Inhibition of B lymphocyte-induced maturation protein-1 reduces the production of autoantibody and alleviates symptoms of systemic lupus erythematosus

References

• Sanz, I., and F. E. H. Lee. 2010. B cells as therapeutic targets in SLE. Nat. Rev. Rheumatol. 6: 326–337
   PubMed Web of Science ®Google Scholar
• Chatenoud, L. 2006. Immune therapies of autoimmune diseases: are we approaching a real cure? Curr. Opin. Immunol. 18: 710–717
   PubMed Web of Science ®Google Scholar
• Levesque, M. C., and E. W. S. Clair. 2008. B cell-directed therapies for autoimmune disease and correlates of disease response and relapse. J. Allergy Clin. Immun. 121: 13–21
   PubMed Web of Science ®Google Scholar
• Tieng, A. T., and E. Peeva. 2008. B-cell-directed therapies in systemic lupus erythematosus. Semin. Arthritis Rheu. 38: 218–227
   PubMed Web of Science ®Google Scholar
• Ding, C., S. Foote, and G. Jones. 2008. B-cell-targeted therapy for systemic lupus erythematosus – an update. Biodrugs 22: 239–249
   PubMed Web of Science ®Google Scholar
• Marino, E., and S. T. Grey. 2012. B cells as effectors and regulators of autoimmunity. Autoimmunity 45: 377–387
   PubMed Web of Science ®Google Scholar
• Stohl, W., and R. J. Looney. 2006. B cell depletion therapy in systemic rheumatic diseases: different strokes for different folks? Clin. Immunol. 121: 1–12
   PubMed Web of Science ®Google Scholar
• Sutter, J. A., J. Kwan-Morley, J. Dunham, et al. 2008. A longitudinal analysis of SLE patients treated with rituximab (anti-CD20): factors associated with B lymphocyte recovery. Clin. Immunol. 126: 282–290
   PubMed Web of Science ®Google Scholar
• Garaud, J. C., J. N. Schickel, G. Blaison, et al. B cell signature during inactive systemic lupus is heterogeneous: toward a biological dissection of lupus. Plos One 6: e23900
   Google Scholar
• Luo, J., X. Niu, H. Liu, et al. 2013. Up-regulation of transcription factor Blimp1 in systemic lupus erythematosus. Mol. Immunol. 56: 574–582
   PubMed Web of Science ®Google Scholar
• Ochiai, K., A. Muto, H. Tanaka, et al. 2008. Regulation of the plasma cell transcription factor Blimp-1 gene by Bach2 and Bcl6. Int.l Immunol. 20: 453–460
   PubMedGoogle Scholar
• John, S. A., J. L. Clements, L. M. Russell, and L. A. Garrett-Sinha. 2008. Ets-1 regulates plasma cell differentiation by interfering with the activity of the transcription factor Blimp-1. J. Biol. Chem. 283: 951–962
   PubMed Web of Science ®Google Scholar
• Hamel, K. M., V. M. Liarski, and M. R. Clark. 2012. Germinal center B-cells. Autoimmunity 45: 333–347
   PubMed Web of Science ®Google Scholar
• Diehl, S. A., H. Schmidlin, M. Nagasawa, et al. 2008. STAT3-mediated up-regulation of BLIMP1 is coordinated with BCL6 down-regulation to control human plasma cell differentiation. J. Immunol. 180: 4805–4815
   PubMed Web of Science ®Google Scholar
• Fairfax, K. A., L. M. Corcoran, C. Pridans, et al. 2007. Different kinetics of blimp-1 induction in B cell subsets revealed by reporter gene. J. Immunol. 178: 4104–4111
   PubMedGoogle Scholar
• Shapiro-Shelef, M., K. I. Lin, L. J. McHeyzer-Williams, et al. 2003. Blimp-1 is required for the formation of immunoglobulin secreting plasma cells and pre-plasma memory B cells. Immunity 19: 607–620
   PubMed Web of Science ®Google Scholar
• Fujita, N., D. L. Jaye, C. Geigerman, et al. MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation. Cell 119: 75–86
   PubMedGoogle Scholar
• Kafri, T., U. Blomer, D. A. Peterson, et al. 1997. Sustained expression of genes delivered directly into liver and muscle by lentiviral vectors. Nat. Genet. 17: 314–317
   PubMed Web of Science ®Google Scholar
• Klinghoffer, R. A., J. Magnus, J. Schelter, M. et al. 2010. Reduced seed region-based off-target activity with lentivirus-mediated RNAi. RNA. 16: 879–884
   PubMedGoogle Scholar
• Rubinson, D. A., C. P. Dillon, A. V. Kwiatkowski, et al. 2003. A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nat. Genet. 33: 401–406
   PubMed Web of Science ®Google Scholar
• Deng, S., T. Yuan, X. Cheng, et al. 2010. B-lymphocyte-induced maturation protein1 up-regulates the expression of B-cell maturation antigen in mouse plasma cells. Mol. Biol. Rep. 37: 3747–3755
   PubMedGoogle Scholar
• Soro, P. G., A. P. Morales, M. J. Martinez, et al. 1999. Differential involvement of the transcription factor Blimp-1 in T cell-independent and -dependent B cell differentiation to plasma cells. J. Immunol. 163: 611–617
   PubMedGoogle Scholar
• Tunyaplin, C., A. L. Shaffer, C. D. Angelin-Duclos, et al. 2004. Direct repression of prdm1 by Bcl-6 inhibits plasmacytic differentiation. J. Immunol. 173: 1158–1165
   PubMed Web of Science ®Google Scholar
• Shaffer, A. L., K. I. Lin, T. C. Kuo, et al. Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program. Immunity 17: 51–62
   PubMed Web of Science ®Google Scholar
• Sciammas, R., and M. M. Davis. 2004. Modular nature of Blimp-1 in the regulation of gene expression during B cell maturation. J. Immunol. 172: 5427–5440
   PubMed Web of Science ®Google Scholar
• Shaffer, A. L., M. Shapiro-Shelef, N. N. Iwakoshi, et al. 2004. XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation. Immunity 21: 81–93
   PubMed Web of Science ®Google Scholar
• Radic, M., M. Herrmann, J. van der Vlag, and O. P. Rekvig. 2011. Regulatory and pathogenetic mechanisms of autoantibodies in SLE. Autoimmunity 44: 349–356
   PubMed Web of Science ®Google Scholar
• Wong, C. K., P. T. Wong, L. S. Tam, E. K. Li, et al. 2009. Activation profile of intracellular mitogen-activated protein kinases in peripheral lymphocytes of patients with systemic lupus erythematosus. J. Clin. Immunol. 29: 738–746
   PubMedGoogle Scholar
• Mason, J. A., and D. Bossingham. 2009. The clinical characterisation of systemic lupus erythematosus in a Far North Queensland Indigenous kindred. Lupus. 18: 144–148
   PubMedGoogle Scholar
• Kallies, A., and S. L. Nutt. 2007. Terminal differentiation of lymphocytes depends on Blimp-1. Curr. Opin. Immunol. 19: 156–162
   PubMed Web of Science ®Google Scholar
• Tarlinton, D. M., and P. D. Hodgkin. 2004. Targeting plasma cells in autoimmune diseases. J. Exp. Med. 199: 1451–1454
   PubMed Web of Science ®Google Scholar
• Shapiro-Shelef, M., K. I. Lin, D. Savitsky, et al. 2005. Blimp-1 is required for maintenance of long-lived plasma cells in the bone marrow. J. Exp. Med. 202: 1471–1476
   PubMedGoogle Scholar
• Shapiro-Shelef, M., and K. Calame. 2005. Regulation of plasma-cell development. Nat. Rev. Immunol. 5: 230–242
   PubMed Web of Science ®Google Scholar
• Zhou, Z., A. Li, Z. Wang, et al. 2013. Blimp-1 siRNA inhibits B cell differentiation and prevents the development of lupus in mice. Human Immunol. 74: 297–301
   PubMedGoogle Scholar
• Birmingham, A., E. M. Anderson, A. Reynolds, et al. 2006. 3′ UTR seed matches, but not overall identity, are associated with RNAi off-targets. Nat. Methods. 3: 199–204
   PubMed Web of Science ®Google Scholar
• Elbashir, S. M., J. Harborth, K. Weber, and T. Tuschl. 2002. Analysis of gene function in somatic mammalian cells using small interfering RNAs. Methods. 26: 199–213
   PubMed Web of Science ®Google Scholar