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Pediatric Hematology and Oncology Volume 13, 1996 - Issue 6
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Original Article

Activity of 5-Formyl Tetrahydrofolate Cyclodehydrase and 5,10-Methenyl Tetrahydrofolate Cyclohydrolase in Primary Brain Tumors in Children

Fotini Tzortzatou-Stathopoulou Oncology Unit, First Department of Paediatrics, University of Athens, Aghia Sophia Children's Hospital, Goudi, Athens, Greece
,
Vasiliki Mikraki Oncology Unit, First Department of Paediatrics, University of Athens, Aghia Sophia Children's Hospital, Goudi, Athens, Greece
,
Athina Xaidara First Department of Paediatrics, University of Athens, Aghia Sophia Children's Hospital, Goudi, Athens, Greece
,
Mary Moschovi Oncology Unit, First Department of Paediatrics, University of Athens, Aghia Sophia Children's Hospital, Goudi, Athens, Greece
,
Vasilis Evangelinos Oncology Unit, First Department of Paediatrics, University of Athens, Aghia Sophia Children's Hospital, Goudi, Athens, Greece
&
Kanaris Panagopoulos Oncology Unit, First Department of Paediatrics, University of Athens, Aghia Sophia Children's Hospital, Goudi, Athens, Greece
Pages 511-519 | Received 14 Sep 1995, Accepted 29 Feb 1996, Published online: 09 Jul 2009

References

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  • Levitt M, Nixon P F, Pincus J H, Bertino J R. Transport characteristics of folates in cerebrospinal fluid; a study utilizing doubly labeled 5-methyltetrahydrofolate and 5-formyltetrahydrofolate. J Clin Invest. 1971; 50: 1301–1308
  • Spector R, Lorenzo A V. Folate transport in the central nervous system. Am J Physiol. 1975; 229: 777–782
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  • Carl G F, Peterson J D, McClain L D, Bridgerrs W F. Subcellular localization of folate turnover and folate-dependent enzyme activity in mouse brain. J Neurochem. 1979; 36: 1442–1452
  • Abelson H T, Forsburg M, Gorka C, Kornblith P. Identification of dihydrofolate reductase in human central-nervous-system tumours. Lancet. 1978; 1: 184–185
  • Duch D S, Bigner D D, Bowers S W, Nichol C A. Dihydrofolate reductase in primary brain tumors, cell cultures of central nervous system origin and normal brain during fetal and neonatal growth. Cancer Res. 1979; 39: 487–491
  • Tzortzatou-Stathopoulou F, Panagiotou J, Xaidara A, Karydis K, Sfakianos G, Evagellinos B. Dihydrofolate reductase activity in primary brain tumors in children. Am J Pediatr Hematol Oncol. 1993; 15: 316–319
  • Tzortzatou F, Hayhoe F GJ. Cytochemical demonstration of dihydrofolate reductase activity. Brit J Haematol. 1974; 28: 199–208
  • Tzortzatou F. Cytochemical demonstration of 5-formyl tetrahydrofolate cyclodehydrase and 5,10-methenyl tetrahydrofolate cyclohydrolase activity. J Histochem Cytochem. 1977; 25: 349–354
  • Tzortzatou-Stathopoulou F, Zannos-Mariolea L, Karayiannis P, Pallis I, Matsaniotis N. Cytochemical demonstration of 5-formyl tetrahydrofolate cyclodehydrase activity in leucocytes of patients with acute leukemia. Scand J Haematol. 1981; 26: 393–397
  • Tzortzatou F. Cytochemical demonstration of dihydrofolate reductase in leukaemia and other haematological diseases. Scand J Haematol. 1977; 19: 5–13

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