Circadian regulation of human sleep and age-related changes in its timing, consolidation and EEG characteristics

References

• Reppert SM. A clockwork explosion!. Neuron 1998; 21: 1–4
   PubMed Web of Science ®Google Scholar
• Hastings MH. The brain, circadian rhythms, and clock genes. BMJ 1998; 317: 1704–7
   PubMedGoogle Scholar
• Meijer J H, Rietveld WJ. Neurophysiology of the suprachiasmatic circadian pacemaker in rodents. Physiol Rev 1989; 69: 571–706
   Google Scholar
• Welsh D K, Logothetis D E, Meister M, Reppert SM. Individual neurons dissociated from rat suprachiasmatic nucleus express independently phased circadian firing rhythms. Neuron 1995; 14: 697–706
   PubMed Web of Science ®Google Scholar
• Liu C, Weaver D R, Strogatz S H, Reppert SM. Cellular construction of a circadian clock: period determination in the suprachiasmatic nuclei. Cell 1997; 91: 855–60
   PubMed Web of Science ®Google Scholar
• Herzog E D, Takahashi J S, Block GD. Clock controls circadian period in isolated suprachiasmatic nucleus neurons. Nat Neurosci 1998; 1: 708–13
   PubMed Web of Science ®Google Scholar
• Czeisler CA. The effect of light on the human circadian pacemaker. Ciba Found Symp 1995; 183: 254–90
   PubMedGoogle Scholar
• Duffy J F, Kronauer R E, Czeisler CA. Phase-shifting human circadian rhythms: influence of sleep timing, social contact and light exposure. J Physiol (Lond) 1996; 495: 289–97
   Google Scholar
• Van Reeth O, Sturis J, Byrne M M, Blackman J D, L'Hermite-Balériaux M, Leproult R. Nocturnal exercise phase delays circadian rhythms of melatonin and thyrotropin secretion in normal men. Am J Physiol 1994; 266: E964–74
   PubMed Web of Science ®Google Scholar
• Klerman E B, Rimmer D W, Dijk D-J, Kronauer R E, Rizzo JF, III, Czeisler CA. Nonphotic entrainment of the human circadian pacemaker. Am J Physiol 1998; 43: R991–6
   Google Scholar
• Åkerstedt T, Gillberg M. The circadian variation of experimentally displaced sleep. Sleep 1981; 4: 159–69
   PubMed Web of Science ®Google Scholar
• Zulley J, Wever R, Aschoff J. The dependence of onset and duration of sleep on the circadian rhythm of rectal temperature. Pflügers Arch 1981; 391: 314–8
   PubMed Web of Science ®Google Scholar
• Czeisler C A, Weitzman E D, Moore-Ede M C, Zimmerman J C, Knauer RS. Human sleep: its duration and organization depend on its circadian phase. Science 1980; 210: 1264–7
   PubMed Web of Science ®Google Scholar
• Edgar D M, Dement W C, Fuller CA. Effect of SCN lesions on sleep in squirrel monkeys: evidence for opponent processes in sleep-wake regulation. J Neurosci 1993; 13: 1065–79
   PubMed Web of Science ®Google Scholar
• Schwartz W J, Busis N A, Hedley-Whyte ET. A discrete lesion of ventral hypothalamus and optic chiasm that disturbed the daily temperature rhythm. J Neurol 1986; 233: 1–4
   PubMedGoogle Scholar
• Cohen R A, Albers HE. Disruption of human circadian and cognitive regulation following a discrete hypothalamic lesion: a case study. Neurology 1991; 41: 726–9
   PubMed Web of Science ®Google Scholar
• Pinto L H, Naylor E, Vitaterna M H, Takahashi J S, Turek FW. Do clock genes affect sleep. Proceedings of the American College of Neuropsychopharmacology 37th Annual Meeting, Las Croabas, Puerto Rico, Dec 14–18, 1998
   Google Scholar
• Myers B L, Badia P. Changes in circadian rhythms and sleep quality with aging: mechanisms and interventions. Neurosci Biobehav Rev 1995; 19: 553–71
   PubMed Web of Science ®Google Scholar
• Van Someren E JW, Mirmiran M, Swaab DF. Non-pharmacological treatment of sleep and wake disturbances in aging and Alzheimer's disease: chronobiological perspectives. Behav Brain Res 1993; 57: 235–53
   PubMed Web of Science ®Google Scholar
• Carskadon M A, Dement WC. Effects of total sleep loss on sleep tendency. Percept Mot Skills 1979; 48: 495–506
   PubMed Web of Science ®Google Scholar
• Carskadon M A, Dement WC. Cumulative effects of sleep restriction on daytime sleepiness. Psychophysiology 1981; 18: 107–13
   PubMed Web of Science ®Google Scholar
• Brunner D P, Dijk D-J, Tobler I, Borbély AA. Effect of partial sleep deprivation on sleep stages and EEG power spectra: evidence for non-REM and REM sleep homeostasis. Electroencephalogr Clin Neurophysiol 1990; 75: 492–9
   PubMedGoogle Scholar
• Dinges D F, Pack F, Williams K, Gillen K A, Powell J A, Ott G E. Cumulative sleepiness, mood disturbance and psychomotor vigilance performance decrements during a week of sleep restricted to 4–5 hours per night. Sleep 1997; 20: 267–77
   PubMed Web of Science ®Google Scholar
• Daan S, Beersma D GM, Borbély AA. Timing of human sleep: recovery process gated by a circadian pacemaker. Am J Physiol 1984; 246: R161–78
   PubMed Web of Science ®Google Scholar
• Borbély AA, Achermann P, Trachsel L, Tobler I. Sleep initiation and initial sleep intensity: interaction of homeo-static and circadian mechanisms. J Biol Rhythms 1989; 4: 149–60
   PubMed Web of Science ®Google Scholar
• Czeisler C A, Allan J S, Kronauer RE. A method for assaying the effects of therapeutic agents on the period of the endogenous circadian pacemaker in man. Sleep and Biological Rhythms: Basic Mechanisms and Applications to Psychiatry, J Montplaisir, R Godbout. Oxford University Press, New York 1990; 87–98
   Google Scholar
• Boivin D B, Duffy J F, Kronauer R E, Czeisler CA. Dose-response relationships for resetting of human circadian clock by light. Nature 1996; 379: 540–2
   PubMed Web of Science ®Google Scholar
• Klerman E B, Dijk D-J, Kronauer R E, Czeisler CA. Simulations of effects of light on the human circadian pacemaker: implications for assessment of intrinsic period. Am J Physiol 1996; 270: R271–82
   PubMed Web of Science ®Google Scholar
• Czeisler C A, Duffy J F, Shanahan T L, Brown E N, Mitchell J F, Dijk D-J. Reassessment of the intrinsic period (τ) of the human circadian pacemaker in young and older subjects. Sleep Res 1995; 24A: 505
   Google Scholar
• Hiddinga A E, Beersma D GM, Van den Hoofdakker RH. Endogenous and exogenous components in the circadian variation of core body temperature in humans. J Sleep Res 1997; 6: 156–63
   PubMed Web of Science ®Google Scholar
• Dijk D-J, Czeisler CA. Paradoxical timing of the circadian rhythm of sleep propensity serves to consolidate sleep and wakefulness in humans. Neurosci Lett 1994; 166: 63–8
   PubMed Web of Science ®Google Scholar
• Dijk D-J, Czeisler CA. Contribution of the circadian pacemaker and the sleep homeostat to sleep propensity, sleep structure, electroencephalographic slow waves and sleep spindle activity in humans. J Neurosci 1995; 15: 3526–38
   PubMed Web of Science ®Google Scholar
• Wyatt J K, Dijk D-J, Czeisler CA. Sleep structure and neurobehavioral performance in a 20-HR forced desynchrony protocol: sleep/wake homeostatic and circadian modulation. Sleep 1998; 21: 244, Suppl
   Google Scholar
• Strogatz S H, Kronauer R E, Czeisler CA. Circadian pacemaker interferes with sleep onset at specific times each day: role in insomnia. Am J Physiol 1987; 253: R172–8
   PubMed Web of Science ®Google Scholar
• Lavie P. Ultrashort sleep-waking schedule III. ‘Gates’ and ‘forbidden zones’ for sleep. Electroencephalogr Clin Neurophysiol 1986; 63: 414–25
   PubMedGoogle Scholar
• Dijk D-J, Shanahan T L, Duffy J F, Ronda J M, Czeisler CA. Variation of electroencephalographic activity during non-rapid eye movement and rapid eye movement sleep with phase of circadian melatonin rhythm in humans. J Physiol (Lond) 1997; 505: 851–8
   Google Scholar
• Shochat T, Luboshitzky R, Lavie P. Nocturnal melatonin onset is phase locked to the primary sleep gate. Am J Physiol 1997; 273: R364–70
   Google Scholar
• Wei H G, Riel E, Czeisler C A, Dijk D-J. Attenuated amplitude of circadian and sleep-dependent modulation of electroencephalographic sleep spindle characteristics in elderly human subjects. Neurosci Lett 1999; 260: 29–32
   PubMed Web of Science ®Google Scholar
• Dollins A B, Zhdanova I V, Wurtman R J, Lynch H J, Deng MH. Effect of inducing nocturnal serum melatonin concentrations in daytime on sleep, mood, body temperature, and performance. Proc Natl Acad Sci USA 1994; 91: 1824–8
   PubMed Web of Science ®Google Scholar
• Tzischinsky O, Lavie P. Melatonin possesses time-dependent hypnotic effects. Sleep 1994; 17: 638–45
   PubMed Web of Science ®Google Scholar
• Hughes R J, Badia P. Sleep-promoting and hypothermic effects of daytime melatonin administration in humans. Sleep 1997; 20: 124–31
   PubMed Web of Science ®Google Scholar
• Cajochen C, Kräuchi K, Von Arx M-A, Möri D, Graw P, Wirz-Justice A. Daytime melatonin administration enhances sleepiness and theta/alpha activity in the waking EEG. Neurosci Lett 1996; 207: 209–13
   PubMed Web of Science ®Google Scholar
• Dijk D-J, Roth C, Landolt H P, Werth E, Aeppli M, Achermann P. Melatonin effect on daytime sleep in men: suppression of EEG low frequency activity and enhancement of spindle frequency activity. Neurosci Lett 1995; 201: 13–6
   PubMed Web of Science ®Google Scholar
• Weaver D R, Reppert SM. The Mella melatonin receptor gene is expressed in human suprachiasmatic nuclei. Neuroreport 1996; 8: 109–12
   PubMed Web of Science ®Google Scholar
• Liu C, Weaver D R, Jin X, Shearman L P, Pieschi R L, Gribkoff V K. Molecular dissection of two distinct actions of melatonin on the suprachiasmatic circadian clock. Neuron 1997; 19: 91–102
   PubMed Web of Science ®Google Scholar
• Kräuchi K, Cajochen C, Wirz-Justice A. A relationship between heat loss and sleepiness: effects of postural change and melatonin administration. J Appl Physiol 1997; 83: 134–9
   PubMed Web of Science ®Google Scholar
• Sherin J E, Shiromani P J, McCarley R W, Saper CB. Activation of ventrolateral preoptic neurons during sleep. Science 1996; 271: 216–9
   PubMed Web of Science ®Google Scholar
• Weitzman E D, Boyar R M, Kapen S, Hellman L. The relationship of sleep and sleep stages to neuroendocrine secretion and biological rhythms in man. Recent Prog Horm Res 1975; 31: 399–441
   Google Scholar
• Lavie P, Oksenberg A, Zomer J. ‘It's time, you must wake up now’. Percept Mot Skills 1979; 49: 447–50
   Google Scholar
• Born J, Hansen K, Marshall L, Mölle M, Fehm HL. Timing the end of nocturnal sleep. Nature 1999; 397: 29–30
   PubMed Web of Science ®Google Scholar
• Kalsbeek A, Van Heerikhuize J J, Wortel J, Buijs RM. A diurnal rhythm of stimulatory input to the hypothalamo-pituitary-adrenal system as revealed by timed intrahypo-thalamic administration of the vasopressin VI antagonist. J Neurosci 1996; 16: 5555–65
   PubMed Web of Science ®Google Scholar
• Czeisler C A, Dijk D-J, Duffy JF. Entrained phase of the circadian pacemaker serves to stabilize alertness and performance throughout the habitual waking day. Sleep Onset: Normal and Abnormal Processes, RD Ogilvie, JR Harsh. American Psychological Association, Washington, DC 1994; 89–110
   Google Scholar
• Wyatt J K, Dijk D-J, Ronda J M, Jewett M E, Powell J W, Dinges D F. Interaction of circadian and sleep/wake homeostatic-processes modulate psychomotor vigilance test (PVT) performance. Sleep Res 1997; 26: 759
   Google Scholar
• Abe K, Suzuki T. Age trends of early awakening and feeling worse in the morning than in the evening in apparently normal people. J Nerv Ment Dis 1985; 173: 495–8
   PubMed Web of Science ®Google Scholar
• Reyner A, Home JA. Gender- and age-related differences in sleep determined by home-recorded sleep logs and actimetry from 400 adults. Sleep 1995; 18: 127–34
   PubMed Web of Science ®Google Scholar
• Carrier J, Monk T H, Buysse D J, Kupfer DJ. Sleep and morningness-eveningness in the ‘middle’ years of life (20–59 y). J Sleep Res 1997; 6: 230–7
   PubMed Web of Science ®Google Scholar
• Ehlers C L, Kupfer DJ. Effects of age on delta and REM sleep parameters. Electroencephalogr Clin Neurophysiol 1989; 72: 118–25
   PubMedGoogle Scholar
• Ehlers C L, Kupfer D J, Buysse D J, Cluss P A, Miewald J M, Bisson E F. The Pittsburgh study of normal sleep in young adults: focus on the relationship between waking and sleeping EEG spectral patterns. Electroencephalogr Clin Neurophysiol 1998; 106: 199–205
   PubMedGoogle Scholar
• Prinz P N, Vitiello M V, Raskind M A, Thorpy MJ. Geriatrics: sleep disorders and aging. N Engl J Med 1990; 323: 520–6
   PubMed Web of Science ®Google Scholar
• Englert S, Linden M. Differences in self-reported sleep complaints in elderly persons living in the community who do or do not take sleep medication. J Clin Psychiatry 1998; 59: 137–44
   PubMed Web of Science ®Google Scholar
• Gleason P P, Schulz R, Smith N L, Newsom J T, Kroboth P D, Kroboth F J. Correlates and prevalence of benzodiazepine use in community-dwelling elderly. J Gen Intern Med 1998; 13: 243–50
   PubMed Web of Science ®Google Scholar
• Foley D J, Monjan A A, Brown S L, Simonsick E M, Wallace R B, Blazer DG. Sleep complaints among elderly persons: an epidemiologic study of three communities. Sleep 1995; 18: 425–32
   PubMed Web of Science ®Google Scholar
• Duffy J F, Dijk D-J, Klerman E B, Czeisler CA. Later endogenous circadian temperature nadir relative to an earlier waketime in older people. Am J Physiol 1998; 275: R1478–87
   PubMed Web of Science ®Google Scholar
• Czeisler C A, Dumont M, Duffy J F, Steinberg J D, Richardson G S, Brown E N. Association of sleep-wake habits in older people with changes in output of circadian pacemaker. Lancet 1992; 340: 933–6
   PubMed Web of Science ®Google Scholar
• Van Coevorden A, Mockel J, Laurent E, Kerkhofs M, L'Hermite-Balériaux M, Decoster C. Neuroendocrine rhythms and sleep in aging men. Am J Physiol 1991; 260: E651–61
   PubMed Web of Science ®Google Scholar
• Sherman B, Wysham C, Pfohl B. Age-related changes in the circadian rhythm of plasma Cortisol in man. J Clin Endocrinol Melab 1985; 61: 439–43
   PubMed Web of Science ®Google Scholar
• Duffy J F, Dijk D-J, Hall E F, Czeisler CA. Relationship of endogenous circadian melatonin and temperature rhythms to self-reported preference for morning or evening activity in young and older people. J Invest Med 1999; 47: 141–50
   PubMed Web of Science ®Google Scholar
• Duffy J F, Rimmer D W, Silva E J, Czeisler CA. Correlation of intrinsic circadian period with morningness-eveningness in young men. Sleep 1999; 47: 141–50
   Google Scholar
• Katzenberg D, Young T, Finn L, Lin L, King D P, Takahashi J S. A clock polymorphism associated with human diurnal preference. Sleep 1998; 21: 569–76
   PubMed Web of Science ®Google Scholar
• Ozaki S, Uchiyama M, Shirakawa S, Okawa M. Prolonged interval from body temperature nadir to sleep offset in patients with delayed sleep phase syndrome. Sleep 1996; 19: 36–40
   PubMed Web of Science ®Google Scholar
• Davis F C, Viswanathan N. Stability of circadian timing with age in Syrian hamsters. Am J Physiol 1998; 275: R960–8
   PubMed Web of Science ®Google Scholar
• Duffy JF. Age-related changes in circadian rhythms in the Syrian hamster (Mesocricetus auratus) and the human (dissertation). Northeastern University, Boston, MA 1998
   Google Scholar
• Rosenberg R S, Zee P C, Turek FW. Phase response curves to light in young and old hamsters. Am J Physiol 1991; 261: R491–5
   PubMed Web of Science ®Google Scholar
• Zhang Y, Kornhauser J M, Zee P C, Mayo K E, Takahashi J S, Turek FW. Effects of aging on light-induced phase-shifting of circadian behavioral rhythms, FOS expression and CREB phosphorylation in the hamster suprachaismatic nucleus. Neurosaence 1996; 70: 951–61
   PubMed Web of Science ®Google Scholar
• Cole R J, Kripke D F, Wisbey J, Mason W J, Gruen W, Hauri P J. Seasonal variation in human illumination exposure at two different latitudes. J Biol Rhythms 1995; 10: 324–34
   PubMed Web of Science ®Google Scholar
• Klerman E B, Duffy J F, Kronauer R E, Czeisler CA. Altered phase resetting characteristics in the elderly. Sleep Res 1995; 24A: 518
   Google Scholar
• Dijk D-J, Duffy J F, Riel E, Czeisler CA. Altered interaction of circadian and homeostatic aspects of sleep propensity results in awakening at an earlier circadian phase in older people. Sleep Res 1997; 26: 710
   Google Scholar
• Dijk D-J, Duffy J F, Riel E, Shanahan T L, Czeisler CA. Ageing and the circadian and homeostatic regulation of human sleep during forced desynchrony of rest, melatonin and temperature rhythms. J Physiol (Lond) 1999; 516: 611–27
   Google Scholar
• Moline M L, Pollak C P, Monk T H, Lester L S, Wagner D R, Zendell S M. Age-related differences in recovery from simulated jet lag. Sleep 1992; 15: 28–410
   PubMed Web of Science ®Google Scholar
• Campbell S S, Terman M, Lewy A J, Dijk D-J, Eastman C I, Boulos Z. Light treatment for sleep disorders: consensus report. V. Age-related disturbances. J Biol Rhythms 1995; 10: 151–4
   PubMed Web of Science ®Google Scholar
• Dijk D-J, Beersma D GM, Van den Hoofdakker RH. All night spectral analysis of EEG sleep in young adult and middleaged male subjects. Neurobiol Aging 1989; 10: 677–82
   PubMed Web of Science ®Google Scholar
• Landolt H-P, Dijk D-J, Achermann P, Borbély AA. Effect of age on the sleep EEG: slow-wave activity and spindle frequency activity in young and middle-aged men. Brain Res 1996; 738: 205–12
   PubMed Web of Science ®Google Scholar
• Steriade M, McCormick D A, Sejnowski TJ. Thalamocortical oscillations in the sleeping and aroused brain. Science 1993; 262: 679–85
   PubMed Web of Science ®Google Scholar
• Haimov I, Lavie P. Circadian characteristics of sleep propensity function in healthy elderly: a comparison with young adults. Sleep 1997; 20: 294–300
   PubMed Web of Science ®Google Scholar
• Reynolds CF, III, Jennings J R, Hoch C C, Monk T H, Berman S R, Hall F T. Daytime sleepiness in healthy “old old”: a comparison with young adults. J Am Geriatr Soc 1991; 39: 957–62
   PubMed Web of Science ®Google Scholar
• Campbell S S, Dawson D, Anderson MW. Alleviation of sleep maintenance insomnia with timed exposure to bright light. J Am Geriatr Soc 1993; 41: 829–36
   PubMed Web of Science ®Google Scholar
• Jewett M E, Rimmer D W, Duffy J F, Klerman E B, Kronauer R E, Czeisler CA. The human circadian pacemaker is sensitive to light throughout subjective day without evidence of transients. Am J Physiol 1997; 273: R1800–9
   PubMed Web of Science ®Google Scholar
• Waldhauser F, Kovács J, Reiter E. Age-related changes in melatonin levels in humans and its potential consequences for sleep disorders. Exp Gerontol 1998; 33: 759–72
   PubMedGoogle Scholar
• Youngstedt S D, Kripke D F, Elliott JA. Melatonin excretion is not related to sleep in the elderly. J Pineal Res 1998; 24: 142–5
   PubMed Web of Science ®Google Scholar
• Hughes R J, Sack R L, Lewy AJ. The role of melatonin and circadian phase in age-related sleep-maintenance insomnia: assessment in a clinical trial of melatonin replacement. Sleep 1998; 21: 52–68
   PubMed Web of Science ®Google Scholar
• Haimov I, Lavie P, Laudon M, Herer P, Vigder C, Zisapel N. Melatonin replacement therapy of elderly insomniacs. Sleep 1995; 18: 598–603
   PubMed Web of Science ®Google Scholar
• Hofman M A, Swaab DF. Alterations in circadian rhythmicity of the vasopressin-producing neurons of the human suprachiasmatic nucleus (SCN) with aging. Brain Res 1994; 651: 134–42
   PubMed Web of Science ®Google Scholar
• Perras B, Pannenborg H, Marshall L, Pietrowsky R, Born J, Fehm HL. Beneficial treatment of age-related sleep disturbances with prolonged intranasal vasopressin. J Clin Psychopharmacol 1999; 19: 28–36
   PubMed Web of Science ®Google Scholar