1,611
Views
44
CrossRef citations to date
0
Altmetric
Laboratory Study

l-Arginine attenuates the ethylene glycol induced urolithiasis in ininephrectomized hypertensive rats: role of KIM-1, NGAL, and NOs

, &
Pages 709-721 | Received 24 Oct 2014, Accepted 04 Jan 2015, Published online: 16 Feb 2015

References

  • Charles L, Smith M, Guay D. Nephrolithiasis Pharmacotherapy – A Pathophysiological Approach. 3rd ed. Appleton and Langue 1999;1033–1036
  • Dole S, Kandhare AD, Ghosh P, Gosavi TP, Bodhankar SL. The health outcome after homeopathic treatment in cases of BPH and LUTS: a prospective clinical study. J Pharm Biomed Sci. 2012;22:1–6
  • Christina A, Packia Lakshmi M, Nagarajan M, Kurian S. Modulatory effect of Cyclea peltata Lam. on stone formation induced by ethylene glycol treatment in rats. Methods Find Exp Clin Pharmacol. 2002;24:77–79
  • Trinchieri A, Castelnuovo C, Lizzano R, Zanetti G. Calcium stone disease: A multiform reality. Urol Res. 2005;33:194–198
  • Gotoh M, Mizuno K, Ono Y, Takahashi M. High blood pressure, bone-mineral loss and insulin resistance in women. Hypertens Res. 2005;28:565–570
  • Cappuccio FP, Kalaitzidis R, Duneclift S, Eastwood JB. Unravelling the links between calcium excretion, salt intake, hypertension, kidney stones and bone metabolism. J Nephrol. 1999;13:169–177
  • Madore F, Stampfer MJ, Rimm EB, Curhan GC. Nephrolithiasis and risk of hypertension. Am J Hypertens 1998;11:46–53
  • Shivakumar V, Kandhare A, Rajmane A, et al. Estimation of the long-term cardiovascular events using ukpds risk engine in metabolic syndrome patients. Indian J Pharm Sci. 2014;76:174–178
  • Kiprov D, Colvin R, McCluskey R. Focal and segmental glomerulosclerosis and porteinuria associated with unilateral renal agenesis. Lab Invest. 1982;46:275–281
  • Kandhare AD, Raygude KS, Ghosh P, Gosavi TP, Bodhankar SL. Patentability of Animal Models: India and the Globe. Int J Pharm Biol Arch. 2011;2:1024–1032
  • Cirillo M, Laurenzi M, Panarelli W, Stamler J. Urinary sodium to potassium ratio and urinary stone disease. The Gubbio Population Study Research Group. Kidney Int. 1994;46:1133–1139
  • Yoshioka I, Tsujihata M, Akanae W, Nonomura N, Okuyama A. Angiotensin type-1 receptor blocker candesartan inhibits calcium oxalate crystal deposition in ethylene glycol-treated rat kidneys. Urology. 2011;77:1007.e9–1007.e14
  • Vermeulen C, Ellis J, Hsu T-C. Experimental observations on the pathogenesis of urinary calculi. J Urol. 1966;95:681–690
  • Robertson W, Peacock M, Nordin B. Calcium crystalluria in recurrent renal-stone formers. Lancet. 1969;294:21–24
  • Yoshioka I, Tsujihata M, Akanae W, Nonomura N, Okuyama A. Angiotensin type-1 receptor blocker candesartan inhibits calcium oxalate crystal deposition in ethylene glycol-treated rat kidneys. Urology. 2011;77:1007.e9–1007
  • Adil M, Visnagri A, Kumar VS, Kandhare AD, Ghosh P. Protective effect of naringin on sodium arsenite induced testicular toxicity via modulation of biochemical perturbations in experimental rats. Pharmacologia. 2014;5:222–234
  • Kandhare A, Raygude K, Ghosh P, Bodhankar S. The ameliorative effect of fisetin, a bioflavonoid, on ethanol-induced and pylorus ligation-induced gastric ulcer in rats. Int J Green Pharm. 2011;5:236–243
  • Kandhare AD, Bodhankar SL, Singh V, Mohan V, Thakurdesai PA. Anti-asthmatic effects of type-A procyanidine polyphenols from cinnamon bark in ovalbumin-induced airway hyperresponsiveness in laboratory animals. Biomed Aging Pathol. 2013;3:23–30
  • Rueckschloss U, Quinn MT, Holtz J, Morawietz H. Dose-dependent regulation of NAD (P) H oxidase expression by angiotensin II in human endothelial cells protective effect of angiotensin II type 1 receptor blockade in patients with coronary artery disease. Arterioscler Thromb Vasc Biol. 2002;22:1845–1851
  • Watanabe D, Tanabe A, Naruse M, Morikawa S, Ezaki T, Takano K. Renoprotective effects of an angiotensin II receptor blocker in experimental model rats with hypertension and metabolic disorders. Hypertens Res. 2009;32:807–815
  • Krambeck AE, Rule AD, Li X, Bergstralh EJ, Gettman MT, Lieske JC. Shock wave lithotripsy is not predictive of hypertension among community stone formers at long-term followup. J Urol. 2011;185:164–169
  • Ghosh P, Kandhare AD, Raygude KS, et al. Determination of the long term diabetes related complications and cardiovascular events using UKPDS risk engine and UKPDS outcomes model in a representative western Indian population. Asian Pac J Trop Dis. 2012;2:S642–S650
  • Bhalsinge RR, Worlikar PS, Tilak AV, Bodhankar SL, Ghosh P, Kandhare AD. Effect of nicotine on brain GABA levels in depressed rats. Am J Pharm Tech Res. 2012;2:556–563
  • Kandhare AD, Ghosh P, Ghule AE, Zambare GN, Bodhankar SL. Protective effect of Phyllanthus amarus by modulation of endogenous biomarkers and DNA damage in acetic acid induced ulcerative colitis: Role of phyllanthin and hypophyllanthin. Apollo Med. 2013;10:87–97
  • Kandhare AD, Kumar VS, Adil M, Rajmane AR, Ghosh P, Bodhankar SL. Investigation of gastro protective activity of Xanthium strumarium L. by modulation of cellular and biochemical marker. Orient Pharm Exp Med. 2012;12:287–299
  • Koppelmann T, Pollak Y, Mogilner J, Bejar J, Coran AG, Sukhotnik I. Dietary L-arginine supplementation reduces Methotrexate-induced intestinal mucosal injury in rat. BMC Gastroenterol. 2012;12:41
  • Cooke JP, Singer A, Tsao P, Zera P, Rowan R, Billingham M. Antiatherogenic effects of L-arginine in the hypercholesterolemic rabbit. J Clin Invest. 1992;90:1168–1172
  • Xekouki P, Papandreou I, Aroni K, et al. The effect of L-Arginine in experimental colitis. Ann Gastroenterol 2004;17:270–275
  • Cao B, Li N, Wang Y, Li J-S. Protective effect of L-arginine preconditioning on ischemia and reperfusion injury associated with rat small bowel transplantation. World J Gastroenterol. 2005;11:2994–2997
  • Acquaviva R, Lanteri R, Destri GL, et al. Beneficial effects of rutin and L-arginine coadministration in a rat model of liver ischemia-reperfusion injury. Am J Physiol Gastrointest Liver Physiol. 2009;296:G664–G670
  • Reyes AA, Karl IE, Kissane J, Klahr S. L-arginine administration prevents glomerular hyperfiltration and decreases proteinuria in diabetic rats. J Am Soc Nephrol. 1993;4:1039–1045
  • Mansour MA, Al-Shabanah OA, El-Khashef HA. L-arginine ameliorates kidney function and urinary bladder sensitivity in experimentally-induced renal dysfunction in rats. J Biochem Mol Biol 2003;36:373–378
  • Mansour M, Hesham Daba M, Gado A, Al-Rikabi A, Al-Majed A. Protective effect of L-arginine against nephrotoxicity induced by cyclosporine in normal rats. Pharmacol Res. 2002;45:441–446
  • Sasaki S, Asano M, Ukai T, et al. Nitric oxide formation and plasma l-arginine levels in pulmonary hypertensive rats. Respir Med. 2004;98:205–212
  • Mehta S, Stewart DJ, Langleben D, Levy RD. Short-term pulmonary vasodilation with L-arginine in pulmonary hypertension. Circulation. 1995;92:1539–1545
  • Nagaya N, Uematsu M, Oya H, et al. Short-term oral administration of L-arginine improves hemodynamics and exercise capacity in patients with precapillary pulmonary hypertension. Am J Respir Crit Care Med. 2001;163:887–891
  • Kurokawa T, An J, Tsunekawa K, et al. Effect of L-arginine supplement on liver regeneration after partial hepatectomy in rats. World J Surg Oncol. 2012;10:99–104
  • Ahmed LA, Obaid AAZ, Zaki HF, Agha AM. Naringenin adds to the protective effect of L-arginine in monocrotaline-induced pulmonary hypertension in rats: Favorable modulation of oxidative stress, inflammation and nitric oxide. Eur J Pharm Sci. 2014;62:161–170
  • Visnagri A, Kandhare AD, Ghosh P, Bodhankar SL. Endothelin receptor blocker bosentan inhibits hypertensive cardiac fibrosis in pressure overload-induced cardiac hypertrophy in rats. Cardiovasc Endocrinol. 2013;2:85–97
  • Kandhare AD, Raygude KS, Shiva Kumar V, et al. Ameliorative effects quercetin against impaired motor nerve function, inflammatory mediators and apoptosis in neonatal streptozotocin-induced diabetic neuropathy in rats. Biomed Aging Pathol. 2012;2:173–186
  • Kandhare AD, Ghosh P, Bodhankar SL. Naringin, a flavanone glycoside, promotes angiogenesis and inhibits endothelial apoptosis through modulation of inflammatory and growth factor expression in diabetic foot ulcer in rats. Chem Biol Interact. 2014;219C:101–112
  • Kandhare AD, Ghosh P, Ghule AE, Bodhankar SL. Elucidation of molecular mechanism involved in neuroprotective effect of Coenzyme Q10 in alcohol induced neuropathic pain. Fundam Clin Pharmacol. 2013;27:603–622
  • Kandhare AD, Shivakumar V, Rajmane A, Ghosh P, Bodhankar SL. Evaluation of the neuroprotective effect of chrysin via modulation of endogenous biomarkers in a rat model of spinal cord injury. J Nat Med. 2014;68:586–603
  • Visnagri A, Kandhare AD, Chakravarty S, Ghosh P, Bodhankar SL. Hesperidin, a flavanoglycone attenuates experimental diabetic neuropathy via modulation of cellular and biochemical marker to improve nerve functions. Pharm Biol. 2014;52:814–828
  • Ajayi L, Jaeger P, Robertson W, Unwin R. Renal stone disease. Medicine. 2007;35:415–419
  • Prien EL, Prien Jr EL. Composition and structure of urinary stone. Am J Med. 1968;45:654–672
  • Hesse A, Miersch W-D. Special aspects of stone composition and aetiology of different types of urinary calculi. Int Urol Nephrol. 1989;21:257–267
  • Hakim RM, Goldszer RC, Brenner BM. Hypertension and proteinuria: Long-term sequelae of uninephrectomy in humans. Kidney Int. 1984;25:930–936
  • Katz A, Epstein F. Relation of glomerular filtration rate and sodium reabsorption to kidney size in compensatory renal hypertrophy. Yale J Biol Med. 1967;40:222–230
  • Kaufman JM, Siegel NJ, Hayslett JP. Functional and hemodynamic adaptation to progressive renal ablation. Circ Res. 1975;36:286–293
  • Thangarathinam N, Jayshree N, Metha AV, Ramanathan L. Effect of polyherbal formulation on ethylene glycol induced urolithiasis. Int J Pharm Pharm Sci. 2013;5:994–997
  • Chavada KS, Fadadu KN, Patel KV, Patel KG, Gandhi TR. Effect of flavanoid rich fraction of Citrus medica Linn.(rutacea) on ethylene glycol induced urolithiasis in rats. J Drug Deliv Ther 2012;2:109–116
  • Leth PM, Gregersen M. Ethylene glycol poisoning. Foren Sci Int. 2005;155:179–184
  • Bashir S, Gilani AH. Antiurolithic effect of Bergenia ligulata rhizome: An explanation of the underlying mechanisms. J Ethnopharmacol. 2009;122:106–116
  • Lee YH, Huang WC, Chang LS, Chen MT, Huang JK. Uninephrectomy enhances urolithiasis in ethylene glycol treated rats. Kidney Int. 1992;42:292–299
  • Pabico RC, McKenna BA, Freeman RB. Renal function before and after unilateral nephrectomy in renal donors. Kidney Int. 1975;8:166–175
  • Hayslett JP. Functional adaptation to reduction in renal mass. Physiol Rev. 1979;59:137–164
  • Halabe A, Wong N, Sutton R. The effect of verapamil and thiazide in the prevention of renal stone formation. Urol Res. 1990;18:155–158
  • Pyrah L, Hodgkinson A. Nephrocalcinosis. Br J Urol. 1960;32:361–373
  • Preminger G, Sakhaee K, Skurla C, Pak C. Prevention of recurrent calcium stone formation with potassium citrate therapy in patients with distal renal tubular acidosis. J Urol. 1985;134:20–23
  • Patel PK, Patel MA, Vyas BA, Shah DR, Gandhi TR. Antiurolithiatic activity of saponin rich fraction from the fruits of Solanum xanthocarpum Schrad. & Wendl.(Solanaceae) against ethylene glycol induced urolithiasis in rats. J Ethnopharmacol. 2012;144:160–170
  • Kok D, Papapoulos S, Bijvoet O. Excessive crystal agglomeration with low citrate excretion in recurrent stone-formers. Lancet. 1986;327:1056–1058
  • Grover PK, Resnick MI. Evidence for the presence of abnormal proteins in the urine of recurrent stone formers. J Urol. 1995;153:1716–1721
  • Ashab I, Peer G, Blum M, et al. Oral administration of L-arginine and captopril in rats prevents chronic renal failure by nitric oxide production. Kidney Int. 1995;47:1515–1521
  • Leth PM. Botulism in greenland. Forensic Sci Int. 2014;238:1–2
  • Taylor EN, Mount DB, Forman JP, Curhan GC. Association of prevalent hypertension with 24-hour urinary excretion of calcium, citrate, and other factors. Am J Kidney Dis. 2006;47:780–789
  • Lucas P, Lacour B, McCarron D, Drueke T. Disturbance of acid-base balance in the young spontaneously hypertensive rat. Clin Sci (Lond). 1987;73:211–215
  • Lucas P, Lacour B, Comte L, McCarron D, Drüeke T. Abnormal parameters of acid-base balance in genetic hypertension. Kidney Int Suppl. 1988;25:S19–S22
  • Morikawa E, Moskowitz MA, Huang Z, Yoshida T, Irikura K, Dalkara T. L-arginine infusion promotes nitric oxide-dependent vasodilation, increases regional cerebral blood flow, and reduces infarction volume in the rat. Stroke. 1994;25:429–435
  • Bartunek J, Dempsey S, Weinberg EO, et al. Chronic l-arginine treatment increases cardiac cyclic guanosine 5′-monophosphate in rats with aortic stenosis: Effects on left ventricular mass and beta-adrenergic contractile reserve. J Am Coll Cardiol. 1998;32:528–535
  • Yagi K. Lipid peroxides and human diseases. Chem Phys Lipids. 1987;45:337–351
  • Kandhare AD, Raygude KS, Ghosh P, et al. Effect of hydroalcoholic extract of Hibiscus rosa sinensis Linn. leaves in experimental colitis in rats. Asian Pac J Trop Biomed. 2012;5:337–344
  • Visnagri A, Kandhare AD, Shiva Kumar V, et al. Elucidation of ameliorative effect of Co-enzyme Q10 in streptozotocin-induced diabetic neuropathic perturbation by modulation of electrophysiological, biochemical and behavioral markers. Biomed Aging Pathol. 2012;2:157–172
  • Kandhare AD, Raygude KS, Ghosh P, Ghule AE, Bodhankar SL. Neuroprotective effect of naringin by modulation of endogenous biomarkers in streptozotocin induced painful diabetic neuropathy. Fitoterapia. 2012;83:650–659
  • Kandhare AD, Raygude KS, Ghosh P, Ghule AE, Bodhankar SL. Therapeutic role of curcumin in prevention of biochemical and behavioral aberration induced by alcoholic neuropathy in laboratory animals. Neurosci Lett. 2012;511:18–22
  • Raygude KS, Kandhare AD, Ghosh P, Bodhankar SL. Anticonvulsant effect of fisetin by modulation of endogenous biomarkers. Biomed Prevent Nutr. 2012;2:215–222
  • Raygude KS, Kandhare AD, Ghosh P, Ghule AE, Bodhankar SL. Evaluation of ameliorative effect of quercetin in experimental model of alcoholic neuropathy in rats. Inflammopharmacology. 2012;20:331–341
  • Goswami S, Kandhare A, Zanwar AA, et al. Oral l-glutamine administration attenuated cutaneous wound healing in Wistar rats. Int Wound J. 2014. [Epub ahead of print]. DOI: 10.1111/iwj.12246
  • Kamble H, Kandhare AD, Bodhankar S, Mohan V, Thakurdesai P. Effect of low molecular weight galactomannans from fenugreek seeds on animal models of diabetes mellitus. Biomed Aging Pathol. 2013;3:145–151
  • Gosavi TP, Ghosh P, Kandhare AD, et al. Therapeutic effect of H. pylori nosode, a homeopathic preparation in healing of chronic H. pylori infected ulcers in laboratory animals. Asian Pac J Trop Dis. 2012;2:S603–S611
  • Gosavi TP, Kandhare AD, Ghosh P, Bodhankar SL. Anticonvulsant activity of Argentum metallicum, a homeopathic preparation. Pharma Lett. 2012;4:626–637
  • Kumar VS, Rajmane AR, Adil M, Kandhare AD, Ghosh P, Bodhankar SL. Naringin ameliorates acetic acid induced colitis through modulation of endogenous oxido-nitrosative balance and DNA damage in rats. J Biomed Res. 2014;28:132–145
  • Patil MVK, Kandhare AD, Bhise SD. Anti-arthritic and anti-inflammatory activity of Xanthium srtumarium L. ethanolic extract in Freund's complete adjuvant induced arthritis. Biomed Aging Pathol. 2012;2:6–15
  • Patil MVK, Kandhare AD, Bhise SD. Effect of aqueous extract of Cucumis sativus Linn. fruit in ulcerative colitis in laboratory animals. Asian Pac J Trop Biomed. 2012;2:S962–S969
  • Patil M, Kandhare A, Bhise S. Pharmacological evaluation of ameliorative effect of aqueous extract of Cucumis sativus L. fruit formulation on wound healing in Wistar rats. Chron Young Scientists. 2011;2:207–213
  • Patil M, Kandhare A, Bhise S. Anti-inflammatory effect of Daucus carota root on experimental colitis in rats. Int J Pharm Pharm Sci. 2012;4:337–343
  • Patil MVK, Kandhare AD, Bhise SD. Pharmacological evaluation of ethanolic extract of Daucus carota Linn root formulated cream on wound healing using excision and incision wound model. Asian Pac J Trop Biomed. 2012;2:S646–S655
  • Ilbey Y, Ozbek E, Simsek A, Cekmen M, Somay A, Tasci AI. Pyrrolidine dithiocarbamate treatment prevents ethylene glycol-induced urolithiasis through inhibition of NF-kB and p38-MAPK signaling pathways in rat kidney. Arch Ital Urol Androl. 2010;82:87–94
  • Uchino S, Kellum JA, Bellomo R, et al. Acute renal failure in critically ill patients: A multinational, multicenter study. JAMA. 2005;294:813–818
  • Parmar A, Langenberg C, Wan L, May CN, Bellomo R, Bagshaw SM. Epidemiology of septic acute kidney injury. Curr Drug Targets. 2009;10:1169–1178
  • Matejovic M, Chvojka J, Radej J, et al. Sepsis and acute kidney injury are bidirectional. Contrib Nephrol. 2011;174:78–88
  • Mishra J, Ma Q, Prada A, et al. Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury. J Am Soc Nephrol. 2003;14:2534–2543
  • Supavekin S, Zhang W, Kucherlapati R, Kaskel FJ, Moore LC, Devarajan P. Differential gene expression following early renal ischemia/reperfusion. Kidney Int. 2003;63:1714–1724
  • Haase M, Bellomo R, Devarajan P, Schlattmann P, Haase-Fielitz A. Accuracy of neutrophil gelatinase-associated lipocalin (NGAL) in diagnosis and prognosis in acute kidney injury: A systematic review and meta-analysis. Am J Kidney Dis. 2009;54:1012–1024
  • Waring WS, Moonie A. Earlier recognition of nephrotoxicity using novel biomarkers of acute kidney injury. Clin Toxicol. 2011;49:720–728
  • Mitani Y, Maruyama K, Sakurai M. Prolonged administration of l-arginine ameliorates chronic pulmonary hypertension and pulmonary vascular remodeling in rats. Circulation 1997;96:689–697
  • Fagan JM, Rex SE, Hayes-Licitra SA, Waxman L. L-arginine reduces right heart hypertrophy in hypoxia-induced pulmonary hypertension. Biochem Biophys Res Commun. 1999;254:100–103
  • Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA. Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA. 1990;87:1620–1624
  • Palmer RM, Ashton D, Moncada S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature. 1988;333:664–666
  • Busse R, Mülsch A, Fleming I, Hecker M. Mechanisms of nitric oxide release from the vascular endothelium. Monogr Am Heart Assoc. 1993;87:V18–V25
  • Nadaud S, Philippe M, Arnal J-F, Michel J-B, Soubrier F. Sustained increase in aortic endothelial nitric oxide synthase expression in vivo in a model of chronic high blood flow. Circ Res. 1996;79:857–863
  • Tan X, Sun WD, Li JC, et al. L-arginine prevents reduced expression of endothelial nitric oxide synthase (NOS) in pulmonary arterioles of broilers exposed to cool temperatures. Vet J. 2007;173:151–157
  • Umekawa T, Hatanaka Y, Kurita T, Khan SR. Effect of angiotensin II receptor blockage on osteopontin expression and calcium oxalate crystal deposition in rat kidneys. J Am Soc Nephrol. 2004;15:635–644

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.