Protective Effect of Docosahexaenoic Acid Against Cyclosporine A-Induced Nephrotoxicity in Rats: A Possible Mechanism of Action

REFERENCES

• Calne R, White D, Thiru S, Cyclosporin A in patients receiving renal allografts from cadaver donors. Lancet. 1978;2(8104–8105):1323–1327.
   PubMedGoogle Scholar
• Busauschina A, Schnuelle P, Vander Woude F. Cyclosporine nephrotoxicity. Transplant Proc. 2004;36(2):229S–233S.
   Google Scholar
• Li C, Lim S, Sun B, Yang C. Chronic cyclosporine nephrotoxicity: New insights and preventive strategies. Yonsei Med J. 2004;45(6):1004–1016.
   Google Scholar
• English J, Evan A, Houghton D, Bennett W. Cyclosporin-induced acute renal dysfunction in the rat. Evidence of arteriolar vasoconstriction with preservation of tubular function. Transplantation. 1987;44(1):135–141.
   Google Scholar
• Gossmann J, Radounikli A, Bernemann A, Pathophysiology of cyclosporine-induced nephrotoxicity in humans: A role for nitric oxide? Kidney Blood Press Res. 2001;24(2):111–115.
   Google Scholar
• Kon V, Sugiura M, Inagami T, Harvie B, Ichikawa I, Hoover R. Role of endothelin in cyclosporine-induced glomerular dysfunction. Kidney Int. 1990;37:1487–1491.
   PubMed Web of Science ®Google Scholar
• Shihab F, Hong Y, Bennett W, Andoh T. Effect of nitric oxide modulation on TGF-beta1 and matrix proteins in chronic cyclosporine nephrotoxicity. Kidney Int. 2000;58(3):1174–1185.
   PubMed Web of Science ®Google Scholar
• Vaziri N, Ni Z, Zhang Y, Ruzics E, Maleki P, Ding Y. Depressed renal and vascular nitric oxide synthase expression in cyclosporine-induced hypertension. Kidney Int. 1998;54: 482–491.
   PubMed Web of Science ®Google Scholar
• Burdmann E, Andoh T, Yu L, Bennett W. Cyclosporine nephrotoxicity. Semin Nephrol. 2003;23(5):465–476.
   PubMed Web of Science ®Google Scholar
• Parra Cid T, Conejo Garcia J, Carballo Alvarez F, de Arriba G. Antioxidant nutrients protect against cyclosporine A nephrotoxicity. Toxicology. 2003;189(1–2):99–111.
   Google Scholar
• Wongmekiat O, Leelarugrayub N, Thamprasert K. Beneficial effect of shallot (Allium ascalonicum L.) extract on cyclosporine nephrotoxicity in rats. Food Chem Toxicol. 2008;46(5): 1844–1850.
   Google Scholar
• Ghaznavi R, Zahmatkesh M, Kadkhodaee M, Mahdavi-Mazdeh M. Cyclosporine effects on the antioxidant capacity of rat renal tissues. Transplant Proc. 2007;39(4):866–867.
   PubMed Web of Science ®Google Scholar
• Gökçe A, Oktar S, Yönden Z, Protective effect of caffeic acid phenethyl ester on cyclosporine A-induced nephrotoxicity in rats. Ren Fail. 2009;31(9):843–847.
   PubMed Web of Science ®Google Scholar
• Pari L, Sivasankari R. Effect of ellagic acid on cyclosporine A-induced oxidative damage in the liver of rats. Fundam Clin Pharmacol. 2008;22(4):395–401.
   PubMed Web of Science ®Google Scholar
• Wongmekiat O, Thamprasert K. Investigating the protective effects of aged garlic extract on cyclosporine-induced nephrotoxicity in rats. Fundam Clin Pharmacol. 2005;19(5):555–562.
   PubMedGoogle Scholar
• Hirunpanich V, Murakoso K, Sato H. Inhibitory effect of docosahexaenoic acid (DHA) on the intestinal metabolism of midazolam: In vitro and in vivo studies in rats. Int J Pharm. 2008;351(1–2):133–143.
   Google Scholar
• Harris W, Rambjor G, Windsor S, Diederich D. n-3 fatty acids and urinary excretion of nitric oxide metabolites in humans. Am J Clin Nutr. 1997;65:459–464.
   Google Scholar
• Nenseter M, Drevon C. Dietary polyunsaturates and peroxidation of low density lipoprotein. Curr Opin Lipidol. 1996; 7(1):8–13.
   Google Scholar
• Pan H, Kao T, Ou Y, Protective effect of docosahexaenoic acid against brain injury in ischemic rats. J Nutr Biochem. 2009;20(9):715–725.
   PubMed Web of Science ®Google Scholar
• Robinson J, Stone N. Antiatherosclerotic and antithrombotic effects of omega-3 fatty acids. Am J Cardiol. 2006;98(4A):39i–49i.
   PubMed Web of Science ®Google Scholar
• Song J, Fujimoto K, Miyazawal T. Polyunsaturated (n-3) Fatty acids susceptible to peroxidation are increased in plasma and tissue lipids of rats fed docosahexaenoic acid–containing oils. J Nutr. 2000;130(12):3028–3033.
   Google Scholar
• Fossati P, Prencipe L. Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide. Clin Chem. 1982;28(10):2077–2080.
   PubMed Web of Science ®Google Scholar
• Roeschlau P, Bernt E, Gruber W. Enzymatic determination of total cholesterol in serum. Z Klin Chem Klin Biochem. 1974; 12(5):226–230.
   PubMedGoogle Scholar
• Hallet G, Cook J. Reduced nicotinamide adenine dinucleotide for emergency blood urea estimation. Clin Chim Acta. 1971;35(1):33–37.
   Google Scholar
• Bonsnes R, Taussky H. On the colorimetric determination of creatinine by the Jaff reaction. J Biol Chem. 1945;158:581–591.
   Web of Science ®Google Scholar
• Moore J, Morris J. A simple automated colorimetric method for determination of N-acetyl-β-D-glucosaminidase. Ann Clin Biochem. 1982;19(3):157–159.
   PubMedGoogle Scholar
• Mihara M, Uchiyama M. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal Biochem. 1978;86(1):271–278.
   PubMed Web of Science ®Google Scholar
• Levine R, Garland D, Oliver C, Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol. 1990;186:464–478.
   PubMed Web of Science ®Google Scholar
• Green L, Wagner D, Glogowski J, Skipper P, Wishnok J, Tannenbaum S. Analysis of nitrate, nitrite and [15N] nitrate in biological fluids. Anal Biochem. 1982;126(1):131–138.
   PubMed Web of Science ®Google Scholar
• Lowry O, Rosebrough N, Farr A, Randall R. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193(1): 265–275.
   PubMed Web of Science ®Google Scholar
• Atessahin A, Ceribasi A, Yilmaz S. Lycopene a carotenoid, attenuates cyclosporine-induced renal dysfunction and oxidative stress in rats. Basic Clin Pharmacol Toxicol. 2007;100(6): 372–376.
   PubMed Web of Science ®Google Scholar
• Mohamadin A, El-Beshbishy H, El-Mahdy M. Green tea extract attenuates cyclosporine A-induced oxidative stress in rats. Pharmacol Res. 2005;51(1):51–57.
   PubMed Web of Science ®Google Scholar
• Shi S, Zheng S, Jia C, Zhu Y, Xie H. Inhibitory effect of tea polyphenals on transforming growth factor-beta1 expression in rat with cyclosporine A-induced chronic nephrotoxicity. Acta Pharmacol Sin. 2004;25(1):98–103.
   PubMed Web of Science ®Google Scholar
• Cheng C, Hsieh C, Shu K, Chen Y, Chen H. Effect of calcium channel antagonist diltiazem and calcium ionophore A23187 on cyclosporine A induced apoptosis of renal tubular cells. FEBS Lett. 2002;516(1–3):191–196.
   Google Scholar
• Satyanarayana P, Chopra K. Oxidative stress-mediated renal dysfunction by cyclosporine A in rats: Attenuation by trimetazidine. Ren Fail. 2002;24(3):259–274.
   PubMed Web of Science ®Google Scholar
• Tirkey N, Kaur G, Vij G, Chopra K. Curcumin a diferuloylmethane, attenuates cyclosporine-induced renal dysfunction and oxidative stress in rat kidneys. BMC Pharmacol. 2005;5: 15–24.
   PubMedGoogle Scholar
• Chander V, Chopra K. Effect of molsidomine and l-arginine in cyclosporine nephrotoxicity: Role of nitric oxide. Toxicology. 2005;207(3):463–474.
   Google Scholar
• De Nicola L, Thomson S, Wead L, Brown M, Gabbai F. Arginine feeding modifies cyclosporine nephrotoxicity in rats. J Clin Invest. 1993;92(4):1859–1865.
   Google Scholar
• Sabry A, El-Husseini A, Sheashaa H, Colchicine vs. omega-3 fatty acids for prevention of chronic cyclosporine nephrotoxicity in Sprague Dawley rats: An experimental animal model. Arch Med Res. 2006;37(8):933–940.
   Google Scholar
• Diederich D, Skopec J, Diederich A, Dai F. Cyclosporine produces endothelial dysfunction by increased production of superoxide. Hypertension. 1994;23(6 Pt 2):957–961.
   PubMed Web of Science ®Google Scholar
• Kim Y, Chung H. Antioxidative and anti-inflammatory actions of docosahexaenoic acid and eicosapentaenoic acid in renal epithelial cells and macrophages. J Med Food. 2007; 10(2):225–231.
   Google Scholar
• El-Mesery M, Al-Gayyar M, Salem H, Darweish M, E‐Mowafy A. Chemopreventive and renal protective effects for docosahexaenoic acid (DHA): Implications of CRP and lipid peroxides. Cell Div. 2009;(4):6–22.
   Google Scholar
• Kubo K, Saito M, Tadokoro T, Maekawa A. Preferential incorporation of docosahexaenoic acid into nonphosphorus lipids and phosphatidylethanolamine protects rats from dietary DHA-stimulated lipid peroxidation. J Nutr. 2000;130(7): 1749–1759.
   Google Scholar
• Bouzidi N, Mekki K, Boukaddoum A, Dida N, Kaddous A, Bouchenak M. Effects of omega-3 polyunsaturated fatty acid supplementation on redox status in chronic renal failure patients with dyslipidemia. J Ren Nutr. 2010;20(5):321–328.
   Google Scholar
• Calviello G, Palozza P, Franceschelli P, Bartoli G. Low-dose eicosapentaenoic or docosahexaenoic acid administration modifies fatty acid composition and does not affect susceptibility to oxidative stress in rat erythrocytes and tissues. Lipids. 1997;32(10):1075–1083.
   Google Scholar
• Sunada S, Kiyose C, Kubo K, Takebayashi J, Sanada H, Saito M. Effect of docosahexaenoic acid intake on lipid peroxidation in diabetic rat retina under oxidative stress. Free Radic Res. 2006;40(8):837–846.
   PubMed Web of Science ®Google Scholar
• Taccone-Gallucci M, Manca-di-Villahermosa S, Battistini L, Stuffler R, Tedesco M, Maccarrone M. N-3 PUFAs reduce oxidative stress in ESRD patients on maintenance HD by inhibiting 5-lipoxygenase activity. Kidney Int. 2006;69(8):1450–1454.
   Google Scholar
• Cattel V. Nitric oxide-potential mediator in glomerulonephritis. Nephrol Dial Transplant. 1995;10:759–774.
   Google Scholar
• Mumtaz F, Dashwood M, Khan M, Thompson C, Mikhailidis D, Morgan R. Down-regulation of nitric oxide synthase in the diabetic rabbit kidney: Potential relevance to the early pathogenesis of diabetic nephropathy. Curr Med Res Opin. 2004;20(1):1–6.
   PubMed Web of Science ®Google Scholar
• Prabhakar S. Pathogenic role of nitric oxide alterations in diabetic nephropathy. Curr Diab Rep. 2005;5:449–454.
   Google Scholar
• Raij L, Baylis C. Glomerular action of nitric oxide. Kidney Int. 1995;48(1):20–32.
   PubMed Web of Science ®Google Scholar
• Pacher P, Obrosova I, Mabley J, Szabo C. Role of nitrosative stress and peroxynitrite in the pathogenesis of diabetic complications: Emerging new therapeutical strategies. Curr Med Chem. 2005;12:267–275.
   PubMed Web of Science ®Google Scholar
• Prabhakar S, Starnes J, Shi S, Lonis B, Tran R. Diabetic nephropathy is associated with oxidative stress and decreased renal nitric oxide production. J Am Soc Nephrol. 2007;18:2945–2952.
   PubMed Web of Science ®Google Scholar
• Shimokawa H, Vanhoutte P. Dietary cod-liver oil improves endothelium dependent responses in hypercholesterolemic and atherosclenotic porcine coronary arteries. Circulation. 1988;78(6):1421–1430.
   PubMed Web of Science ®Google Scholar