581
Views
11
CrossRef citations to date
0
Altmetric
Disorders of coagulation

Lupus Anticoagulant Positivity in Pediatric Patients With Prolonged Activated Partial Thromboplastin Time: A Single-Center Experience and Review of Literature

, MD, & , MD,
Pages 495-504 | Received 10 Feb 2015, Accepted 19 Jun 2015, Published online: 18 Sep 2015

REFERENCES

  • Dlott JS, Rpubey RA. Drug-induced lupus anticoagulants and antiphospholipid antibodies. Curr Rheumatol Rep. 2012;14:71–78.
  • Giordano P, Tesse R, Lassandro G, et al. Clinical and laboratory characteristics of children positive for antiphospholipid antibodies. Blood Transfus. 2012;10:296–301.
  • Currimbhoy Z. Transitory anticoagulants in healthy children. Am J Pediatr Hematol Oncol. 1984;6:210–212.
  • Burk CD, Miller L, Handler SD, Cohen AR. Preoperative history and coagulation screening in children undergoing tonsillectomy. Pediatrics. 1992;89:691–695.
  • Lee MT, Nardi MA, Hadzi-Nesic J, Karpatkin M. Transient hemorrhagic diathesis associated with and inhibitor of prothrombin with lupus anticoagulant in 1 1/2-year-old girl: report of a case and review of the literature. Am J Hematol. 1996;51:307–314.
  • Becton DL, Stine KC. Transient lupus anticoagulants associated with hemorrhage rather than thrombosis: the hemorrhagic lupus anticoagulant syndrome. J Pediatr. 1997;130:998–1000.
  • Johnston AM, Hill K, Woodcock BE. Lupus anticoagulant in a patient with parvovirus B19 infection case report. Clin Lab Haematol. 2000;22:109–110.
  • Manco-Johnson MJ, Nuss R, Key N, et al. Lupus anticoagulant and protein S deficiency in children with postvaricella purpura fulminans or thrombosis. J Pediatr. 1996;128:319–323.
  • Kurugöl Z, Vardar F, Ozkinay F, et al. Lupus anticoagulant and protein S deficiency in otherwise healthy children with acute varicella infection. Acta Paediatr. 2000;89:1186–1189.
  • Brodeur GM, O'Neill PJ, Willimas JA. Acquired inhibitors of coagulation in nonhemophiliac children. J Pediatr. 1980;96:439–441.
  • Mingers AM, Sutor AH. Lupus inhibitors in childhood. Haemostaseologie. 1992;12:101–106.
  • Orris DJ, Lewis JH, Spero JA, Hasiba U. Blocking coagulation inhibitors in children taking penicillin. J Pediatr. 1980;97:426–429.
  • Peker E, Kavakli K, Balkan C, et al. Incidence and clinical importance of lupus anticoagulant in children with recurrent upper respiratory tract infection. Clin Appl Thromb Hemost. 2011;17:220–224.
  • Mizumoto H, Maihara T, Hiejima E, et al. Transient antiphospholipid antibodies associated with acute infections in children: a report of three cases and a review of the literature. Eur J Pediatr. 2006;165:484–488.
  • Jude B, Goudemand J, Dolle I, et al. Lupus anticoagulant: a clinical and laboratory study of 100 cases. Clin Lab Haematol. 1988;10:41–51.
  • Asherson RA, Cervera R. Antiphospholipid antibodies and infections. Ann Rheum Dis. 2003;62:388–393.
  • Hughes GRV. The antiphospholipid syndrome: ten years on. Lancet. 1993;342:341–344.
  • Knobe K, Tedgård U, Ek T, et al. Lupus anticoagulants in two children—bleeding due to nonphospholipid-dependent antiprothrombin antibodies. Eur J Pediatr. 2012;171:1383–1387.
  • Bernini JC, Buchanan GR, Ashcraft J. Hypoprothrombinemia and severe hemorrhage associated with a lupus anticoagulant. J Pediatr. 1993;123:937–939.
  • Bernstein ML, Salusinsky-Sternbach M, Bellefleur M, Esseltine DW. Thrombotic and hemorrhagic complications in children with the lupus anticoagulant. Am J Dis Child. 1984;138:1132–1135.
  • Asherson RA, Khamashta MA, OrdiRos J, et al. The “primary” antiphospholipid syndrome: major clinical and serological features. Medicine (Baltimore). 1989;68:366–374.
  • Pengo V, Tripodi A, Reber G, et al. Update of the guidelines for lupus anticoagulant detection. Subcommittee on lupus anticoagulant/antiphospholipid antibody of the scientific and standardisation committee of the International Society on Thrombosis and Haemostasis. J Thromb Haemost. 2009;7:1737–1740.
  • Desposito F, Arkel Y. Inhibitors of coagulation in children. Crit Rev Oncol Hematol. 1987;7:53–69.
  • Male C, Lechner K, Eichinger S, et al. Clinical significance of lupus anticoagulants in children. J Pediatr. 1999;134:199–205.
  • Frauenknecht K, Lackner K, von Landenberg P. Antiphospholipid antibodies in pediatric patients with prolonged activated partial thromboplastin time during infection. Immunobiology. 2005;210:799–805.
  • Venugopalan P, Bushra R, Gravell D. Accidental detection of lupus anticoagulants in children. Ann Trop Paediatr. 2001;21:277–279.
  • Ravelli A, Martini A, Burgio GR. Antiphospholipid antibodies in paediatrics. Eur J Pediatr. 1994;153:472–479.
  • Molta C, Meyer O, Dosquet C, et al. Childhood-onset systemic lupus erythematosus: antiphospholipid antibodies in 37 patients and their first-degree relatives. Pediatrics. 1993;92:849–853.
  • Seaman DE, Londino AV Jr, Kwoh CK, et al. Antiphospholipid antibodies in pediatric systemic lupus erythematosus. Pediatrics. 1995;96:1040–1045.
  • Gattorno M, Buoncompagni A, Molinari AC, et al. Antiphospholipid antibodies in paediatric systemic lupus erythematosus, juvenile chronic arthritis and overlap syndromes: SLE patients with both lupus anticoagulant and high-titre anticardiolipin antibodies are at risk for clinical manifestations related to the antiphospholipid syndrome. Br J Rheumatol. 1995;34:873–881.
  • Shergy WJ, Kredich DW, Pisetsky DS. The relationship of anticardiolipin antibodies to disease manifestations in pediatric systemic lupus erythematosus. J Rheumatol. 1988;15:1389–1394.
  • Ravelli A, Caporali R, Di Fuccia G, et al. Anticardiolipin antibodies in pediatric systemic lupus erythematosus. Arch Pediatr Adolesc Med. 1994;148:398–402.
  • von Scheven E, Athreya BH, Rose CD, et al. Clinical characteristics of antiphospholipid antibody syndrome in children. J Pediatr. 1996;129:339–345.
  • Andrews PA, Frampton G, Cameron JS. Antiphospholipid syndrome and systemic lupus erythematosus. Lancet. 1993;342:988–989.
  • Ehrenstein MR, Swana M, Keeling D, et al. Anti-DNA antibodies in the primary antiphospholipid antibody syndrome (PAPS). Br J Rheumatol. 1993;32:362–365.
  • Gherman RB, Tramont J, Connito DJ. Postpartum hemolytic-uremic syndrome associated with lupus anticoagulant. A case report. J Reprod Med. 1999;44:471–474.
  • Kniaz D, Eisenberg GM, Elrad H, et al. Postpartum hemolytic uremic syndrome associated with antiphospholipid antibodies. A case report and review of the literature. Am J Nephrol. 1992;12:126–133.
  • Meyrier A, Becquemont L, Weill B, et al. Hemolytic-uremic syndrome with anticardiolipin antibodies revealing paraneoplastic systemic scleroderma. Nephron. 1991;59:493–496.
  • Schleider MA, Nachman RL, Jaffe EA, Coleman M. A clinical study of the lupus anticoagulant. Blood. 1976;48:499–509.
  • Alarcon-Segovia D, Fishbein E, Reyes PA, et al. Antinuclear antibodies in patients on anticonvulsant therapy. Clin Exp Immunol. 1972;12:39–47.
  • Beernink DH, Miller JJ III. Anticonvulsant-induced antinuclear antibodies and lupus-like disease in children. J Pediatr. 1973;82:113–117.
  • Drory VE, Korczyn AD. Hypersensitivity vasculitis and systemic lupus erythematosus induced by anticonvulsants. Clin Neuropharmacol. 1993;16:19–29.
  • Triplett DA, Brandt JT, Musgrave KA, Orr CA. The relationship between lupus anticoagulants and antibodies to phospholipid. JAMA. 1988;259:550–554.
  • Walker TS, Triplett DA, Javed N, Musgrave K. Evaluation of lupus anticoagulants: antiphospholipid antibodies, endothelium associated immunoglobulin, endothelial prostacyclin secretion, and antigenic protein S levels. Thromb Res. 1988;51:267–281.
  • Harrison RL, Alperin JB, Kumar D. Concurrent lupus anticoagulants and prothrombin deficiency due to phenytoin use. Arch Pathol Lab Med. 1987;111:719–722.
  • Bell WR, Boss GR, Wolfson JS. Circulating anticoagulant in the procainamide-induced lupus syndrome. Arch Intern Med. 1977;137:1471–1473.
  • Finazzi G, Brancaccio V, Moia M, et al. Natural history and risk factors for thrombosis in 360 patients with antiphospholipid antibodies: a four-year prospective study from the Italian Registry. Am J Med. 1996;100:530–536.
  • Galli M, Luciani D, Bertolini G, Barbui T. Lupus anticoagulants are stronger risk factors for thrombosis than anticardiolipin antibodies in the antiphospholipid syndrome: a systematic review of the literature. Blood. 2003;101:1827–1832.
  • Galli M, Finazzi G, Norbis F, et al. The risk of thrombosis in patients with lupus anticoagulants is predicted by their specific coagulation profile. Thromb Haemost. 1999;81:695–700.
  • Cassidy JT, Petty RE. Pediatric Rheumatology. 6th ed. Toronto: W.B. Saunders; 1995.
  • Pazzola G, Zuily S, Erkan D. The challenge of bleeding in antiphospholipid antibody- positive patients. Curr Rhematol Rep. 2015;17:1–11.
  • Schmugge M, Tolle S, Marbet GA, et al. Gingival bleeding, epistaxis and haematoma three days after gastroenteritis: the haemorrhagic lupus anticoagulant syndrome. Eur J Pediatr. 2001;160:43–46.
  • Vivaldi P, Rossetti G, Galli M, Finazzi G. Severe bleeding due to acquired hypoprothrombinemia–lupus anticoagulant syndrome. Case report and review of literature. Haematologica. 1997;82:345–347.
  • Humphries JE, Acker MN, Pinkston JE, Ruddy S. Transient lupus anticoagulant associated with prothrombin deficiency: unusual cause of bleeding in a 5-year-old girl. Am J Pediatr Hematol Oncol. 1994;16:372–376.
  • Arnaud L, Mathian A, Ruffatti A, et al. Efficacy of aspirin for the primary prevention of thrombosis in patients with antiphospholipid antibodies: an international and collaborative meta-analysis. Autoimmun Rev. 2014;13:281–291.
  • Quintero-Del-Rio AI. Antiphospholipid antibodies in pediatrics. Curr Rheumatol Rep. 2002;4:387–391.
  • Kaiser R, Cleveland CM, Criswell LA. Risk and protective factors for thrombosis in systemic lupus erythematosus: results from a large, multi-ethnic cohort. Ann Rheum Dis. 2009;68:238–241.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.