5
Views
3
CrossRef citations to date
0
Altmetric
Original Article

Monoclonal Antibody Against the Lupus Antigen Sm Cross-Reacts with RNA Polymerase I

&
Pages 241-251 | Received 25 Jul 1988, Published online: 07 Jul 2009

References

  • Tan EM. Autoantibodies to nuclear antigens (ANA): Their immunobiology and medicine. Adv Immunol 1982; 33: 167–240
  • Stetler D A, Rose K M, Wenger M E, Berlin C, Jacob M. ST. Antibodies to distinct polypeptides of RNA polymerase I in sera from patients with rheumatic autoimmune disease. Proc Nad Acad Sci USA 1982; 79: 7499–7503
  • Stetler D A, Rose K M, Wenger M E, Berlin C M, Jacob ST. Anti-protein kinase Nil antibodies in rheumatic autoimmune diseases. J Biol Chem. 1984; 259: 2077–2079
  • Stetler D A, Reichlin M, Berlin C M, Jacob ST. Antibodies against nuclear poly(A) polymerases in rheumatic autoimmune diseases. J Clin Immunol 1987; 7: 24–28
  • Shero J H, Bordwell B, Rothfield N F, Earnshaw WC. High titers of autoantibodies to topoisomerase 1 (Scl-70) in sera from scleroderma patients. Science 1986; 231: 737–740
  • Tan E M, Kunkel HG. Characteristics of a soluble nuclear antigen precipitating with sera of patients with systemic lupus erythematosus. J Immunol 1966; 96: 464–471
  • Williams D G, Brennan F M, Stocks M R, Maini RN. Individual variation of anti-Sm autoantibodies in the MRL/MP-lpr/lpr mouse: age related increase in diversity. Clin Exp Immunol 1986; 65: 506–512
  • Shores EW., Eisenberg R A, Cohen PL. Role of the Sm antigen in the generation of anti-Sm autoantibodies in the SLE-prone MRL mouse. J Immunol 1986; 136: 3662–3667
  • Hardin J A, Rahn D R, Shen C, Lerner M R, Wolin S L, Rosa M D, Steitz JA. Antibodies from patients with connective tissue diseases bind specific subsets of cellular RNA-protein particles. J Clin Invest 1982; 70: 1412–147
  • Fisher D E, Reeves W H, Conner G E, Blobel G, Kunkel HG. Pulse labeling of small nuclear ri-bonucleoproteins in vivo reveals distinct patterns of antigen recognition by human autoimmune antibodies. Proc Natl Acad Sci USA 1984; 81: 3185–3189
  • Lerner M R, Steitz JA. Antibodies to small nuclear RNAs complexed with proteins are produced by patients with systemic lupus erythematosus. Proc Natl Acad Sci USA 1979; 76: 5495–5499
  • Yang V W, Lerner M R, Steitz J A, Flint SJ. A small nuclear ribonucleoprotein is required for splicing of adenoviral early RNA sequences. Proc Natl Acad Sci USA 1981; 78: 1371–1374
  • Volker G, Steitz JA. A protein associated with small nuclear ribonucleoprotein particles recognizes the 3′ splice site of premessenger RNA. Cell 1986; 47: 973–984
  • Moore C L, Sharp PA. Site-specific polyadenylation in a cell-free reaction. Cell 1984; 36: 581–591
  • Eisenberg R A, Tan E M, Dixon FJ. Presence of anti-Sm reactivity in autoimmune mouse strains. J Exp Med. 1978; 147: 582–587
  • Andres B S, Eisenberg A N, Theofilopoulos A N, Izui S, Wilson C B, McConahey P J, Murphy E D, Roths J B, Dixon FJ. Spontaneous murine lupus-like syndromes. Clinical and immunological manitestations in several strains. J Exp Med 1978; 148: 1198–1215
  • Lerner E A, Boyle J A, Hardin J A, Steitz JA. Two novel classes of small ribonucleoproteins detected by antibodies associated with lupus erythematosus. Science 1981; 211: 400–402
  • Lerner E A, Lerner M R, Janeway C A, Steitz JA. Monoclonal antibodies to nucleic acid-containing cellular constituents: Probes for molecular biology and autoimmune disease. Proc Natl Acad Sci USA 1981; 78: 2737–2741
  • Stetler D A, Sipes D E, Jacob ST. Anti-RNA polymerase I antibodies in sera of MRL lpr/lpr and MRL + + autoimmune mice. J Exp Med 1985; 162: 1760–1770
  • Stetler D A, Cavallo T. Anti-RNA polymerase I antibodies: Potential role in the induction and progression of murine lupus nephritis. J Immunol 1987; 138: 2119–2123
  • Stetler D A, Jacob ST. Structurally and immunologically distinct poly(A) polymerases in rat liver. Occurrence of a tumor-type enzyme in normal liver. J Biol Chem. 1984; 259: 7239–7244
  • Stetler D A, Jacob ST. Structural and immunological identity of rat hepatoma and fetal liver nuclear poly(A) polymerase. Carcinogenesis 1985; 6: 259–262
  • Stetler D A, Reichlin M, Berlin C M, Jacob ST. Autoantibodies against RNA polymerase I in scleroderma and Sjogren's syndrome sera. Biochem Biophys Res Commun. 1987; 144: 1296–1302
  • Rose K M, Stetler D A, Jacob ST. Protein kinase activity of RNA polymerase 1 purified from a rat hepatoma: Probable function of Mr 42,000 and 24,600 polypeptides. Proc Natl Acad Sci USA 1981; 78: 2833–2837
  • Rose K M, Bell L E, Siefken D A, Jacob ST. A heparin-sensitive nuclear protein kinase. Purification, properties and increased activity in rat hepatoma relative to liver. J Biol Chem 1981; 256: 7468–7477
  • Stetler D A, Rose KM. Phosphorylation of deoxyribonucleic acid dependent RNA polymerase II by nuclear protein kinase Nil: Mechanism of enhanced ribonucleic acid synthesis. Biochemistry 1982; 21: 3721–3728
  • Petterson I, Hinterberger M, Mimori T, Gottlieb E, Steitz JA. The structure of mammalian small nuclear ribonucleoproteins. J Biol Chem 1984; 259: 5907–5914
  • Pisetsky D, Hoch S O, Klatt C L, O'Donnell M A, Keene JD. Specificity and idiotypic analysis of a monoclonal anti-Sm antibody with anti-DNA activity. J Immunol 1985; 135: 4080–4085
  • Stetler D, Jacob A. ST. Immunization of rabbits with purified RNA polymerase I induces a distinct population of antibodies against nucleic acids as well as anti-RNA polymerase I antibodies, both characteristic of systemic lupus erythematosus. Proc Nail Acad Sci USA 1985; 82: 6797–6801
  • Stetler D A, Rose KM. Protein Kinase NII: Interaction with RNA polymerase II and contribution to immunological cross-reactivity of RNA polymerases I and II. Biochim Biophys Acta. 1983; 739: 105–113
  • Stetler D A, Jacob ST. Phosphorylation of RNA polymerase I augments its interaction with autoantibodies of systemic lupus erythematosus patients. J Biol Chem 1984; 259: 13629–13632
  • Swanson M S, Nakagawa T Y, Le Van K, Dreyfuss G. Primary structure of human nuclear ribonucleoprotein particle C proteins: Conservation of sequence and domain structures in heterogeneous nuclear RNA, mRNA and pre-rRNA-binding proteins. Mol Cell Biol 1987; 7: 1731–1739
  • Pfeifle J, Anderer F A, Franke M. Characterisation of nucleolar proteins as autoantigens using human autoimmune sera. Ann Rheum Dis 1986; 45: 987–986
  • Reimer G, Rose K M, Scheer U, Tan EM. Autoantibody to RNA polymerase I in scleroderma sera. J Clin Invest. 1987; 79: 65–72
  • Thornburg W, Lindell TJ. Purification of rat liver nuclear protein kinase NII. J Biol Chem 1977; 252: 6660–6665
  • Lafer E M, Rauch J, Andrzejewski C, Jr., Mudd D, Furie B, Schwartz R S, Stollar BD. Polyspecific monoclonal lupus autoantibodies reactive with both polynucleotides and phospholipids. J Exp Med 1981; 153: 897–909
  • Jacob L, Tron F, Bach J-F, Louvard D. A monoclonal anti-DNA antibody also binds to cell surface protein(s). Proc Natl Acad Sci USA 1984; 81: 3843–3845
  • Carroll P, Stafford D, Schwartz R S, Stollar BD. Murine monoclonal anti-DNA autoantibodies bind to endogenous bacteria. J Immunol 1985; 135: 1086–1090
  • Andre-Schwartz J, Datta S K, Shoenfeld Y, Isenberg D A, Stollar B D, Schwartz RS. Binding of cytoskeletal proteins by monoclonal anti-DNA lupus autoantibodies. Clin Immunol Imnmnopathol 1984; 31: 261–271
  • Migliorine P, Ardman B, Kaburaki J, Schwartz RS. Parallel sets of autoantibodies in MRL-lpr lpr mice, an anti-DNA, anti-SmRNP, anti-gp70 network. J Exp Med. 1987; 165: 483–499
  • Darwin B S, Grudier J P, Klatt C L, Pisetsky DS. IgG antinuclear antibodies with cross-reactive rheumatoid factor activity. J Immunol 1986; 137: 3796–3801

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.