Localization of key amino acid residues in the dominant conformational epitopes on thyroid peroxidase recognized by mouse monoclonal antibodies

References

• Czarnocka B, Ruf J, Ferrand M, . Purification of the human thyroid peroxidase and its identification as the microsomal antigen involved in autoimmune thyroid diseases. FEBS Lett. 1985; 190:147–152.
   PubMed Web of Science ®Google Scholar
• McLachlan SM, Rapoport B. Thyroid peroxidase as an autoantigen. Thyroid. 2007; 17:939–948.
   PubMed Web of Science ®Google Scholar
• Hadj-Kacem H, Rebuffat S, Mnif-Féki M, . Autoimmune thyroid diseases: genetic susceptibility of thyroid-specific genes and thyroid autoantigens contributions. Int J Immunogenet. 2009; 36:85–96.
   PubMed Web of Science ®Google Scholar
• Saravanan P, Dayan CM. Thyroid autoantibodies. Endocrinol Metab Clin North Am. 2001; 30:315–337.
   PubMed Web of Science ®Google Scholar
• Ruf J, Toubert ME, Czarnocka B, . Relationship between immunological structure and biochemical properties of human thyroid peroxidase. Endocrinology. 1989; 125:1211–1218.
   PubMed Web of Science ®Google Scholar
• Jastrzębska-Bohaterewicz E, Gardas A. Proportion of antibodies to the A and B immunodominant regions of thyroid peroxidase in Graves and Hashimoto disease. Autoimmunity. 2004; 37:211–216.
   PubMed Web of Science ®Google Scholar
• Chazenbalk GD, Costante G, Portolano S, . The immunodominant region on human thyroid peroxidase recognized by autoantibodies does not contain the monoclonal antibody 47/c21 linear epitope. J Clin Endocrinol Metab. 1993; 77:1715–1718.
   PubMed Web of Science ®Google Scholar
• Czarnocka B, Janota-Bzowski M, McIntosh RS, . Immunoglobulin G kappa antithyroid peroxidase antibodies in Hashimoto's thyroiditis: epitope-mapping analysis. J Clin Endocrinol Metab. 1997; 82:2639–2644.
   PubMed Web of Science ®Google Scholar
• Taurog A, Dorris ML, Doerge DR. Mechanism of simultaneous iodination and coupling catalyzed by thyroid peroxidase. Arch Biochem Biophys. 1996; 330:24–32.
   PubMed Web of Science ®Google Scholar
• Hobby P, Gardas A, Radomski R, . Identification of an immunodominant region recognized by human autoantibodies in a three-dimensional model of thyroid peroxidase. Endocrinology. 2000; 141:2018–2026.
   PubMed Web of Science ®Google Scholar
• Estienne V, Duthoit C, Vinet L, . A conformational B-cell epitope on the C-terminal end of the extracellular part of human thyroid peroxidase. J Biol Chem. 1998; 273:8056–8062.
   PubMed Web of Science ®Google Scholar
• Nishikawa T, Nagayama Y, Seto P, . Human thyroid peroxidase-myeloperoxidase chimeric molecules: tools for the study of antigen recognition by thyroid peroxidase autoantibodies. Endocrinology. 1993; 133:2496–2501.
   PubMed Web of Science ®Google Scholar
• Nishikawa T, Rapoport B, McLachlan SM. Exclusion of two major areas on thyroid peroxidase from the immunodominant region containing the conformational epitopes recognized by human autoantibodies. J Clin Endocrinol Metab. 1994; 79:1648–1654.
   PubMed Web of Science ®Google Scholar
• Czarnocka B, Pastuszko D, Carayon P, . Majority of thyroid peroxidase autoantibodies in patients with autoimmune thyroid disease are directed to a single TPO domain. Autoimmunity. 1996; 23:145–154.
   PubMed Web of Science ®Google Scholar
• Gardas A, Watson PF, Hobby P, . Human thyroid peroxidase: mapping of autoantibodies, conformational epitopes to the enzyme surface. Redox Rep. 2000; 5:237–241.
   PubMed Web of Science ®Google Scholar
• Banga JP, Barnett PS, Ewins DL, . Mapping of autoantigenic epitopes on recombinant thyroid peroxidase fragments using the polymerase chain reaction. Autoimmunity. 1990; 6:257–268.
   PubMed Web of Science ®Google Scholar
• Arscott PL, Koenig RJ, Kaplan MM, . Unique autoantibody epitopes in an immunodominant region of thyroid peroxidase. J Biol Chem. 1996; 271:4966–4973.
   PubMed Web of Science ®Google Scholar
• Grennan Jones F, Ziemnicka K, Sanders J, . Analysis of autoantibody epitopes on human thyroid peroxidase. Autoimmunity. 1999; 30:157–169.
   PubMed Web of Science ®Google Scholar
• Xiong Z, Farilla L, Guo J, . Does the autoantibody immunodominant region on thyroid peroxidase include amino acid residues 742-771?. Thyroid. 2001; 11:227–231.
   PubMed Web of Science ®Google Scholar
• Blanchin S, Estienne V, Guo J, . Human thyroperoxidase folds in one complex B-cell immunodominant region. Biochem Biophys Res Commun. 2002; 295:1118–1124.
   PubMed Web of Science ®Google Scholar
• Nishikawa T, Rapoport B, McLachlan SM. The quest for the autoantibody immunodominant region on thyroid peroxidase: guided mutagenesis based on a hypothetical three-dimensional model. Endocrinology. 1996; 137:1000–1006.
   PubMed Web of Science ®Google Scholar
• Estienne V, Duthoit C, Blanchin S, . Analysis of a conformational B cell epitope of human thyroid peroxidase: identification of a tyrosine residue at a strategic location for immunodominance. Int Immunol. 2002; 14:359–366.
   PubMed Web of Science ®Google Scholar
• Bresson D, Cerutti M, Devauchelle G, . Localization of the discontinuous immunodominant region recognized by human anti-thyroperoxidase autoantibodies in autoimmune thyroid diseases. J Biol Chem. 2003; 278:9560–9569.
   PubMed Web of Science ®Google Scholar
• Bresson D, Pugniere M, Roquet F, . Directed mutagenesis in region 713-720 of human thyroperoxidase assigns 713KFPED717 residues as being involved in the B domain of the discontinuous immunodominant region recognized by human autoantibodies. J Biol Chem. 2004; 279:39058–39067.
   PubMed Web of Science ®Google Scholar
• Gora M, Gardas A, Watson PF, . Key residues contributing to dominant conformational autoantigenic epitopes on thyroid peroxidase identified by mutagenesis. Biochem Biophys Res Commun. 2004; 320:795–801.
   PubMed Web of Science ®Google Scholar
• Rebuffat SA, Bresson D, Nguyen B, . The key residues in the immunodominant region 353-363 of human thyroid peroxidase were identified. Int Immunol. 2006; 18:1091–1099.
   PubMed Web of Science ®Google Scholar
• Dubska M, Banga JP, Plochocka D, . Structural insights into autoreactive determinants in thyroid peroxidase composed of discontinuous and multiple key contact amino acid residues contributing to epitopes recognized by patients' autoantibodies. Endocrinology. 2006; 147:5995–6003.
   PubMed Web of Science ®Google Scholar
• Guo J, Yan XM, McLachlan SM, . Search for the autoantibody immunodominant region on thyroid peroxidase: epitopic footprinting with a human monoclonal autoantibody locates a facet on the native antigen containing a highly conformational epitope. J Immunol. 2001; 166:1327–1333.
   PubMed Web of Science ®Google Scholar
• Bresson D, Rebuffat SA, Nguyen B, . New insights into the conformational dominant epitopes on thyroid peroxidase recognized by human autoantibodies. Endocrinology. 2005; 146:2834–2844.
   PubMed Web of Science ®Google Scholar
• Gora M, Gardas A, Wiktorowicz W, . Evaluation of conformational epitopes on thyroid peroxidase by antipeptide antibody binding and mutagenesis. Clin Exp Immunol. 2004; 136:137–144.
   PubMed Web of Science ®Google Scholar
• Finke R, Seto P, Rapoport B. Evidence for the highly conformational nature of the epitope(s) on human thyroid peroxidase that are recognized by sera from patients with Hashimoto's thyroiditis. J Clin Endocrinol Metab. 1990; 71:53–59.
   PubMed Web of Science ®Google Scholar
• Czarnocka B, Pastuszko D, Janota-Bzowski M, . Is there loss or qualitative changes in the expression of thyroid peroxidase protein in thyroid epithelial cancer?. Br J Cancer. 2001; 85:875–880.
   PubMed Web of Science ®Google Scholar
• Bossowski A, Stasiak-Barmuta A, Czarnocka B, . Application of mouse monoclonal antibodies for identification of antigen regions of human thyroid peroxidase in adolescents with Graves' disease and non-toxic multinodular goiter by flow cytometry. Autoimmunity. 2005; 38:605–611.
   PubMed Web of Science ®Google Scholar
• Le Fourn V, Siffroi-Fernandez S, Ferrand M. Competition between calnexin and BiP in the endoplasmic reticulum can lead to the folding or degradation of human thyroperoxidase. Biochemistry. 2006; 45:7380–7388.
   PubMed Web of Science ®Google Scholar
• Song Y, Ruf J, Lothaire P, Dequanter D, . Association of duoxes with thyroid peroxidase and its regulation in thyrocytes. J Clin Endocrinol Metab. 2010; 95:375–382.
   PubMed Web of Science ®Google Scholar
• Ewins DL, Barnett PS, Tomlinson RW, . Mapping epitope specificities of monoclonal antibodies to thyroid peroxidase using recombinant antigen preparations. Autoimmunity. 1992; 11:141–149.
   PubMed Web of Science ®Google Scholar
• Jin L, Fendly BM, Wells JA. High resolution functional analysis of antibody-antigen interactions. J Mol Biol. 1992; 226:851–865.
   PubMed Web of Science ®Google Scholar
• Malby RL, Tulip WR, Harley VR, . The structure of a complex between the NC10 antibody and influenza virus neuraminidase and comparison with the overlapping binding site of the NC41 antibody. Structure. 1994; 2:733–746.
   PubMed Web of Science ®Google Scholar
• Van Regenmortel MHV. Mapping epitope structure and activity: from one-dimensional prediction to four-dimensional description of antigenic specificity. Methods. 1996; 9:465–472.
   PubMedGoogle Scholar
• Gershoni JM, Roitburd-Berman A, Siman-Tov DD, . Epitope mapping: the first step in developing epitope-based vaccines. BioDrugs. 2007; 21:145–156.
   PubMed Web of Science ®Google Scholar
• Benjamin DC, Perdue SS. Site-directed mutagenesis in epitope mapping. Methods. 1996; 9:508–515.
   Google Scholar
• Gardas A, Sohi MK, Sutton BJ, . Purification and crystallisation of the autoantigen thyroid peroxidase from human Graves' thyroid tissue. Biochem Biophys Res Commun. 1997; 234:366–370.
   PubMed Web of Science ®Google Scholar
• Hendry E, Taylor G, Ziemnicka K, . Recombinant human thyroid peroxidase expressed in insect cells is soluble at high concentrations and forms diffracting crystals. J Endocrinol. 1999; 160:R13–R15.
   PubMed Web of Science ®Google Scholar
• Guo J, McIntosh RS, Czarnocka B, . Relationship between autoantibody epitopic recognition and immunoglobulin gene usage. Clin Exp Immunol. 1998; 111:408–414.
   PubMed Web of Science ®Google Scholar