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Autoimmunity Volume 34, 2001 - Issue 3
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Original Article

Heart-infiltrating and Peripheral T Cells in the Pathogenesis of Human Chagas' Disease Cardiomyopathy

Edecio Cunha-Neto Laboratory of Immunology, Heart Institute (InCor), University of São Paulo School of Medicine, An Dr. Enéas de Carvalho Aguiar, 500 3o. andar, São Paulo, SP, 05403-000, Brazil; Department of Medicine, Division of Clinical Immunology and Allergy, University of São Paulo School of Medicine, Sao Paulo, BrazilCorrespondence[email protected]
&
Jorge Kalilf Laboratory of Immunology, Heart Institute (InCor), University of São Paulo School of Medicine, An Dr. Enéas de Carvalho Aguiar, 500 3o. andar, São Paulo, SP, 05403-000, Brazil; Department of Medicine, Division of Clinical Immunology and Allergy, University of São Paulo School of Medicine, Sao Paulo, Brazil; JK is an International Scholar of the Howard Hughes Medical Institute
Pages 187-192 | Published online: 07 Jul 2009

References

  • Cunha-Neto E., Kalil J. Molecular mimicry and Chagas' disease. Molecular Mimicry, Microbes and Autoimmunity, M Cunningham, R Fuiinami. ASM Press, Washington, DC 2000; 245–257
  • dos Santos R. R., Rossi M. A., Laus J. L., Silva J. S., Savino W., Mengel J. Anti-CD4 abrogates rejection and reestablishes long-term tolerance to syngeneic newborn hearts grafted in mice chronically infected witTrypanosoma cruzi. J. Exp. Med. 1992; 175: 29–39
  • Rizzo L. V., Cunha-Neto E., Teixeira A. R. Autoimmunity in Chagas' disease: specific inhibition of reactivity of CD4+ T cells against myosin in mice chronically infected wit Trypanosoma cruzi. Infect. Immun. 1989; 57: 2640–2644
  • Cunha-Neto E., Coelho V., Guilherme L., Fiorelli A., Stolf N., Kalil J. Autoimmunity in Chagas' disease. Identification of cardiac myosin-B13 Trypanosoma cruzi protein crossreactive T cell clones in heart lesions of a chronic Chagas' cardiomyopathy patient. J. Clin. Invest. 1996; 98: 1709–1712
  • Cunha-Neto E., Duranti M., Gruber A., et al. Autoimmunity in Chagas disease cardiopathy: biological relevance of a cardiac myosin-specific epitope crossreactive to an immunodominant Trypanosoma cruzi antigen. Proc. Natl. Acad. Sci. USA 1995; 92: 3541–3545
  • Cunha-Neto E., Moliterno R., Coelho V., et al. Restricted heterogeneity of T cell receptor variable alpha chain transcripts in hearts of Chagas' disease cardiomyopathy patients. Parasite Immunol. 1994; 16: 171–179
  • Cunha-Neto E., Rizzo L. V., Albuquerque E., et al. Cytokine production profile of heart-infiltrating T cells in Chagas' disease cardiomyopathy. Braz J. Med. Biol. Res. 1998; 31: 133–137
  • Reis M. M., Higuchi M. D., Benvenuti L. A., et al. An in situ quantitative immunohistochemical study of cytokines and IL-2R+ in chronic human chagasic myocarditis: correlation with the presence of myocardial Trypanosoma cruzi antigens. Clin. Immunol. Immunopathol. 1997; 83: 165–172
  • Cunha-Neto E., Abel L. C., Rizzo L. V., et al. Autoimmunity in human Chagas' disease cardiomyopathy: cytokine production and antigen recognition by T cells. Mem. Inst, hwaldo Cruz 1997; 92(Suppl. I)40–41
  • Abel L. C., Kalil J., Cunha-Neto E. Molecular mimicry between cardiac myosin and Trypanosoma cruzi antigen B13: identification of a B13-driven human T cell clone that recognizes cardiac myosin. Braz. J. Med. Biol. Res. 1997; 30: 1305–1308
  • Cunha-Neto E., Abel L., Rizzo L. V., et al. Checkpoints for autoimmunity-induced heart tissue damage in human Chagas' disease: a multistep process?. Mem. Inst. Oswaldo Cruz 1998; 93(Suppl. I)40–41
  • Ribeirao M., Pereira-Chioccola V. L., Nia L., Augusto Fragata F. A., Schenkman S., Rodrigues M. M. Chagasic patients develop a type 1 immune response to Trypanosoma cruzi trans-sialidase. Parasite Immunol. 2000; 22: 49–53
  • Bahia-Oliveira L. M., Gomes J. A., Rocha M. O., et al. IFN-gamma in human Chagas' disease: protection or pathology?. Braz-J. Med. Biol. Res. 1998; 31: 127–131

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