Intrathyroidal Activated (Ia⁺) T-Lymphocyte CD⁺ Subsets and B Cells in Graves' Hyperthyroidism Respond Rapidly to Propylthiouracil Therapy: Demonstration using Fine Needle Aspirates and Two-Colour Laser Flow Cytometry

References

• Burman KD, Baker, Jr. Immune mechanisms and Graves' disease. Endocr Rev 1985; 6: 183–232
   PubMed Web of Science ®Google Scholar
• DeGroot LJ, Quintans J. The causes of autoimmune thyroid disease. Endocr Rev 1989; 10: 537–562
   PubMedGoogle Scholar
• Totterman TH. Distribution of T-, B-, and thyroglobulin-binding lymphocytes infiltrating the gland in Graves' disease, Hashimoto's thyroiditis and de Quervain's thyroiditis. Clin Immunol Immunopathol 1978; 10: 270–277
   PubMedGoogle Scholar
• Canonica GW, Caria M, Torre G, Risso A, Cosulich ME, Bagnasco M. Autoimmune thyroid disease: Purification and phenotypic analysis of intrathyroid T cells. J Endocrinol Invest 1984; 7: 641–645
   PubMedGoogle Scholar
• MacKenzie WA, Schwartz AE, Friedman EW, Davies TF. Intrathyroidal T cell clones from patients with autoimmune thyroid disease. J Clin Endocrinol Metab 1987; 64: 818–824
   PubMed Web of Science ®Google Scholar
• Jansson R, Totterman TH, Sallstrom J, Dahlberg PA. Thyroid-infiltrating T-lymphocyte subsets and Hashimoto's thyroiditis. J Clin Endocrinol Metab 1983; 56: 1164–1168
   PubMed Web of Science ®Google Scholar
• Margolick JB, Hsu S-M, Volkman DJ, Burman KD, Fauci AS. Immunohistochemical characterization of intrathyroidal lymphocytes in Graves' disease. Am J Med 1984; 76: 815–821
   PubMed Web of Science ®Google Scholar
• Martin A, Goldsmith NK, Friedman EW, Schwartz AE, Davies TF, Roman SR. Intrathyroidal accumulation of T cell phenotypes in autoimmune thyroid disease. Autoimmunity 1990; 6: 269–281
   PubMed Web of Science ®Google Scholar
• Ahmann AJ, Burman KD. The role of T-lymphocytes in autoimmune thyroid disease. Endocrinol Metab Clin North Amer 1987; 16: 287–326
   PubMedGoogle Scholar
• DeGroot LJ, Sridama V, Hara Y, Mori H, Hamada N, Ryan M. Quantitative and qualitative abnormalities in circulating lymphocytes in autoimmune thyroid diseases. Autoimmunity and the Thyroid, PG Walfish, JR Wall, R. Volpé. Academic Press, Orlando, FL 1985; 67–78
   Google Scholar
• Chan JYC, Walfish PG. Activated (Ia+) T-lymphocytes and their subsets in autoimmune thyroid diseases: Analysis by dual-laser flow microfluorocytometry. J. Clin Endocrinol Metab 1986; 62: 403–409
   PubMed Web of Science ®Google Scholar
• Chan JYC, Walfish PG. Activated (Ia+) T-cells and their subsets in Graves' disease and Hashimoto's thyroiditis using dual-laser flow microfluorocytometric analysis. Mol Biol Med 1986; 3: 99–112
   PubMedGoogle Scholar
• Helderman JH, Strom TB. Role of protein and RNA synthesis in the development of insulin binding sites on activated thy-mus-derived lymphocytes. J Biol Chem 1979; 254: 7203–7209
   PubMedGoogle Scholar
• Trowbridge IS, Omary MB. Human cell surface glycoprotein related to cell proliferation is the receptor for transferrin. Proc Natl Acad Sci USA 1981; 78: 3039–3043
   PubMed Web of Science ®Google Scholar
• Uchiyama T, Broder S, Waldman TA. A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells. I. Production of anti-Tac monoclonal antibody and distribution of Tac+ cells. J. Immunol 1981; 126: 1393–1397
   PubMed Web of Science ®Google Scholar
• Evans RL, Faldetta TJ, Humphreys RE, Pratt DM, Yunis EJ, Schlossman SF. Peripheral human T cells sensitized in mixed lymphocyte culture synthesize and express la-like antigens. J Exp Med 1978; 148: 1440–1445
   PubMedGoogle Scholar
• Fox DA, Hussey RE, Fitzgerald KA, Acuto D, Poole C, Palley L. Tal, a novel 105 kd human T-cell activation antigen defined by a monoclonal antibody. J Immunol 1984; 133: 1250–1256
   PubMed Web of Science ®Google Scholar
• Ishikawa N, Eguchi K, Otsubo T, Ueki Y, Fukuda T, Tezuka H, Matsunaga M. Reduction in the suppressor-inducer T cells subset and increase in the helper T cells subset in thyroid tissue from patients with Graves' disease. J. Clin Endocrinol Metab 1987; 65: 17–23
   PubMed Web of Science ®Google Scholar
• Eguchi K, Ueki Y, Shimomura C, Otsubo T, Nakao H, Migita K, Kawakami A. Increment in the Tal+ cells in the peripheral blood and thyroid tissue of patients with Graves' disease. J Immunol 1989; 142: 4233–4240
   PubMedGoogle Scholar
• Ludgate ME, McGregor AM, Weetman AP, Ratanachaiyavong S, Lazarus JH, Hall R, Middleton GW. Analysis of T cells subsets in Graves' disease: Alternations associated with carbima-zole. Br Med J 1984; 288: 526–530
   PubMed Web of Science ®Google Scholar
• Gerstein HC, Rastogi B, Iwatani Y, Iitaka M, Row BV, Volpé R. The decrease in non-specific suppressor T lymphocytes in female hyperthyroid Graves' disease is secondary to the hyperthyroidism. Clin Invest Med 1987; 10: 337–344
   PubMed Web of Science ®Google Scholar
• McGregor AM, Petersen MM, McLachlan SM, Rooke P, Rees Smith R., Hall R. Carbimazole and immunoimmune response in Graves' disease. N Engl J Med 1980; 303: 302–307
   PubMed Web of Science ®Google Scholar
• Canonica GW, Bagnasco M, Ferrini S, Biassoni P, Giordano G, Corte G. Circulating T-cells subsets in Graves' disease. Differences between patients with active disease and in remission after l3'I therapy. Clin Immunol Immunopathol 1983; 28: 265–271
   PubMedGoogle Scholar
• Madec AM, Allanic H, Genetet N, Gueguen M, Genetet G, Fauchet R. T-Iymphocyte subsets at various stages of hyperthryoid Graves' disease: effect of carbimazole treatment and relationship with thyroid-stimulating antibody levels on HLA status. J. Clin Endocrinol Metab 1986; 62: 117–121
   PubMedGoogle Scholar
• Jackson RA, Haynes BF, Burch WM, Shimizu K, Bowring MA, Eisenbarth GS. Ia+ T cells in new onset Graves' disease. J Clin Endocrinol Metab 1984; 59: 187–190
   PubMed Web of Science ®Google Scholar
• Totterman TH, Karlsson FA, Bengtsson M, Mendel-Hartvig IB. Induction of circulating activated suppressor-like T cells by methimazole therapy for Graves' disease. N Engl J Med 1987; 316: 15–22
   PubMed Web of Science ®Google Scholar
• Vargas MT, Briones-Urbina R, Gladman T, Papsin FR, Walfish PG. Anti-thyroid microsomal antibodies and HLA-DR5 are associated with post-partum thyroid dysfunction. Evidence supporting autoimmune pathogenesis. J Clin Endocrinol Metab 1988; 67: 327–333
   PubMedGoogle Scholar
• McLachlan SM, Pegg CAS, Atherto MC, Middleton SL, Dickinson AM, Clark F, Proctor SJ, Proud G, Rees Smith B. Subpopulations of thyroid autoantibodies secreting lymphocytes in Graves' and Hashimoto thyroid glands. Clin Exp Immunol 1986; 65: 319–328
   PubMed Web of Science ®Google Scholar
• Kendall-Taylor P, Knox AJ, Steel MR, Atkinson S. Evidence that thyroid-stimulating antibody is produced in thyroid gland. Lancet 1984; 1: 654–656
   PubMedGoogle Scholar
• Volpé R, Karlsson FA, Jansson R, Dahlberg PA. Evidence that antithyroid drugs induce remissions in Graves' disease by modulating thyroid cellular activity. Clin Endocrinol (Oxf) 1986; 25: 453–462
   PubMed Web of Science ®Google Scholar