651
Views
9
CrossRef citations to date
0
Altmetric
Laboratory Study

Association of PAX2 with Cell Apoptosis in Unilateral Ureteral Obstruction Rats

, , , &
Pages 194-202 | Received 18 Jun 2011, Accepted 13 Sep 2011, Published online: 09 Jan 2012

REFERENCES

  • Meran S, Steadman R. Fibroblasts and myofibroblasts in renal fibrosis. Int J Exp Pathol. 2011;92:158–167.
  • Terashima H, Kato M, Yasumo H, Tsuchida H, Mizuno M, Sada T. A sensitive short-term evaluation of antifibrotic effects using newly established type I collagen reporter transgenic rats. Am J Physiol Renal Physiol. 2010;299:792–801.
  • Barnes JL, Glass WN. Renal interstitial fibrosis: A critical evaluation of the origin of myofibroblasts. Contrib Nephrol. 2011;169:73–93.
  • Correa-Costa M, Semedo P, Monteiro AP, . Induction of heme oxygenase-1 can halt and even reverse renal tubule-interstitial fibrosis. PLoS One. 2010;5:e14298.
  • Morisada N, Nomura M, Nishii H, . Complete disruption of all nitric oxide synthase genes causes markedly accelerated renal lesion formation following unilateral ureteral obstruction in mice in vivo. J Pharmacol Sci. 2010;114:379–389.
  • Okamura DM, Pasichnyk K, Lopez-Guisa JM, . Galectin-3 preserves renal tubules and modulates extracellular matrix remodeling in progressive fibrosis. Am J Physiol Renal Physiol. 2011;300:245–253.
  • Luu VD, Boysen G, Struckmann K, . Loss of VHL and hypoxia provokes PAX2 up-regulation in clear cell renal cell carcinoma. Clin Cancer Res. 2009;15:3297–3304.
  • Sehgal R, Sheibani N, Rhodes SJ, Belecky AT. BMP7 and SHH regulate Pax2 in mouse retinal astrocytes by relieving TLX repression. Dev Biol. 2009;332:429–443.
  • Busse A, Rietz A, Schwartz S, Thiel E, Keilholz U. An intron 9 containing splice variant of PAX2. J Transl Med. 2009;7:36.
  • Warchol ME, Richardson GP. Expression of the Pax2 transcription factor is associated with vestibular phenotype in the avian inner ear. Dev Neurobiol. 2009;69:191–202.
  • Bose SK, Gibson W, Bullard RS, Donald CD. PAX2 oncogene negatively regulates the expression of the host defense peptide human beta defensin-1 in prostate cancer. Mol Immunol. 2009;46:1140–1148.
  • Meng L, Qu L, Tang J, Cai SQ, Wang H, Li X. A combination of Chinese herbs, Astragalus membranaceus var. mongholicus and Angelica sinensis, enhanced nitric oxide production in obstructed rat kidney. Vascul Pharmacol. 2007;47:174–183.
  • Kim DS, Kim B, Tahk H, . Transglutaminase 2 gene ablation protects against renal ischemic injury by blocking constant NF-kappaB activation. Biochem Biophys Res Commun. 2010;403:479–484.
  • Kaneyama T, Kobayashi S, Aoyagi D, Ehara T. Tranilast modulates fibrosis, epithelial-mesenchymal transition and peritubular capillary injury in unilateral ureteral obstruction rats. Pathology 2010;42:564–573.
  • Cheng J, Truong LD, Wu X, Kuhl D, Lang F, Du J. Serum- and glucocorticoid-regulated kinase 1 is upregulated following unilateral ureteral obstruction causing epithelial-mesenchymal transition. Kidney Int. 2010;78:668–678.
  • Tang R, Yang C, Tao JL, . Epithelial-mesenchymal transdifferentiation of renal tubular epithelial cells induced by urinary proteins requires the activation of PKC-alpha and betaI isozymes. Cell Biol Int. 2011;35:953–959.
  • Wang QL, Tao YY, Yuan JL, Shen L, Liu CH. Salvianolic acid B prevents epithelial-to-mesenchymal transition through the TGF-beta1 signal transduction pathway in vivo and in vitro. BMC Cell Biol. 2010;11:31.
  • Minz RW, Bakshi A, Chhabra S, Joshi K, Sakhuja V. Role of myofibroblasts and collagen type IV in patients of IgA nephropathy as markers of renal dysfunction. Indian J Nephrol. 2010;20:34–39.
  • Ma FY, Tesch GH, Ozols E, Xie M, Schneider MD, Nikolic-Paterson DJ. TGF- beta1 activated kinase-1 (TAK1) regulates inflammation and fibrosis in the obstructed kidney. Am J Physiol Renal Physiol. 2011;300:F1410–F1421.
  • Barnes JL, Gorin Y. Myofibroblast differentiation during fibrosis: Role of NAD(P)H oxidases. Kidney Int. 2011;79:944–956.
  • Djamali A, Vidyasagar A, Yagci G, Huang LJ, Reese S. Mycophenolic acid may delay allograft fibrosis by inhibiting transforming growth factor-beta1-induced activation of Nox-2 through the nuclear factor-kappaB pathway. Transplantation. 2010;90:387–393.
  • Zhou G, Li C, Cai L. Advanced glycation end-products induce connective tissue growth factor-mediated renal fibrosis predominantly through transforming growth factor beta-independent pathway. Am J Pathol. 2004;165:2033–2043.
  • Kelley R, Werdin ES, Bruce AT, . Tubular cell-enriched subpopulation of primary renal cells improves survival and augments kidney function in rodent model of chronic kidney disease. Am J Physiol Renal Physiol. 2010;299:1026–1039.
  • Mohamed SA, Misfeld M, Hanke T, . Inhibition of caspase-3 differentially affects vascular smooth muscle cell apoptosis in the concave versus convex aortic sites in ascending aneurysms with a bicuspid aortic valve. Ann Anat. 2010;192:145–150.
  • Cai H, Gu Y, Sun Q, Zeng J, Dong N, Zhao G. Effect of hematoporphyrin monomethyl ether-mediated photodynamic therapy on hypertrophic scar fibroblasts. Photodermatol Photoimmunol Photomed. 2011;27:90–96.
  • Yue Z, She RP, Bao HH, . Necrosis and apoptosis of renal tubular epithelial cells in rats exposed to 3-methyl-4-nitrophenol. Environ Toxicol. doi:10.1002/tox.20688.
  • He W, Wang Y, Zhang MZ, . Sirt1 activation protects the mouse renal medulla from oxidative injury. J Clin Invest. 2010;120:1056–1068.
  • Li L, Zepeda-Orozco D, Black R, Lin F. Autophagy is a component of epithelial cell fate in obstructive uropathy. Am J Pathol. 2010;176:1767–1778.
  • Mandache E, Gherghiceanu M, Serafinceanu C, Penescu M, Mircescu G. Myofibroblast involvement in tubular basement membrane remodeling in type II diabetic nephropathy. Rom J Morphol Embryol. 2011;52:75–79.
  • Murer L, Caridi G, Della VM, . Expression of nuclear transcription factor PAX2 in renal biopsies of juvenile nephronophthisis. Nephron 2002;91:588–593.
  • Lindoso RS, Verdoorn KS, Einicker-Lamas M. Renal recovery after injury: The role of Pax-2. Nephrol Dial Transplant. 2009;24:2628–2633.
  • Huang B, Pi L, Chen C, . WT1 and Pax2 re-expression is required for epithelial-mesenchymal transition in 5/6 nephrectomized rats and cultured kidney tubular epithelial cells. Cells Tissues Organs. doi:10.1159/000327530.
  • Lozanoff S, Johnston J, Ma W, Jourdan-Le SC. Immunohistochemical localization of Pax2 and associated proteins in the developing kidney of mice with renal hypoplasia. J Histochem Cytochem. 2001;49:1081–1097.
  • Hueber PA, Iglesias D, Chu LL, Eccles M, Goodyer P. In vivo validation of PAX2 as a target for renal cancer therapy. Cancer Lett. 2008;265:148–155.
  • Xie P, Sun L, Nayak B, . C/EBP-beta modulates transcription of tubulointerstitial nephritis antigen in obstructive uropathy. J Am Soc Nephrol. 2009;20:807–819.
  • Zhang D, Sun L, Xian W, . Low-dose paclitaxel ameliorates renal fibrosis in rat UUO model by inhibition of TGF-beta/Smad activity. Lab Invest. 2010;90:436–447.
  • Zhou TB, Qin YH, Zhou C, . Less expression of prohibition is associated with the increased caspase-3 expression and cell apoptosis in renal interstitial fibrosis rats. Nephrology (Carlton). doi:10.1111/j.1440-1797.2011.01522.x.
  • Hu X, Zhou X, He B, . Minocycline protects against myocardial ischemia and reperfusion injury by inhibiting high mobility group box 1 protein in rats. Eur J Pharmacol. 2010;638:84–89.
  • Ha T, Hua F, Liu X, . Lipopolysaccharide-induced myocardial protection against ischemia/reperfusion injury is mediated through a PI3K/Akt-dependent mechanism. Cardiovasc Res. 2008;78:546–553.
  • Zhou TB, Qin YH, Lei FY, Su LN, Zhao YJ, Huang WF. apoE expression in glomerulus and correlation with glomerulosclerosis induced by adriamycin in rats. Ren Fail. 2011;33:348–354.
  • Zhou TB, Qin YH, Lei FY, Su LN, Zhao YJ, Huang WF. All-trans retinoic acid regulates the expression of apolipoprotein E in rats with glomerulosclerosis induced by adriamycin. Exp Mol Pathol. 2011;90:287–294.
  • Zhou TB, Qin YH, Ou C, . All-trans retinoic acid can regulate the expressions of gelatinases and apolipoprotein E in glomerulosclerosis rats. Vasc Pharmacol. 2011;55:169–177.
  • Dressler GR. Patterning and early cell lineage decisions in the developing kidney: The role of Pax genes. Pediatr Nephrol. 2011;26:1387–1394.
  • Negrisolo S, Benetti E, Centi S, . PAX2 gene mutations in pediatric and young adult transplant recipients: Kidney and urinary tract malformations without ocular anomalies. Clin Genet. 2011;80:581–585.
  • Raca G, Jackson CA, Kucinskas L, . Array comparative genomic hybridization analysis in patients with anophthalmia, microphthalmia, and coloboma. Genet Med. 2011;13:437–442.
  • Li L, Wu Y, Zhang W. PAX2 re-expression in renal tubular epithelial cells and correlation with renal interstitial fibrosis of rats with obstructive nephropathy. Ren Fail. 2010;32:603–611.
  • Benetti E, Caridi G, Vella MD, . Immature renal structures associated with a novel UMOD sequence variant. Am J Kidney Dis. 2009;53:327–331.
  • Mure PY, Gelas T, Dijoud F, . Complete unilateral ureteral obstruction in the fetal lamb. Part II: Long-term outcomes of renal tissue development. J Urol. 2006;175:1548–1558.
  • Zhang SL, Chen YW, Tran S, Chenier I, Hebert MJ, Ingelfinger JR. Reactive oxygen species in the presence of high glucose alter ureteric bud morphogenesis. J Am Soc Nephrol. 2007;18:2105–2115.
  • Chen YW, Liu F, Tran S, . Reactive oxygen species and nuclear factor-kappa B pathway mediate high glucose-induced Pax-2 gene expression in mouse embryonic mesenchymal epithelial cells and kidney explants. Kidney Int. 2006;70:1607–1615.
  • Yeh CH, Chiang HS, Lai TY, Chien CT. Unilateral ureteral obstruction evokes renal tubular apoptosis via the enhanced oxidative stress and endoplasmic reticulum stress in the rat. Neurourol Urodyn. 2011;30:472–479.
  • Meng L, Qu L, Tang J, Cai SQ, Wang H, Li X. A combination of Chinese herbs, Astragalus membranaceus var. mongholicus and Angelica sinensis, enhanced nitric oxide production in obstructed rat kidney. Vascul Pharmacol. 2007;47:174–183.
  • Fujita H, Hida M, Kanemoto K, Fukuda K, Nagata M, Awazu M. Cyclic stretch induces proliferation and TGF-beta1-mediated apoptosis via p38 and ERK in ureteric bud cells. Am J Physiol Renal Physiol. 2010;299:648–655.
  • Liu S, Cieslinski DA, Funke AJ, Humes HD. Transforming growth factor-beta 1 regulates the expression of Pax-2, a developmental control gene, in renal tubule cells. Exp Nephrol. 1997;5:295–300.
  • Huang S, Zhang F, Miao L, . Lentiviral-mediated Smad4 RNAi induced anti-proliferation by p16 up-regulation and apoptosis by caspase 3 down-regulation in hepatoma SMMC-7721 cells. Oncol Rep. 2008;20:1053–1059.
  • van der Heide LP, van Dinther M, Moustakas A, ten Dijke P. TGFbeta activates mitogen- and stress-activated protein kinase-1 (MSK1) to attenuate cell death. J Biol Chem. 2011;286:5003–5011.
  • Zheng X, Boerboom D, Carriere PD. Transforming growth factor-beta1 inhibits luteinization and promotes apoptosis in bovine granulosa cells. Reproduction 2009;137:969–977.
  • Dziarmaga A, Hueber PA, Iglesias D, . Neuronal apoptosis inhibitory protein is expressed in developing kidney and is regulated by PAX2. Am J Physiol Renal Physiol. 2006;291:913–920.
  • Hueber PA, Iglesias D, Chu LL, Eccles M, Goodyer P. In vivo validation of PAX2 as a target for renal cancer therapy. Cancer Lett. 2008;265:148–155.
  • Cai Q, Dmitrieva NI, Ferraris JD, Brooks HL, van Balkom BW, Burg M. Pax expression occurs in renal medullary epithelial cells in vivo and in cell culture, is osmoregulated, and promotes osmotic tolerance. Proc Natl Acad Sci USA. 2005;102:503–508.
  • Mansour H, Chamberlain CG, Weible MN, Hughes S, Chu Y, Chan-Ling T. Aging-related changes in astrocytes in the rat retina: Imbalance between cell proliferation and cell death reduces astrocyte availability. Aging Cell 2008;7:526–540.
  • Chevalier RL, Forbes MS, Thornhill BA. Formation of atubular glomeruli in the developing kidney following chronic urinary tract obstruction. Pediatr Nephrol. 2011;26:1381–1385.
  • Li L, Zepeda-Orozco D, Black R, Lin F. Autophagy is a component of epithelial cell fate in obstructive uropathy. Am J Pathol. 2010;176:1767–1778.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.