils. Blood 1998; 91: 1527–32
  • Schneitler C, Kahler C, Wiedermann C J, Hogue-Angeletti R, Fischer-Colbrie R. Specific binding of a 1251-secretoneurin analogue to a human monocytic cell line. J Neuroimmunol 1998; 86: 87–91
  • Santing R E, Olymulder C G, Van der Molen K, Meurs H, Zaagsma J. Phosphodiesterase inhibitors reduce bronchial hyperreactivity and airway inflammation in unrestrained guinea-pigs. Eur J Pharmacol 1995; 275: 75–82
  • Thelen M, Uguccioni M, Bosiger J. PI 3-kinase-dependent and independent chemotaxis of human neutrophil leukocytes. Biochem Biophys Res Commun 1995; 217: 1255–62
  • Nault M A, Vincent S G, Fisher JT. Mechanisms of capsaicin-and lactic acid-induced bronchoconstriction in the newborn dog. J Physiol (Lond) 1999; 515: 567–78
  • Vesely K R, Hyde D M, Stovall M Y, Harkema J R, Green J F, Schelegle ES. Capsaicin-sensitive C-fiber-mediated protective responses in ozone inhalation in rats. J Appl Physiol 1999; 86: 951–62
  • Baluk P, Thurston G, Murphy T J, Bunnett N W, McDonald DM. Neurogenic plasma leakage in mouse airways. Br J Pharmacol 1999; 126: 522–8
  • Walsh D T, Weg V B, Williams T J, Nourshargh S. Substance P-induced inflammatory responses in guinea-pig skin: the effect of specific NK1 receptor antagonists and the role of endogenous mediators. Br J Pharmacol 1995; 114: 1343–50
  • Iwamoto I, Tomoe S, Tomioka H, Yoshida S. Leukotriene B4 mediates substance P-induced granulocyte infiltration into mouse skin. Comparison with antigen-induced granulocyte infiltration. J Immunol 1993; 151: 2116–23
  • Bellibas SE. The effect of human calcitonin gene-related peptide on eosinophil chemotaxis in the rat airway. Peptides 1996; 17: 563–4
  • Smith C H, Barker J N, Lee TH. Adhesion molecules in allergic inflammation. Am Rev Respir Dis 1993; 148: S75–8
  • Smith C H, Barker J N, Morris R W, MacDonald D M, Lee TH. Neuropeptides induce rapid expression of endothelial cell adhesion molecules and elicit granulocytic infiltration in human skin. J Immunol 1993; 151: 3274–82
  • Fajac I, Braunstein G, Ickovic M R, Lacronique J, Frossard N. Selective recruitment of eosinophils by substance P after repeated allergen exposure in allergic rhinitis. Allergy 1995; 50: 970–5
  • Piotrowski W, Foreman JC. Some effects of calcitonin generelated peptide in human skin and on histamine release. Br J Dermatol 1986; 114: 37–46
  • Fryer A D, Adamko D J, Yost B L, Jacoby DB. Effects of inflammatory cells on neuronal M2 muscarinic receptor function in the lung. Life Sci 1999; 64: 449–55
  • Costello R W, Schofield B H, Kephart G M, Gleich G J, Jacoby D B, Fryer AD. Localization of eosinophils to airway nerves and effect on neuronal M2 muscarinic receptor function. Am J Physiol 1997; 273: L93–103
  • Adamko D J, Yost B L, Gleich G J, Fryer A D, Jacoby DB. Ovalbumin sensitization changes the inflammatory response to subsequent parainfluenza infection. Eosinophils mediate airway hyperresponsiveness, m(2) muscarinic receptor dysfunction, and antiviral effects. J Exp Med 1999; 190: 1465–78
  • Coyle A J, Perretti F, Manzini S, Hin CG. Cationic protein-induced sensory nerve activation: role of substance P in airway hyperresponsiveness and plasma protein extravasation. J Clin Invest 1994; 94: 2301–6
  • Garland A, Necheles J, White S R, Neeley S P, Leff A R, Carson S S. Activated eosinophils elicit substance P release from cultured dorsal root ganglion neurons. Am J Physiol 1997; 273: L1096–102
  • El-Shazly A E, Masuyama K, Ishikawa T. Mechanisms involved in activation of human eosinophil exocytosis by substance P: an in vitro model of sensory neuroimmunomodulation. Immunol Invest 1997; 26: 615–29
  • Gleich G J, Loegering D A, Bell M P, Checkel J L, Ackerman S J, McKean DJ. Biochemical and functional similarities between human eosinophil-derived neurotoxin and eosinophil cationic protein: Homology with ribonuclease. Proc Natl Acad Sci USA 1986; 83: 3146–50
  • Lehrer R I, Szklarek D, Barton A, Ganz T, Hamann K J, Gleich GJ. Antibacterial properties of eosinophil major basic protein and eosinophil cationic protein. J Immunol 1989; 142: 4428–34
  • Kraneveld A D, Folkerts G, Van Oosterhout A J, Nijkamp FP. Airway hyperresponsiveness: first eosinophils and then neuropeptides. Int J Immunopharmacol 1997; 19: 517–27
  • Wu Z X, Lee LY. Airway hyperresponsiveness induced by chronic exposure to cigarette smoke in guinea pigs: role of tachykinins. J Appl Physiol 1999; 87: 1621–8
  • Daffonchio L, Hernandez A, Gallico L, Omini C. Airway hyperreactivity induced by active cigarette smoke exposure in guinea-pigs: possible role of sensory neuropeptides. Pulm Pharmacol 1990; 3: 161–6
  • Meeker DP. Pulmonary infiltrates and eosinophilia revisited. Cleve Clin J Med 1989; 56: 199–211
  • Laine P, Naukkarinen A, Heikkila L, Penttila A, Kovanen IT. Adventitial mast cells connect with sensory nerve fibers in atherosclerotic coronary arteries. Circulation 2000; 101: 1665–9
  • Hoffman G S, Sechler J M, Gallin J I, Shelhamer J H, Suffredini A, Ognibene F P. Bronchoalveolar lavage analysis in Wegener's granulomatosis. A method to study disease pathogenesis. Am Rev Respir Dis 1991; 143: 401–7
  • Yousem S A, Lombard CM. The eosinophilic variant of Wegener's granulomatosis. Hum Pathol 1988; 19: 682–8
  • Schnabel A, Csernok E, Braun J, Gross WL. Inflammatory cells and cellular activation in the lower respiratory tract in Churg-Strauss syndrome. Thorax 1999; 54: 771–8
  • Trull A, Steel L, Cornelissen J, Smith T, Sharples L, Cary N. Association between blood eosinophil counts and acute cardiac and pulmonary allograft rejection. J Heart Lung Transplant 1998; 17: 517–24
  • Dosanjh A K, Elashoff D, Kawalek A, Moss R B, Esrig S. Activation of eosinophils in the airways of lung transplantation patients. Chest 1997; 112: 1180–3
  • Gursel G, Turktas H, Gokcora N, Tekin IO. Comparison of sputum and serum eosinophil cationic protein (ECP) levels in nonatopic asthma and chronic obstructive pulmonary disease. J Asthma 1997; 34: 313–9
  • Stefanini M, Claustro J C, Motos R A, Bendigo LL. Blood and bone marrow eosinophilia in malignant tumors. Role and nature of blood and tissue eosinophil colony-stimulating factor(s) in two patients. Cancer 1991; 68: 543–8
  • Williams W J, James DG. Pulmonary Langerhans' cell granulomatosis (LCG). Sarcoidosis 1993; 10: 104–7
  • Hance A J, Basset F, Saumon G, Danel C, Valeyre D, Battesti J P. Smoking and interstitial lung disease. The effect of cigarette smoking on the incidence of pulmonary histiocytosis X and sarcoidosis. Ann N Y Acad Sci 1986; 465: 643–56
  • Nohr D, Buob A, Gartner K, Weihe E. Changes in pulmonary calcitonin gene-related peptide and protein gene product 9.5 innervation in rats infected with Mycoplasma pulmonis. Cell Tissue Res 1996; 283: 215–9
  • Stevens T P, McBride J T, Peake J L, Pinkenon K E, Stripp BR. Cell proliferation contributes to PNEC hyperplasia after acute airway injury. Am J Physiol 1997; 272: L486–93
  • Ito T. Differentiation and proliferation of pulmonary neuro-endocrine cells. Prog Histochem Cytochem 1999; 34: 247–322

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