IgG⁺, CD5⁺ Human Chronic Lymphocytic Leukemia B Cells. Production of IgG Antibodies That Exhibit Diminished Autoreactivity and IgG Subclass Skewing

References

• Kipps T. J. The CD5 B cell. Adv. Immunol. 1989; 47: 117–185
   PubMed Web of Science ®Google Scholar
• Dighiero G., Travade P., Chevret S., Fenaux P., Chastang C., Binet J. L. B-cell chronic lymphocytic leukemia: present status and future directions. Blood 1991; 78: 1901–1914
   PubMed Web of Science ®Google Scholar
• Herzenberg L. A., Stall A. M., Lalor P. A., Sidman C., Moore W. A., Parks D. R., Herzenberg L. A. The Ly-1 B cell lineage. Immunol. Rev. 1986; 93: 81–102
   PubMed Web of Science ®Google Scholar
• Hayakawa K., Hardy R. R. Normal, autoimmune, and malignant CD5+ B cells: the Ly-1 B lineage?. Annu. Rev. Immunol. 1988; 6: 197–218
   PubMed Web of Science ®Google Scholar
• Sthoeger Z. M., Wakai M., Tse D. B., Vinciguerra V. P., Allen S. L., Budman D. R., Lichtman S. M., Schulman P., Weiselberg L. R., Chiorazzi N. Production of autoantibodies by CD5-expressing B lymphocytes from patients with chronic lymphocytic leukemia. J. Exp. Med. 1989; 169: 255–268
   PubMed Web of Science ®Google Scholar
• Preud'homme J. L., Seligman M. Anti-human immunoglobulin G activity of membrane-bound immunoglobulin M in lymphoproliferative disorders. Proc. Natl. Acad. Sci. USA 1972; 69: 2132–2135
   PubMed Web of Science ®Google Scholar
• Broker B. M., Klajman A., Youinou P., Jouquan J., Worman C. P., Murphy J., Mackenzie L., Quartey-Papfio R., Blaschek M., Collins P., Lai S., Lydyard P. M. Chronic lymphocytic leukemia cells secrete multispecific antibodies. J. Autoimmunity 1988; 1: 469–481
   PubMed Web of Science ®Google Scholar
• Borche L., Lim A., Binet J-L., Dighiero G. Evidence that chronic lymphocytic leukemia B lymphocytes are frequently committed to production of natural autoantibodies. Blood 1990; 76: 562–569
   PubMed Web of Science ®Google Scholar
• Kipps T. J., Carson D. A. Autoantibodies in chronic lymphocytic leukemia and related systemic autoimmune diseases. Blood 1993; 81: 2475–2487
   PubMed Web of Science ®Google Scholar
• Kipps T. J., Tomhave E., Chen P. P., Carson D. A. Autoantibody-associated kappa light chain variable region gene expressed in chronic lymphocytic leukemia with little or no somatic mutation. Implications for etiology and immunothcrapy. J. Exp. Med. 1988; 167: 840–852
   PubMed Web of Science ®Google Scholar
• Meeker T. C., Grimaldi J. C., O'Rourke R., Loeb J., Juliusson G., Einhorn S. Lack of detcctablc somatic mutation in the V region of thc Ig H chain gene of a human chronic B lymphocytic leukemia. J. Immunol. 1988; 141: 3994–3998
   PubMed Web of Science ®Google Scholar
• Pratt L. F., Rassenti L., Larrick J., Robbins B., Banks P. M., Kipps T. J. Ig V region gene expression in small lymphocytic lymphoma with little or no somatic mutation. J. Immunol. 1989; 143: 699–705
   PubMed Web of Science ®Google Scholar
• Friedman D. F., Moore J. S., Erikson J., Manz J., Goldman J., Nowell P. C., Silberstein L. E. Variable region gene analysis of an isotype-switched (IgA) variant of chronic lymphocytic leukemia. Blood 1992; 80: 2287–2297
   PubMed Web of Science ®Google Scholar
• Wagner S. D., Luzzatto L. Vk gene segments rearranged in chronic lymphocytic leukemia are distributed over a large portion of the Vk locus and do not show somatic mutation. Eur. J. Imrnunol. 1993; 23: 391–397
   PubMedGoogle Scholar
• Rai K. R., Sawitsky A., Cronkite E. P., Chanana A. D., Levy R. N., Pasternack B. S. Clinical staging of chronic lymphocytic leukemia. Blood 1975; 46: 219–234
   PubMed Web of Science ®Google Scholar
• Koduru P. R.K., Lichtman S. M., Similari T. F., Sun T., Goh J. C., Karp L., Hall W., Hashimoto S., Chiorazzi N., Broome J. D. Serial phenotypic, cytogenetic and molecular genetic studies in Richter's syndrome: demonstration of lymphoma development from the chronic lymphocytic leukaemia cells. Br. J. Haematol. 1993; 85: 613–616
   PubMed Web of Science ®Google Scholar
• Posner M. R., Elbiom H., Santos D. The construction and use of a human-mouse myeloma analogue suitable for the routine production of hybridomas secreting human monoclonal antibodies. Hybridoma. 1987; 6: 611–624
   PubMed Web of Science ®Google Scholar
• Deane M., Norton J. D. Immunoglobulin gene “fingerprinting”: an approach to analysis of B lymphocyte clonality in lymphoproliferative disorders. Br. J. Haematol. 1991; 77: 274–281
   PubMed Web of Science ®Google Scholar
• Hingorani R., Choi I. H., Akolkar P., Gulwani-Akolkar B., Pergolizzi R., Silver J., Gregersen P. K. Clonal predominance of T cell receptors within the CD8+ CD45RO+ subset in normal human subjects. J. Immunol. 1993; 151: 5762–5769
   PubMed Web of Science ®Google Scholar
• Chirgwin J. M., Przybyla A. E., MacDonald R. J., Rutter W. J. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 1979; 18: 5294–5299
   PubMed Web of Science ®Google Scholar
• Larrick J. W., Danielsson L., Breener C. A., Wallace E. F., Abrahamson M., Fry K. E., Borrebaeck C. A.K. Polymerase chain reaction using mixed primers: cloning of human antibody variable region genes from single hybridoma cells. Bio/Technology 1989; 7: 934–938
   Web of Science ®Google Scholar
• Bertin P. A., Marti G. E. Expression of immunoglobulin heavy chain variable region genes in B-chronic lymphocytic leukemia and B-prolymphocytic leukemia cell lines. “Restricted” usage of VH3 family. Ann. NY. Acad. Sci. 1992; 651: 464–466
   PubMedGoogle Scholar
• Kaplan S., Hyman K., Brooks R., Wakai M., Hashimoto S., Furie R., Chiorazzi N. Monoclonal IgM, IgG, and IgA human rheumatoid factors produced by synovial tissuederived, EBV-transformed B cell lines. Clin. Immunol. Immunopathol. 1993; 66: 18–25
   PubMedGoogle Scholar
• Davidson A., Preud'homme J. L., Solomon A., Chang M.-d., Beede S., Diamond B. Idiotypic analysis of myeloma proteins: anti-DNA activity of monoclonal immunoglobulins bearing an SLE idiotype is more common in IgG than IgM antibo dies. J. Immunol. 1987; 138: 1515–1518
   PubMed Web of Science ®Google Scholar
• Paul E., Iliev A. A., Livneh A., Diamond B. The anti-DNA-associated idiotype 8.12 is encoded by the VγII gene family and maps to the vicinity of L chain CDR1. J. Immunol 1992; 149: 3588–3595
   PubMed Web of Science ®Google Scholar
• Davidson A., Smith A., Katz J., Preud'homme J. L., Solomon A., Diamond B. A cross-reactive idiotype on DNA antibodies defines a heavy chain determinant present almost exclusively on IgG antibodies. J. Immunol. 1989; 143: 174–180
   PubMed Web of Science ®Google Scholar
• Aisenberg A. C., Bloch K. J., Long J. C. Cell-surface immunoglobulins in chronic lymphocytic leukemia and allied disorders. Am. J. Med. 1973; 55: 184–191
   PubMed Web of Science ®Google Scholar
• Froland S. S., Natvig J. B. Class, subclass and allelic exclusion of membrane-bound Ig on human B lymphocytes. J. Exp. Med. 1972; 136: 409–414
   PubMedGoogle Scholar
• Mayumi M., Kuritani T., Kubagawa H., Cooper M. D. IgG subclass expression by human B lymphocytes and plasma cells: B lymphocytes precommitted to IgG subclass can be preferentially induced by polyclonal mitogens with T cell help. J. Immunol. 1983; 130: 671–677
   PubMed Web of Science ®Google Scholar
• Perelmutter L. Cell surface IgG subclasses. Monogr. Allergy 1986; 19: 36–40
   PubMedGoogle Scholar
• Sideras P., Nilsson L., Islam K. B., Quintana I. Z., Freihof L., Rosen A., Juliusson G., Hammarstrom L., Smith C. I.E. Transcription of unrearranged IgH chain genes in human B cell malignancies. Biased expression of genes encoded within the first duplication unit of the Ig H chain locus. J Immunol. 1992; 149: 244–252
   PubMedGoogle Scholar
• Sidman C. L., Shultz L. D., Hardy R. R., Hayakawa K., Herzenberg L. A. Production of immunoglobulin isotypes by Ly1+ B cells in viable motheaten and normal mice. Science 1986; 232: 1423–1425
   PubMed Web of Science ®Google Scholar
• Guilbert B., Dighiero G., Avrameas S. Naturally occurring antibodies against nine common antigens in human sera. I. Detection, isolation, and characterization. J. Immunol. 1982; 128: 2179–2781
   Google Scholar
• Dighiero G., Lymberi P., Holmberg D., Lundqvist I., Coutinho A., Avrameas S. High frequency of natural auto-antibodies in normal newborn mice. J. Immunol. 1985; 134: 765–771
   PubMed Web of Science ®Google Scholar
• Rossi F., Kazatchkine M. D. Anti idiotypes against autoantibodies in pooled normal human polyspecific Ig. J. Immunol. 1989; 143: 4104–4109
   PubMed Web of Science ®Google Scholar
• Berneman A., Ternyck T., Avrameas S. Natural mouse IgG reacts with self antigens including molecules involved in the immune response. Eur. J. Immunol. 1992; 22: 625–633
   PubMed Web of Science ®Google Scholar
• Hurez V., Kaveri S-V., Kazatchine M. D. Expression and control of the natural autoreactive IgG repertoire in normal human serum. Eur. J. Immunol. 1993; 23: 783–789
   PubMed Web of Science ®Google Scholar
• Kang C-Y, Cheng H-L, Rudikoff S., Kohler H. Idiotypic self binding of a dominant germline idiotype (T15). Autobody activity is affected by antibody valency. J. Exp. Med. 1987; 165: 1332–1343
   PubMedGoogle Scholar
• Caron P. C., Laird W., Co M. S., Avdalovic N. M., Queen C., Scheinberg D. A. Engineered humanized dimeric forms of IgG are more effective antibodies. J. Exp. Med. 1992; 176: 1191–1195
   PubMed Web of Science ®Google Scholar
• Cavacini L. A., Emes C. L., Power J., Duval M., Posner M. R. Effect of antibody valency on interaction with cell-surface expressed HIV-1 and viral neutralization. J. Immunol. 1994; 152: 2538–2545
   PubMedGoogle Scholar
• Diamond B., Scharff M. D. Somatic mutations of the T15 heavy chain gives rise to an antibody with autoantibody specificity. Proc. Natl. Acad. Sci. USA 1984; 81: 5841–5844
   PubMed Web of Science ®Google Scholar
• Chen C., Roberts V. A., Rittenberg M. B. Generation and analysis of random point mutations in an antibody CDR2 sequence: many mutated antibodies lose their ability to bind antigen. J. Exp. Med. 1992; 176: 855–866
   PubMed Web of Science ®Google Scholar
• Kussie P. H., Parhami-Seren B., Wysocki L. J., Margolies M. N. A single engineered amino acid substitution changes antibody fine specificity. J. Immunol. 1994; 152: 146–152
   PubMed Web of Science ®Google Scholar
• Pennell C. A., Arnold L. W., Haughton G., Clark S. H. Restricted Ig variable region gene expression in Ly-1+ B cell lymphomas. J. Immunol. 1988; 141: 2788–2796
   PubMed Web of Science ®Google Scholar
• Tarlinton D., Stall A. M., Herzenberg L. A. Repetitive usage of immunoglobulin VH and D segments in CD5+ Ly-1 B clones of (NZB/NZW)F1 mice. EMBO. J. 1988; 7: 3705–3710
   PubMed Web of Science ®Google Scholar
• Baccala R., VoQuang T., Gilbert M., Ternynck T., Avrameas S. Two murinc natural polyreactive autoantibodies are encoded by nonmutated germ-line genes. Proc. Natl. Acad. Sci. USA 1989; 86: 4624–4628
   PubMed Web of Science ®Google Scholar
• Braun J., King L. Unique V gene usage by B-Ly-1 cell lines, and a discordance between isotype switch commitment and variable region hypermutation. J. Mol. Cell Immunol. 1989; 4: 121–127
   PubMedGoogle Scholar
• Cal J., Humphries C., Richardson A., Tucker P. W. Extensive and selective mutation of a rearranged VH5 gene in human B cell chronic lymphocytic leukemia. J. Exp. Med. 1992; 176: 1073–1081
   PubMedGoogle Scholar
• Rassenti L. Z., Kipps T. J. Lack of extensive mutations in the VH5 genes used in common B cell chronic lymphocytic leukemia. J. Exp. Med. 1993; 177: 1039–1046
   PubMed Web of Science ®Google Scholar
• Zupo S., Dono M., Azzoni L., Chiorazzi N., Ferrarini M. Evidence for differential responsiveness of human CD5 + B cell subsets to T cell-independent mitogens. Eur. J. Immunol. 1991; 21: 351–359
   PubMedGoogle Scholar
• Fu S. M., Chiorazzi N., Kunkel H. G., Halper J. P., Harris S. R. Induction of in vitro differentiation and immunoglobulin synthesis of human leukemic B lymphocytes. J. Exp. Med. 1978; 148: 1570–1578
   PubMed Web of Science ®Google Scholar
• Chiorazzi N., Fu S. M., Kunkel H. G. Induction of polyclonal antibody synthesis by human allogeneic and autologous helper factors. J. Exp. Med. 1979; 149: 1543–1548
   PubMedGoogle Scholar
• Zupo S., Dono M., Massara R., Taborelli G., Chiorazzi N., Ferrarini M. Expression of CD5 and CD38 by human CD5- B cells: requirement for special stimuli. Eur. J. Immunol. 1994; 24: 1426–1433
   PubMed Web of Science ®Google Scholar
• Gauchat J-F, Henchoz S., Mazzei G., Aubry J-P, Brunner T., Blasey H., Life P., Talabot D., Flores-Romo L., Thompson J., Kishi K., Butterfield J., Dahinden C., Bonnefoy J-Y. Induction of human IgE synthesis in B cells by mast cells and basophils. Nature 1993; 365: 340–344
   PubMed Web of Science ®Google Scholar