Activation of the α3 Integrin Affects TRAF6 Function In The IL-1 Signaling Pathway of CACO-2 Epithelial Cells

REFERENCES

• Al-Sadi, R. M., Ma, T. Y. (2007). IL-1β causes an increase in intestinal epithelial tight junction permeability. J. Immunol. 178:4641–4649.
   PubMed Web of Science ®Google Scholar
• Beaulieu, J.-F. (1999). Integrins and human intestinal cell functions. Frontiers Biosci. 4:d310–d321.
   PubMedGoogle Scholar
• Bouatrouss, Y., Herring-Gillam, F.E., Gosselin, J., Poisson, J., Beaulieu, J.-F. (2000). Altered expression of laminins in Crohn's disease small intestinal mucosa. Am. J. Pathol. 156:45–50.
   PubMedGoogle Scholar
• Burns, K., Clatworthy, J., Martin, L., Martinon, F., Plumpton, C., Maschera, B., Lewis, A., Ray, K, Tschopp, J., Volpe, F. (2000). Tollip, a new component of the IL-RI pathway, links IRAK to the IL-1 receptor. Nat. Cell Biol. 2:346–351.
   PubMed Web of Science ®Google Scholar
• Burns, K., Janssens, S., Brissoni, B., Olivos, N., Beyaert, R., Tschopp, J. (2003). Inhibition of interleukin-1 receptor/toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4. J. Exp. Med. 197:263–268.
   PubMed Web of Science ®Google Scholar
• Conze, D. B., Wu, C.-J., Thomas, J. A., Landstrom, A., Ashwell, J. D. (2008). Lys(K) 63-linked polyubiquitination of IRAK-1 is required for IL-1 receptor- and Toll-like receptor-mediated NF-κB activation. Mol. Cell Biol. 28:3538–3547.
   PubMed Web of Science ®Google Scholar
• Dendorfer, U., Oettgen, P., Libermann, T. A. (1994). Multiple regulatory elements in the interleukin-6 gene mediate induction by prostaglandins, cyclic AMP, and lipopolysaccharide. Mol. Cell Biol. 14:4443–4454.
   PubMed Web of Science ®Google Scholar
• Deng, L., Wang, C., Spencer, E., Yang, L., Braun, A., You, J., Slaughter, C., Pickart, C., Chen, Z.J. (2000). Activation of the IκB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell 103:351–361.
   PubMed Web of Science ®Google Scholar
• Ea, C.-K., Sun, L., Inoue, J.-I., Chen, Z.J. (2004). TIFA activates IκB kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6. Proc. Natl. Acad. Sci USA 101:15318–15323.
   PubMedGoogle Scholar
• Jiang, Z., Ninomiya-Tsuji, J., Qian, Y., Matsumoto, K., Li, X. (2002). Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol. Mol. Cell Biol. 22:7158–7167.
   PubMedGoogle Scholar
• Jung, H. C., Eckmann, L., Yang, S.-K., Panja, A., Fierer, J., Morzycka-Wroblewska, E., Kagnoff, M. F. (1995). A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion. J. Clin. Invest. 95:55–65.
   PubMed Web of Science ®Google Scholar
• Kagnoff, M. F., Eckmann, L. (1997). Epithelial cells as sensors for microbial infection. J. Clin. Invest. 100:6–10.
   PubMed Web of Science ®Google Scholar
• Kanayama, A., Seth, R. B., Sun, L., Ea, C.-K., Hong, M., Shaito, A., Chiu, Y.-H., Deng, L., Chen, Z. J. (2004). TAB2 and TAB3 activate the NF-κB pathway through binding to polyubiquitin chains. Mol. Cell. 15:535–548.
   PubMed Web of Science ®Google Scholar
• Kishida, S., Sanjo, H., Akira, S., Matsumoto, K., Ninomiya-Tsuji, J. (2005). TAK1-binding protein 2 facilitates ubiquitination of TRAF6 and assembly of TRAF6 with IKK in the IL-1 signaling pathway. Genes Cells 10:447–454.
   PubMed Web of Science ®Google Scholar
• Kobayashi, N., Kadono, Y., Naito, A., Mastumoto, K., Yamamoto, T., Tanaka, S., Inoue, J. (2001). Segregation of TRAF6-mediated signaling paways clarifies its role in osteoclastogenesis. EMBO J. 20:1271–1280.
   PubMed Web of Science ®Google Scholar
• Kollewe, C., Mackensen, A.-C., Neumann, D., Knop, J., Cao, P., Li, S., Wesche, H., Martin, M. U. (2004). Sequential autophosphorylation steps in the interleukin-1 receptor-associated kinase-1 regulate its availability as an adapter in interleukin-1 signaling. J. Biol. Chem. 279:5227–5236.
   PubMed Web of Science ®Google Scholar
• Lamothe, B., Besse, A., Campos, A. D., Webster, W. K., Wu, H., Darnay, B. G. (2007). Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of IκB kinase activation. J. Biol. Chem. 282:4102–4212.
   PubMed Web of Science ®Google Scholar
• Leivo, I., Tani, T., Laitinen, L., Bruns, R., Kivilaakso, E., Lehto, V. P., Burgeson, R. E., Virtanen, I. (1996). Anchoring complex components laminin-5 and type VII collagen in the intestine: Association with migration and differentiating enterocytes. J. Histochem. Cytochem. 44:1267–1277.
   PubMedGoogle Scholar
• Li, G., Lubin, F. D., McGee, D. W. (2004). α3β1 integrin induced suppression of the Caco-2 epithelial cell IL-1 signaling pathway leading to NF-κB activation. Cell Immunol. 231:30–39.
   PubMedGoogle Scholar
• Lomaga, M. A., Yeh, W. C., Sarosi, I., Duncan, G. S., Furlonger, C., Ho, A., Morony, S., Capparelli, C., Van, G., Kaufman, S., van der Heiden, A., Itie, A., Wakeham, A., Khoo, W., Sasaki, T., Cao, Z., Penninger, J. M., Paige, C. J., Lacey, D. L., Dunstan, C. R., Boyle, W. J., Goeddel, D. V., Mak, T. W. (1999). TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev. 13:1015–1024.
   PubMed Web of Science ®Google Scholar
• Lubin, F. D., Segal, M., McGee, D. W. (2003). Regulation of epithelial cell cytokine responses by the α3β1 integrin. Immunology 108:204–210.
   PubMedGoogle Scholar
• Martin, T., CardarellI, P. M., Parry, G. C. N., Felts, K. A., Cobb, E. R. (1997). Cytokine induction of monocyte chemoattractant protein-1 gene expression in human endothelial cells depends on the cooperative action of NF-κB and AP-1. Eur. J. Immunol. 27:1091–1097.
   PubMed Web of Science ®Google Scholar
• McGee, D. W., Beagley, K. W., Aicher, W. K., McGhee, J. R. (1993). Transforming growth factor-β and IL-1β act in synergy to enhance IL-6 secretion by the intestinal epithelial cell line, IEC-6. J. Immunol. 151:970–978.
   PubMedGoogle Scholar
• McGee, D. W., Bamberg, T., Vitkus, S. J. D., McGhee, J. R. (1995). A synergistic relationship between TNF-α, IL-1β, and TGF-β1 on IL-6 secretion by the IEC-6 intestinal epithelial cell line. Immunology 86:6–11.
   PubMed Web of Science ®Google Scholar
• O'Neill, L. A., Greene, C. (1998). Signal transduction pathways activated by the IL-1 receptor family: ancient signaling machinery in mammals, insects, and plants. J. Leukoc. Biol. 63:650–657.
   PubMed Web of Science ®Google Scholar
• Qian, Y., Commane, M., Ninomiya-Tsuji, J., Matsumoto, K., Li, X. (2001). IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NF-κB. J. Biol. Chem. 276:41661–41667.
   PubMed Web of Science ®Google Scholar
• Reddig, P. J., Juliano, R. L. (2005). Clinging to life: cell to matrix adhesion and cell survival. Cancer Metastasis Rev. 24:425–439.
   PubMed Web of Science ®Google Scholar
• Roebuck, K. A. (1999). Regulation of interleukin 8 gene expression. J. Interferon Cytokine Res. 19:429–438.
   PubMed Web of Science ®Google Scholar
• Rogler, G., Andus, T. (1998). Cytokines in inflammatory bowel disease. World J. Surg. 22:382–389.
   PubMed Web of Science ®Google Scholar
• Stulic, M., Lubin, F. D., O'Donnell, P. M., Tammariello, S. P., McGee, D. W. (2007). Effect of the α3β1 integrin on the IL-1 stimulated activation of c-Jun N-terminal kinase (JNK) in Caco-2 cells. Cytokine 37:163–170.
   PubMedGoogle Scholar
• Takatsuna, H., Kato, H., Gohda, J., Akiyama, T., Moriya, A., Okamoto, Y., Yamagata, Y., Otsuka, M., Umezawa, K., Semba, K., Inoue, J.-I. (2003). Identification of TIFA as an adapter protein that links tumor necrosis factor receptor-associated factor 6 (TRAF6) to interleukin-1 (IL-1) receptor-associated kinase-1 (IRAK-1) in IL-1 receptor signaling. J. Biol. Chem. 278:12144–12150.
   PubMed Web of Science ®Google Scholar
• Teller, I. C., Beaulieu, J.-F. (2001). Interactions between laminin and epithelial cells in intestinal health and disease. Expert Rev. Mol. Med. 3:1–18.
   PubMedGoogle Scholar
• Tsuji, T., Kawada, Y., Kai-Murozono, M., Komatsu, S., Han, S. A., Takeuchi, K., Mizushuma, H., Miyazaki, K., Irimura, T. (2002). Regulation of melanoma cell migration and invasion by laminin-5 and α3B1 integrin (VLA-3). Clin. Exp. Metastasis 19:127–134.
   PubMed Web of Science ®Google Scholar
• Vitkus, S. J. D., Hanifin, S. A., McGee, D. W. (1998). Factors affecting Caco-2 intestinal epithelial cell interleukin-6 secretion. In Vitro Cell Dev Biol. 34:660–664.
   Google Scholar
• Wang, C., Deng, L., Hong, M., Akkaraju, G. R., Inoue, J.-I., Chen, Z. J. (2001). TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature 412:346–351.
   PubMed Web of Science ®Google Scholar
• Windheim, M., Stafford, M., Peggie, M., Cohen, P. (2008). Interleukin-1 (IL-1) induces the Lys 63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IκBα kinase. Mol. Cell Biol. 28:1783–1791.
   PubMedGoogle Scholar
• Yamin, T.-T., Miller, D.K. (1997). The interleukin-1 receptor-associated kinase is degrades by proteosomes following its phosphorylation. J. Biol. Chem. 272:21540–21547.
   PubMedGoogle Scholar
• Zuk, A., Matlin, K. S. (2002). Induction of a laminin isoform and α3β1-integrin in renal ischemic injury and repair in vivo. Am. J. Physiol. Renal Physiol. 283:F971–F984.
   Google Scholar