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Pediatric Hematology and Oncology Volume 27, 2010 - Issue 1
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STRIKING DECREASE IN THE TOTAL PRECURSOR B-CELL COMPARTMENT DURING EARLY CHILDHOOD AS EVIDENCED BY FLOW CYTOMETRY AND GENE EXPRESSION CHANGES

Kristin JensenDepartments of Pediatrics and Pediatric Surgery, Section of Hematology/Oncology, Department of Clinical Chemistry, and Faculty Division Ullevål, University of Oslo, Oslo, NorwayCorrespondence[email protected]
, MD,
Lana SchafferDNA Array Core Facility, The Scripps Research Institute, La Jolla, California, USA
, MS,
Ole K. OlstadDepartment of Clinical Chemistry, University of Oslo, Oslo, Norway
, PhD,
Anne G. BechensteenDepartments of Pediatrics and Pediatric Surgery, Section of Hematology/Oncology, University of Oslo, Oslo, Norway
, MD, PhD,
Marit HellebostadDepartments of Pediatrics and Pediatric Surgery, Section of Hematology/Oncology, University of Oslo, Oslo, Norway
, MD, PhD,
Geir E. TjønnfjordMedical Department, Rikshospitalet-Radiumhospitalet Medical Centre and Faculty Division Rikshospitalet, University of Oslo, Oslo, Norway
, MD, PhD,
Peter KierulfDepartment of Clinical Chemistry, University of Oslo, Oslo, Norway
, MD, PhD,
Kaare M. GautvikDepartment of Clinical Chemistry, Faculty Division Ullevål, and Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
, MD, PhD &
Liv T. N. OsnesImmunology and Transfusion Medicine, Ullevål University Hospital, Oslo, Norway
, MD, PhD show all
Pages 31-45 | Accepted 09 Oct 2009, Published online: 02 Feb 2010

REFERENCES

  • Blebea JS, Houseni M, Torigian DA, . Structural and functional imaging of normal bone marrow and evaluation of its age-related changes. Semin Nucl Med. 2007;37:185–194.
  • Suvas S. Advancing age and immune cell dysfunction: is it reversible or not? Expert Opin Biol Ther. 2008;8:657–668.
  • Comans-Bitter WM, de Groot R, Van Den Beemd R, . Immunophenotyping of blood lymphocytes in childhood: reference values for lymphocyte subpopulations. J Pediatr. 1997;130:388–393.
  • Schatz DG, Oettinger MA, Baltimore D. The V(D)J recombination activating gene, RAG-1. Cell. 1989;59:1035–1048.
  • Oettinger MA, Schatz DG, Gorka C, Baltimore D. RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science. 1990;248(4962):1517–1523.
  • McBlane JF, van Gent DC, Ramsden DA, . Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps. Cell. 1995;83:387–395.
  • Langebrake C, Gunther K, Lauber J, Reinhardt D. Preanalytical mRNA stabilization of whole bone marrow samples. Clin Chem. 2007;53:587–593.
  • Bolstad BM, Irizarry RA, Astrand M, Speed TP. A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics.2003;19:185–194.
  • Irizarry RA, Hobbs B, Collin F, . Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics. 2003;4:249–264.
  • Hardin J, Mitani A, Hicks L, VanKoten B. A robust measure of correlation between two genes on a microarray. BMC Bioinformatics. 2007;8:220.
  • van Zelm MC, Van Der Burg M, de Ridder D, . Ig gene rearrangement steps are initiated in early human precursor B cell subsets and correlate with specific transcription factor expression. J Immunol. 2005;175:5912–5922.
  • Matthias P, Rolink AG. Transcriptional networks in developing and mature B cells. Nat Rev Immunol. 2005;5:497–508.
  • Boyd RS, Adam PJ, Patel S, . Proteomic analysis of the cell-surface membrane in chronic lymphocytic leukemia: identification of two novel proteins, BCNP1 and MIG2B. Leukemia. 2003;17:1605–1612.
  • Sanz C, Benito A, Inohara N, Ekhterae D, Nunez G, Fernandez-Luna JL. Specific and rapid induction of the proapoptotic protein Hrk after growth factor withdrawal in hematopoietic progenitor cells. Blood. 2000;95:2742–2747.
  • Yagi T, Takeichi M. Cadherin superfamily genes: functions, genomic organization, and neurologic diversity. Genes Dev. 2000;14:1169–1180.
  • Noordzij JG, de Bruin-Versteeg S, Comans-Bitter WM, . Composition of precursor B-cell compartment in bone marrow from patients with X-linked agammaglobulinemia compared with healthy children. Pediatr Res. 2002;51:159–168.
  • Hystad ME, Bo TH, Rian E, . Characterization of Early Human B Cell Development by Gene Expression Profiling. ASH Annual Meeting Abstracts 2006;108:1352.
  • Palmer C, Diehn M, Alizadeh AA, Brown PO. Cell-type specific gene expression profiles of leukocytes in human peripheral blood. BMC Genomics. 2006;7:115.
  • Heng TS, Painter MW. The Immunological Genome Project: networks of gene expression in immune cells. Nat Immunol. 2008;9:1091–1094.

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