CTLA-4 -1722T/C Polymorphism and Systemic Lupus Erythematosus Susceptibility: A Meta-analysis Involving Ten Separate Studies

REFERENCES

• Aguilar, F., Torres, B., Sanchez-Roman, J., Nunez-Roldan, A., Gonzalez-Escribano, M. F. (2003). CTLA4 polymorphism in Spanish patients with systemic lupus erythematosus. Hum. Immunol. 64:936–940.
   PubMedGoogle Scholar
• Ahmed, S., Ihara, K., Kanemitsu, S., Nakashima, H., Otsuka, T., Tsuzaka, K., Takeuchi, T., Hara, T. (2001). Association of CTLA-4 but not CD28 gene polymorphisms with systemic lupus erythematosus in the Japanese population. Rheumatology (Oxford) 40:662–667.
   PubMed Web of Science ®Google Scholar
• Arasteh, J. M., Sarvestani, E. K., Aflaki, E., Amirghofran, Z. (2010). Fas gene polymorphisms in systemic lupus erythematosus and serum levels of some apoptosis-related molecules. Immunol. Invest. 39:27–38.
   PubMedGoogle Scholar
• Balakrishnan, K., Adams, L. E. (1995). The role of the lymphocyte in an immune response. Immunol. Invest. 24:233–244.
   PubMed Web of Science ®Google Scholar
• Barreto, M., Santos, E., Ferreira, R., Fesel, C., Fontes, M. F., Pereira, C., Martins, B., Andreia, R., Viana, J. F., Crespo, F., Vasconcelos, C., Ferreira, C., Vicente, A. M. (2004). Evidence for CTLA4 as a susceptibility gene for systemic lupus erythematosus. Eur. J. Hum. Genet. 12:620–626.
   PubMed Web of Science ®Google Scholar
• Caputo, M., Cerrone, G. E., Mazza, C., Cedola, N., Targovnik, H. M., Gustavo, D. F. (2007). No evidence of association of CTLA-4 -318 C/T, 159 C/T, 3′ STR and SUMO4 163 AG polymorphism with autoimmune diabetes. Immunol. Invest. 36:259–270.
   PubMed Web of Science ®Google Scholar
• Chua, K. H., Puah, S. M., Chew, C. H., Tan, S. Y., Lian, L. H. (2010). Study of the CTLA-4 gene polymorphisms in systemic lupus erythematosus (SLE) samples from Malaysia. Ann. Hum. Biol. 37:274–280.
   PubMedGoogle Scholar
• Cochran, W. G. (1954). The combination of estimates from different experiments. Biometrics 10:101–129.
   Web of Science ®Google Scholar
• D’Alfonso, S., Rampi, M., Bocchio, D., Colombo, G., Scorza-Smeraldi, R., Momigliano-Richardi, P. (2000). Systemic lupus erythematosus candidate genes in the Italian population: Evidence for a significant association with interleukin-10. Arthritis Rheum. 43:120–128.
   PubMedGoogle Scholar
• DerSimonian, R., Laird, N. (1986). Meta-analysis in clinical trials. Control Clin. Trials 7:177–188.
   PubMed Web of Science ®Google Scholar
• Eagar, T. N., Karandikar, N. J., Bluestone, J. A., and Miller, S. D. (2002). The role of CTLA-4 in induction and maintenance of peripheral T cell tolerance. Eur. J. Immunol. 32:972–981.
   PubMed Web of Science ®Google Scholar
• Egger, M., Davey Smith, G., Schneider, M., Minder, C. (1997). Bias in meta-analysis detected by a simple, graphical test. BMJ 315:629–634.
   PubMed Web of Science ®Google Scholar
• Fernandez-Blanco, L., Perez-Pampin, E., Gomez-Reino, J. J., Gonzalez, A. (2004). A CTLA-4 polymorphism associated with susceptibility to systemic lupus erythematosus. Arthritis Rheum. 50:328–329.
   PubMed Web of Science ®Google Scholar
• Finck, B. K., Linsley, P. S., Wofsy, D. (1994). Treatment of murine lupus with CTLA4Ig. Science 265:1225–1227.
   PubMed Web of Science ®Google Scholar
• Gao, S. N., Jiang, Z. M., Meng, W., Jiang, F., Gu, W. M., Hu, W. Z., Fu, C. W., Xu, A. E., Lai, S. H. (2007). Cytotoxic T lymphocyte-associated antigen-4 gene promoter polymorphisms in patients with systemic lupus erythematosus in southern Chinese population. Fudan Univ. J. Med. Sci. 34:193–197.
   Google Scholar
• Greenwald, R. J., Latchman, Y. E., Sharpe, A. H. (2002). Negative co-receptors on lymphocytes. Curr. Opin. Immunol. 14:391–396.
   PubMed Web of Science ®Google Scholar
• Gribben, J. G., Freeman, G. J., Boussiotis, V. A., Rennert, P., Jellis, C. L., Greenfield, E., Barber, M., Restivo, V. A., Jr., Ke, X., Gray, G. S., (1995). CTLA4 mediates antigen-specific apoptosis of human T cells. Proc. Natl. Acad. Sci. USA 92:811–815.
   PubMed Web of Science ®Google Scholar
• Harley, J. B., Moser, K. L., Gaffney, P. M., Behrens, T. W. (1998). The genetics of human systemic lupus erythematosus. Curr. Opin. Immunol. 10:690–696.
   PubMed Web of Science ®Google Scholar
• Hellquist, A., Jarvinen, T. M., Koskenmies, S., Zucchelli, M., Orsmark-Pietras, C., Berglind, L., Panelius, J., Hasan, T., Julkunen, H., D’Amato, M., Saarialho-Kere, U., Kere, J. (2009). Evidence for genetic association and interaction between the TYK2 and IRF5 genes in systemic lupus erythematosus. J. Rheumatol. 36:1631–1638.
   PubMed Web of Science ®Google Scholar
• Heward, J., Gordon, C., Allahabadia, A., Barnett, A. H., Franklyn, J. A., Gough, S. C. (1999). The A-G polymorphism in exon 1 of the CTLA-4 gene is not associated with systemic lupus erythematosus. Ann. Rheum. Dis. 58, 193–5.
   PubMedGoogle Scholar
• Heward, J. M., Allahabadia, A., Carr-Smith, J., Daykin, J., Cockram, C. S., Gordon, C., Barnett, A. H., Franklyn, J. A., Gough, S. C. (1998). No evidence for allelic association of a human CTLA-4 promoter polymorphism with autoimmune thyroid disease in either population-based case-control or family-based studies. Clin. Endocrinol. (Oxf.) 49:331–334.
   PubMedGoogle Scholar
• Higgins, J. P., Thompson, S. G. (2002). Quantifying heterogeneity in a meta-analysis. Stat. Med. 21:1539–1558.
   PubMed Web of Science ®Google Scholar
• Hochberg, M. C. (1997). Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 40:1725.
   PubMed Web of Science ®Google Scholar
• Hudson, L. L., Rocca, K., Song, Y. W., Pandey, J. P. (2002). CTLA-4 gene polymorphisms in systemic lupus erythematosus: A highly significant association with a determinant in the promoter region. Hum. Genet 111:452–455.
   PubMed Web of Science ®Google Scholar
• Jury, E. C., Flores-Borja, F., Kalsi, H. S., Lazarus, M., Isenberg, D. A., Mauri, C., Ehrenstein, M. R. (2010). Abnormal CTLA-4 function in T cells from patients with systemic lupus erythematosus. Eur. J. Immunol. 40:569–578.
   PubMed Web of Science ®Google Scholar
• Kimkong, I., Nakkuntod, J., Sae-Ngow, S., Snabboon, T., Avihingsanon, Y., Hirankarn, N. (2011). Association between CTLA-4 polymorphisms and the susceptibility to systemic lupus erythematosus and Graves’ disease in Thai population. Asian Pac. J. Allergy Immunol. 29:229–235.
   PubMed Web of Science ®Google Scholar
• Kotzin, B. L. (1996). Systemic lupus erythematosus. Cell 85:303–306.
   PubMed Web of Science ®Google Scholar
• Kristiansen, O. P., Larsen, Z. M., Pociot, F. (2000). CTLA-4 in autoimmune diseases–a general susceptibility gene to autoimmunity? Genes Immun. 1:170–184.
   PubMed Web of Science ®Google Scholar
• Lee, J. H., Wang, L. C., Lin, Y. T., Yang, Y. H., Lin, D. T., Chiang, B. L. (2006). Inverse correlation between CD4+ regulatory T-cell population and autoantibody levels in paediatric patients with systemic lupus erythematosus. Immunology 117:280–286.
   PubMed Web of Science ®Google Scholar
• Lee, Y. H., Kim, Y. R., Ji, J. D., Sohn, J., Song, G. G. (2001). Polymorphisms of the CTLA-4 exon 1 and promoter gene in systemic lupus erythematosus. Lupus 10:601–605.
   PubMed Web of Science ®Google Scholar
• Lindqvist, A. K., Alarcon-Riquelme, M. E. (1999). The genetics of systemic lupus erythematosus. Scand J Immunol 50:562–571.
   PubMed Web of Science ®Google Scholar
• Liu, M. F., Wang, C. R., Chen, P. C., Fung, L. L. (2003). Increased expression of soluble cytotoxic T-lymphocyte-associated antigen-4 molecule in patients with systemic lupus erythematosus. Scand. J. Immunol. 57:568–572.
   PubMed Web of Science ®Google Scholar
• Liu, M. F., Wang, C. R., Lin, L. C., Wu, C. R. (2001). CTLA-4 gene polymorphism in promoter and exon-1 regions in Chinese patients with systemic lupus erythematosus. Lupus 10:647–649.
   PubMedGoogle Scholar
• Liu, W., Li, J. (2004). Expression of CD80/CD86 and CTLA-4 mRNA in peripheral blood mononuclear cells of the patients with systemic lupus erythematosus. J. Huazhong Univ. Sci. Technolog. Med. Sci. 24:247–249.
   PubMedGoogle Scholar
• Mantel, N., Haenszel, W. (1959). Statistical aspects of the analysis of data from retrospective studies of disease. J. Natl. Cancer Inst. 22:719–748.
   PubMed Web of Science ®Google Scholar
• Matsushita, M., Tsuchiya, N., Shiota, M., Komata, T., Matsuta, K., Zama, K., Oka, T., Juji, T., Yamane, A., Tokunaga, K. (1999). Lack of a strong association of CTLA-4 exon 1 polymorphism with the susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese: an association study using a novel variation screening method. Tissue Antigens 54:578–584.
   PubMedGoogle Scholar
• Mehrian, R., Quismorio, F. P., Jr., Strassmann, G., Stimmler, M. M., Horwitz, D. A., Kitridou, R. C., Gauderman, W. J., Morrison, J., Brautbar, C., Jacob, C. O. (1998). Synergistic effect between IL-10 and bcl-2 genotypes in determining susceptibility to systemic lupus erythematosus. Arthritis Rheum. 41:596–602.
   PubMed Web of Science ®Google Scholar
• Montoya-Diaz, E., Cervera-Castillo, H., Chavez-Sanchez, L., Legorreta-Haquet, M. V., Sanchez-Gonzalez, L., Chavez-Rueda, K., Blanco-Favela, F. (2011). Prolactin promoter polymorphism (-1149 G/T) is associated with anti-DNA antibodies in Mexican patients with systemic lupus erythematosus. Immunol. Invest. 40:614–626.
   PubMed Web of Science ®Google Scholar
• Mosaad, Y. M., Elsharkawy, A. A., El-Deek, B. S. (2012). Association of CTLA-4 (+49A/G) gene polymorphism with type 1 diabetes mellitus in Egyptian children. Immunol. Invest. 41:28–37.
   PubMed Web of Science ®Google Scholar
• Mosaad, Y. M., Hammad, A., Youssef, H. M., Elhanbly, S. (2010). HLA-DRB1*15 confers susceptibility to juvenile SLE but is not associated with disease presentation: an Egyptian Study. Immunol. Invest. 39:235–244.
   PubMed Web of Science ®Google Scholar
• Parks, C. G., Hudson, L. L., Cooper, G. S., Dooley, M. A., Treadwell, E. L., St Clair, E. W., Gilkeson, G. S., Pandey, J. P. (2004). CTLA-4 gene polymorphisms and systemic lupus erythematosus in a population-based study of whites and African-Americans in the southeastern United States. Lupus 13:784–791.
   PubMedGoogle Scholar
• Perez, V. L., Van Parijs, L., Biuckians, A., Zheng, X. X., Strom, T. B., Abbas, A. K. (1997). Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement. Immunity 6:411–417.
   PubMed Web of Science ®Google Scholar
• Pullmann, R., Jr., Lukac, J., Skerenova, M., Rovensky, J., Hybenova, J., Melus, V., Celec, S., Pullmann, R., Hyrdel, R. (1999). Cytotoxic T lymphocyte antigen 4 (CTLA-4) dimorphism in patients with systemic lupus erythematosus. Clin. Exp. Rheumatol. 17:725–729.
   PubMed Web of Science ®Google Scholar
• Taha Khalaf, A., Song, J. Q., Gao, T. T., Yu, X. P., Lei, T. C. (2011). CTLA-4 gene polymorphism and the risk of systemic lupus erythematosus in the Chinese population. J. Biomed. Biotechnol. 2011:167395.
   PubMedGoogle Scholar
• Takeuchi, F., Kawasugi, K., Nabeta, H., Mori, M., Tanimoto, K. (2003). CTLA-4 dimorphisms in Japanese patients with systemic lupus erythematosus. Clin. Exp. Rheumatol. 21:527–528.
   PubMed Web of Science ®Google Scholar
• Takeuchi, F., Kuwata, S., Mori, M. (2005). CTLA-4 -1661A/G and -1772T/C dimorphisms in Japanese patients with systemic lupus erythematosus. J. Rheumatol. 32:2062.
   PubMed Web of Science ®Google Scholar
• Tan, E. M., Cohen, A. S., Fries, J. F., Masi, A. T., McShane, D. J., Rothfield, N. F., Schaller, J. G., Talal, N., Winchester, R. J. (1982). The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 25:1271–1277.
   PubMed Web of Science ®Google Scholar
• Torres, B., Aguilar, F., Franco, E., Sanchez, E., Sanchez-Roman, J., Jimenez Alonso, J., Nunez-Roldan, A., Martin, J., Gonzalez-Escribano, M. F. (2004). Association of the CT60 marker of the CTLA4 gene with systemic lupus erythematosus. Arthritis Rheum. 50:2211–2215.
   PubMed Web of Science ®Google Scholar
• Ulker, M., Yazisiz, V., Sallakci, N., Avci, A. B., Sanlioglu, S., Yegin, O., Terzioglu, E. (2009). CTLA-4 gene polymorphism of exon 1(+49 A/G) in Turkish systemic lupus erythematosus patients. Int. J. Immunogenet. 36:245–250.
   PubMed Web of Science ®Google Scholar
• Vyse, T. J., Kotzin, B. L. (1996). Genetic basis of systemic lupus erythematosus. Curr. Opin. Immunol. 8:843–851.
   PubMed Web of Science ®Google Scholar
• Wang, M., Sun, H., Zhang, W., Zhang, Y. (2009). Functional activation of proline-rich tyrosine kinase2 (PYK2) in peripheral blood mononuclear cells from patients with systemic lupus erythematosus. BMC Musculoskelet. Disord. 10:141.
   PubMedGoogle Scholar
• Waterhouse, P., Penninger, J. M., Timms, E., Wakeham, A., Shahinian, A., Lee, K. P., Thompson, C. B., Griesser, H., Mak, T. W. (1995). Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science 270:985–988.
   PubMed Web of Science ®Google Scholar
• Wong, C. K., Lit, L. C., Tam, L. S., Li, E. K., Lam, C. W. (2005). Aberrant production of soluble costimulatory molecules CTLA-4, CD28, CD80 and CD86 in patients with systemic lupus erythematosus. Rheumatology (Oxford) 44:989–994.
   PubMed Web of Science ®Google Scholar
• Xing, Q., Su, H., Cui, J., Wang, B. (2012). Role of Treg cells and TGF-beta1 in patients with systemic lupus erythematosus: A possible relation with lupus nephritis. Immunol. Invest. 41:15–27.
   PubMed Web of Science ®Google Scholar
• Xu, A. P., Yin, P. D., Su, X. Y. (2004). [Association of CTLA-4 promoter -1722 polymorphism with systemic lupus erythematosus in Chinese]. Di Yi Jun Yi Da Xue Xue Bao 24:1107–1112.
   PubMedGoogle Scholar
• Zhou, S. L., Ye, R. G., Zhang, H., Xu, H. S., Du, Y., Li, Y. J., Yang, N. S., Yang, X., Dong, X. Q., Yu, X. Q. (2003). The polymorphism at position -318 in promoter of CTLA-4 gene in patients with systemic lupus erythematosus in sourthern China. New Chin. Med. 34:291–293.
   Google Scholar
• Zhou, Y., Xiao, L. S. (2007). Association of the polymorphism of CTLA-4 gene with systemic lupus erythematosus or rheumatoid arthitis in the Chinese population. J. Immunol. 23:349–350.
   Google Scholar