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Research Article

Specific immunoglobulin isotypes correlate with disease activity, morphology, duration and HLA association in Pemphigus vulgaris

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Pages 516-526 | Received 22 Aug 2011, Accepted 10 Jun 2012, Published online: 17 Aug 2012

References

  • Hertl M. Humoral and cellular autoimmunity in autoimmune bullous skin disorders. Int Arch Allergy Immunol. 2000; 122 2: 91–100.
  • Schmidt E, Brocker EB, Zillikens D. Pemphigus. Verlust des desmosomalen Zell-Zell-Kontaktes [Pemphigus. Loss of desmosomal cell-cell contact]. Hautarzt. 2000; 51 5: 309–318.
  • Spaeth S, Riechers R, Borradori L, . IgG, IgA and IgE autoantibodies against the ectodomain of desmoglein 3 in active pemphigus vulgaris. Br J Dermatol. 2001; 144 6: 1183–1188.
  • Amagai M, Klaus-Kovtun V, Stanley JR. Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion. Cell. 1991; 67 5: 869–877.
  • Lee E, Lendas KA, Chow S, . Disease relevant HLA class II alleles isolated by genotypic, haplotypic, and sequence analysis in North American Caucasians with pemphigus vulgaris. Hum Immunol. 2006; 67 1–2: 125–139.
  • Sinha AA, Brautbar C, Szafer F, . A newly characterized HLA DQ beta allele associated with pemphigus vulgaris. Science. 1988; 239 4843: 1026–1029.
  • Sinha AA, Lopez MT, McDevitt HO. Autoimmune diseases: the failure of self tolerance. Science. 1990; 248 4961: 1380–1388.
  • Todd JA, Acha-Orbea H, Bell JI, . A molecular basis for MHC class II–associated autoimmunity. Science. 1988; 240 4855: 1003–1009.
  • Hertl M, Amagai M, Sundaram H, . Recognition of desmoglein 3 by autoreactive T cells in pemphigus vulgaris patients and normals. J Invest Dermatol. 1998; 110 1: 62–66.
  • Lin MS, Swartz SJ, Lopez A, . Development and characterization of desmoglein-3 specific T cells from patients with pemphigus vulgaris. J Clin Invest. 1997; 99 1: 31–40.
  • Rizzo C, Fotino M, Zhang Y, . Direct characterization of human T cells in pemphigus vulgaris reveals elevated autoantigen-specific Th2 activity in association with active disease. Clin Exp Dermatol. 2005; 30 5: 535–540.
  • Wucherpfennig KW, Yu B, Bhol K, . Structural basis for major histocompatibility complex (MHC)-linked susceptibility to autoimmunity: charged residues of a single MHC binding pocket confer selective presentation of self-peptides in pemphigus vulgaris. Proc Natl Acad Sci USA. 1995; 92 25: 11935–11939.
  • Chow S, Rizzo C, Ravitskiy L, . The role of T cells in cutaneous autoimmune disease. Autoimmunity. 2005; 38 4: 303–317.
  • Hertl M, Veldman C. Pemphigus–paradigm of autoantibody-mediated autoimmunity. Skin Pharmacol Appl Skin Physiol. 2001; 14 6: 408–418.
  • Cirillo N, Gombos F, Lanza A. Pemphigus vulgaris immunoglobulin G can recognize a 130 000 MW antigen other than desmoglein 3 on peripheral blood mononuclear cell surface. Immunology. 2007; 121 3: 377–382.
  • Evangelista F, Dasher DA, Diaz LA, . E-cadherin is an additional immunological target for pemphigus autoantibodies. J Invest Dermatol. 2008; 128 7: 1710–1718.
  • Kalantari-Dehaghi M, Molina DM, Farhadieh M, . New targets of pemphigus vulgaris antibodies identified by protein array technology. Exp Dermatol. 2011; 20 2: 154–156.
  • Kurzen H, Brenner S. Significance of autoimmunity to non-desmoglein targets in pemphigus. Autoimmunity. 2006; 39 7: 549–556.
  • Nguyen VT, Ndoye A, Shultz LD, . Antibodies against keratinocyte antigens other than desmogleins 1 and 3 can induce pemphigus vulgaris-like lesions. J Clin Invest. 2000; 106 12: 1467–1479.
  • Kalish RS. Pemphigus vulgaris: the other half of the story. J Clin Invest. 2000; 106 12: 1433–1435.
  • Ayatollahi M, Joubeh S, Mortazavi H, . IgG4 as the predominant autoantibody in sera from patients with active state of pemphigus vulgaris. J Eur Acad Dermatol Venereol. 2004; 18 2: 241–242.
  • Bhol K, Mohimen A, Ahmed AR. Correlation of subclasses of IgG with disease activity in pemphigus vulgaris. Dermatology. 1994; 189 Suppl 1: 85–89.
  • David M, Katzenelson V, Hazaz B, . Determination of IgG subclasses in patients with pemphigus with active disease and in remission. Arch Dermatol. 1989; 125 6: 787–790.
  • Hacker MK, Janson M, Fairley JA, . Isotypes and antigenic profiles of pemphigus foliaceus and pemphigus vulgaris autoantibodies. Clin Immunol. 2002; 105 1: 64–74.
  • Jones CC, Hamilton RG, Jordon RE. Subclass distribution of human IgG autoantibodies in pemphigus. J Clin Immunol. 1988; 8 1: 43–49.
  • Kim YH, Geoghegan WD, Jordon RE. Pemphigus immunoglobulin G subclass autoantibodies: studies of reactivity with cultured human keratinocytes. J Lab Clin Med. 1990; 115 3: 324–331.
  • Yamada H, Hashimoto T, Nishikawa T. IgG subclasses of intercellular and basement membrane zone antibodies: the relationship to the capability of complement fixation. J Invest Dermatol. 1989; 92 4: 585–587.
  • Kricheli D, David M, Frusic-Zlotkin M, . The distribution of pemphigus vulgaris-IgG subclasses and their reactivity with desmoglein 3 and 1 in pemphigus patients and their first-degree relatives. Br J Dermatol. 2000; 143 2: 337–342.
  • Nagel A, Lang A, Engel D, . Clinical activity of pemphigus vulgaris relates to IgE autoantibodies against desmoglein 3. Clin Immunol. 2010; 134 3: 320–330.
  • Futei Y, Amagai M, Ishii K, . Predominant IgG4 subclass in autoantibodies of pemphigus vulgaris and foliaceus. J Dermatol Sci. 2001; 26 1: 55–61.
  • Murrell DF, Dick S, Ahmed AR, . Consensus statement on definitions of disease, end points, and therapeutic response for pemphigus. J Am Acad Dermatol. 2008; 58 6: 1043–1046.
  • Olerup O, Zetterquist H. HLA-DR typing by PCR amplification with sequence-specific primers (PCR-SSP) in 2 hours: an alternative to serological DR typing in clinical practice including donor-recipient matching in cadaveric transplantation. Tissue Antigens. 1992; 39 5: 225–235.
  • Hamilton RG, Morrison SL. Epitope mapping of human immunoglobulin-specific murine monoclonal antibodies with domain-switched, deleted and point-mutated chimeric antibodies. J Immunol Meth. 1993; 158 1: 107–122.
  • Amagai M, Komai A, Hashimoto T, . Usefulness of enzyme-linked immunosorbent assay using recombinant desmogleins 1 and 3 for serodiagnosis of pemphigus. Br J Dermatol. 1999; 140 2: 351–357.
  • Bhol K, Natarajan K, Nagarwalla N, . Correlation of peptide specificity and IgG subclass with pathogenic and nonpathogenic autoantibodies in pemphigus vulgaris: a model for autoimmunity. Proc Natl Acad Sci USA. 1995; 92 11: 5239–5243.
  • Amagai M, Tsunoda K, Zillikens D, . The clinical phenotype of pemphigus is defined by the anti-desmoglein autoantibody profile. J Am Acad Dermatol. 1999; 40 2 Pt 1: 167–170.
  • Yoshida K, Takae Y, Saito H, . Cutaneous type pemphigus vulgaris: a rare clinical phenotype of pemphigus. J Am Acad Dermatol. 2005; 52 5: 839–845.
  • Mimouni D, Bar H, Gdalevich M, . Pemphigus–analysis of epidemiological factors in 155 patients. J Eur Acad Dermatol Venereol. 2008; 22 10: 1232–1235.
  • Robinson WH, Steinman L, Utz PJ. Protein arrays for autoantibody profiling and fine-specificity mapping. Proteomics. 2003; 3 11: 2077–2084.
  • Hueber W, Utz PJ, Steinman L, . Autoantibody profiling for the study and treatment of autoimmune disease. Arthritis Res. 2002; 4 5: 290–295.
  • Sinha AA. Constructing immunoprofiles to deconstruct disease complexity in pemphigus. Autoimmunity. 2012; 45 1: 36–43.
  • Warren SJ, Arteaga LA, Rivitti EA, . The role of subclass switching in the pathogenesis of endemic pemphigus foliaceus. J Invest Dermatol. 2003; 120 1: 104–108.
  • Suzuki M, Harada S, Kanazawa K, . Relationship between antigens and IgG subclasses in bullous pemphigoid. Autoimmunity. 1994; 18 3: 217–225.
  • Brooks WS, Lee YY, Abell E, . Comparison of IgG subclasses and complement binding activity of autoantibodies from patients with bullous pemphigoid and pemphigus. J Clin Lab Anal. 1989; 3 5: 307–311.
  • Brandsen R, Frusic-Zlotkin M, Lyubimov H, . Circulating pemphigus IgG in families of patients with pemphigus: comparison of indirect immunofluorescence, direct immunofluorescence, and immunoblotting. J Am Acad Dermatol. 1997; 36 1: 44–52.
  • Dmochowski M, Hashimoto T, Nishikawa T. The analysis of IgG subclasses of anti-intercellular antibodies in pemphigus by an immunoblot technique. Arch Dermatol Res. 1992; 284 5: 309–311.
  • Shirakata Y, Shiraishi S, Sayama K, . Subclass characteristics of IgG autoantibodies in bullous pemphigoid and pemphigus. J Dermatol. 1990; 17 11: 661–666.
  • Belloni-Fortina A, Faggion D, Pigozzi B, . Detection of autoantibodies against recombinant desmoglein 1 and 3 molecules in patients with pemphigus vulgaris: correlation with disease extent at the time of diagnosis and during follow-up. Clin Dev Immunol. 2009187864.
  • Manz RA, Hauser AE, Hiepe F, . Maintenance of serum antibody levels. Annu Rev Immunol. 2005; 23:367–386.
  • Harman KE, Gratian MJ, Bhogal BS, . A study of desmoglein 1 autoantibodies in pemphigus vulgaris: racial differences in frequency and the association with a more severe phenotype. Br J Dermatol. 2000; 143 2: 343–348.
  • Mahoney MG, Wang Z, Rothenberger K, . Explanations for the clinical and microscopic localization of lesions in pemphigus foliaceus and vulgaris. J Clin Invest. 1999; 103 4: 461–468.
  • Amagai M, Ahmed AR, Kitajima Y, . Are desmoglein autoantibodies essential for the immunopathogenesis of pemphigus vulgaris, or just “witnesses of disease”?. Exp Dermatol. 2006; 15 10: 815–831.
  • Saha M, Harman K, Mortimer NJ, . Pemphigus vulgaris in White Europeans is linked with HLA Class II allele HLA DRB1*1454 but not DRB1*1401. J Invest Dermatol. 2010; 130 1: 311–314.
  • Aalberse RC, Stapel SO, Schuurman J, . Immunoglobulin G4: an odd antibody. Clin Exp Allergy. 2009; 39 4: 469–477.
  • Herbst A, Bystryn JC. Patterns of remission in pemphigus vulgaris. J Am Acad Dermatol. 2000; 42 3: 422–427.

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