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Microbial Ecology in Health and Disease Volume 5, 1992 - Issue 6
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Original Article

Short Communication: Effect of a New Carbapenem Antibacterial Agent, Meropenem, on Normal Human Faecal Microflora

J. Watabe Intestinal Flora Laboratory, Calpis Food Industry Co. Ltd, 11-10, 5-chome, Fuchinobe, Sagamihara, Kanagawa, 229, Japan
,
J. Mizutani Intestinal Flora Laboratory, Calpis Food Industry Co. Ltd, 11-10, 5-chome, Fuchinobe, Sagamihara, Kanagawa, 229, Japan
,
H. Suzuki Intestinal Flora Laboratory, Calpis Food Industry Co. Ltd, 11-10, 5-chome, Fuchinobe, Sagamihara, Kanagawa, 229, Japan
,
K. Wada Intestinal Flora Laboratory, Calpis Food Industry Co. Ltd, 11-10, 5-chome, Fuchinobe, Sagamihara, Kanagawa, 229, Japan
,
K. Watanabe Institute of Anaerobic Bacteriology, School of Medicine, University of Gifu, Tsukasa machi, 40, Gifu, 500, Japan
&
K. Ueno Institute of Anaerobic Bacteriology, School of Medicine, University of Gifu, Tsukasa machi, 40, Gifu, 500, Japan
Pages 315-321 | Received 08 Jun 1992, Published online: 11 Jul 2009

References

  • Bax RP, Bastain W, Featherstone A, Wilkinson DH, Hutchison M, Haworth SJ. The pharmaco-kinetics of meropenem in volunteers. Journal of Antimicrobial Chemotherapy 1989; 24(suppl A)311–320
  • Bergan T, Nord CE, Thorsteinsson SB. Effect of meropenem on the intestinal microflora. European Journal of Clinical Microbiology and Infectious Diseases 1991; 10: 524–527
  • Kagar L, Brisnar B, Malmoborg A, Nord C. Imipenem concentrations on colorectal surgery and impact on the colonic microflora. Antimicrobial Agents and Chemotherapy 1989; 33: 204–208
  • Harrison MP, Moss SR, Featherstone A, Fowkes AG, Sanders AM. The disposition and metabolism of meropenem in laboratory animals and man. Journal of Antimicrobial Chemotherapy 1989; 24(suppl A)265–277
  • MacGregor RB, Gibson GA, Bland JA. Imipenem pharmacokinetics and body fluid concentrations in patients receiving high-dose treatment for serious infections. Antimicrobial Agents and Chemotherapy 1986; 29: 188–192
  • Norrby SR, Rogers JD, Ferber F, Jones KH, Zacchel AG, Weidner LL, Demetriades JL, Gravallese DA, Hsieh JYK. Disposition of radiolabeled imipenem and cilastatin in normal human volunteers. Antimicrobial Agents and Chemotherapy 1984; 26: 707–714
  • Sumita Y, Inoue M, Mitsuhashi S. In vitro antibacterial activity and β-lactamase stability of the new carbapenem SM-7338. European Journal of Microbiology and Infectious Disease 1989; 8: 908–916
  • Watabe J, Mizutani J, Suzuki H, Hayakawa K, Nakashima M, Kanamaru M, Watanabe K, Ueno K. Effects of a new pyridone carboxylic antibacterial agent sparfloxacin, on normal human intestinal microflora. Microbial Ecology in Health and Disease 1991; 4: 285–291

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