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Pediatric Hematology and Oncology Volume 13, 1996 - Issue 2
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Original Article

Dramatic Effect of High-Dose Methylprednisolone on Orbital Granulocytic Sarcoma

Gönül Hiçsonmez Department of Pediatric Hematology, Hacettepe University, Medical Faculty, Ankara, Turkey
,
Namik Özbek Department of Pediatric Hematology, Hacettepe University, Medical Faculty, Ankara, Turkey
,
Gülsev Kale Department of Pediatric Pathology, Hacettepe University, Medical Faculty, Ankara, Turkey
,
Güliz Erdem Department of Pediatrics, Hacettepe University, Medical Faculty, Ankara, Turkey
,
Sevgül Bilgiç Department of Ophthalmology, Hacettepe University, Medical Faculty, Ankara, Turkey
&
Volkan Hazar Department of Pediatric Oncology, Hacettepe University, Medical Faculty, Ankara, Turkey
Pages 187-190 | Received 08 Mar 1995, Accepted 24 May 1995, Published online: 09 Jul 2009

References

  • Meiss J M, Butler J J, Osborne B M, Manning J T. Granulocytic sarcoma in nonleukemic patients. Cancer 1986; 58: 2697–2709
  • Çavdar A O, Babacan E, Gözdaşoĝlu S. High-risk subgroup of acute myelomonocytic leukemia (AMML) with orbito-ocular granulocytic sarcoma (OGGS) in Turkish children. Acta Haematol. 1989; 81: 80–85
  • Hiçsönmez G, Gürgey A, Zamani V P, Yetgin S, Altay Ç, Özsoylu Ş. Poor prognosis in children with acute nonlymphoblastic leukemia in Turkey. Am J Pediatr Hematol Oncol. 1988; 10: 268–273
  • Hiçsönmez G, Ozsoylu Ş, Gürgey A, Zamani V P, Irken G. High-dose methylprednisolone for remission induction in children with acute nonlymphoblastic leukemia. Eur J Haematol. 1989; 42: 498–500
  • Hiçsönmez G, Özsoylu Ş, Tuncer A M. Differentiation of myeloid leukemic cells induced by high-dose methylprednisolone in patients with acute myeloblastic leukemia and its therapeutic potential. Leuk Res. 1991; 15: 537–541
  • Hiçsönmez G, Tuncer A M, Güler E, Tan E, Tekelioĝlu M. The potential role of high-dose methylprednisolone on the maturation of leukemic cells in children with acute promyelocytic leukemia (APL). Exp Hematol. 1993; 21: 599–601
  • Sachs L. Control of normal cell differentiation and phenotypic reversion of malignancy in myeloid leukemia. Nature 1978; 274: 535–539
  • Hiçsönmez G, Karadeniz N, Zamani V P. High remission rate in acute myeloblastic leukemia in children treated with high-dose methylprednisolone. Eur J Haematol. 1992; 48: 215–220
  • Prystowsky J H, Johnson B L, Bolwell B J, Lazarus G S. Treatment of cutaneus granulocytic sarcoma in a patient with myelodysplasia. Am J Med. 1989; 86: 477–480
  • Blewitt R W, Abbott A C, Bird C C. Mode of cell death induced in human lymphoid cells by high and low doses of glucocorticoid. Br J Cancer 1983; 47: 477–486
  • Hiçsönmez G, Erdemli E, Tekelioĝlu M. Morphologic evidence of apoptosis in childhood acute myeloblastic leukemia treated with high-dose methylprednisolone. Leukemia and Lymphoma, (in press)
  • Lotem J, Sachs L. Control of sensitivity to induction of apoptosis in myeloid leukemic cells by differentiation and bcl-2 dependent and independent pathways. Cell Growth Differ. 1994; 5: 321–327
  • Hall T C, Choi O S, Abadi A, Krant M J. High-dose corticoid therapy in Hodgkin's disease and other lymphomas. Ann Intern Med. 1967; 66: 1144–1153

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