The Roles of Lysosomes in Inflammation and Autoimmune Diseases

REFERENCES

• Carlstedt-Duke J, Wrange O, Dahlberg E, et al. Transformation of the glucocorticoid receptor in rat liver cytosol by lysosomal enzymes. J Biol Chem 1979;254:1537–1539.
   PubMed Web of Science ®Google Scholar
• Vandevyver S, Dejager L, Libert C. On the trail of the glucocorticoid receptor: into the nucleus and back. Traffic 2012;13:364–374.
   PubMed Web of Science ®Google Scholar
• Kassel O, Herrlich P. Crosstalk between the glucocorticoid receptor and other transcription factors: molecular aspects. Mol Cell Endocrinol 2007;275:13–29.
   PubMed Web of Science ®Google Scholar
• Vandevyver S, Dejager L, Tuckermann J, et al. New insights into the anti-inflammatory mechanisms of glucocorticoids: an emerging role for glucocorticoid-receptor-mediated transactivation. Endocrinology 2013;154:933–1007.
   Web of Science ®Google Scholar
• Rhen T, Cidlowski JA. Antiinflammatory action of glucocorticoids–new mechanisms for old drugs. N Engl J Med 2005;353:1711–1723.
   PubMed Web of Science ®Google Scholar
• Tanaka J, Fujita H, Matsuda S, et al. Glucocorticoid- and mineralocorticoid receptors in microglial cells: the two receptors mediate differential effects of corticosteroids. Glia 1997;20:23–37.
   PubMed Web of Science ®Google Scholar
• He Y, Xu Y, Zhang C, et al. Identification of a lysosomal pathway that modulates glucocorticoid signaling and the inflammatory response. Sci Signal 2011;4:ra44. doi:10.1126/scisignal.2001450
   PubMed Web of Science ®Google Scholar
• Settembre C, Fraldi A, Medina DL, et al. Signals from the lysosome: a control centre for cellular clearance and energy metabolism. Nat Rev Mol Cell Biol 2013;14:283–296.
   PubMed Web of Science ®Google Scholar
• Blott EJ, Griffiths GM. Secretory lysosomes. Nat Rev Mol Cell Biol 2002;3:122–131.
   PubMed Web of Science ®Google Scholar
• Andrei C, Dazzi C, Lotti L, et al. The secretory route of the leaderless protein interleukin 1beta involves exocytosis of endolysosome-related vesicles. Mol Biol Cell 1999;10:1463–1475.
   PubMed Web of Science ®Google Scholar
• Becker CE, Creagh EM, O'Neill LA. Rab39a binds caspase-1 and is required for caspase-1-dependent interleukin-1beta secretion. J Biol Chem 2009;284:34531–34537.
   PubMed Web of Science ®Google Scholar
• Dinarello CA. Immunological and inflammatory functions of the interleukin-1 family. Annu Rev Immunol 2009;27:519–550.
   PubMed Web of Science ®Google Scholar
• Eder C. Mechanisms of interleukin-1 beta release. Immunobiology 2009;214:543–553.
   PubMed Web of Science ®Google Scholar
• Andrei C, Margiocco P, Poggi A, et al. Phospholipases C and A2 control lysosome-mediated IL-1 beta secretion: implications for inflammatory processes. Proc Natl Acad Sci USA 2004;101:9745–9750.
   PubMed Web of Science ®Google Scholar
• Carta S, Tassi S, Semino C, et al. Histone deacetylase inhibitors prevent exocytosis of interleukin-1beta-containing secretory lysosomes: role of microtubules. Blood 2006;108:1618–1626.
   PubMed Web of Science ®Google Scholar
• Stow JL, Murray RZ. Intracellular trafficking and secretion of inflammatory cytokines. Cytokine Growth Factor Rev 2013;24:227–239.
   PubMed Web of Science ®Google Scholar
• Holt OJ, Gallo F, Griffiths GM. Regulating secretory lysosomes. J Biochem 2006;140:7–12.
   PubMed Web of Science ®Google Scholar
• Stow JL, Manderson AP, Murray RZ. SNAREing immunity: the role of SNAREs in the immune system. Nat Rev Immunol 2006;6:919–929.
   PubMed Web of Science ®Google Scholar
• Li J, Yin HL, Yuan J. Flightless-I regulates proinflammatory caspases by selectively modulating intracellular localization and caspase activity. J Cell Biol 2008;181:321–333.
   PubMed Web of Science ®Google Scholar
• Lei N, Franken L, Ruzehaji N, et al. Flightless, secreted through a late endosome/lysosome pathway, binds LPS and dampens cytokine secretion. J Cell Sci 2012;125:4288–4296.
   PubMed Web of Science ®Google Scholar
• Gardella S, Andrei C, Poggi A, et al. Control of interleukin-18 secretion by dendritic cells: role of calcium influxes. FEBS Lett 2000;481:245–248.
   PubMed Web of Science ®Google Scholar
• Semino C, Angelini G, Poggi A, et al. NK/iDC interaction results in IL-18 secretion by DCs at the synaptic cleft followed by NK cell activation and release of the DC maturation factor HMGB1. Blood 2005;106:609–616.
   PubMed Web of Science ®Google Scholar
• Lahat N, Rahat MA, Kinarty A, et al. Hypoxia enhances lysosomal TNF-alpha degradation in mouse peritoneal macrophages. Am J Physiol Cell Physiol 2008;295:C2–12.
   PubMed Web of Science ®Google Scholar
• Eltzschig HK, Carmeliet P. Hypoxia and inflammation. N Engl J Med 2011;364:656–665.
   PubMed Web of Science ®Google Scholar
• Bastow ER, Last K, Golub S, et al. Evidence for lysosomal exocytosis and release of aggrecan-degrading hydrolases from hypertrophic chondrocytes, in vitro and in vivo. Biol Open 2012;1:318–328.
   Google Scholar
• Pushparaj PN, Tay HK, Wang CC, et al. VAMP8 is essential in anaphylatoxin-induced degranulation, TNF-alpha secretion, peritonitis, and systemic inflammation. J Immunol 2009;183:1413–1418.
   PubMed Web of Science ®Google Scholar
• Antonin W, Holroyd C, Tikkanen R, et al. The R-SNARE endobrevin/VAMP-8 mediates homotypic fusion of early endosomes and late endosomes. Mol Biol Cell 2000;11:3289–3298.
   PubMed Web of Science ®Google Scholar
• Advani RJ, Yang B, Prekeris R, et al. VAMP-7 mediates vesicular transport from endosomes to lysosomes. J Cell Biol 1999;146:765–776.
   PubMed Web of Science ®Google Scholar
• Dodeller F, Gottar M, Huesken D, et al. The lysosomal transmembrane protein 9B regulates the activity of inflammatory signaling pathways. J Biol Chem 2008;283:21487–21494.
   PubMed Web of Science ®Google Scholar
• Wang Y, Chen T, Han C, et al. Lysosome-associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Blood 2007;110:962–971.
   PubMed Web of Science ®Google Scholar
• Yao M, Liu X, Li D, et al. Late endosome/lysosome-localized Rab7b suppresses TLR9-initiated proinflammatory cytokine and type I IFN production in macrophages. J Immunol 2009;183:1751–1758.
   PubMed Web of Science ®Google Scholar
• He D, Chen T, Yang M, et al. Small Rab GTPase Rab7b promotes megakaryocytic differentiation by enhancing IL-6 production and STAT3-GATA-1 association. J Mol Med (Berl) 2011;89:137–150.
   PubMed Web of Science ®Google Scholar
• German CL, Sauer BM, Howe CL. The STAT3 beacon: IL-6 recurrently activates STAT 3 from endosomal structures. Exp Cell Res 2011;317:1955–1969.
   PubMed Web of Science ®Google Scholar
• Tanaka Y, Tanaka N, Saeki Y, et al. c-Cbl-dependent monoubiquitination and lysosomal degradation of gp130. Mol Cell Biol 2008;28:4805–4818.
   PubMed Web of Science ®Google Scholar
• Radtke S, Wüller S, Yang XP, et al. Cross-regulation of cytokine signalling: pro-inflammatory cytokines restrict IL-6 signalling through receptor internalisation and degradation. J Cell Sci 2010;123:947–959.
   PubMed Web of Science ®Google Scholar
• Hao X, Wang Y, Ren F, et al. SNX25 regulates TGF-beta signaling by enhancing the receptor degradation. Cell Signal 2011;23:935–946.
   PubMed Web of Science ®Google Scholar
• Tian H, Mythreye K, Golzio C, et al. Endoglin mediates fibronectin/alpha5beta1 integrin and TGF-beta pathway crosstalk in endothelial cells. EMBO J 2012;31:3885–3900.
   PubMed Web of Science ®Google Scholar
• Iyer JK, Khurana T, Langer M, et al. Inflammatory cytokine response to Bacillus anthracis peptidoglycan requires phagocytosis and lysosomal trafficking. Infect Immun 2010;78:2418–2428.
   PubMed Web of Science ®Google Scholar
• Hakala JK, Lindstedt KA, Kovanen PT, et al. Low-density lipoprotein modified by macrophage-derived lysosomal hydrolases induces expression and secretion of IL-8 via p38 MAPK and NF-kappaB by human monocyte-derived macrophages. Arterioscler Thromb Vasc Biol 2006;26:2504–2509.
   PubMed Web of Science ®Google Scholar
• Chinenov Y, Gupte R, Rogatsky I. Nuclear receptors in inflammation control: repression by GR and beyond. Mol Cell Endocrinol 2013;380:55–64.
   PubMed Web of Science ®Google Scholar
• Castaneda JA, Lim MJ, Cooper JD, et al. Immune system irregularities in lysosomal storage disorders. Acta Neuropathol 2008;115:159–174.
   PubMed Web of Science ®Google Scholar
• Darmoise A, Teneberg S, Bouzonville L, et al. Lysosomal alpha-galactosidase controls the generation of self lipid antigens for natural killer T cells. Immunity 2010;33:216–228.
   PubMed Web of Science ®Google Scholar
• Hsing LC, Rudensky AY. The lysosomal cysteine proteases in MHC class II antigen presentation. Immunol Rev 2005;207:229–241.
   PubMed Web of Science ®Google Scholar
• Neefjes J, Jongsma ML, Paul P, et al. Towards a systems understanding of MHC class I and MHC class II antigen presentation. Nat Rev Immunol 2011;11:823–836.
   PubMed Web of Science ®Google Scholar
• Chow A, Toomre D, Garrett W, et al. Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane. Nature 2002;418:988–994.
   PubMed Web of Science ®Google Scholar
• Kis-Toth K, Tsokos GC. Dendritic cell function in lupus: Independent contributors or victims of aberrant immune regulation. Autoimmunity 2010;43:121–130.
   PubMed Web of Science ®Google Scholar
• Marshak-Rothstein A. Toll-like receptors in systemic autoimmune disease. Nat Rev Immunol 2006;6:823–835.
   PubMed Web of Science ®Google Scholar
• Gaipl US, Kuhn A, Sheriff A, et al. Clearance of apoptotic cells in human SLE. Curr Dir Autoimmun 2006;9:173–187.
   PubMedGoogle Scholar
• Odaka C, Mizuochi T. Role of macrophage lysosomal enzymes in the degradation of nucleosomes of apoptotic cells. J Immunol 1999;163:5346–5352.
   PubMed Web of Science ®Google Scholar
• Nagata S, Hanayama R, Kawane K. Autoimmunity and the clearance of dead cells. Cell 2010;140:619–630.
   PubMed Web of Science ®Google Scholar
• Su DL, Lu ZM, Shen MN, et al. Roles of pro- and anti-inflammatory cytokines in the pathogenesis of SLE. J Biomed Biotechnol 2012;2012:347141.
   PubMed Web of Science ®Google Scholar
• Ronnblom L, Elkon KB. Cytokines as therapeutic targets in SLE. Nat Rev Rheumatol 2010;6:339–347.
   PubMed Web of Science ®Google Scholar
• Holcombe RF, Baethge BA, Wolf RE, et al. Correlation of serum interleukin-8 and cell surface lysosome-associated membrane protein expression with clinical disease activity in systemic lupus erythematosus. Lupus 1994;3:97–102.
   PubMed Web of Science ®Google Scholar
• Hiraoka M, Abe A, Shayman JA. Cloning and characterization of a lysosomal phospholipase A2, 1-O-acylceramide synthase. J Biol Chem 2002;277:10090–10099.
   PubMed Web of Science ®Google Scholar
• Abe A, Shayman JA. Purification and characterization of 1-O-acylceramide synthase, a novel phospholipase A2 with transacylase activity. J Biol Chem 1998;273:8467–8474.
   PubMed Web of Science ®Google Scholar
• Shayman JA, Kelly R, Kollmeyer J, et al. Group XV phospholipase A(2), a lysosomal phospholipase A(2). Prog Lipid Res 2011;50:1–13.
   PubMed Web of Science ®Google Scholar
• Shayman JA, Abe A, Kelly Ret al., , inventors; The Regents Of The University Of Michigan, assignee. Lysosomal phospholipase A2 (LPLA2) activity as a diagnostic and therapeutic target for identifying and treating systemic lupus erythematosis. United States patent US8052970 B2. 2009 Jun 30, 2009.
   Google Scholar
• Banchereau J, Pascual V, Palucka AK. Autoimmunity through cytokine-induced dendritic cell activation. Immunity 2004;20:539–550.
   PubMed Web of Science ®Google Scholar
• Wallace DJ, Gudsoorkar VS, Weisman MH, et al. New insights into mechanisms of therapeutic effects of antimalarial agents in SLE. Nat Rev Rheumatol 2012;8:522–533.
   PubMed Web of Science ®Google Scholar
• Everts V, Hou WS, Rialland X, et al. Cathepsin K deficiency in pycnodysostosis results in accumulation of non-digested phagocytosed collagen in fibroblasts. Calcif Tissue Int 2003;73:380–386.
   PubMed Web of Science ®Google Scholar
• Hou WS, Li Z, Gordon RE, et al. Cathepsin k is a critical protease in synovial fibroblast-mediated collagen degradation. Am J Pathol 2001;159:2167–2177.
   PubMed Web of Science ®Google Scholar
• Skoumal M, Haberhauer G, Kolarz G, et al. Serum cathepsin K levels of patients with longstanding rheumatoid arthritis: correlation with radiological destruction. Arthritis Res Ther 2005;7:R65–70.
   PubMed Web of Science ®Google Scholar
• Morko J, Kiviranta R, Joronen K, et al. Spontaneous development of synovitis and cartilage degeneration in transgenic mice overexpressing cathepsin K. Arthritis Rheum 2005;52:3713–3717.
   PubMed Web of Science ®Google Scholar
• Schurigt U, Hummel KM, Petrow PK, et al. Cathepsin K deficiency partially inhibits, but does not prevent, bone destruction in human tumor necrosis factor-transgenic mice. Arthritis Rheum 2008;58:422–434.
   PubMed Web of Science ®Google Scholar
• Li P, Schwarz EM. The TNF-alpha transgenic mouse model of inflammatory arthritis. Springer Semin Immunopathol 2003;25:19–33.
   PubMed Web of Science ®Google Scholar
• Gauthier JY, Chauret N, Cromlish W, et al. The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K. Bioorg Med Chem Lett 2008;18:923–928.
   PubMed Web of Science ®Google Scholar
• Svelander L, Erlandsson-Harris H, Astner L, et al. Inhibition of cathepsin K reduces bone erosion, cartilage degradation and inflammation evoked by collagen-induced arthritis in mice. Eur J Pharmacol 2009;613:155–162.
   PubMed Web of Science ®Google Scholar
• Sun P, Liu Y, Deng X, et al. An inhibitor of cathepsin K, icariin suppresses cartilage and bone degradation in mice of collagen-induced arthritis. Phytomedicine 2013;20:975–979.
   PubMed Web of Science ®Google Scholar
• Nakagawa TY, Brissette WH, Lira PD, et al. Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null mice. Immunity 1999;10:207–217.
   PubMed Web of Science ®Google Scholar
• Pozgan U, Caglic D, Rozman B, et al. Expression and activity profiling of selected cysteine cathepsins and matrix metalloproteinases in synovial fluids from patients with rheumatoid arthritis and osteoarthritis. Biol Chem 2010;391:571–579.
   PubMed Web of Science ®Google Scholar
• Weidauer E, Yasuda Y, Biswal BK, et al. Effects of disease-modifying anti-rheumatic drugs (DMARDs) on the activities of rheumatoid arthritis-associated cathepsins K and S. Biol Chem 2007;388: 331–336.
   PubMed Web of Science ®Google Scholar
• Baugh M, Black D, Westwood P, et al. Therapeutic dosing of an orally active, selective cathepsin S inhibitor suppresses disease in models of autoimmunity. J Autoimmun 2011;36:201–209.
   PubMed Web of Science ®Google Scholar
• Schurigt U, Eilenstein R, Gajda M, et al. Decreased arthritis severity in cathepsin L-deficient mice is attributed to an impaired T helper cell compartment. Inflamm Res 2012;61:1021–1029.
   PubMed Web of Science ®Google Scholar
• Schedel J, Seemayer CA, Pap T, et al. Targeting cathepsin L (CL) by specific ribozymes decreases CL protein synthesis and cartilage destruction in rheumatoid arthritis. Gene Ther 2004;11:1040–1047.
   PubMed Web of Science ®Google Scholar
• Pancewicz S, Popko J, Rutkowski R, et al. Activity of lysosomal exoglycosidases in serum and synovial fluid in patients with chronic Lyme and rheumatoid arthritis. Scand J Infect Dis 2009;41:584–589.
   PubMed Web of Science ®Google Scholar
• Boyce BF, Li P, Yao Z, et al. TNF-alpha and pathologic bone resorption. Keio J Med 2005;54:127–131.
   PubMedGoogle Scholar
• Connor AM, Mahomed N, Gandhi R, et al. TNFalpha modulates protein degradation pathways in rheumatoid arthritis synovial fibroblasts. Arthritis Res Ther 2012;14:R62.
   PubMed Web of Science ®Google Scholar
• Lin NY, Beyer C, Giessl A, et al. Autophagy regulates TNFalpha-mediated joint destruction in experimental arthritis. Ann Rheum Dis 2013;72:761–768.
   PubMed Web of Science ®Google Scholar
• Tanaka Y, Matsumoto I, Iwanami K, et al. Six-transmembrane epithelial antigen of prostate4 (STEAP4) is a tumor necrosis factor alpha-induced protein that regulates IL-6, IL-8, and cell proliferation in synovium from patients with rheumatoid arthritis. Mod Rheumatol 2012;22:128–136.
   PubMed Web of Science ®Google Scholar
• Vijayan V, Shyni GL, Helen A. Efficacy of Bacopa monniera (L.) Wettst in alleviating lysosomal instability in adjuvant-induced arthritis in rats. Inflammation 2011;34:630–638.
   PubMed Web of Science ®Google Scholar
• Ekambarama SP, Perumala SS, Subramanianb V. Strychnos potatorum Linn Seed Extract Enhances Lysosomal Membrane Stability and Collagen Formation in Freunds Complete Adjuvant-Induced Arthritic Rats. J Herbs Spices Med Plants 2011;17:392–402.
   Google Scholar
• Kawada A, Hara K, Kominami E, et al. Processing of cathepsins L, B and D in psoriatic epidermis. Arch Dermatol Res 1997;289:87–93.
   PubMed Web of Science ®Google Scholar
• Abdou AG, Maraee AH, Shoeib MA, et al. Cathepsin D expression in chronic plaque psoriasis: an immunohistochemical study. Acta Dermatovenerol Croat 2011;19:143–149.
   PubMed Web of Science ®Google Scholar
• Schonefuss A, Wendt W, Schattling B, et al. Upregulation of cathepsin S in psoriatic keratinocytes. Exp Dermatol 2010;19:e80–88.
   PubMed Web of Science ®Google Scholar
• Higaki M, Higaki Y, Kawashima M. Increased expression of CD208 (DC-LAMP) in epidermal keratinocytes of psoriatic lesions. J Dermatol 2009;36:144–149.
   PubMed Web of Science ®Google Scholar
• Wei-yuan M, Wen-ting L, Chen Z, et al. Significance of DC-LAMP and DC-SIGN expression in psoriasis vulgaris lesions. Exp Mol Pathol 2011;91:461–465.
   PubMed Web of Science ®Google Scholar
• Haves-Zburof D, Paperna T, Gour-Lavie A, et al. Cathepsins and their endogenous inhibitors cystatins: expression and modulation in multiple sclerosis. J Cell Mol Med 2011;15:2421–2429.
   PubMed Web of Science ®Google Scholar
• Martino S, Montesano S, di Girolamo I, et al. Expression of cathepsins S and D signals a distinctive biochemical trait in CD34+ hematopoietic stem cells of relapsing-remitting multiple sclerosis patients. Mult Scler 2013;19:1443–1453.
   PubMed Web of Science ®Google Scholar
• Sohar N, Sohar I, Hammer H. Lysosomal enzyme activities: new potential markers for Sjogren's syndrome. Clin Biochem 2005;38:1120–1126.
   PubMed Web of Science ®Google Scholar
• Li X, Wu K, Edman M, et al. Increased expression of cathepsins and obesity-induced proinflammatory cytokines in lacrimal glands of male NOD mouse. Invest Ophthalmol Vis Sci 2010;51:5019–5029.
   PubMed Web of Science ®Google Scholar
• Komosinska-Vassev K, Olczyk K, Kozma EM, et al. Graves’ disease-associated changes in the serum lysosomal glycosidases activity and the glycosaminoglycan content. Clin Chim Acta 2003;331:97–102.
   PubMed Web of Science ®Google Scholar
• Chen MH, Liao SL, Chen MH, et al. Lysosome-related genes are regulated in the orbital fat of patients with graves’ ophthalmopathy. Invest Ophthalmol Vis Sci 2008;49:4760–4764.
   PubMed Web of Science ®Google Scholar
• Wong VW, Saunders AE, Hutchings A, et al. The autoimmunity-related GIMAP5 GTPase is a lysosome-associated protein. Self Nonself 2010;1:259–268.
   PubMedGoogle Scholar
• Yamada A, Ishimaru N, Arakaki R, et al. Cathepsin L inhibition prevents murine autoimmune diabetes via suppression of CD8(+) T cell activity. PLoS One 2010;5:e12894.
   PubMed Web of Science ®Google Scholar
• Hsing LC, Kirk EA, McMillen TS, et al. Roles for cathepsins S, L, and B in insulitis and diabetes in the NOD mouse. J Autoimmun 2010;34:96–104.
   PubMed Web of Science ®Google Scholar
• Zou F, Schafer N, Palesch D, et al. Regulation of cathepsin G reduces the activation of proinsulin-reactive T cells from type 1 diabetes patients. PLoS One 2011;6:e22815. doi:10.1371/journal.pone.0022815
   Google Scholar
• Werneburg N, Guicciardi ME, Yin XM, et al. TNF-alpha-mediated lysosomal permeabilization is FAN and caspase 8/Bid dependent. Am J Physiol Gastrointest Liver Physiol 2004;287:G436–443.
   PubMed Web of Science ®Google Scholar