Determinant-Regulated Onset of Experimental Autoimmune Encephalomyelitis: Distinct Epitopes of Myelin Proteolipid Protein Mediate Either Acute or Delayed Disease in SJL/J Mice

References

• McFarlin D E., McFarland H F. Multiple sclerosis. N. Eng. J. Med 1982; 307: 1183
   PubMed Web of Science ®Google Scholar
• Waksman B H. Mechanisms in multiple sclerosis. Nature 1985; 318: 104–105
   PubMed Web of Science ®Google Scholar
• Zamvil S S., Steinman L. The T lymphocyte in experimental allergic encephalomyelitis. Ann. Rev. Immunol 1990; 8: 579–621
   PubMed Web of Science ®Google Scholar
• Tuohy V K. Peptide determinants of myelin proteolipid protein (PLP) in autoimmune demyelinating disease: A review. Neurochem. Res 1994; 19: 935–944
   Google Scholar
• Clayton J P., Gammon G M., Ando D G., Kono D H., Hood L., Sercarz E E. Peptide-specific prevention of experimental allergic encephalomyelitis. Neonatal tolerance induced to the dominant T cell determinant of myelin basic protein. J. Exp. Med 1989; 169: 1681–1691
   PubMedGoogle Scholar
• Lehmann P V., Forsthuber T., Miller A., Sercarz E E. Spreading of T cell autoimmunity to cryptic determinants of an autoantigen. Nature 1992; 358: 155–157
   PubMed Web of Science ®Google Scholar
• Tuohy V K., Thomas D M. Sequence 104–117 of myelin proteolipid protein is a cryptic encephalitogenic T cell determinant for SJL/J mice. J. Neuroimmunol 1995; 56: 161–170
   PubMed Web of Science ®Google Scholar
• Tuohy V K., Lu Z., Sobel R A., Laursen R A., Lees M B. Idenincation of an encephalitogenic determinant of myelin proteolipid protein for SJL mice. J. Immunol 1989; 142: 1523–1526
   PubMed Web of Science ®Google Scholar
• Greer J M., Kuchroo V K., Sobel R A., Lees M B. Identification and characterization of a second encephalitogenic determinant of myelin proteolipid protein (residues 178–191) for SJL mice. J. Immunol 1992; 149: 783–788
   PubMed Web of Science ®Google Scholar
• Milner R J., Lai C, Nave K-A., Lenoir D., Ogata J., Sutcliffe J G. Nucleotide sequences of two mRNAs for rat brain myelin proteolipid protein. Cell 1985; 42: 931–939
   PubMed Web of Science ®Google Scholar
• Macklin W B., Campagnoni C W., Deininger P L., Gar-Dinier M V. Structure and expression of the mouse myelin proteolipid protein gene. J. Neurosci. Res 1987; 18: 383–394
   PubMedGoogle Scholar
• Folch J., Lees M., Sloane Stanley G H. A simple method for the isolation and purification of total lipides from animal tissues. J. Biol. Chem 1957; 226: 497–509
   PubMed Web of Science ®Google Scholar
• Tuohy V K., Sobel R A., Lees M B. Myelin proteolipid protein-induced experimental allergic encephalomyelitis. Variations of disease expression in different strains of mice. J. Immunol 1988; 140: 1868–1873
   PubMed Web of Science ®Google Scholar
• Taylor P M., Thomas D B., Mills K H.G. In vitro culture of T cell lines and clones. Lymphocytes -A Practical Approach, G G.B Klaus. IRL Press, OxfordEngland 1987; 133–147
   Google Scholar
• Weaver C T., Hawrylowicz CM., Unanue E. T helper cell subsets require the expression of distinct costimulatory signals by antigen-presenting cell. Proc. Natl Acad. Sci. USA 1988; 85: 8181–8185
   PubMed Web of Science ®Google Scholar
• van der Veen R C., Trotter J L., Kapp J A. Immune processing of proteolipid protein by subsets of antigen-presenting spleen cells. J. Neuroimmunol 1992; 38: 139–146
   Google Scholar
• Powell M B., Mitchell D., Lederman J., Buckmeier J., Zamvil S S., Graham M., Ruddle N H., Steinman L. Lym-photoxin and tumor necrosis factor-alpha production by myelin basic protein-specific T cell clones correlates with encephalitogenicity. Internal. Immunol 1990; 2: 539–544
   PubMed Web of Science ®Google Scholar
• Yednock T A., Cannon C, Fritz L C., Sanchez-Madrid F., Steinman L., Karin N. Prevention of experimental allergic encephalomyelitis by antibodies against α4β1 inte-grin. Nature 1992; 356: 63–66
   PubMed Web of Science ®Google Scholar
• Baron J L., Mardi J A., Ruddle N H., Hashim G., Jan-Eway C A. Surface expression of a4 integrin by CD4 T cells is required for their entry into brain parenchyma. J. Exp. Med 1993; 177: 57–68
   PubMed Web of Science ®Google Scholar
• Kuchroo V K., Martin C A., Greer J M., Ju S T., Sobel R A.A, Dorf M E. Cytokines and adhesion molecules contribute to the ability of myelin proteolipid protein-specific T cell clones to mediate experimental allergic encephalomyelitis. J. Immunol 1993; 151: 4371–4382
   PubMed Web of Science ®Google Scholar
• Tuohy V K., Lu Z., Sobel R A., Laursen R A., Lees M B. A synthetic peptide from myelin proteolipid protein induces experimental allergic encephalomyelitis. J. Immunol 1988; 141: 1126–1130
   PubMed Web of Science ®Google Scholar
• Sobel R A., Tuohy V K., Lees M B. Parental MHC molecule haplotype expression in (SJL/J × SWR)F1 mice with acute experimental allergic encephalomyelitis induced with two different synthetic peptides of myelin proteolipid protein. J Immunol 1991; 146: 543–549
   Google Scholar
• Zamvil S S., Mitchell D J., Lee N E., Moore A C., Waldor M K., Sakai K., Rothbard J B., McDevitt H O., Steinman L., Acha-Orbea H. Predominant expression of a T cell receptor V beta gene subfamily in autoimmune encephalomyelitis. J. Exp. Med 1988; 167: 1586–1596
   PubMed Web of Science ®Google Scholar
• Happ M P., Kiraly A S., Offner H., Vandenbark A., Heber-Katz E. The autoreactive T cell population in experimental allergic encephalomyelitis: T cell receptor beta-chain rearrangements. J. Neuroimmunol 1988; 19: 191–204
   Google Scholar
• Chluba J., Steeg C, Becker A., Wekerle H., Epplen J T. T cell receptor beta chain usage in myelin basic protein-specific rat T lymphocytes. Eur. J. Immunol 1989; 19: 279–284
   PubMedGoogle Scholar
• Burns F R., Li X B., Shen N., Offner H., Chou Y K., Vandenbark A A., Heber-Katz E. Both rat and mouse T cell receptors specific for the encephalitogenic determinant of myelin basic protein use similar V alpha and V beta chain genes even though the major histocompatibility complex and encephalitogenic determinants being recognized are different. J. Exp. Med 1989; 169: 27–39
   PubMed Web of Science ®Google Scholar
• Kono D H., Urban J L., Horvath S J., Ando D G., Saavedra R A., Hood L. Two minor determinants of myelin basic protein induce experimental allergic encephalomyelitis in SJL/J mice. J. Exp. Med 1988; 168: 213–227
   PubMed Web of Science ®Google Scholar
• Sakai K., Sinha A A., Mitchell D J., Zamvil S S., Rothbard J B., McDevitt H O., Steinman L. Involvement of distinct murine T-cell receptors in the autoimmune encephalitogenic response to nested epitopes of myelin basic protein. Proc. Natl Acad. Sci. USA 1988; 85: 8608–8612
   PubMed Web of Science ®Google Scholar
• Madrenas J., Wange R L., Wang J L., Isakov N., Samelson L E., Germain R N. ζ Phosphorylation withiout ZAP-70 activation induced by TCR antagonists or partial agonists. Science 1995; 267: 515–518
   PubMed Web of Science ®Google Scholar
• Kuchroo V K., Greer J M., Kaul D., Ishioka G., Franco A., Sette A., Sobel R A., Lees M B. A single TCR antagonist peptide inhibits experimental allergic encephalomyelitis mediated by a diverse Tcell repertoire. J. Immunol 1994; 153: 3326–3336
   PubMed Web of Science ®Google Scholar
• Whitham R H., Kotzin B L., Buenafe A C., Weinberg A D., Jones R E., Hashim G A., Hoy CM., Vandenbark A A., Offner H. Treatment of relapsing experimental autoimmune encephalomyelitis with T cell receptor peptides. J. Neurosci. Res 1993; 35: 115–128
   Google Scholar
• van der Veen R C., Stohlman S A. encephalitogenic Th 1 cells are inhibited by Th2 cells with related peptide specificity: Relative roles of interleukin (IL)-4 and IL-10. J. Neuroimmunol 1993; 48: 213–220
   PubMed Web of Science ®Google Scholar
• Kuchroo V K., Das M P., Brown J A., Ranger A M., Zamvil S S., Sobel R A., Weiner H L., Nabavi N., Glimcher L H. B7–1 and B7–2 costimulatory molecules activate differentially the Thl/Th2 developmental pathways: Application to autoimmune disease therapy. Cell 1995; 80: 707–718
   PubMed Web of Science ®Google Scholar
• Cross A H., Hasim G A., Raine C S. Adoptive transfer of experimental allergic encephalomyelitis and localization of the encephalitogenic epitope in the SWR mouse. J. Neuroimmunol 1991; 31: 59–66
   Google Scholar
• Cross A H., Tuohy V K., Raine C S. Development of reactivity to new myelin antigens during chronic relapsing autoimmune demyelination. Cell. Immunol 1993; 146: 261–269
   PubMed Web of Science ®Google Scholar
• Shaw M K., Kim C, Ho K-L., Lisak R P., Tse H Y. A combination of adoptive transfer and antigenic challenge induces consistent murine experimental autoimmune encephalomyelitis in C57BL/6 mice and other reputed resistant strains. J. Neuroimmunol 1992; 39: 139–150
   PubMed Web of Science ®Google Scholar
• van der Veen R C, Trotter J L., Hickey W F., Kapp J A. The development and characterization of encephalitogenic cloned T cells specific for myelin proteolipid protein. J. Neuroimmunol 1990; 26: 139–145
   PubMedGoogle Scholar
• Kuchroo V K., Sobel R A., Laning J C., Martin C A., Greenfield E., Dorf M E., Lees M B. Experimental allergic encephalomyelitis mediated by cloned T cells specific for a synthetic peptide of myelin proteolipid protein. Fine specificity and T cell receptor V beta usage. J. Immunol 1992; 148: 3776–3782
   Google Scholar
• McCarron R M., Fallis R J., McFarlin D E. Alterations in T cell antigen specificity and class II restriction during the course of chronic relapsing experimental allergic encephalomyelitis. J. Neuroimmunol 1990; 29: 73–79
   PubMed Web of Science ®Google Scholar
• Perry L L., Barzaga-Gilbert E., Trotter J L. T cell sensi-tization to proteolipid protein in myelin basic protein-induced relapsing experimental allergic encephalomyelitis. J. Neuroimmunol 1991; 33: 7–15
   PubMed Web of Science ®Google Scholar
• Lobb R R., Hemler M E. The pathophysiologic role of a4 integrins in vivo. J. Clin. Invest 1994; 94: 1722–1728
   PubMed Web of Science ®Google Scholar
• Jakubowski A., Newman-Ehrenfels B., Pepinsky R B., Burkly L C. Vascular cell adhesion molecule-Ig fusion protein selectively targets activated a4-integrin receptors in vivo. Inhibition of autoimmune diabetes in an adoptive transfer model in nonobese diabetic mice. J. Immunol 1995; 155: 1204–1210
   Google Scholar
• Linthicum D S., Frelinger J A. Acute autoimmune encephalomyelitis in mice. II. Susceptibility is controlled by the combination of H-2 and histamine sensitization genes. J. Exp. Med 1982; 156: 31–40
   PubMedGoogle Scholar