15
Views
3
CrossRef citations to date
0
Altmetric
Original Article

6-Mercaptopurine: Total Body Autoradiograms and Plasma Concentration-Time Curves of 6MP and Metabolites from Marmoset Monkeys

, , , &
Pages 159-165 | Received 10 May 1985, Accepted 24 Dec 1985, Published online: 09 Jul 2009

References

  • LePage G A. Purine antagonists. Cancer 5: A Comprehensive Treatise, FF Becker. Plenum Press, New York 1977; 309–326
  • Paterson A RP, Tidd D M. 6-Thiopurines. Handbook of Pharmacology XXXVIII/2 (Antineoplastic and Immunosuppressive Agents). Springer, Berlin 1975; 384–403
  • De Abreu R A, Van Baal J M, Schouten T J, Schretlen E DAM, De Bruyn C HMM. High-performance liquid chromatographic determination of plasma 6-mercaptopurine in clinically relevant concentrations. J Chromatogr 1982; 227: 526–533
  • Schouten T J, De Abreu R A, De Bruyn C HMM. 6-Mercaptopurine: Pharmacokinetics in animals and preliminary results in children. Adv Exp Med Biol 1984; 165B: 367–370
  • Van Baal J M, Van Leeuwen M B, Schouten T J, De Abreu R A. Sensitive high-performance liquid chromatographic determination of 6-mercaptopurine, 6-thioguanine, 6-mercaptopurine riboside and 6-thioguanosine in biological fluids. J Chromatogr 1984; 336: 422–428
  • Schouten T J, De Abreu R A, Schretlen E DAM. 6-Mercaptopurine: Oral administration and i.v. bolus injections in dogs. Eur Paediatr Haematol Oncol 1985; 2: 93–98
  • Schouten T J, De Abreu R A, Schretlen E DAM, Van Baal J M, Van Leeuwen M B, De Vaan G AM. 6-Mercaptopurine: high-dose 24 hour infusions in goats. J Cancer Res Clin Oncol 1986, in press
  • Ding T L, Benet LZ. Comparative bioavailability and pharmacokinetic studies of azathioprine and 6-mercaptopurine in the rhesus monkey. Drug Metab Dispos 1979; 7: 373–377
  • Zimm S, Collins J M, Riccardi R. Variable bioavailability of oral mercaptopurine. Is maintenance chemotherapy in acute lymphoblastic leukemia being optimally delivered. N Engl J Med 1983; 308: 1005–1009
  • Zimm S, Collins J M, O'Neill D, Chabner B A, Poplack D G. Inhibition of first-pass metabolism in cancer chemotherapy: Interaction of 6-mercaptopurine and allopurinol. Clin Pharmacol Ther 1983; 34: 810–817
  • Narang P K, Chatterji D C, O'Neill D, Poplack D G. Pharmacokinetics of 6-mercaptopurine (6MP) in the monkey. I. Disposition from plasma and cerebrospinal fluid following i.v. bolus. Drug Metab Dispos 1983; 11: 5–9
  • Zimm S, Ettinger L, Holcenberg J. 6-Mercaptopurine administered as a prolonged intravenous (iv) infusion: Plasma and CSF pharmacokinetics. Proc Am Soc Clin Oncol 1984; 3(37)C-143
  • Van der Kleijn E. Kinetics of distribution and metabolism of ataractics of the meprobumate group in mice. Arch Int Pharmacodyn Ther 1969; 178: 457–480
  • Nelson J A, Cserr H F, Chu S H. Distribution of 6-mercaptopurine ribonucleoside and other purine analogs to brain. Cancer Res 1974; 34: 1889–1891
  • Mellett L B. Physicochemical considerations and pharmacokinetic behavior in delivery of drugs to the central nervous system. Cancer Treat Rep 1977; 61: 527–531

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.