Advanced search
Publication Cover
Pediatric Hematology and Oncology Volume 30, 2013 - Issue 8
Submit an article Journal homepage
165
Views
4
CrossRef citations to date
0
Altmetric
Research Article

The Effect of HFE Polymorphisms on Cardiac Iron Overload in Patients with Beta-Thalassemia Major

Aysen TurediDepartment of Pediatric Hematology, Diyarbakir Children's Hospital, Diyarbakir, TurkeyCorrespondence[email protected]
,
Yesim OymakDepartment of Pediatric Hematology, School of Medicine, Harran University, Sanliurfa, Turkey
,
Timur MeşePediatric Cardiology, Dr. Behçet Uz Children's Hospital, Izmir, Turkey
,
Yöntem YamanDivision of Pediatric Hematology, Dr. Behçet Uz Children's Hospital, Izmir, Turkey
,
Selen BayraktarogluDepartment of Radiology, Faculty of Medicine, Ege University, Izmir, Turkey
,
Asude AlpmanDepartment of Medical Genetics, Faculty of Medicine, Ege University, Izmir, Turkey
,
Ferda OzkinayDepartment of Medical Genetics, Faculty of Medicine, Ege University, Izmir, Turkey
,
Yeşim AydınokDepartment of Pediatric Hematology, Faculty of Medicine, Ege University, Izmir, Turkey
&
Canan VerginDivision of Pediatric Hematology, Dr. Behçet Uz Children's Hospital, Izmir, Turkey
 show all
Pages 755-760 | Received 17 Jun 2013, Accepted 12 Jul 2013, Published online: 02 Oct 2013

REFERENCES

  • Hanson EH, Imperatore G, Burke W. HFE gene and hereditary hemochromatosis: a HuGE review. Human Genome Epidemiology. Am J Epidemiol. 2001;154(3):193–206.
  • Walker JM. The heart in thalassaemia. Eur Heart J. 2002;23:102–105.
  • Qunones MA, Otto CM, Stoddard M, Recommendation for quantification of Doppler echocardiography: a report from the Doppler quantification task force of the nomenclature and standards committee of the American Society of Echocardiography. J Am Soc Echocardiogr. 2002;15(2):167–184.
  • Jazeyeri M, Bakayev V, Adibi P, Frequency of HFE gen mutations in Iranian beta-thalassemia minor patients. Eur J Haematol. 2003;71(6):408–411.
  • Garewal G, Das R, Ahluwalia J, Marwaha RK. Prevalence of the H63D mutation of the HFE in north India: its presence does not cause iron overload in beta thalassemia trait. Eur J Haematol. 2005;74(4):333–336.
  • López-Escribano H, Ferragut JF, Parera MM, Effect of co-inheritance of thalassemia and hemochromatosis mutations on iron overload. Hemoglobin. 2012;36(1):85–92.
  • Martins R, Picanco I, Fonseca A, The role of HFE mutations on iron metabolism in beta-thalassemia carriers. J Hum Genet. 2004;49(12):651–655.
  • Melis MA, Cau M, Deidda F, H63D mutation in the HFE gene increases iron overload in beta-thalassemia carriers. Haematologica. 2002;87:242–245.
  • Mellouli F, El Borgi W, Kaabi H, HFE gene mutations in Tunisian major beta-thalassemia and iron overload. Transfus Clin Biol. 2006;13(6):353–357.
  • Pignatti C, Solinas A, Bombieri C, The haemochromatosis mutations do not modify the clinical picture of thalassaemia major in patients regularly transfused and chelated. Br J Haematol. 1998;103:813–816.
  • Longo F, Zecchina G, Sbaiz L, The influence of hemochromatosis mutations on iron overload of thalassemia major. Haematologica. 1999;84:799–803.
  • Beutler E. Genetic irony beyond haemochromatosis: clinical effects of HLA-H mutations. Lancet. 1997;349:296–297.
  • Pennel DJ. T2* magnetic resonance and myocardial iron in Thalassemia. Ann N Y Acad Sci. 2005;1054:373–378.
  • Isaaz K, Thompson A, Ethevenot G, Doppler echocardiographic measurement of low velocity motion of the left ventricular posterior wall. Am J Cardiol. 1989;64:66–75.
  • Ho CY. Echocardiographic assessment of diastolic function. In: Solomon SD, ed. Essential Echocardiography: A Practical Handbook with DVD. New Jersey: Humana Press Inc.; 2007:119–131.
  • Rossvol O, Hatle LK. Pulmonary venous flow velocities recorded by transthoracic Doppler ultrasound: relation to left ventricular pressures. J Am Coll Cardiol. 1993;21:1687–1696.
  • Kimura K, Murata K, Tanaka N, The importance of pulmonary venous flow measurement for evaluating left ventricular end-diastolic pressure in patients with coronary artery disease in the early stage of diastolic dysfunction. J Am Soc Echocardiogr. 2001;14(10):987–993.
  • Palka P, Macdonald G, Lange A, Burstow DJ. The role of Doppler left ventricular filling indexes and Doppler tissue echocardiography in the assessment of cardiac involvement in hereditary hemochromatosis. J Am Soc Echocardiogr. 2002;15(9):884–890.
  • Du ZD, Roguin N, Milgram E, Pulmonary hypertension in patients with thalassemia major. Am Heart J. 1997;134(3):532–537.
  • Aessopos A, Farmakis D. Pulmonary hypertension in beta-thalassemia. Ann N Y Acad Sci. 2005; 1054:342–349.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.