Sjögren's syndrome-like autoimmune sialadenitis in MRL-Fas^lpr mice is associated with expression of glucocorticoid-induced TNF receptor-related protein (GITR) ligand and 4-1BB ligand

References

• Jonsson R., Moen K., Vestrheim D., . Current issues in Sjögren's syndrome. Oral Dis.. 2002; 8:130–140.
   PubMed Web of Science ®Google Scholar
• Borchers A. T., Naguwa S. M., Keen C. L., . Immunopathogenesis of Sjögren's syndrome. Clin. Rev. Allergy Immunol.. 2003; 225:89–104.
   Google Scholar
• Manganelli P., Fietta P.. Apoptosis and Sjögren's syndrome. Sem. Arthritis Rheum.. 2003; 33:49–65.
   PubMed Web of Science ®Google Scholar
• Delaleu N., Jonsson D. N., Koller M. M.. Sjögren's syndrome. Eur. J. Oral Sci.. 2005; 113:101–113.
   PubMed Web of Science ®Google Scholar
• Keir M. E., Sharpe A. H.. The B7/CD28 costimulatory family in autoimmunity. Immunol Rev.. 2005; 204:128–143.
   PubMed Web of Science ®Google Scholar
• Gough M. J., Weinberg A. D.. OX40 (CD134) and OX40L. Adv. Exp. Med. Biol.. 2009; 647:94–107.
   PubMed Web of Science ®Google Scholar
• Redmond W. L., Ruby C. E., Weinberg A. D.. The role of OX40-mediated co-stimulation in T-cell activation and survival. Crit. Rev. Immunol.. 2009; 29:187–201.
   PubMed Web of Science ®Google Scholar
• Lee S. W., Croft M.. 4-1BB as a therapeutic target for human disease. Adv. Exp. Med. Biol.. 2009; 647:120–129.
   PubMed Web of Science ®Google Scholar
• Nocentini G., Riccardi C.. GITR: A modulator of immune response and inflammation. Adv. Exp. Med. Biol.. 2009; 647:156–173.
   PubMed Web of Science ®Google Scholar
• Felix N. J., Suri A., Salter-Cid L., . Targeting lymphocyte co-stimulation: From bench to bedside. Autoimmunity. 2010; 43:514–525.
   PubMed Web of Science ®Google Scholar
• Shulga-Morskaya S., Dobles M., Walsh M. E., . B Cell-activating factor belonging to the TNF family acts through separete receptors to support B cell survival and T cell-independent antibody formation. J. Immunol.. 2004; 173:2331–2341.
   PubMed Web of Science ®Google Scholar
• Groom J. R., Fletcher C. A., Walters S. N., . BAFF and MyD88 signals promote a lupuslike disease independent of T cells. J. Exp. Med.. 2007; 204:1959–1971.
   PubMed Web of Science ®Google Scholar
• Ryan M. C., Grewal I. S.. Targeting of BAFF and APRIL for autoimmunity and oncology. Adv. Exp. Med. Biol.. 2009; 647:52–63.
   PubMed Web of Science ®Google Scholar
• O'Neill S. K., Cao Y., Hamel K. M., . Expression of CD80/86 on B cells is essential for autoreactive T cell activation and the development of arthritis. J. Immunol.. 2007; 179:5109–5116.
   PubMed Web of Science ®Google Scholar
• Bae E., Kim W. J., Kang Y. M., . Glucocorticoid-induced tumour necrosis factor receptor-related protein-mediated macrophage stimulation may induce cellular adshesion and cytokine expression in rheumatoid arthritis. Clin. Exp. Immunol.. 2007; 148:410–418.
   PubMed Web of Science ®Google Scholar
• Croft M.. Control of immunity by the TNFR-related molecule OX40 (CD134). Ann. Rev. Immunol.. 2010; 28:57–78.
   PubMed Web of Science ®Google Scholar
• Ishii N., Takahashi T., Soroosh P., . OX40-OX40 ligand interraction in T-cell-mediated immunity and immunopathology. Adv. Immunol.. 2010; 105:63–98.
   PubMed Web of Science ®Google Scholar
• Patschan S., Dolff S., Kribben A., . CD134 expression on CD4+T cells is associated with nephritis and disease activity in patients with systemic lupus erythematosus. Clin. Exp. Immunol.. 2006; 145:235–242.
   PubMed Web of Science ®Google Scholar
• Ding D., Mehta H., McCune W. J., . Aberrant phenotype and function of myeloid dendritic cells in systemic lupus erythematosus. J. Immunol.. 2006; 177:5878–5889.
   PubMed Web of Science ®Google Scholar
• Morimoto S., Nakano S., Watanabe T., . Expression of B-cell activating factor of the tumor necrosis factor family (BAFF) in T cells in active systemic lupus erythematosus: the role of BAFF in T cell-dependent B cell pathogenic autoantibody production. Rheumatology. 2007; 46:1083–1086.
   PubMed Web of Science ®Google Scholar
• Croft M.. The role of TNF superfamily members in T-cell function and diseases. Nat. Rev. Immunol.. 2009; 9:271–285.
   PubMed Web of Science ®Google Scholar
• Routsias J. G., Tzioufas A. G.. Autoimmune response and target autoantigens in Sjogren's syndrome. Eur. J. Clin. Invest.. 2010; 40:1026–1036.
   PubMed Web of Science ®Google Scholar
• Manoussakis M. N., Kapsogeorgou E. K.. The role of intrinsic epithelial activation in the pathogenesis of Sjogren's syndrome. J. Autoimmun.. 2010; 35:219–224.
   PubMed Web of Science ®Google Scholar
• Watson M. L., Rao J. K., Gilkeson G. S., . Genetic analysis of MRL-lpr mice: Relationship of Fas apoptosis gene to disease manifestations and renal disease-modifying loci. J. Exp. Med.. 1992; 176:1645–1656.
   PubMed Web of Science ®Google Scholar
• Nishihara M., Terada M., Kamogawa J., . Genetic basis of autoimmune sialadenitis in MRL/lpr lupus-prone mice. Arthritis Rheum.. 1999; 42:2616–2623.
   PubMed Web of Science ®Google Scholar
• Soyfoo M. S., Steinfeld S., Delporte C.. Usefulness of mouse models to study the pathogenesis of Sjögren's syndrome. Oral Diseas.. 2007; 13:366–375.
   PubMedGoogle Scholar
• Tsunawaki S., Nakamura S., Ohyama Y., . Possible function of salivary gland epithelial cells as nonprofessional antigen-presenting cells in the development of Sjögren's syndrome. J. Rheumatol.. 2002; 29:1884–1896.
   PubMed Web of Science ®Google Scholar
• Matsumura R., Umemiya K., Goto T., . Glandular and extraglandular expression of costimulatory molecules in patients with Sjögren's syndrome. Ann. Rheum. Dis.. 2001; 60:473–482.
   PubMed Web of Science ®Google Scholar
• Kinoshita K., Tesch G., Schwarting A., . Costimulation by B7-1 and B7-2 is required for autoimmune disease in MRL-Faslpr Mice. J. Immunol.. 2000; 164:6046–6056.
   PubMedGoogle Scholar
• Hayashi Y., Haneji N., Hamano H.. Cytokine gene expression and autoantibody production in Sjögren's syndrome of MRL/lpr mice. Autoimmunity. 1996; 23:269–277.
   PubMed Web of Science ®Google Scholar
• Ndhlovu L. C., Takeda I., Suganuma K., . Expanding role of T-cell costimulations in regulatory T-cell function: Recent advances in accessory molecules expressed on both regulatory and non regulatory T cells. Crit. Rev. Immunol.. 2004; 24:251–266.
   PubMedGoogle Scholar
• Kober J., Leitner J., Klauser C., . The capacity of the TNF family members 4-1BBL, OX40L, GITRL, CD30L and LIGHT to costimulate human T cells. Eur. J. Immunol.. 2008; 38:2678–2688.
   PubMed Web of Science ®Google Scholar
• Azuma M.. Role of the glucocorticoid-induced TNFR-related protein (GITR)-GITR ligand pathway in innate and adaptive immunity. Crit. Rev. Immunol.. 2010; 30:547–557.
   PubMed Web of Science ®Google Scholar
• Gramaglia I., Weinberg A. D., Lemon M., . Ox-40 Ligand: A potent costimulatory molecule for sustaining primary CD4 T cell responses. J. Immunol.. 1998; 16:6510–6517.
   Google Scholar
• Munks M. W., Mourich D. V., Mittler R. S., . 4-1BB and OX40 stimulation enhance CD8 and CD4 T-cell responses to a DNA prime, poxvirus boost vaccine. Immunology. 2004; 112:559–566.
   PubMed Web of Science ®Google Scholar
• Lee S. J., Myers L., Muralimohan G., . 4-1BB and OX40 dual costimulation synergistically stimulate primary specific CD8 T cells for robust effector funtion. J. Immunol.. 2004; 173:3002–3012.
   PubMed Web of Science ®Google Scholar
• Habib-Agahi M., Phan T. T., Searie P. F.. Co-stimulation with 4-1BB ligand allows extended T-cell proliferation, synergizes with CD80/CD86 and can reactivate anergic T cells. Int. Immunol.. 2007; 19:1383–1394.
   PubMed Web of Science ®Google Scholar
• Shimizu J., Yamazaki S., Takahashi T., . Stimulation of CD25+CD4+regulatory T cells through GITR breaks immunological self-tolerance. Nat. Immunol.. 2002; 3:135–142.
   PubMed Web of Science ®Google Scholar
• Walker L. S. K.. Regulatory T cells overturned: the effectors fight back. Immunology. 2009; 126:466–474.
   Google Scholar
• Monk C. R., Spachidou M., Rovis F., . MRL/Mp CD4+CD25- T cells show reduced sensitivity to nsuppression by CD4+, CD25+rergulatory T cells in vitro. Arthtitis Rheum.. 2005; 52:1180–1184.
   PubMed Web of Science ®Google Scholar
• Parietti V., Monneaux F., Décossas M., . Function of CD4+CD25+Treg cells in MRL/lpr mice is compromised by intrinsic defects in antigen-presenting cells and effector T cells. Arthritis Rheum.. 2008; 58:1751–1761.
   PubMed Web of Science ®Google Scholar
• So T., Lee S. W., Croft M.. Immune regulation and control of regulatory T cells by OX40 and 4-1BB. Cytokine Growth Factor Rev.. 2008; 19:253–262.
   PubMed Web of Science ®Google Scholar
• Kitamura N., Murata S., Ueki T., . OX40 costimulation can abrogate Foxp3+regulatory Tcell-mediated suppression of antitumor immunity. Int. J. Cancer. 2009; 125:630–638.
   PubMed Web of Science ®Google Scholar
• Ji H., Liao G., Faubion W. A., . The natural ligand for glucocorticoid-induced TNF receptor-related protein abrogates regulatory T cell suppression. J. Immunol.. 2004; 172:5823–5827.
   PubMedGoogle Scholar
• Joatham A., Ohnishi H., Okamoto M., . Loss of regulatory cell suppression following signaling through glucocorticoid-induced tumor necrosis receptor (GITR) is dependent on c-Jun N-terminal kinase activation. J. Biol. Chem.. 2012; 287:17100–17108.
   PubMedGoogle Scholar
• Nocentini G., Ronchetti S., Petrillo M. G., . Pharmacological modulation of GITRL/GITR system: therapeutic perspectives. Br. J. Pharmacol.. 2012; 165:2089–2099.
   PubMed Web of Science ®Google Scholar
• Ye Q., Wang L., Wells A. D., . BAFF binding to T cell-expressed BAFF-R costimulates T cell proliferation and alloresponses. Eur. J. Immunol.. 2004; 34:2750–2759.
   PubMedGoogle Scholar
• Mackay F., Leung H.. The role of the BAFF/APRIL system on T cell function. Semin Immunol.. 2006; 18:284–289.
   PubMed Web of Science ®Google Scholar
• Gross J. A., Johnston J., Mmudri S., . TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease. Nature. 2000; 404:995–999.
   PubMed Web of Science ®Google Scholar
• Pers J. O., d'Arbonneau F., Devauchelle-Pensec V., . Is priodontal disease mediated by salivary BAFF in Sjögren's syndrome?. Arthritis Rheum.. 2005; 52:2411–2414.
   PubMed Web of Science ®Google Scholar
• Jonsson M. V., Szodoray P., Jellestad S., . Association between circulating levels of novel TNF family members APRIL and BAFF and lymphoid organization in primary Sjögren's syndrome. J. Clin. Immunol.. 2005; 25:189–201.
   PubMed Web of Science ®Google Scholar
• Candon S., Gottenberg J. E., Bengoufa L., . Quantitative assessment of antibodies to ribonucleoproteins in primary Sjögren's syndrome: correlation with B-cell biomarkers and disese activity. Ann. Rheum. Dis.. 2009; 68:1208–1212.
   PubMed Web of Science ®Google Scholar
• Varin M. M., Pottier L. L., Youinou P., . B-cell tolerance breakdown in Sjögren's syndrome: Focus on BAFF. Autoimmun. Rev.. 2010; 9:604–608.
   PubMed Web of Science ®Google Scholar
• Buckner J. H.. Mechanisms of impaired regulation by CD4+CD25+FOXP3+regulatory T cells in human autoimmune diseases. Nat. Rev. Immunol.. 2010; 10:849–859.
   PubMed Web of Science ®Google Scholar