Comparison of Tissue Doppler Imaging with MRI T2* and 24-Hour Rhythm Holter Heart Rate Variability for Diagnosing Early Cardiac Impairment in Thalassemia Major Patients

REFERENCES

• Weatherall DJ, Clegg JB, Higgs DR, Wood WG. The Thalassemias. In: Scriver CR, Arthur AL, Sly WS, Valle D, eds. The Metabolic and Molecular Bases of Inherited Diseases. New York, NY: Mc Graw Hill; 2001: 4571–4636.
   Google Scholar
• Rouault TA, Klausner RD. Molecular basis of iron metabolism. In: Stamatoyannopoulos M, Perlmutter V, eds. The Molecular Basis of Blood Diseases. 3rd ed. Philadelphia, PA: W. B. Saunders; 2001:363–381.
   Google Scholar
• Gutteridge JMC, Halliwell B. Iron toxicity and oxygen radicals. Baillieres Clin Haematol. 1989;2:195–256.
   PubMedGoogle Scholar
• Mattera R, Stone GP, Bahhur N, Kuryshev YA. Increased release of arachidonic acid and eicosanoids in iron-overloaded cardiomyocytes. Circulation. 2001;103:2395–2401.
   PubMed Web of Science ®Google Scholar
• Zeitz O, Maass AE, Van Nguyen P, Hydroxyl radical-induced acute diastolic dysfunction is due to calcium overload via reversemode Na+-Ca2 +exchange. Circ Res. 2002;90:988–995.
   PubMed Web of Science ®Google Scholar
• Kumar V, Abbas A, Fausto N. Cellular adaptations, cell injury, and cell death. In: Kumar V, Abbas A, Fausto N, eds. Robbins and Cotran Pathologic Basis of Disease, 7th ed. Philadelphia, PA: Elsevier Saunders, 2005:3–46.
   Google Scholar
• Kim JS, He L, Lemasters JJ. Mitochondrial permeability transition: a common pathway to necrosis and apoptosis. Biochem Biophys Res Commun. 2003;304:463–470.
   PubMed Web of Science ®Google Scholar
• Schwartz KA, Li Z, Schwartz DE, Earliest cardiac toxicity induced by iron overload selectively inhibits electrical conduction. J Appl Physiol. 2002;93:746–751.
   PubMed Web of Science ®Google Scholar
• Kremastinos DT, Tsetsos GA, Tsiapras DP, Heart failure in beta thalassemia: a 5-year follow-up study. Am J Med. 2001;111:349–354.
   PubMed Web of Science ®Google Scholar
• Veglio F, Melchio R, Rabbia F, Blood pressure and heart rate in young thalassemia major patients. Am J Hypertens. 1998;11:539–547.
   PubMed Web of Science ®Google Scholar
• Vogel M, Anderson LJ, Holden S, Tissue doppler echocardiography in patients with thalassaemia detects early myocardial dysfunction related to myocardial iron overload. Eur Heart J. 2003;24:113–119.
   PubMed Web of Science ®Google Scholar
• De Chiara B, Crivellaro W, Sara R, Early detection of cardiac dysfunction in thalassemic patients by radionuclide angiography and heart rate variability analysis. Eur J Haematol. 2005;74:517–522.
   PubMed Web of Science ®Google Scholar
• Spirito P, Lupi G, Melevendi C, Vecchio C. Restrictive diastolic abnormalities identified by Doppler echocardiography in patients with thalassemia major. Circulation. 1990;82:88–94.
   PubMed Web of Science ®Google Scholar
• Suarez WA, Snyder SA, Berman BB, Preclinical cardiac dysfunction in transfusion-dependent children and young adults detected with low-dose dobutamine stres echocardiography. J Am Soc Echocardiogr. 1998;11:948–956.
   PubMed Web of Science ®Google Scholar
• Hahalis G, Manolis AS, Gerasimidou I, Right ventricular diastolic function in beta-thalassemia major: Echocardiographic and clinical correlates. Am Heart J. 2001;141:428–434.
   PubMed Web of Science ®Google Scholar
• Aessopos A, Farmakis D. Pulmonary hypertension in betathalassemia. Ann N Y Acad Sci. 2005;1054:342–349.
   PubMed Web of Science ®Google Scholar
• Aessopos A, Farmakis D, Karagiorga M, Cardiac involvement in thalassemia intermedia: a multicenter study. Blood. 2001;97:3411–3416.
   PubMed Web of Science ®Google Scholar
• Olivieri NF, Brittenham GM. Iron-chelating therapy and the treatment of thalassemia. Blood. 1997;89:739–761. (Erratum in 1997;89:2621).
   PubMed Web of Science ®Google Scholar
• Aessopos A, Farmakis D, Hatziliami A, Cardiac status in well-treated patients with thalassemia major. Eur J Haematol. 2004;73:359–366.
   PubMed Web of Science ®Google Scholar
• Anderson LJ, Holden S, Davis B, Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload. Eur Heart J. 2001;22:2171–2179.
   PubMed Web of Science ®Google Scholar
• Berdoukas V, Dakin C, Freema A, Lack of correlation between iron overload cardiac dysfunction and needle liver biopsy iron concentration. Haematologica. 2005;90:685–686.
   PubMed Web of Science ®Google Scholar
• Fitchett DH, Coltart DJ, Littler WA, Cardiac involvement in secondary haemochromatosis: a catheter biopsy study and analysis of myocardium. Cardiovasc Res. 1980;14:719–724.
   PubMed Web of Science ®Google Scholar
• Hoffbrand AV. Diagnosing myocardial iron overload. Eur Heart J. 2001;22:2140–2141.
   PubMed Web of Science ®Google Scholar
• Allen HD, Driscoll JD, Shaddy RE, Feltes TF. Moss and Adams’ Heart Disease in İnfants Children and Adolescents. Baltimore, MD: Lipincott Williams and Wilkins. 2013;177.
   Google Scholar
• Kremastinos DT, Tsiapras DP, Tsetsos GA. Left ventricular diastolic Doppler characteristics in beta- thalassemia major. Circulation. 1993;88:1127–1135.
   PubMed Web of Science ®Google Scholar
• Yaprak I, Aksit S, Ozturk C, Left ventricular diastolic abnormalities in children with b-thalassemia major: A Doppler echocardiography study. Turk JPediatr. 1998;40:201–209.
   PubMed Web of Science ®Google Scholar
• Grenaider E, Lima CD, Allen HD, Normal intracardiac and great vessel Doppler flow velocities in infants and children. J AM Coll Cardiol. 1984;4(2):343–350.
   PubMed Web of Science ®Google Scholar
• Eroğlu GA, Sarıoğlu A, Sarıoğlu T. Right ventricular diastolic function after repair of tetralogy of Fallot: its relationship to the insertion of a transannular patch. Cardiol Young. 1999;9:384–391.
   PubMed Web of Science ®Google Scholar
• Appleton CP, Hattle LK, Popp RL. Demonstration of restrictive physiology by Doppler echocardiography. J Am Coll Cardiol. 1988;11:757–768.
   PubMed Web of Science ®Google Scholar
• Zoghbi WA, Habib GB, Quinones MA. Doppler assesment of right ventricular filling in a normal population: comparison with left ventricular filling dynamics. Circulation. 1990;82:1316–1324.
   PubMed Web of Science ®Google Scholar
• Wann LS, Weyman AE, Dillion JC, Feigenbaum H. Premature pulmonary valve opening. Ciculation. 1977;55(1):128–133.
   PubMed Web of Science ®Google Scholar
• Ksanuki A, Tei C, Otsuji Y, Doppler echocardiographic documentation of diastolic pulmonary artery forward flow. Am J Cardiol. 1987;59:711–713.
   PubMed Web of Science ®Google Scholar
• Doyle T, Troup PJ, Wann LS. Mid-diastolic opening of the pulmonary valve after right ventricular infarction. J Am Coll Cardiol. 1985;5:366–368.
   PubMed Web of Science ®Google Scholar
• Gatzoulis MA, Clark AL, Cullen S, Right ventricular diastolic function 15 to 35 years after repair of tetralogy of Fallot. Restrictive physiology predicts superior exercise performance. Circulation. 1995;91:1775–1781.
   PubMed Web of Science ®Google Scholar
• Du ZD, Roguin N, Milgram E, Pulmonary hypertension in patients with thalassemia major. Am Heart J. 1997;134:532–537.
   PubMed Web of Science ®Google Scholar
• Hahalis G, Manolis AS, Apostolopoulos D, Right ventricular cardiomyopathy in beta-thalassemia major. Eur Heart J. 2002;23:147–156.
   PubMed Web of Science ®Google Scholar
• Hamdy AM, Zein El-Abdin MY, Abdel-Hafez MA. Right ventricular function in patients with beta thalassemia: relation to serum ferritin level. Echocardiography. 2007;24:795–801.
   PubMed Web of Science ®Google Scholar
• Larussi D, Di Salvo G, Pergola V, Pulsed Doppler tissue imaging and myocardial function in thalassemia major. Heart Vessels. 2003;18:1–6.
   PubMed Web of Science ®Google Scholar
• Olivieri NF, Nathan DG, MacMillan JH, Survival in medically treated patients with homozygous beta-thalassemia. N Engl J Med. 1994;331(9):574–578.
   PubMed Web of Science ®Google Scholar
• Borgna-Pignatti C, Rugolotto S, De Stefano P, Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine. Haematologica. 2004;89(10):1187–1193.
   PubMed Web of Science ®Google Scholar
• Tanner MA, Galanello R, Dessi C, Myocardial iron loading in patients with thalassaemia majoron deferoxamine chelation. J Cardiovasc Magn Reson. 2006;8:543–547.
   PubMed Web of Science ®Google Scholar
• Kirk P, Roughton M, Porter JB, Cardiac T2* magnetic resonance for prediction of cardiac complications in thalassemia major. Journal of Cardiovascular Magnetic Resonance. 2009;120(20): 1961–1968.
   Google Scholar
• Aydınok Y, Levent E, Bayraktaroğlu S. Talasemi Major olgularında kardiyak demir birikiminin başlangıç yaşı, kardiyak fonksiyonlar, karaciğer demir yoğunluğu ve serum ferritin düzeyleri ile ilişkisi. 7. Ulusal Pediatrik Hematoloji Kongresi, 2009;2(3):74–75.
   Google Scholar
• Jensen PD. Evaluation of iron overload. Br J Haematol. 2004;124(6):697–711.
   PubMed Web of Science ®Google Scholar
• Hayabuchi Y, Matsuoka S, Kubo M, Age-related criteria for signal-averaged electrocardiographic late potentials in children. Ped Cardiol. 1994;15:107–111.
   PubMed Web of Science ®Google Scholar
• Heart Rate Variability. Standarts of Measurement, Physiological Interpretation, and Clinical Use. Task Force of the European Society of Cardiology and the North American Society of Pacing and electrophysiology. Circulation. 1996;13:1043–1064.
   Google Scholar
• Yeragani VK, Sobolewski E, Kay J,et al. Effect of age on long term heart rate variability. Cardiovasc Research. 1997;35:35–42.
   PubMed Web of Science ®Google Scholar
• Glaeser DH, Vybrial T. Changes of heart rate variability preceding ventricular arrhythmias. In: Malik M, Camm AJ, eds. Heart Rate Variability. Armonk, NY: Futura Publishing Company; 1995:21–428.
   Google Scholar
• Kleiger RE, Stein PK, Bosner MS, Rottman JN. Time-domain measurements of heart rate variability. In Malik M, Camm AJ, eds. Heart Rate Variability. Armonk NY: Futura Publishing Company; 1995:33–45.
   Google Scholar
• Odemuyiwa O. The relationship between ventricular function and heart rate variability. In Malik M, Camm AJ, eds. Heart Rate Variability. Armonk, NY: Futura Publishing Company; 1995:241–244.
   Google Scholar
• Franzoni F, Galeta F, Di Muro C, Heart rate variability and ventricular late potentials in b-thalassemia major. Haematologica. 2004;89:233–234.
   PubMed Web of Science ®Google Scholar
• Gürses D, Ülger Z, Levent E, Time domain heart rate variability analysis in patients with thalassaemia major. Acta Cardiologica. 2005 ;60:477–482.
   PubMed Web of Science ®Google Scholar