β-Andrenoceptors in the Hearts of Diabetic-hypertensive Rats: Radioligand Binding and Functional Experiments

References

• Atkins FL, Dowell RT, Love S. β-Adrenergic receptors, adenylate cyclase activity, and cardiac dysfunction in the diabetic rat. J Cardiovasc Pharmacol 1985; 7: 66–70
   PubMedGoogle Scholar
• Heyliger CE, Pierce GN, Singal PK, Beamish RE, Dhalla NS. Cardiac alpha- and beta-adrenergic receptor alterations in diabetic cardiomyopathy. Basic Res Cardiol 1982; 77: 610–8
   PubMedGoogle Scholar
• Ramanadham S, Tenner TE. Alterations in the myocardial Beta-adrenoceptor system of streptozotocin-diabetic rats. Eur J Pharmacol 1987; 136: 377–89
   PubMedGoogle Scholar
• Ganguly PK, Beamish RE, Dhalla KS, Innes IR, Dhalla NS. Norepinephrine storage, distribution, and release in diabetic cardiomyopathy. Am J Physiol 1987; 252: E734–E739
   PubMed Web of Science ®Google Scholar
• Wartofsky L, Burman KD. Alterations in thyroid function in patients with systemic: illness: The “euthyroid sick syndrome”. Endocr Rev 1982; 3: 164–217
   PubMed Web of Science ®Google Scholar
• Bilezikian JP, Loeb JN. The influence of hyperthyroid-ism and hypothyroidism on a- and b-adrenergic receptor systems and adrenergic responsiveness. Endocr Rev 1983; 4: 378–88
   PubMed Web of Science ®Google Scholar
• Yu Z, McNeill JH. Altered inotropic responses in diabetic cardiomyopathy and hypertensive-diabetic cardiomyopathy. J Pharmacol Exp Meth 1991; 257: 64–71
   PubMedGoogle Scholar
• Vadlamudi RV, McNeill JH. Effect of experimental diabetes on isolated rat heart responsiveness to isoproterenol. Can J Physiol Pharmacol 1984; 62: 124–31
   PubMedGoogle Scholar
• Masuyama Y, Fukuda K. Adrenoceptors in experimental hypertension. Clin Exp Hypertens A 1989; 11: 31–42
   PubMed Web of Science ®Google Scholar
• Böhm M, Beuckelmann D, Diet F, Feiler G, Lohse MJ, Erdmann E. Properties of cardiac alpha- and beta-adrenoceptors in spontaneously hypertensive rats. Naunyn-Schmiedeberg's Arch Pharmacol 1988; 338: 383–91
   Google Scholar
• Michel MC, Kanczik R, Khamssi M. Alpha- and beta-adrenoceptors in hypertension. I. Cardiac and renal alpha 1-, beta 1-, and beta 2-adrenoceptors in rat models of acquired hypertension. J Cardiovasc Pharmacol 1989; 13: 421
   Google Scholar
• Murakami T, Katada T, Yasuda H. Reduction in the activity of the stimulatory guanine nucleotide-binding protein in the myocardium of spontaneously hypertensive rats. J Molec Cell Cardiol 1987; 19: 199–208
   PubMedGoogle Scholar
• Factor SM, Bhan R, Minase T, Wolinsky H, Sonnen-Blick EH. Hypertensive-diabetic cardiomyopathy in the rat: an experimental model of human disease. Am J Pathol 1981; 102: 219–28
   PubMed Web of Science ®Google Scholar
• Epstein M, Sowers JR. Diabetes mellitus and hypertension. Hypertension 1992; 19: 403–18
   PubMed Web of Science ®Google Scholar
• Rodrigues B, McNeill JH. Cardiac function in spontaneously hypertensive diabetic rats. Am J Physiol 1986; 251: H571–H580
   PubMed Web of Science ®Google Scholar
• Engel G, Hoyer D, Berthold R, Wagner H. (±)[125Iodo] cyanopindolol, a new ligand for beta-adrenoceptors: identification and quantitation of subclasses of beta-adrenoceptors in guinea pig. Naunyn-Schmiedeberg's Arch Pharmacol 1981; 317: 277–85
   Google Scholar
• Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analyt Biochem 1976; 72: 248–54
   PubMed Web of Science ®Google Scholar
• Scatchard G. The attraction of proteins for small molecules and ions. Ann NY Acad Sci 1949; 51: 660–72
   Web of Science ®Google Scholar
• Yamamoto J. Blood pressure and metabolic effects of streptozotocin in wistar kyoto and spontaneously hypertensive rats. Clin Exp Hypertens A 1988; 10: 1065–83
   PubMed Web of Science ®Google Scholar
• Susic D, Mandal AK, Jovovic DJ, Radujkovic G, Kentera D. Streptozotocin-induced diabetes mellitus lowers blood pressure in spontaneously hypertensive rat. Clin Exp Hypertens A 1990; 12: 1021–35
   PubMed Web of Science ®Google Scholar
• Tahiliani AG, McNeill JH. Diabetes-induced abnormalities in the myocardium. Life Sci 1986; 38: 959–74
   PubMedGoogle Scholar
• Lopaschuk GD, Tahiliani AG, Vadlamudi RV, Katz S, McNeill JH. Cardiac sarcoplasmic reticulum function in insulin- or carnitine-treated diabetic rats. Am J Physiol 1983; 245: H969–H976
   Google Scholar
• Dillmann WH. Diabetes and thyroid-hormone-induced changes in cardiac function and their molecular basis. [Review]. A Rev Med 1989; 40: 373–94
   PubMed Web of Science ®Google Scholar
• Kashiwagi A, Nishio Y, Saeki Y, Kida Y, Kodama M, Shigeta Y. Plasma membrane-specific deficiency in cardiac b-adrenergic receptor in streptozotocin-diabetic rats. Am J Physiol 1989; 257: E127–E132
   Google Scholar
• Pfaffendorf M, Batink HD, Kam KL, Pijl AJ, Mathy M-J, van Zwieten PA. Characteristics of b-adrenoceptors in cardiac tissue from spontaneously hypertensive rats with streptozotocin-induced diabetes mellitus. Br J Pharmacol 1994; 112: 40P
   Google Scholar
• Michel MC, Wang XL, Schlicker E, Göthert M, Beckeringh JJ, Brodde OE. Increased beta 2–adrenoreceptor density in heart, kidney and lung of spontaneously hypertensive rats. J Auton Pharmacol 1987; 7: 41–51
   PubMedGoogle Scholar
• Ikawa H, Suzuki A. Effects of aging and drugs on myocardial beta-adrenergic receptors in M-SHRSP and SHRSP. Clin Exp Hypertens A 1991; 13: 1091–106
   PubMed Web of Science ®Google Scholar
• Yamada S, Ishima T, Tomita T, Hayashi M, Okada T, Hayashi E. Alterations in cardiac alpha and beta adrenoceptors during the development of spontaneous hypertension. J Pharmacol Exp Ther 1984; 228: 454–60
   PubMed Web of Science ®Google Scholar
• Limas CJ, Limas C. Altered intracellular adrenoceptor distribution in myocardium of spontaneously hypertensive rats. Am J Physiol 1987; 253: H904–H908
   PubMed Web of Science ®Google Scholar
• Matsumori Y, Ohyanagi M, Kawamoto H, Shibata R, Iwasaki T. Intracellular distribution of cardiac beta-adrenoceptors in SHR and WKY. Jpn Circ J 1989; 53: 113–20
   PubMedGoogle Scholar
• Böhm M, Gierschik P, Knorr A, Larisch K, Weismann K, Erdmann E. Role of altered G-protein expression in the regulation of myocardial adenylate cyclase activity and force of contraction in spontaneous hypertensive cardiomyopathy in rats. J Hypertens 1992; 10: 1115–28
   PubMedGoogle Scholar
• Michel MC, Brodde OE, Insel PA. Are cardiac G-proteins altered in rat models of hypertension?. J Hypertens 1993; 11: 355–63
   PubMedGoogle Scholar
• Mertens MJF, Mathy M-J, Pfaffendorf M, van Zwieten PA. Depressed inotropic response to beta-adrenoceptor agonists in the presence of advanced cardiac hypertrophy in hearts from rats with induced aortic stenosis and from spontaneously hypertensive rats. J Hypertens 1992; 10: 1361–8
   PubMedGoogle Scholar
• Asano M, Masuzawa K, Matsuda T, Asano T. Decreased responsiveness to beta-adrenoceptor agonists in arterial strips from spontaneously hypertensive rats is not associated with alterations in beta-adrenoceptors. J Hypertens 1991; 9: 607–13
   PubMedGoogle Scholar