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Articles

EXCESSIVE NAKED MEGAKARYOCYTE NUCLEI IN MYELODYSPLASTIC SYNDROME MIMICKING IDIOPATHIC THROMBOCYTOPENIC PURPURA: A Complicated Pre- and Post-transplantation Course

, MD, , MD, , PhD, , MD, , MD, , MD, , MD & , MD show all
Pages 387-397 | Accepted 10 Jan 2009, Published online: 11 Nov 2009

REFERENCES

  • Menke DM, Colon-Otero G, Cockerill KJ, Jenkins RB, Noel P, Pierre RV. Refractory thrombocytopenia: a myelodysplastic syndrome that may mimic immune thrombocytopenic purpura. Am J Clin Pathol. 1992;98:502–510.
  • Rosati S, Mick R, Xu F, Refractory cytopenia with multilineage dysplasia: further characterization of an ‘Unclassifiable’ myelodysplastic syndrome. Leukemia. 1996;10:20–26.
  • Brunning RD. Morphologic classifications of myelodysplastic syndromes: French-American-British (FAB) and World Health Organization (WHO). In: Greenberg PL, ( ed.), Myelodysplastic Syndromes: Clinical and Biological Advances. Cambridge, UK: Cambridge University Press; 2006:95–128.
  • Hasle H. Myelodysplastic Syndrome. In: Childhood Leukemias, 2nd. Pui C-H, ( Ed.), Cambridge University Press; Cambridge, UK: 2006548–570.
  • Yetgin S, Olcay L, Özsoylu Ş, Hiçsönmez G, Gürgey A, Tuncer AM. Retrospective analysis of 78 children with chronic idiopathic thrombocytopenic purpura: follow-up from 1976 to 1996. Pediatr Hematol Oncol. 1997;14:399–412.
  • Olcay L, Yetgin S, Okur H, Erdemli E. Rapid cell senescence and apoptosis in lymphocytes and granulocytes and absence of GM-CSF receptor in congenital dysgranulopoietic neutropenia. Leuk Res. 2007;32:235–242.
  • Kerr JFR. Definition of apoptosis and overview of its incidence. In: Lavin M, Watters D, eds. Cell Death: The Cellular & Molecular Biology of Apoptosis. Brisbane: Harwood Academic; 1993:1–19.
  • Thiele J, Lorenzen J, Manich B, Kvasnicka HM, Zirbes TK, Fischer R. Apoptosis (programmed cell death) in idiopathic (primary) osteo-/myelofibrosis: naked nuclei in megakaryopoiesis reveal features of para-apoptosis. Acta Haematol. 1997;97:137–143.
  • Martin SJ, Reutelingsperger CPM, Green DR. Annexin V: a specific probe for apoptotic cells. In: Cotter TG, Martin SJ, ( eds. Techniques in Apoptosis: A User's Guide. Portland Press; London: 1996;105–119.
  • Hicsonmez G, Cetin M, Yenicesu I, Evaluation of children with myelodysplastic syndrome:importance of extramedullary disease as a presenting symptom. Leuk Lymphoma. 2001;42:665–674.
  • Olcay L, Yetgin S, Okur H, Erekul S, Tuncer M. Dysplastic changes in idiopathic thrombocytopenic purpura and the effect of corticosteroids to increase dysplasia and cause hyperdiploid macropolycytes. Am J Hematol. 2000;65:99–104.
  • Houwerzijl EJ, Blom NR, van der Want JJL, Increased peripheral platelet destruction and caspase-3-independent programmed cell death of bone marrow megakaryocytes in myelodysplastic patients. Blood. 2005;105:3472–3479.
  • Hu T, Shi XD, Feng YL, Comperative study on bone marrow megakaryocytes in children with thrombocytopenic purpura, aplastic anemia and myelodysplastic syndrome. Zhonghua Er Ke Za Zhi. 2005;43:183–187.
  • Raza A, Gezer S, Mundle S, Apoptosis in bone marrow biopsy samples involving stromal and hematopoietic cells in 50 patients with myelodysplastic syndromes. Blood. 1995;86:268–726.
  • Houwerzijl EJ, Blom NR, van der Want JJL, Ultrastructural study shows morphologic features of apoptosis and para-apoptosis in megakaryocytes from patients with idiopathic thrombocytopenic purpura. Blood. 2004;103:500–506.
  • Hofmann W-K, Kalina U, Koschmieder S, Seipelt G, Hoelzer D, Ottmann OG. Defective megakaryocytic development in myelodysplastic syndromes. Leuk Lymphoma. 2000;38:13–19.
  • Howard MR, Kesteven PJL. Sea blue histiocytosis: a common abnormality of the bone marrow in myelodysplastic syndromes. J Clin Pathol. 1993;46:1030–1032.
  • Aslan D, Yetgin S. Megakaryocyte emperipolesis in a child with chronic neutropenia: an unusual coexistence. Turk J Pediatr. 2001;43:255–256.
  • Bauer S, Khan A, Klein A, Starasoler L. Naked megakaryocyte nuclei as an indicator of human immunodeficiency virus infection. Arch Pathol Lab Med. 1992;116:1025–1029.
  • Gordon S, Lee S. Naked megakaryocyte nuclei in bone marrows of patients with acquired immunodeficiency syndrome: a somewhat specific finding. Modern Pathol. 1994;7:166–168.
  • Li X, Pu Q. Megakaryocytopoiesis and apoptosis in patients with myelodysplastic syndromes. Leuk Lymphoma. 2005;46:387–391.
  • Olsson B, Andersson P-O, Jacobsson S, Carlsson L, Wadenvik H. Disturbed apoptosis of T-cells in patients with active idiopathic thrombocytopenic purpura. Thromb Haemost. 2005;93:139–144.
  • Hamada K, Takahashi I, Matsuoka M, Apoptosis of peripheral leukocytes in patients with myelodysplastic syndromes. Rinsho Ketsueki. 1998;39:1079–1084.
  • Fedorko ME, Lichtman MA. Megakaryocyte structure, maturation and ecology. In: Colman RW, ed. Hemostasis and Thrombosis: Basic Principles and Clinical Practice. Philadelphia: JBLippincott, 1982:210–224.
  • Olney HJ, Le Beau MM. Cytogenetic abnormalities in myelodysplastic syndromes. In: Greenberg PL, ed. Myelodysplastic Syndromes: Clinical and Biological Advances. Cambridge, UK: Cambridge University Press; 2006:95–128.
  • Hebbar M, Kaplan C, Caulier MT, Low incidence of specific anti-platelet antibodies detected by the MAIPA assay in the serum of thrombocytopenic MDS patients and lack of correlation between platelet autoantibodies, platelet lifespan and response to danazol therapy. Br J Haematol. 1996;94:112–115.

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