180
Views
72
CrossRef citations to date
0
Altmetric
Original Article

Autoantibodies in Primary Sjögren's Syndrome: New Insights into Mechanisms of Autoantibody Diversification and Disease Pathogenesis

, , , &
Pages 123-132 | Received 14 Sep 2000, Published online: 07 Jul 2009

References

  • Jonsson R, Haga H -J, Gordon T P. Sjögren's syndrome. Arthritis and Allied Conditions, 14th edn., W. Koopman. Lea and Febiger, Philadelphia 2000; 1826–1849
  • McCluskey J, Farris A D, Keech C L, Purcell A W, Rischmueller M, Kinoshita G, Reynolds P, Gordon T P. Determinant spreading: lessons from animal models and human disease. Immunological Reviews 1998; 164: 209–229
  • Vitali C, Bombardieri S, Moutsopoulos H, Balestrieri G, Bencivelli N, Bernstein R. M., et al. Preliminary criteria for the classification of Sjögren's syndrome: results of a prospective concerted action supported by the European Community. Arthritis Rheum 1993; 36: 340–347
  • Wahren-Herlenius M, Muller S. Isenberg Analysis of B-cell epitopes of the Ro/SS-A autoantigen. Immunology Today 1999; 20: 234–240
  • Scofield R H, Farris A D, Horsfall A C, Harley J B. Fine specificity of the autoimmune response to the Ro/SSA and La/SSB ribonucleoproteins. Arthritis Rheum 1999; 42: 199–209
  • Gordon T, Topfer F, Keech C, Reynolds P, Chen W, Rischm-Ueller M, McCluskey J. How does autoimmunity to La and Ro initiate and spread?. Autoimmunity 1994; 18: 87–92
  • Farris A D, Keech C L, Gordon T P, McCluskey J. Epitope mimics and determinant spreading: pathways to autoimmunity. Cell Mol. Life Sci 2000; 57: 569–578
  • Reynolds P, Gordon T P, Purcell A W, Jackson D C, McCluskey J. Hierarchical self-tolerance to T cell determinants within the ubiquitous nuclear self antigen La (SS-B) permits induction of systemic autoimmunity in normal mice. J. Exp. Med. 1996; 184: 1–14
  • Farris A D, Keech C L, Gordon T P, McCluskey J. Immune tolerance to the nuclear antigen La and constitutive presentation of nuclear antigen by autoreactive B cells. J. Immunol., In press
  • Ben-Chetrit E, Chan E K, Sullivan K F, Tan E M. A 52-kD protein is a novel component of the SSA-Ro antigen particle. J Exp. Med. 1988; 167: 1560–1571
  • Boire G, Gendron M, Monast N, Bastin B, Menard H A. Purification of antigenically intact Ro ribonucleoproteins: biochemical and immunological evidence that the 52-kD protein is not a Ro protein. Clin. Exp. Immunol. 1995; 100: 489–498
  • Casciola-Rosen L A, Anhalt G, Rosen A. Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J Exp. Med. 1994; 179: 1317–1330
  • Beer R G, Rischmueller M, Coates T, Purcell A, Keech C, McCluskey J., et al. Non-precipitating anti-La(SS-B) autoantibodies in primary Sjögren's syndrome. Clin. Immunol. Immunopathol. 1996; 79: 314–318
  • McCauliffe D P, Wang L, Satoh M, Reeves W H, Small D. Recombinant 52kDa Ro(SS-A) ELISA detects autoantibodies in Sjögren's syndrome that go undetected by conventional serologic assays. J. Rheumatol. 1997; 24: 860–866
  • Kinoshita G, Purcell A W, Keech C L, Farris A D, McCluskey J, Gordon T P. Molecular chaperones are targets of autoimmunity in Ro(SS-A) immune mice. Clin. Exp. Immunol. 1999; 115: 268–274
  • Purcell A W, Kinoshita G, Rosen A, Todd A, Gething M -J, Gordon T P. Autoimmunity heats up - a role for endogenous heat shock proteins?. Arthritis Rheum 1999; 42(supp 1)S361, (abstract)
  • Sato R, Srivastava P K. A mechanism for the specific immu-nogenicity of heat shock protein - chaperoned peptides. Science 1995; 269: 1585–1588
  • Castellino F, Boucher P E, Eichelberg K, Mayhew M, Roth-Man J E, Houghton A N, Germain R N. Receptor-mediated uptake of antigen/heat shock protein complexes results in major histocompatibility complex class I antigen presentation via two distinct processing pathways. J. Exp. Med. 2000; 191: 1957–1964
  • Todryk S M, Melcher A A, Dalgleish A G, Vile R G. Heat shock proteins refine danger theory. Immunology 2000; 99: 334–337
  • Rischmueller M, Lester S, Chen Z, Champion G, Van Den Berg R, Beer R, Coates T, McCluskey J, Gordon T P. HLA Class II phenotype controls diversification of the autoantibody response in primary Sjögren's syndrome (pSS). Clin. Exp. Immunol. 1998; 111: 365–371
  • Walport M J. Lupus, DNase and defective disposal of cellular debris. Nature Genetics 2000; 25: 135–136
  • Sumida T, Matsumoto I, Murata H, Namekawa T, Mat-Sumura R, Tomioka H, et al. TCR in Fassensitive T cells from labial salivary glands of patients with Sjögren's syndrome. J. Immunol. 1997; 158: 1020–1025
  • Kong L, Ogawa N, McGulf H S, Nakabayashi T, Sakata K, Masago R., et al. Bcl-2 family expression in salivary glands from patients with primary Sjögren's syndrome: involvement of Bax in salivary gland destruction. Clin. Immunol. Immun-opathol. 1998; 88: 133–144
  • Rischmueller M, Scott J, Beroukas D, Gannot G, Fletcher D, Gordon T P, Fox P C. Salivary gland apoptosis in primary Sjögren's syndrome: a controlled study. Arthritis Rheum 1998; 41(supp. 1)S325, (abstract)
  • Ohlsson M, Skarstein K, Bolstad A I, Johannessen A C, Jonsson R. Fas-induced apoptosis is a rare event in Sjögren's syndrome. Lab. Invest. 2001; 81: 95–105
  • Reveille J D. The molecular genetics of systemic lupus erythematosus and Sjögren's syndrome. Curr. Opin. Rheumatol. 1992; 4: 644–656
  • Wilson R W, Provost T T, Bias W B, Alexander E L, Edlow D W, Hochberg M. C., et al. Sjögren's syndrome. Influence of multiple HLA-D region alloantigens on clinical and serologic expression. Arthritis Rheum 1984; 27: 1245–1253
  • Harley J B, Alexander E L, Bias W B, Fox O F, Provast T T, Yamagata H., et al. Anti-Ro (SS-A) and anti-La (SS-B) in patients with Sjögren's syndrome. Arthritis Rheum 1986; 29: 196–206
  • Hamilton R G, Harley J B, Bias W B, Roebber M, Reichlin M, Hochberg M. C., et al. Two Ro (SS-A) autoantibody responses in systemic lupus erythematosus. Correlation of HLA-DR/DQ specificities with quantitative expression of Ro (SS-A) autoantibody. Arthritis Rheum 1988; 31: 496–505
  • Bolstad A I, Wassmuth R, Haga H -J. HLA markers and clinical characteristics in primary Sjögren's syndrome. J. Rheumatol., In press
  • Guggenbuhl P, Jean S, Jego P, Grosbois B, Chales G, Semana G., et al. Primary Sjögren's syndrome: role of the HLA-DRB 1*0301- 1501 heterozygotes. J. Rheumatol. 1998; 25: 900–905
  • Kang H I, Fei H M, Saito I, Sawada S, Chen S L, Yi D., et al. Comparison of HLA class II genes in Caucasoid, Chinese, and Japanese patients with primary Sjögren's syndrome. J. Immunol. 1993; 150: 3615–3623
  • Reveille J D, Macleod M J, Whittington K, Arnett F C. Specific amino acid residues in the second hypervariable region of HLA- DQA1 and DQB1 chain genes promote the Ro (SS-A)/La (SS-B) autoantibody responses. J. Immunol. 1991; 146: 3871–3876
  • Kerttula T O, Collin P, Polvi A, Korpela M, Partanen J, Maki M. Distinct immunologic features of Finnish Sjögren's syndrome patients with HLA alleles DRB1*0301, DQA1*0501, and DQB 1*0201. Alterations in circulating T cell receptor gamma/delta subsets. Arthritis. Rheum. 1996; 39: 1733–1739
  • Harley J B, Reichlin M, Arnett F C, Alexander E L, Bias W B, Provost T T. Gene interaction at HLA-DQ enhances autoantibody production in primary Sjögren's syndrome. Science 1986; 232: 1145–1147
  • Fei H M, Kang H, Scharf S, Erlich H, Peebles C, Fox R. Specific HLA-DQ A and HLA-DRB 1 alleles confer susceptibility to Sjögren's syndrome and autoantibody production. J. Clin. Lab. Anal. 1991; 5: 382–391
  • Scofield R H, Harley J B. Association of anti-Ro/SS-A autoantibodies with glutamine in position 34 of DQA1 and leucine in position 26 of DQB1. Arthritis Rheum 1994; 37: 961–962
  • Roitberg-Tambur A, Friedmann A, Safirman C, et al. Molecular analysis of HLA class II genes in primary Sjögren's syndrome. A study of Israeli Jewish and Greek non-Jewish patients. Hum. Immunol. 1993; 36: 235–242
  • Nakken B, JR, Jonsson R, Bolstad A I. Polymorphims of the Ro52 gene associated with anti-Ro 52-kd autoantibodies in patients with primary Sjögren's syndrome. Arthritis Rheum 2001; 44: 638–646
  • Ricchiuti V, Isenberg D, Muller S. HLA association of anti-Ro60 and anti-Ro52 antibodies in Sjögren's syndrome. J Autoimmun 1994; 7: 611–621
  • Nepom G T. Class II antigens and disease susceptibility. Annu. Rev. Med. 1995; 46: 17–25
  • Foster H, Walker D, Charles P, Kelly C, Cavanagh G, Griffiths I. Association of DR3 with susceptibility to and severity of primary Sjögren's syndrome in a family study. Br. J. Rheumatol. 1992; 31: 309–314
  • MacSween R NM, Govidie R B, Anderson J R, Armstrong E, Murray M A, Mason D. K., et al. Occurrence of antibody to salivary duct epithelium in Sjögren's disease. Rheumatoid arthritis and other arthritides - a clinical and laboratory study. Ann. Rheum. Dis. 1967; 26: 402–411
  • Feltkamp T EW, Van Rossum A L. Antibodies to salivary duct cells and other autoantibodies, in patients with Sjögren's syndrome and other idiopathic autoimmune diseases. Clin. Exp. Immunol. 1968; 3: 1–16
  • Whaley K, Chisholm D M, Goudie R B, Downie W W, Dick W C, Boyle J. A., et al. Salivary duct autoantibody in Sjögren's syndrome: correlation with focal sialadenitis in the labial mucosa. Clin. Exp. Immunol. 1969; 4: 273–282
  • Goldblatt F, Beroukas D, Gillis D, Cavil D, Bradwell A, Rischmueller M, Gordon T P. Antibodies to AB blood group antigens mimic anti-salivary duct autoantibodies in patients with limited sicca symptoms. Rheumatol 2000; 27: 2382–2388
  • Prakobphol A, Leffler H, Fischer S J. The high-molecular weight human mucin is the primary salivary carrier of ABH, Le a and Le b blood group antigens. Crit. Rev. Oral. Biol. Med. 1993; 4: 325–333
  • Feist E, Kuckelkorn U, Dorner T, Donitz H, Scheffler S, Hiepe F., et al. Autoantibodies in primary Sjögren's syndrome are directed against proteosomal subunits of the alpha and beta type. Arthritis Rheum 1999; 42: 697–702
  • Inagaki Y, Jinno-Yoshida Y, Hamasaki Y, Ueki H. A novel autoantibody reactive with carbonic anhydrase in sera from patients with systemic lupus erythematosus and Sjögren's syndrome. Dermatol. Sci 1991; 2: 147–154
  • Kino-Ohsaki J, Nishimori I, Morita M, Okazaki K, Yamamoto Y, Onishi S, Hollingsworth M A. Serum antibodies to carbonic anhydrase I and II in patients with idiopathic chronic pancreatitis. Gastroenterology 1996; 110: 1579–1586
  • Henriksson G, Manthorpe R, Bredberg A. Antibodies to CD4 in primary Sjögren's syndrome. Rheumatology 2000; 39: 142–147
  • Heneji N, Nakamura T, Takio K, Yanagi K, Higashiyama H, Saito I, et al. Identification of a-fodrin as a candidate autoan-tigen in primary Sjögren's syndrome. Science 1997; 276: 604–607
  • Zandbelt M, Degen W, Van de Putte L, van Venrooij W, van den Hoogen F. Anti-a-fodrin antibodies: not specific nor sensitive for Sjögren's syndrome. Arthritis Rheum 1999; 42(Supp 1)S142, (abstract)
  • Fox R I. Sjögren's syndrome. Curr. Opin. Rheumatol. 1995; 7: 409–416
  • Fox R I, Tornwall J, Maruyama T, Sterm M. Evolving concepts of diagnosis, pathogenesis and therapy of Sjögren's syndrome. Curr. Opin. Rheumatol. 1988; 10: 446–456
  • Daniels T E, Whitcher J P. Association of patterns of labial salivary gland inflammation with keratoconjunctivitis: analysis of 618 patients with suspected Sjögren's syndrome. Arthritis Rheum 1994; 37: 869–877
  • Jonsson R, Kroneld U, Backman K, Magnusson B, Tarkowski A. Progression of sialadenitis in Sjögren's syndrome. Brit. J. Rheumatol. 1993; 32: 578–581
  • Dawson L J, Smith P M, Moots R J, Field E A. Sjögren's syndrome - time for a new approach. Rheumatology 2000; 39: 234–237
  • Dawson L J, Christmas S E, Smith P M. An investigation of interactions between the immune system and stimulus secretion coupling in mouse submandibular acinar cells. A possible mechanism to account for reduced salivary flow rates associated with the onset of Sjögren's syndrome. Rheumatology 2000; 39: 1226–1233
  • Robinson C P, Brayer J, Yamachika S, Esch T R, Peck A B, Stewart C. A., et al. Transfer of human serum IgG to nonobese diabetic Igu mice reveals a role for autoantibodies in the loss of secretory function of exocrine tissues in Sjögren's syndrome. Proc. Natl. Acad. Sci. USA 1998; 95: 7538–7543
  • Nguyen K HT, Brayer J, Cha S, Siggs S, Yasunari U, Hilal G, Peck A B, Humphreys-Beher M G. Evidence for antimuscarinic acetylcholine receptor antibody-mediated secretory dysfunction in NOD mice. Arthritis Rheum 2000; 43: 2297–2306
  • Bacman S, Sterin-Borda L, Camusso J J, Arana R, Hubscher O, Borda E. Circulating antibodies against rat parotid gland M3 muscarinic receptors in primary Sjögren's syndrome. Clin. Exp. Immunol. 1996; 104: 454–459
  • Bacman S, PerezLeiros C, Sterin-Borda L, Hubscher O, Arana R, Borda E. Autoantibodies against lacrimal gland M3 muscarinic acetylcholine receptors in patients with primary Sjögren's syndrome. Invest. Ophthalmol. Vis. Sci. 1998; 39: 151–156
  • Waterman S A, Gordon T P, Rischmueller M. Inhibitory effects of muscarinic receptor autoantibodies on parasympathetic neurotransmission in Sjögren's syndrome. Arthritis Rheum 2000; 43: 1647–1653
  • Van de Merwe J, Jamerling R, Arendsen E, Mulder D, Hooi-Jkaas H. Sjögren's syndrome in patients with interstitial cystitis. J. Rheumatol. 1993; 20: 962–966
  • Bachmeyer C, Zuber M, Dupont S, Blanch P, Dhote R, Mas J L. Adie syndrome as the initial sign of primary Sjögren's syndrome. Am J Ophthalmol 1997; 123: 691–692
  • Wright R A, Grant I A, Low P A. Autonomic neuropathy associated with sicca complex. J. Auton Nerv. Syst. 1999; 75: 70–76
  • Katz J S, Houroupian D, Ross M A. Multisystem neuronal involvement and sicca complex: broadening the spectrum of complications. Muscle Nerve 1999; 22: 404–407
  • Andonopoulos A P, Christodoulou J, Ballas C, Bounas A. Alexopoulos D. Autonomic cardiovascular neuropathy in Sjögren's syndrome: a controlled study. J Rheumatol 1998; 25: 2385–2388
  • Hakala M, Niemela R K. Does autonomic nervous impairment have a role in pathophysiology of Sjögren's syndrome. Lancet 2000; 355: 1032–1033
  • Humphreys-Beher M G, Brayer J, Yamachika S, Peck A B, Jonsson R. An alternative perspective to the immune response in autoimmune exocrinopathy: induction of functional quiescence rather than destructive autoaggression. Scand. J. Immunol. 1999; 49: 7–10
  • Van De Merwe J P, Arendsen H J. Interstitial cystitis: a review of immunological aspects of the aetiology and pathogenesis, with a hypothesis. BJU International 2000; 85: 995–999
  • Gooin J C, Borda E, Leiros C, Storino R, Sterin-Borda L. Identification of antibodies with muscarinic cholinergic activity in human Chagas' disease: pathological implications. J. Auton. Nerv. Syst. 1994; 47: 45–52
  • Magnusson Y, Marullo S, Hoyer S, Waagstein F, Andersson B, Vahlne A., et al. Mapping of a functional autoimmune epitope on the beta 1-adrenergic receptor in patients with idiopathic dilated cardiomyopathy. J Clin. Invest. 1990; 86: 1658–63
  • Wallukat G, Homuth V, Fischer T, Lindschau C, Horstkamp B, Jupner A, et al. Patients with preeclampsia develop agonistic autoantibodies against angiotensin ATI receptor. J. Clin. Invest. 1999; 103: 945–52

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.