Genetic Susceptibility Markers in Danish Patients with Type 1 (Insulin-Dependent) Diabetes-Evidence for Polygenecity in Man

References

• Pociot F., Nørgaard K., Hobolth N., Andersen O., Nerup J. The Danish Study Group of Diabetes in Childhood. A nationwide population‐based study of the familial aggregation of type 1 (insulin‐dependent) diabetes in Denmark. Diabetologia 1993; 36: 870–875
   PubMed Web of Science ®Google Scholar
• Nerup J., Mandrup‐Poulsen T., Mølvig J., Spinas G. A., Nielsen J. H., Dinarello C. A., . Pathogenesis of insulin‐dependent diabetes mellitus (IDDM). Highlights in endocrinology, C. Christiansen, B. J. Riis, et al. Nørhaven, ViborgDenmark 1987; 37–410
   Google Scholar
• Spielman R. S., Baur M. P., Clerget‐Darpoux F. Genetic analysis of IDDM: Summary of GAW5 IDDM results. Genet. Epidemiol 1989; 6: 43–58
   PubMed Web of Science ®Google Scholar
• Olmos P., A'Hern R., Heaton D. A., Millward B. A., Risley D., Pyke D. A., et al. The Significance of the concordance rate for type 1 (insulin‐dependent) diabetes in identical twins. Diabetologia 1988; 31: 747–750
   PubMed Web of Science ®Google Scholar
• Thomson G., Robinson W. P., Kuhner M. K., Joe S., Mac‐Donald M. J., Gottschall J. L., et al. Genetic heterogeneity, modes of inheritance, and risk estimates for a joint study of Caucasians with insulin‐dependent diabetes mellitus. Am. J. Hum. Genet 1988; 43: 799–816
   PubMed Web of Science ®Google Scholar
• Ghosh S., Palmer S. M., Rodrigues N. R., Cordell H. J., Hearne C. M., Prins J. B., et al. Polygenic control of autoimmune diabetes in nonobese diabetic mice. Nature Genet 1993; 4: 404–409
   PubMed Web of Science ®Google Scholar
• Crisà L., Mordes J. P., Rossini A. A. Autoimmune diabetes mellitus in the BB rat. Diabetes Metab. Rev 1992; 8: 9–37
   Google Scholar
• Mølvig J. A model of the pathogenesis of insulin‐dependent diabetes mellitus. Dan. Med. Bull 1992; 39: 509–541
   PubMedGoogle Scholar
• Bengsch N., Kobberling J., Eckert G., Willams B. HLA‐typing in juvenile diabetics with and without positive family history and in families with one and two diabetic siblings. Diabelologia 1978; 15: 447–451
   PubMedGoogle Scholar
• Svejgaard A., Platz P., Ryder L. P. Insulin‐dependent diabetes mellitus. Histocompatibility testing 1980, P. Terasaki. UCLA Tissue Typing Laboratory, Los Angeles 1980; 638–656
   Google Scholar
• Jaworski M. A., Colle E., Guttmann R. D., et al. Insulin dependent diabetes: A comparison of families with single and multiple affected siblings. Diabetologia 1980; 19: 97–100
   PubMedGoogle Scholar
• Anderson C. E., Hodge S. E., Rubin R., et al. A search for heterogeneity in insulin‐dependent diabetes mellitus (IDDM): HLA and autoimmune studies in simplex, multiplex and multigenerational families. Metabolism 1983; 32: 471–477
   PubMedGoogle Scholar
• Bertrams J., Baur M. P. Disease reports: Insulin‐dependent diabetes mellitus. Histocompatibility testing 1984, E. D. Albert, M. P. Baur, W. R. Mayr. Springer Verlag, Berlin 1984; 348–358
   Google Scholar
• Svejgaard A., Jakobsen B. K., Platz P., Ryder L. P., Nerup J., Christy M., et al. HLA associations in insulin‐dependent diabetes: search for heterogeneity in different groups of patients from a homogeneous population. Tissue Antigens 1986; 28: 237–244
   PubMedGoogle Scholar
• Rubinstein P., Walker M., Ginsberg‐Fellner F. Excess of DR3/4 in type 1 diabetes. What does it portend?. Diabetes 1986; 35: 985–989
   PubMedGoogle Scholar
• O'Leary L. A., Dorman J. S., Laporte R. E., et al. Familial and sporadic insulin‐dependent diabetes: evidence for heterogeneous etiologies. Diabetes Res. Clin. Practice 1991; 14: 183–190
   PubMed Web of Science ®Google Scholar
• Lorenzen T., Pociot F., Hougaard P., Nerup J. Long‐term risk of IDDM in first‐degree relatives of patients with IDDM. Diabetologia 1994; 37: 321–327
   PubMed Web of Science ®Google Scholar
• Pociot F., Mølvig J., Wogensen L., Worsaae H., Nerup J. A Taql polymorphism in the human interleukin‐lβ (IL‐lβ) gene correlates with IL‐lβ secretion, in vitro. Eur. J. Clin. Invest 1992; 22: 396–402
   PubMed Web of Science ®Google Scholar
• Rønningen K. S., Iwe T., Halstensen T. S., Spurkland A., Thorsby E. The amino acid at position 57 of the HLA‐DQβ chain and susceptibility to develop insulin‐dependent diabetes mellitus (IDDM). Hum. Immunol 1989; 26: 215–225
   PubMed Web of Science ®Google Scholar
• Rønningen K. S., Spurkland A., Markussen G., Iwe T., Vartdal F., Thorsby E. Distribution of HLA class II alleles among Norwegian Caucasians. Hum. Immunol 1990; 29: 275–281
   PubMed Web of Science ®Google Scholar
• Rønningen K. S., Gjertsen H. A., Iwe T., Spurkland A., Hansen T., Thorsby E. Particular HLA DQαβ heterodimer associated with IDDM susceptibility in both DR4‐DQw4 Japanese and DR4‐DQw8/DRw8‐DQw4 Whites. Diabetes 1991; 40: 759–763
   PubMedGoogle Scholar
• Olerup O., Zetterquist H. HLA‐DR typing by pcr amplification with sequence‐specific primers (PCR‐SSP) in 2 hours: An alternative to serological DR typing in clinical practice including donor‐recipient matching in cadaveric transplantation. Tissue Antigens 1992; 39: 225–235
   PubMed Web of Science ®Google Scholar
• Messer G., Spengler U., Jung M. C., Honold G., Eisenburg J., Scholz S., et al. Allelic variation in the TNF‐β gene does not explain the low TNF‐β response in patients with primary biliary cirrhosis. Scand. J. Immunol 1991; 34: 735–740
   PubMedGoogle Scholar
• Jongeneel C. V., Briant L., Udalova I. A., Sevin A., Nedospasov S. A., Cambon‐Thomsen A. Extensive genetic polymorphism in the human tumour necrosis factor region and relation to extended HLA haplotypes. Proc. Natl Acad. Sci. USA 1991; 88: 9717–9721
   PubMed Web of Science ®Google Scholar
• Pociot F., Briant L., Jongeneel C. V., Worsaae H., Mølvig J., Abbal M., et al. Association of tumour necrosis factor (TNF) and class II MHC alleles with the secretion of TNFα and TNFβ by human mononuclear cells: A possible link to insulin‐dependent diabetes mellitus. Eur. J. Immunol 1993; 23: 224–231
   PubMed Web of Science ®Google Scholar
• Udalova I. A., Nedospasov S. A., Webb G. C., Chaplin D. D., Turetskaya R. L. Highly informative typing of the human TNF locus using six adjacent polymorphic markers. Genomics 1993; 16: 180–186
   PubMed Web of Science ®Google Scholar
• Pociot F., Rønningen K. S., Nerup J. Polymorphic analysis of the human MHC‐linked heat shock protein 70 (HSP70–2) and HSP70‐Hom genes in insulin‐dependent diabetes mellitus (IDDM). Scand. J. Immunol 1993; 38: 491–495
   PubMed Web of Science ®Google Scholar
• Milner C. M., Campbell R. D. Polymorphic analysis of the three MHC‐linked HSP70 genes. Immunogenetics 1992; 36: 357–362
   PubMed Web of Science ®Google Scholar
• Steinkasserer A., Koelble K., Sim R. B. Length variation within intron 2 of the human IL‐1 receptor antagonist protein gene (IL1RN). Nucl. Acids Res 1992; 19: 5095
   Google Scholar
• Tarlow J. K., Blakemore A. I.F., Lennard A., Solari R., Hughes H. N., Steinkasserer A., et al. Polymorphism in the human IL‐1 receptor antagonist gene intron 2 is caused by variable numbers of an 86‐bp tandem repeat. Hum. Genet 1993; 91: 403–404
   PubMed Web of Science ®Google Scholar
• Xiang K., Cox N. J., Hallewell R. A., Bell G. I. Multiple Taq I RFLPs at the human manganese superoxide dismutase (SOD2) locus on chromosome 6. Nucleic. Acids Res 1987; 15: 7654
   PubMedGoogle Scholar
• Pociot F., Lorenzen T., Nerup J. A manganese superoxide dismutase (SOD2) gene polymorphism in insulin‐dependent diabetes mellitus. Disease Markers 1993; 11: 267–274
   PubMed Web of Science ®Google Scholar
• Mattiuz P. L., Ihde D., Piazza A., Ceppellini R., Bodmer W. F. New approaches to the population genetic and segregation analysis of the HL‐A system. Histocompatibility Testing, P. I. Terazaki. Munksgaard, Copenhagen 1970; 193–205
   Google Scholar
• HLA 1991. Proceedings of the eleventh international histocompatibility workshop and conference, K. Tsuji, M. Aizawa, T. Sasazuki. Oxford University Press, Oxford 1992
   Google Scholar
• Khalil I., d'Aurol L., Gobet M., Morin L., Lepage V., Deschamps I., et al. A combination of HLA‐DQβ Asp‐57 negative and HLA‐DQα Arg52 confers susceptibility to insulin‐dependent diabetes mellitus. J. Clin. Invest 1990; 85: 1315–1319
   PubMed Web of Science ®Google Scholar
• Auron P. E., Webb A. C., Rosenwasser L. J., Mucci S. F., Rich A., Wolff S. M., Dinarello C. A. Nucleotide sequence of human monocyte interleukin 1 precursor cDNA. Proc. Natl Acad. Sci. USA 1984; 81: 7907–7911
   PubMed Web of Science ®Google Scholar
• Ye K., Dinarello C. A., Clark B. D. Identification of the promotor region of human interieukin 1 type I receptor gene: multiple initiation sites, high G + C content, and constitutive expression. Proc. Natl Acad. Sci. USA 1993; 90: 2295–2299
   PubMedGoogle Scholar
• Barbosa J., Saner B. Do genetic factors play a role in the pathogenesis of diabetic microangiopathy?. Diabetologia 1984; 27: 487–492
   PubMedGoogle Scholar
• Barnett A. H., Pyke D. A. The genetics of diabetic complications. Clinics. Endocrinol. Metabol 1986; 15: 715–726
   PubMedGoogle Scholar
• Irvin W. J., McCallum C. J., Gray R. S., et al. Pancreatic islet‐cell antibodies in diabetes mellitus correlated with the duration and type of diabetes, coexistent autoimmune disease, and HLA type. Diabetes 1977; 26: 138–147
   PubMedGoogle Scholar
• Ludvigsson J., Säfwenberg J., Heding L. G. HLA‐types, c‐peptide and insulin antibodies in juvenile diabetes. Diabetologia 1977; 13: 13–17
   PubMed Web of Science ®Google Scholar
• Möller E., Persson B., Sterky G. HLA phenotypes and diabetic retinopathy. Diabetologia 1978; 14: 155–158
   PubMedGoogle Scholar
• Christau B., Kromann H., Andersen O. O., et al. Incidence, seasonal and geographical patterns of juvenile‐onset insulin‐dependent diabetes mellitus in Denmark. Diabetologia 1977; 13: 281–284
   PubMed Web of Science ®Google Scholar
• Mølbak A. G., Nørgaard K., Christau B., Kjaer M., Nerup J. Secular trend in the incidence on insulin‐dependent diabetes mellitus in Denmark. Acta. Endocrinol 1987; 115(Suppl. 289)48
   Google Scholar
• Khalil L., Deschamps I., Lepage V., Al‐Daccak R., Degos L., Hors J. Dose effect of cis‐and trans‐encoded HLA‐DQαβ heterodimers in IDDM susceptibility. Diabetes 1992; 41: 387–384
   Google Scholar
• Nepom B. S., Schwarz D., Palmer J. P., Nepom G. T. Transcomplementation of HLA genes in IDDM. HLA‐DQ α‐and β‐chains produce hybris molecules in DR3/4 heterozygous. Diabetes 1987; 36: 114–117
   PubMed Web of Science ®Google Scholar
• Thorsby E., Rønningen K. S. Particular HLA‐DQ molecules play a dominant role in determining susceptibility or resistance to type I (insulin‐dependent) diabetes mellitus. Diabetologia 1993; 36: 371–377
   PubMedGoogle Scholar
• Deschamps I., Khalil I. The role of DQ alpha‐beta heterodimers in genetic susceptibility to insulin‐dependent diabetes. Diabetes/Metab. Rev 1993; 9: 71–92
   PubMedGoogle Scholar
• Mandrup‐Pulsen T., Pociot F., Mølvig J., Shapiro I., Nilsson P., Emdal T., et al. Monokine antagonism is reduced in patients with insulin‐dependent diabetes mellitus. Diabetes 1994; 43: 1242–1247
   PubMedGoogle Scholar
• Blom L., Nyström L., Dahlquist G. The Swedish childhood diabetes study. Vaccinations and infections as risk determinants for diabetes in childhood. Diabetologia 1991; 34: 176–181
   PubMed Web of Science ®Google Scholar
• Malaisse W. J., Malaissc‐Lagae F., Sener A., Pipelers D. G. Determinants of the selective toxicity of alloxan to the pancreatic B cell. Proc. Nail Acad. Sci. USA 1982; 79: 927–930
   PubMed Web of Science ®Google Scholar
• Oberley L. W. Free radicals and diabetes. Free Radicals. Biol. Med 1988; 5: 113–124
   PubMed Web of Science ®Google Scholar
• Mandrup‐Poulsen T., Helqvist S., Wogensen L. D., Mølvig J., Pociot F., Janannesen J., et al. Cytokines and free radicals as effector molecules in the destruction of the pancreatic β‐cells. Curr. Top. Microbiol. Immunol 1990; 164: 169–193
   PubMed Web of Science ®Google Scholar
• Asayama K., Kooy N. W., Burr I. M. Effects of vitamin E deficiency on insulin secretory reserve and free radical scavenging systems in islets. J. Lab. Clin. Med 1986; 107: 459–464
   PubMed Web of Science ®Google Scholar
• Borgstahl G. E.O., Parge H. E., Hickey M. J., Bayer W. F., Hallewell R. A., Tainer J. A. The structure of human mitochondrial manganese supcroxide dismutase reveals a novel tetrameric interface of two 4‐helix bundles. Cell 1992; 71: 107–118
   PubMed Web of Science ®Google Scholar
• Easton D. F. Linkage analysis and genetic models for IDDM. Genet. Epidemiol 1989; 6: 83–88
   PubMedGoogle Scholar
• Kockum I., Wassmuth R., Holmberg E., Michelsen B., Lernmark A. HLA‐DQ primarily confers protection and HLA‐DR susceptibility in type 1 (insulin‐dependent) diabetes studied in population‐based affected families and controls. Am. J. Hum. Genet 1994; 53: 150–167
   Google Scholar
• MacDonald M. J., Gottschall J., Hunter J. B., Winter K. L. HLA‐DR4 in insulin‐dependent parents and their offspring: a clue to dominant inheritance. Proc. Natl Acad. Sci. USA 1986; 83: 7049–7053
   PubMedGoogle Scholar
• Pociot F., Mølvig J., Wogensen L., Worsaae H., Dalbøge H., Baek L., et al. A tumour necrosis factor beta gene polymorphism in relation to monokine secretion and insulin‐dependent diabetes mellitus. Scand. J. Immunol 1991; 33: 37–49
   PubMed Web of Science ®Google Scholar
• Pociot F., Wilson A. G., Nerup J., Duff G. W. No independent association between a TNF‐α promotor region polymorphism and insulin‐dependent diabetes mellitus (IDDM). Eur. J. Immunol 1993; 23: 3050–3053
   PubMed Web of Science ®Google Scholar