Drug-Phospholipid Interactions: Role in Aminoglycoside Nephrotoxicity

References

• Chung L, Kaloyanides G, McDaniel R, McLaughlin A, McLaughlin S. Interaction of gentamicin and spermine with bilayer membranes containing negatively charged phospholipids. Biochemistry 1985; 24: 442–452
   PubMed Web of Science ®Google Scholar
• Gaver E, Kasianowicz J, Abbott T, McLaughlin S. Binding of neomycin to phosphatidylinositol 4,5-bisphosphate (PIP2. Biochim Biophys Acta 1989; 979: 105–112
   Google Scholar
• Au S, Weiner N D, Schacht J. Aminoglycosides preferentially increase permeability in phosphoinositide-containing membranes: A study with carboxyfluorescein in liposomes. Biochim Biophys Acta 1987; 902: 80–86
   PubMedGoogle Scholar
• Sastrasinh M, Knauss T C, Weinberg J M, Humes HD. Identification of the aminoglycoside receptor of renal brush border membranes. J Pharmacol Exp Ther 1982; 222: 350–358
   PubMed Web of Science ®Google Scholar
• Schact J. Isolation of the aminoglycoside receptor from guinea pig inner ear tissues and kidneys. Arch Otorhinolaryngol 1979; 224: 129–134
   Google Scholar
• Wang B M, Weiner N D, Ganesan M G, Schacht J. Interaction of calcium and neomycin with anionic phospholipid-lecithin liposomes. Biochem Pharmacol 1984; 33: 3787–3791
   PubMed Web of Science ®Google Scholar
• Williams S E, Schacht J. Binding of neomycin and calcium to phospholipids and other anionic compounds. J Antibiot 1986; 39: 457–462
   PubMedGoogle Scholar
• Ramsammy L S, Kaloyanides GJ. Effect of gentamicin on the transition temperature and permeability of glycerol of phospha-tidylinositol-containing liposomes. Biochem Pharmacol 1987; 36: 1179–1811
   Google Scholar
• Kaloyanides G J, Ramsammy LS. Alterations of biophysical properties of liposomes predict aminoglycoside toxicity: Inhibitory effect of polyaspartic acid. Proceedings of the Fourth International Symposium on Nephrotoxicity, PH Bach, L Delacruz, NJ Gregg, MF Wilks. Dekker, New York 1990; 109–116
   Google Scholar
• Ramsammy L S, Kaloyanides GJ. The effect of gentamicin on the biophysical properties of phosphatide acid liposomes is influenced by the 0-C=O group of the lipid. Biochemistry 1988; 27: 8249–8254
   PubMed Web of Science ®Google Scholar
• Brasseur R, Laurent G, Ruysschaert J M, Tulkens P. Interactions of aminoglycoside antibiotics with negatively charged lipid layers. Biochem Pharmacol 1984; 33: 629–637
   PubMed Web of Science ®Google Scholar
• Schacht J, Weiner N D, Lodhi S. Interaction of aminocylitol antibiotics with polyphosphoinositides in mammalian tissues and artificial membranes. Cyclitols and Phosphoinositides, WW Wells, F Eisenberg. Academic Press, New York 1978; 153–169
   Google Scholar
• Wang B M, Weiner N D, Takada K, Schacht J. Characterization of aminoglycoside-lipid interactions and development of a refined model for ototoxicity testing. Biochem Pharmacol 1984; 33: 3257–3262
   PubMed Web of Science ®Google Scholar
• Au S, Schacht J, Weiner N. Membrane effects of aminoglycoside antibiotics measures in liposomes containing the fluorescent probe, l-anilino-8-naphthalene sulfonate. Biochim Biophys Acta 1986; 862: 205–210
   PubMedGoogle Scholar
• Schacht J. Molecular mechanisms of drug-induced hearing loss. Hearing Res 1986; 22: 297–304
   PubMed Web of Science ®Google Scholar
• Kaloyanides GJ. Aminoglycoside-induced functional and biochemical defects in the renal cortex. Fund Appl Toxicol 1984; 4: 930–943
   PubMedGoogle Scholar
• Jospovitz C, Levine R, Lane B, Kaloyanides GJ. Contrasting effects of gentamicin and mercuric chloride on urinary excretion of enzymes and phospholipids in the rat. Lab Invest 1985; 52: 375–386
   Google Scholar
• Ibrahim S, van der Auwera P, Meumier F, Tulkens PM. Effect of netilmicin and amikacin on urinary phospholipid excretion in humans. Arch Toxicol 1989; 13: 413–416
   Google Scholar
• Josepovitz C, Farruggella T, Levine R, Lane B, Kaloyanides GJ. Effect of netilmicin on the phospholipid composition of subcellular fractions of rat renal cortex. J Pharmacol Exp Ther 1985; 235: 810–819
   PubMed Web of Science ®Google Scholar
• Kozek J C, Mazze R I, Cousins MJ. Nephrotoxicity of gentamicin. Lab Invest 1979; 30: 48–57
   Google Scholar
• Giuliano R AA, Paulus G J, Verpooten GA, Pattyn U M, Pollet D E, Nouwen E J, Laurent G, Carlier M B, Maldague P, Tulkens P M, DeBroe ME. Recovery of cortical phospholipidosis and necrosis after acute gentamicin loading in rats. Kidney Int 1984; 26: 838–847
   PubMed Web of Science ®Google Scholar
• Aubert-Tulkens G, Van Hoof F, Tulkens P. Gentamicin-induced lysosomal phospholipidosis in cultured rat fibroblasts: Quantitative ultrastructural and biochemical study. Lab Invest 1979; 40: 481–491
   PubMed Web of Science ®Google Scholar
• Ramsammy L S, Josepovitz C, Lane B, Kaloyanides GJ. Effect of gentamicin on phospholipid metabolism in cultured rabbit proximal tubular cells. Am J Physiol 1989; 256: C204–C213
   PubMedGoogle Scholar
• Carlier M B, Laurent G, Claes P J, Vanderhaeghe H J, Tulkens PM. Inhibition of lysosomal phospholipases by aminoglycoside antibiotics: In vitro comparative studies. Antimicrob Agents Chemother 1983; 23: 440–449
   PubMed Web of Science ®Google Scholar
• Hostetler K Y, Hall LB. Inhibition of kidney lysosomal phospholipases A and D by aminoglycoside antibiotics: Possible mechanism of aminoglycoside toxicity. Proc Natl Acad Sci USA 1982; 79: 1663–1667
   PubMedGoogle Scholar
• Laurent C, Carlier M-B, Rollman B, Van Hoof F, Tulkens P. Mechanism of aminoglycoside-induced lysosomal phospholipidosis: In vitro and in vivo studies with gentamicin and amikacin. Biochem Pharmacol 1982; 31: 3861–3870
   PubMed Web of Science ®Google Scholar
• de Broe M E, Paulus G J, Verpooten G A, Roels F, Buyssens N, Weeden R, Van Hoof F, Tulkens PM. Early effects of gentamicin, tobramycin and amikacin on the human. Kidney. Kidney Int 1984; 25: 643–652
   PubMed Web of Science ®Google Scholar
• Mingeot-Laclercq M P, Laurent G, Tulkens PM. Biochemical mechanism of aminoglycoside-induced inhibition of phosphatidylcholine hydrolysis by lysosomal phospholipases. Biochem Pharmacol 1988; 37: 591–599
   Google Scholar
• Mingeot-Leclercq M P, Piret J, Brasseur R, Tulkens PM. Effect of acidic phospholipids on the activity of lysosomal phospholipases and on their inhibition by aminoglycoside antibiotics—I. Biochem Pharmacol 1990; 40: 489–497
   Google Scholar
• Ramsammy L, Van Cott C, Kaloyanides GJ. Effect of gentamicin on phosphatidylinositol and phosphatidylcholine hydrolysis by phospholipase Cin vitro. FASEB J 1991; 5: A1406
   Google Scholar
• Schwertz D W, Kreisberg J I, Venkatachalam MA. Effects of aminoglycosides on proximal tubule brush border membrane phosphatidylinositol-specific phospholipase C. J Pharmacol Exp Ther 1984; 231: 48–55
   Google Scholar
• Laurent G, Kishore B K, Tulkens PM. Aminoglycoside-induced renal phospholipidosis and nephrotoxicity. Biochem Pharmacol 1990; 40: 2383–2392
   PubMed Web of Science ®Google Scholar
• Laurent G, Maldague P, Carlier M D, Tulkens PM. Increased renal DNA synthesis in vivo after administration of low doses of gentamicin to rats. Antimicrob Agents Chemother 1983; 24: 586–593
   PubMed Web of Science ®Google Scholar
• Laurent G, Toubeau G, Heuson-Stiennon J A, Tulkens P, Maldague P. Kidney tissues repair after nephrotoxic injury: Biochemical and morphological characterization. CRC Crit Rev Toxicol 1988; 19: 147–183
   Web of Science ®Google Scholar
• Toubeau G, Laurent G, Carlier M B, Abid S, Maldague P, Heuson-Stiennon J A, Tulkens PM. Tissue repair in rat kidney cortex after short treatment with aminoglycosides at low doses. Lab Invest 1986; 54: 385–393
   PubMed Web of Science ®Google Scholar
• Josepovitz Levine C. R., Farruggella T, Kaloyanides GJ. Comparative effects of aminoglycosides on renal cortical urinary phospholipids in the rat (42300). Proc Soc Exp Biol Med 1986; 182: 1–5
   Google Scholar
• Giurgea-Marion L, Toubeau G, Heuson-Stieraion J A, Tulkens PM. Impairment of lysosome-pinocytic vesicle fusion in rat kidney proximal tubules afer treatment with gentamicinat low doses. Toxicol Appl Pharmacol 1986; 86: 271–285
   PubMed Web of Science ®Google Scholar
• Powell J, Reidenberg MN. In vitro response of rat and human kidney lysosomes to aminoglycosides. Bioohem Pharmacol 1982; 31: 3447–3453
   PubMed Web of Science ®Google Scholar
• Powell J H, Reidenberg MM. Further studies of the response of kidney lysosomes to aminoglycosides and other cations. Biochem Pharmacol 1983; 32: 3213–3220
   Google Scholar
• Morin J P, Viotte G, Vanderwalle A, Van Hoof F, Tulkens P, Fillastre JP. Gentamicin-induced nephrotoxicity: A cell biology approach. Kidney Int 1980; 18: 583–590
   PubMed Web of Science ®Google Scholar
• Ngaha E O, Ogunleye JO. Studies on gentamicin-induced labilization of rat kidney lysosomes in vitro. Biochem Pharmacol 1983; 32: 2659–2664
   PubMed Web of Science ®Google Scholar
• Ramsammy L S, Josepovitz C, Kaloyanides GJ. Gentamicin inhibits agonist stimulation of the phosphatidylinositol cascade in primary cultures of rabbit proximal tubular cells and in rat renal cortex. J Pharmacol Exp Ther 1988; 247: 989–996
   PubMed Web of Science ®Google Scholar
• Williams P D, Hottendorf G H, Bennett DB. Inhibition of renal membrane binding and nephrotoxicity of aminoglycosides. J Pharmacol Exp Ther 1986; 237: 919–925
   PubMed Web of Science ®Google Scholar
• Ramsammy L S, Josepovitz C, Lane B P, Kaloyanides GJ. Polyaspartic acid protects agianst gentamicin nephrotoxicity in the rat. J Pharmacol Exp Ther 1989; 250: 149–153
   PubMedGoogle Scholar
• Gilbert D N, Wood C A, Kohlhepps S J, Kohnen P W, Houghton D C, Finkbeiner H C, Lindsley J, Bennett WM. Polyaspartic acid prevents experimental aminoglycoside nephrotoxicity. J Infect Dis 1989; 159: 945–953
   PubMed Web of Science ®Google Scholar
• Ramsammy L S, Josepovitz C, Lane B, Kaloyanides GJ. Pretreatment of rats with polyaspartic acid protects against gentamicin nephrotoxicity. Clin Res 1991; 39: 248A
   Google Scholar
• Ramsammy L, Josepovitz C, Lane B, Kaloyanides GJ. Polyaspartic acid inhibits gentamicin-induced perturbations of phospholipid metabolism. Am J Physiol 1990; 258: C1141–C1149
   PubMedGoogle Scholar
• Josepovitz C, Pastoriza-Munoz E, Timmerman D, Scott M, Feldman S, Kaloyanides GJ. Inhibition of gentamicin uptake in rat renal cortex in vivo by aminoglycosides and organic polyca-tions. J Pharmacol Exp Ther 1982; 223: 314–321
   PubMed Web of Science ®Google Scholar