Mesenchymal Stem Cell-Mediated Immature Dendritic Cells Induce Regulatory T Cell-Based Immunosuppressive Effect

REFERENCES

• Bartholomew, A., Sturgeon, C., Siatskas, M., Ferrer, K., McIntosh, K., Patil, S., Hardy, W., Devine, S., Ucker, D., Deans, R., Moseley, A., Hoffman, R. (2002). Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo. Exp. Hematol. 30:42–48.
   PubMed Web of Science ®Google Scholar
• Cronwright, G., Le Blanc, K., Gotherstrom, C., Darcy, P., Ehnman, M., Brodin, B. (2005). Cancer/testis antigen expression in human mesenchymal stem cells: down-regulation of SSX impairs cell migration and matrix metalloproteinase 2 expression. Cancer Res. 65:2207–2215.
   PubMed Web of Science ®Google Scholar
• Fu, F., Li, Y., Qian, S., Lu, L., Chambers, F., Starzl T. E., Fung, J. J., Thomson, A. W. (1996). Costimulatory molecule-deficient dendritic cell progenitors (MHC class II+, CD80dim, CD86-) prolong cardiac allograft survival in nonimmunosuppressed recipients. Transplantation 62:659–665.
   PubMed Web of Science ®Google Scholar
• de Heusch, M., Oldenhove, G., Urbain, J., Thielemans, K., Maliszewski, C., Leo, O., Moser, M. (2004). Depending on their maturation state, splenic dendritic cells induce the differentiation of CD4(+) T lymphocytes into memory and/or effector cells in vivo. Eur. J. Immunol. 34:1861–1869.
   PubMed Web of Science ®Google Scholar
• Kadiyala, S., Young, R. G., Thiede, M. A., Bruder, S. P. (1997). Culture expanded canine mesenchymal stem cells possess osteochondrogenic potential in vivo and in vitro. Cell Transplant. 6:125–134.
   PubMed Web of Science ®Google Scholar
• Lim, D. S., Kang, M. S., Jeong, J. A., Bae, Y. S. (2009). Semi-mature DC are immunogenic and not tolerogenic when inoculated at a high dose in collagen-induced arthritis mice. Eur. J. Immunol. 39:1334–1343.
   PubMed Web of Science ®Google Scholar
• Lim, D. S., Kim, J. H., Lee, D. S., Yoon, C. H., Bae, Y. S. (2007). DC immunotherapy is highly effective for the inhibition of tumor metastasis or recurrence, although it is not efficient for the eradication of established solid tumors. Cancer Immunol. Immunother. 56:1817–1829.
   Google Scholar
• Lutz, M. B., Schuler, G. (2002). Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity? Trends Immunol. 23:445–449.
   PubMed Web of Science ®Google Scholar
• Lutz, M. B., Suri, R. M., Niimi, M., Oqilvie, A. L., Kukutsch, N. A., Rossner, S., Schuler, G., Austyn, J. M. (2000). Immature dendritic cells generated with low doses of GM-CSF in the absence of IL-4 are maturation resistant and prolong allograft survival in vivo. Eur. J. Immunol. 30:1813–1822.
   PubMed Web of Science ®Google Scholar
• Meirelles Lda, S., Nardi, N. B. (2003). Murine marrow-derived mesenchymal stem cell: isolation, in vitro expansion, and characterization. Br. J. Haematol. 123:702–711.
   PubMed Web of Science ®Google Scholar
• Miura, M., Miura, Y., Padilla-Nash, H. M., Molinolo, A. A., Fu, B., Patel, V., Seo, B. M., Sonoyama, W., Zheng, J. J., Baker, C. C., Chen, W., Ried, T., Shi, S. (2006). Accumulated chromosomal instability in murine bone marrow mesenchymal stem cells leads to malignant transformation. Stem Cells 24:1095–1103.
   PubMed Web of Science ®Google Scholar
• Pereira, R. F., Halford, K. W., O’Hara, M. D., Leeper, D. B., Sokolov, B. P., Pollard, M. D., Bagasra, O., Prockop, D. J. (1995). Cultured adherent cells from marrow can serve as long-lasting precursor cells for bone, cartilage, and lung in irradiated mice. Proc. Natl. Acad. Sci. USA 92:4857–4861.
   PubMed Web of Science ®Google Scholar
• Phinney, D. G., Kopen, G., Isaacson, R. L., Prockop, D. J. (1999). Plastic adherent stromal cells from the bone marrow of commonly used strains of inbred mice: variations in yield, growth, and differentiation. J. Cell. Biochem. 72:570–585.
   PubMed Web of Science ®Google Scholar
• Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S., Marshak, D. R. (1999). Multilineage potential of adult human mesenchymal stem cells. Science 284:143–147.
   PubMed Web of Science ®Google Scholar
• Riggi, N., Cironi, L., Provero, P., Suva, M. L., Kaloulis, K., Garcia-Echeverria, C., Hoffmann, F., Trumpp, A., Stamenkovic, I. (2005). Development of Ewing’s sarcoma from primary bone marrow-derived mesenchymal progenitor cells. Cancer Res. 65:11459–11468.
   PubMed Web of Science ®Google Scholar
• Ringden, O., Labopin, M., Bacigalupo, A., Arcese, W., Schaefer, U. W., Willemze, R., Koc, H., Bunjes, D., Gluckman, E., Rocha, V., Schattenberg, A., Frassoni, F. (2002). Transplantation of peripheral blood stem cells as compared with bone marrow from HLA-identical siblings in adult patients with acute myeloid leukemia and acute lymphoblastic leukemia. J. Clin. Oncol. 20:4655–4664.
   PubMed Web of Science ®Google Scholar
• Sakaguchi, S. (2004). Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu. Rev. Immunol. 22:531–562.
   PubMed Web of Science ®Google Scholar
• Shevach, E. M. (2000). Regulatory T cells in autoimmunity. Annu. Rev. Immunol. 18:423–449.
   PubMed Web of Science ®Google Scholar
• Steinman, R. M., Hawiger, D., Nussenzweig, M. C. (2003). Tolerogenic dendritic cells. Annu. Rev. Immunol. 21:685–711.
   PubMed Web of Science ®Google Scholar
• Yang, S. H., Park, M. J., Yoon, I. H., Kim, S. Y., Hong, S. H., Shin, J. Y., Nam, H. Y., Kim, Y. H., Kim, B., Park, C. G. (2009). Soluble mediators from mesenchymal stem cells suppress T cell proliferation by inducing IL-10. Exp. Mol. Med. 41:315–324.
   PubMed Web of Science ®Google Scholar