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Original Article

Comparative Antihypertensive Effects of Losartan 50 mg and Losartan 50 mg Titrated to 100 mg in Patients with Essential Hypertension

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Pages 35-43 | Received 01 Apr 1996, Accepted 12 Aug 1996, Published online: 08 Jul 2009

References

  • Siegl PKS. Discovery of losartan, the first specific non-peptide angiotensin II receptor antagonist. J Hypertens 1993; 11: S19–S22
  • Smith RD, Chiu AT, Wong PC, Herblin WF, Timmermans PBMWM. Pharmacology of nonpeptide angiotensin I1 receptor antagonists. A Rev Pharmacol Toxicol 1992; 32: 135–65
  • Timmermans PBMWM, Benfield P, Chiu AT, Herblin WF, Wong PC, Smith RD. Angiotensin II receptors and functional correlates. Am J Hypertens 1992; 5: 221s–2358
  • Ganison JC, Peach MJ. Renin and angiotensin. The pharmacological basis of therapeutics 8th ed, AG Gilman, TW Rall, AS Nies, P. Taylor. McGraw-Hill, New York 1990; 749–63
  • Erdos EG. Some old and some new ideas on kinin metabolism. J Cardiovasc Pharmacol 1990; 15: S20–24
  • O'Hollaren MT, Porter M. Angiotensin converting enzyme inhibitors and the allergist. Ann Allergy 1990; 64: 503–6
  • Karlberg BE. Cough and inhibition of the renin-angiotensin system. J Hypertens 1993; 11: S49–S52
  • Cockcroft JR, Sciberras DG, Goldberg MR, Ritter Jm. Comparison of angiotensin converting enzyme inhibition with angiotensin II receptor antagonism in the human forearm. J Cardiovasc Pharmacol 1993; 22: 579–84
  • Lacourciere Y, Brunner H, Irwin R. Effects of modulators of the renin-angiotensin-aldosterone system on cough. J Hypertens 1994; 12: 387
  • Goldberg AI, Dunlay MC, Sweet CS. The safety and tolerability of losartan potassium, an angiotensin II receptor antagonist in comparison to hydrochlorothiazide, atenolol, felodipine ER and ACE-Inhibitors for the treatment of systemic hypertension. Am J Cardiol 1995; 75: 793–5
  • Nelson EB, Merrill DM, Sweet CS, Bradstreet T, Parebianco D, Byyny R. Efficacy and safety of oral MK-954 (DuP753), an angiotensin receptor antagonist in essential hypertension. J Hypertens 1991; 9: S468–S469
  • Gradman AH, Arcuri KE, Goldberg AI. A randomized, placebo-controlled, double-blind, parallel study of various doses of losartan potassium compared to enalapril maleate in patients with essential hypertension. Hypertension 1995; 25: 1339
  • Christen Y, Waeber B, Nussberger J. Oral administration of DuP 753, a specific angiotensin II receptor antagonist, to normal male volunteers. Inhibition of pressor response to exogenous angiotensin I and II. Circulation 1991; 83: 1333
  • Christen Y, Waeber B, Nussberger J, Lee RJ, Timmermans PBMWM, Brunner HR. Dose-response relationship following oral administration of DuP 753 to normal humans. Am J Hypertens 1991; 4: 350s–53s
  • Meredith PA. Trough/peak ratios for antihypertensive agents. Drugs 1994; 48: 661–6
  • Schnaper HW, Stein G, Schoenberger JA. Enalapril, hydrochlorothiazide and plasma renin activity in elderly patients with essential hypertension. Curr Opin Cardiol 1987; 2: S39–S50
  • Forette F, Handfield-Jones R, Henry-Amar M. Rationale for ACE inhibitors in the elderly, trial of arterial hypertension with enalapril. Gerontology 1987; 33: 9–16

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