24
Views
22
CrossRef citations to date
0
Altmetric
Original Article

Successful Carboxypeptidase G2 Rescue in Delayed Methotrexate Elimination Due to Renal Failure

, , , , , , , & show all
Pages 471-477 | Received 23 Jan 1995, Accepted 20 Mar 1995, Published online: 09 Jul 2009

References

  • Borsi J D., Sagen E, Romslo I, Moe P J. Rescue after intermediate and high‐dose methotrexate: background, rationale, and current practice. Pediatr Hematol Oncol 1990; 7: 347–363
  • Ahmad S, Shen F H., Bleyer W A. Methotrexate induced renal failure and ineffectiveness of peritoneal dialysis. Arch Intern Med 1978; 138: 1146–1147
  • Minton N P., Atkinson T, Sherwood R F. Molecular cloning of the Pseudomonas carboxypeptidase G2 gene and its expression in Escherichia coli and Pseudomonas putida. J Bacterial 1983; 156: 1222–1227
  • Sherwood R F., Melton R G., Alwan S M., Hughes P. Purification and properties of carboxypeptid‐ase‐G2 from Pseudomonas sp. strain RS‐16. Eur J Biochem 1985; 148: 447–453
  • Adamson P C., Balis F M., McCully C L., Godwin K S., Poplack D G. Methotrexate pharmacokinetics following administration of recombinant carboxypeptidase‐G2 in rhesus monkeys. J Clin Oncol 1992; 10: 1359–1364
  • Adamson P C., Balis F M., McCully C L., Godwin K S., Bacher J D., Walsh T J. Rescue of experimental intrathecal methotrexate overdose with carboxypeptidase‐G‐2. J Clin Oncol 1991; 9: 670–674
  • Chabner B A., Johns D G., Bertino J R. Enzymatic cleavage of methotrexate provides a method for prevention of drug toxicity. Nature 1972; 239: 395–397
  • Winkler K, Bielack S, Delling G, Salzer‐Kuntschik M, Kotz R, Greenshaw C, Jürgens H, Ritter J, Kusnierz‐Glaz C, Erttmann R, Gädicke G, Graf N, Ladenstein R, Leyvraz S, Mertens R, Weinel P. Effect of intraarterial versus intravenous cisplatin in addition to systemic doxorubicin, high‐dose methotrexate and ifosfamide on histologic tumor response. Cancer 1990; 60: 1703–1710
  • Lawrenz‐Wolf B, Wolfrom C, Frickel C, Fengler R, Wehinger H, Henze G. Severe unexpected impairment of renal methotrexate elimination after high‐dose therapy. Klin Padiatr 1994; 206: 319–326

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.