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Full-Length Research Papers

B cell TLR1/2, TLR4, TLR7 and TLR9 interact in induction of class switch DNA recombination: Modulation by BCR and CD40, and relevance to T-independent antibody responses

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Pages 1-12 | Received 07 Nov 2014, Accepted 24 Nov 2014, Published online: 23 Dec 2014

References

  • Xu, Z., H. Zan, E. J. Pone, et al. 2012. Immunoglobulin class-switch DNA recombination: induction, targeting and beyond. Nat. Rev. Immunol. 12: 517–531
  • Casali, P. 2014. Somatic recombination and hypermutation in the immune system. In Lewin's Genes XI. J. E. Krebs, E. S. Goldstein, and S. T. Kilpatrick, eds. Jones & Bartlett, Sudbury, MA. p. 459–507
  • Stavnezer, J., J. E. Guikema, and C. E. Schrader. 2008. Mechanism and regulation of class switch recombination. Annu. Rev. Immunol. 26: 261–292
  • Cerutti, A., I. Puga, and M. Cols. 2011. Innate control of B cell responses. Trends Immunol. 32: 202–211
  • Pone, E. J., J. Zhang, T. Mai, et al. 2012. BCR-signalling synergizes with TLR-signalling for induction of AID and immunoglobulin class-switching through the non-canonical NF-κB pathway. Nat. Commun. 3: 767. doi:10.1038/ncomms1769
  • Li, G., H. Zan, Z. Xu, and P. Casali. 2013. Epigenetics of the antibody response. Trends Immunol. 34: 460–470
  • Vaidyanathan, B., W. F. Yen, J. N. Pucella, and J. Chaudhuri. 2014. AIDing chromatin and transcription-coupled orchestration of immunoglobulin class-switch recombination. Front. Immunol. 5: 120. doi:10.3389/fimmu.2014.00120
  • Xu, Z., Z. Fulop, G. Wu, et al. 2010. 14-3-3 adaptor proteins recruit AID to 5′-AGCT-3′-rich switch regions for class switch recombination. Nat. Struct. Mol. Biol. 17: 1124–1135
  • Lam, T., L. M. Thomas, C. A. White, et al. 2013. Scaffold functions of 14-3-3 adaptors in B cell immunoglobulin class switch DNA recombination. PLoS One 8: e80414
  • Li, G., C. A. White, T. Lam, et al. 2013. Combinatorial H3K9acS10ph histone modification in IgH locus S regions targets 14-3-3 adaptors and AID to specify antibody class-switch DNA recombination. Cell Rep. 5: 702–714
  • Gururajan, M., J. Jacob, and B. Pulendran. 2007. Toll-like receptor expression and responsiveness of distinct murine splenic and mucosal B-cell subsets. PLoS One 2: e863
  • Bekeredjian-Ding, I., and G. Jego. 2009. Toll-like receptors–sentries in the B-cell response. Immunology 128: 311–323
  • Shay, T., and J. Kang. 2013. Immunological Genome Project and systems immunology. Trends Immunol. 34: 602–609
  • Pasare, C., and R. Medzhitov. 2005. Control of B-cell responses by Toll-like receptors. Nature 438: 364–368
  • Kasturi, S. P., I. Skountzou, R. A. Albrecht, et al. 2011. Programming the magnitude and persistence of antibody responses with innate immunity. Nature. 470: 543–547
  • Hou, B., P. Saudan, G. Ott, et al. 2011. Selective utilization of Toll-like receptor and MyD88 signaling in B cells for enhancement of the antiviral germinal center response. Immunity 34: 375–384
  • Hwang, I. Y., C. Park, K. Harrison, and J. H. Kehrl. 2009. TLR4 signaling augments B lymphocyte migration and overcomes the restriction that limits access to germinal center dark zones. J. Exp. Med. 206: 2641–2657
  • Lee, M. S., and Y. J. Kim. 2007. Signaling pathways downstream of pattern-recognition receptors and their cross talk. Annu. Rev. Biochem. 76: 447–480
  • Bezbradica, J. S., and R. Medzhitov. 2009. Integration of cytokine and heterologous receptor signaling pathways. Nat. Immunol. 10: 333–339
  • Ivashkiv, L. B. 2009. Cross-regulation of signaling by ITAM-associated receptors. Nat. Immunol. 10: 340–347
  • Pone, E. J., H. Zan, J. Zhang, et al. 2010. Toll-like receptors and B-cell receptors synergize to induce immunoglobulin class-switch DNA recombination: relevance to microbial antibody responses. Crit. Rev. Immunol. 30: 1–29
  • Ruprecht, C. R., and A. Lanzavecchia. 2006. Toll-like receptor stimulation as a third signal required for activation of human naive B cells. Eur. J. Immunol. 36: 810–816
  • Liu, N., N. Ohnishi, L. Ni, et al. 2003. CpG directly induces T-bet expression and inhibits IgG1 and IgE switching in B cells. Nat. Immunol. 4: 687–693
  • Pone, E. J., T. Lam, A. L. Edinger, et al. 2014. B Cell Rab7 mediates induction of AID expression and class-switching in T-dependent and T-independent antibody responses. J. Immunol.: in revision
  • Lioudyno, M. I., J. A. Kozak, A. Penna, et al. 2008. Orai1 and STIM1 move to the immunological synapse and are up-regulated during T cell activation. Proc. Nat. Acad. Sci. U.S.A. 105: 2011–2016
  • Pulendran, B., P. Kumar, C. W. Cutler, et al. 2001. Lipopolysaccharides from distinct pathogens induce different classes of immune responses in vivo. J. Immunol. 167: 5067–5076
  • Reynolds, J. M., and C. Dong. 2013. Toll-like receptor regulation of effector T lymphocyte function. Trends Immunol. 34: 511–519
  • Haniuda, K., T. Nojima, K. Ohyama, and D. Kitamura. 2011. Tolerance induction of IgG+ memory B cells by T cell-independent type II antigens. J. Immunol. 186: 5620–5628
  • Bernasconi, N. L., E. Traggiai, and A. Lanzavecchia. 2002. Maintenance of serological memory by polyclonal activation of human memory B cells. Science. 298: 2199–2202
  • Ahmed, S. S., S. A. Plotkin, S. Black, and R. L. Coffman. 2011. Assessing the safety of adjuvanted vaccines. Sci. Transl. Med. 3: 93rv92
  • Zanoni, I., R. Ostuni, G. Capuano, et al. 2009. CD14 regulates the dendritic cell life cycle after LPS exposure through NFAT activation. Nature. 460: 264–268
  • Phan, T. G., D. Paus, T. D. Chan, et al. 2006. High affinity germinal center B cells are actively selected into the plasma cell compartment. J. Exp. Med. 203: 2419–2424
  • Tomita, H., M. Yamada, I. Sekigawa, et al. 2003. Systemic lupus erythematosus-like autoimmune abnormalities induced by bacterial infection. Clin. Exp. Rheum. 21: 497–499
  • Doria, A., M. Canova, M. Tonon, et al. 2008. Infections as triggers and complications of systemic lupus erythematosus. Autoimmunity Rev. 8: 24–28
  • Walsh, E. R., P. Pisitkun, E. Voynova, et al. 2012. Dual signaling by innate and adaptive immune receptors is required for TLR7-induced B-cell-mediated autoimmunity. Proc. Nat. Acad. Sci. U.S.A. 109: 16276–16281
  • Groom, J. R., C. A. Fletcher, S. N. Walters, et al. 2007. BAFF and MyD88 signals promote a lupuslike disease independent of T cells. J. Exp. Med. 204: 1959–1971
  • Park, S. R., H. Zan, Z. Pal, et al. 2009. HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation. Nat. Immunol. 10: 540–550
  • White, C. A., J. Seth Hawkins, E. J. Pone, et al. 2011. AID dysregulation in lupus-prone MRL/Faslpr/lpr mice increases class switch DNA recombination and promotes interchromosomal c-Myc/IgH loci translocations: modulation by HoxC4. Autoimmunity 44: 585–598
  • White, C. A., E. J. Pone, T. S. Lam, et al. 2014. Histone deacetylase inhibitors upregulate B cell microRNAs that silence AID and Blimp-1 expression for epigenetic modulation of antibody and autoantibody response. J. Immunol. 193: 5933–5950
  • Zan, H., C. Tat, and P. Casali. 2014. MicroRNAs in lupus. Autoimmunity. 47: 272–285
  • Ivashkiv, L. B. 2008. A signal-switch hypothesis for cross-regulation of cytokine and TLR signalling pathways. Nat. Rev. Immunol. 8: 816–822
  • Shen, P., T. Roch, V. Lampropoulou, et al. 2014. IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases. Nature. 507: 366–370
  • West, A. P., A. A. Koblansky, and S. Ghosh. 2006. Recognition and signaling by toll-like receptors. Annu. Rev. Cell. Dev. Biol. 22: 409–437
  • Verstrepen, L., T. Bekaert, T. L. Chau, et al. 2008. TLR-4, IL-1R and TNF-R signaling to NF-κB: variations on a common theme. Cell. Mol. Life Sci. 65: 2964–2978
  • Graham, J. P., K. M. Arcipowski, and G. A. Bishop. 2010. Differential B-lymphocyte regulation by CD40 and its viral mimic, latent membrane protein 1. Immunol. Rev. 237: 226–248
  • Vinuesa, C. G., and P. P. Chang. 2013. Innate B cell helpers reveal novel types of antibody responses. Nat. Immunol. 14: 119–126
  • Heikenwalder, M., M. Polymenidou, T. Junt, et al. 2004. Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration. Nat. Med. 10: 187–192

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