11
Views
9
CrossRef citations to date
0
Altmetric
Original Article

Regulation of CD4 T Cell Reactivity to Self and Non-Self

, , , , , , & show all
Pages 147-160 | Received 08 May 1995, Published online: 10 Jul 2009

References

  • Lo D., Reilly C. R., Scott B., Liblau R., McDevitt H. O., Burkly L. C. Antigen presenting cells in adoptively transferred and spontaneous diabetes. Eur. J. Immunol 1993; 23: 1693
  • Swain S. L., Bradley L. M., Croft M., Tonkonogy S., Atkins G., Weinberg A. D., Duncan D. D., Hedrick S. M., Dutton R. W., Huston G. Helper T-cell subsets: Phenotype, function, and the role of lymphokines in regulating their development. Immunological Rev 1991; 123: 115
  • Mosmann T. R., Coffman R. L. TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol 1989; 7: 145
  • Fowell D., McKnight A. J., Powrie F., Dyke R., Mason D. Subsets of CD4+ T cells and their roles in the induction and prevention of autoimmunity. Immunol. Rev 1991; 123: 37
  • Powrie F., Leach M. W., Mauze S., Menon S., Caddie L. B., Coffman R. L. Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells. Immunity 1994; 1: 553
  • Chen Y., Kuchroo V. K., Inobe J., Hafler D. A., Weiner H. L. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 1994; 265: 1237
  • Prud'homme G. J., Kono D. H., Theofilopoulos A. N. Quantitative polymerase chain reaction analysis reveals marked overexpression of interleukin-1β, interleukin-10 and interferon-γ mRNA in the lymph nodes of lupus-prone mice. Molec. Immunol 1995, in press
  • O'Garra A., Murphy K. Role of cytokines in determining T-lymphocyte function. Curr. Opin. Immunol 1994; 6: 458
  • Ghosh S., Palmer S. M., Rodrigues N. R., Cordell H. J., Hearne C. M., Cornall R. J., Prins J. B., McShane P., Lathrop G. M., Peterson L. B., Wicker L. S., Todd J. A. Polygenic control of autoimmune diabetes in nonobese diabetic mice. Nature Genetics 1993; 4: 404
  • Green A. The role of genetic factors in development of insulin dependent diabetes mellitus. Curr. Top. Micro. Immunol 1990; 164: 3
  • Yoon J. W. The role of viruses and environmental factors in induction of diabetes. Curr. Top. Micro. Immunol 1990; 164: 95
  • Nepom G. T., Erlich H. MHC class-II molecules and autoimmunity. Annu. Rev. Immunol 1991; 9: 349
  • Sorger S. B., Hedrick S. M., Fink P. J., Bookman M. A., Matis L. A. Generation of diversity in T cell receptor repertoire specific for pigeon cytochrome c. J. Exp. Med 1987; 165: 279
  • Evavold B. D., Allen P. M. Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand. Science 1991; 252: 1308
  • Sloan-Lancaster J., Evavold B. D., Allen P. M. Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen presenting cells. Nature 1993; 363: 156
  • DeMagistris M. T., Alexander J., Coggeshall M., Altman A., Gaeta F. C. A., Grey H. M., Sette A. Analog antigen/MHC complexes act as antagonists of the T cell receptor. Cell 1992; 68: 625
  • Franco A., Southwood S., Arrhenius T., Kuchroo V. K., Grey H. M., Sette A., Ishioka G. Y. T cell receptor antagonist peptides are highly effective inhibitors of experimental allergic encephalomyelitis. Eur. J. Immunol 1994; 24: 940
  • Pfeiffer C., Stein J., Southwood S., Ketelaar H., Sette A., Bottomly K. Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo. J. Exp. Med 1995; 181: 1569
  • Sercarz E. E., Lehmann P. V., Ametani A., Benichou G., Miller A., Moudgil K. Dominance and crypticity of T cell antigenic determinants. Annu. Rev. Immunol 1993; 11: 729
  • Scott B., Liblau R., Degermann S., Marconi L. A., Ogata L., Caton A. J., McDevitt H. O., Lo D. A role for non-MHC genetic polymorphism in susceptibility to spontaneous autoimmunity. Immunity 1994; 1: 73
  • Sher A., Coffman R. L. Regulation of immunity to parasites by T cells and T cell-derived cytokines. Annu. Rev. Immunol 1992; 10: 385
  • Kojima A., Prehn R. T. Genetic susceptibility to post-thymectomy autoimmune diseases in mice. Immunogenetics 1981; 14: 15
  • Castaño L., Eisenbarth G. S. Type-1 diabetes: a chronic autoimmune disease of human, mouse and rat. Annu. Rev. Immunol 1990; 8: 647
  • Yasunami R., Bach J. F. Anti-suppressor effect of cyclophosphamide on the development of spontaneous diabetes in NOD mice. Eur. J. Immunol 1990; 18: 481
  • Huber S. A., Pfaeffle B. Differential Th1 and Th2 cell responses in male and female BALB/c mice infected with coxsackievirus group B type 3. J. Virol 1994; 68: 5126
  • Tian J., Lehmann P. V., Kaufman D. L. T cell cross-reactivity between coxsackievirus and glutamate decarboxylase is associated with a murine diabetes susceptibility gene. J. Exp. Med 1994; 180: 1979
  • Hsieh C. S., Macatonia S. E., Tripp C. S., Wolf S. E., O'Garra A., Murphy K. M. Development of Th1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. Science 1993; 260: 547
  • Trembleau S., Penna G., Bosi E., Mortara A., Gately M. K., Adorini L. Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice. J. Exp. Med 1995; 181: 817
  • Romball C. G., Weigle W. O. In vivo induction of tolerance in murine CD4+ cell subsets. J. Exp. Med 1993; 178: 1637
  • Day M. J., Tse A. G. D., Puklavec M., Simmonds S. J., Mason D. W. Targeting autoantigen to B cells prevents the induction of a cell-mediated autoimmune disease in rats. J. Exp. Med 1992; 175: 655
  • Eynon E. E., Parker D. C. Small B cells as antigen presenting cells in the induction of tolerance to soluble protein antigens. J. Exp. Med 1992; 175: 131
  • Gilbert K. M., Hoang K. D., Weigle W. O. Th1 and Th2 clones differ in their response to a tolerogenic signal. J. Immunol 1990; 144: 2063
  • Green J. M., Noel P. J., Sperling A. I., Waluna T. L., Gray G. S., Bluestone J. A., Thompson C. B. Absence of B7-dependent responses in CD28-deficient mice. Immunity 1994; 1: 501
  • Lo D., Quill H., Burkly L., Scott B., Palmiter R. D., Brinster R. L. A recessive defect in lymphocyte and/or granulocyte function caused by an integrated transgene. Am. J. Pathology 1992; 141: 1237
  • Burkly L., Hession C., Ogata L., Reilly C., Marconi L. A., Olson D., Tizard R., Cate R., Lo D. Expression of relB is required for the development of thymic medulla and dendritic cells. Nature 1995; 373: 531
  • Knight S. C., Stagg A., Hill S., Fryer P., Griffiths S. Development and function of dendritic cells in health and disease. J. Invest. Derm 1992; 99: 33S
  • Hsieh C. S., Heimberger A. B., Gold J. S., O'Garra A., Murphy K. M. Differential regulation of T helper phenotype development by interleukins 4 and 10 in an αβ T-cell-receptor transgenic system. Proc. Natl. Acad. Sci. USA 1992; 89: 6065
  • Degermann S., Reilly C., Scott B., Ogata L., von Boehmer H., Lo D. On the various manifestations of spontaneous autoimmune diabetes in rodent models. Eur. J. Immunol 1994; 24: 3155

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.