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Original Article

Characterisation of the Antibody Response to the Extracellular Region of Recombinant Thyrotropin Receptor

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Pages 75-84 | Received 17 Feb 1997, Accepted 23 Apr 1997, Published online: 07 Jul 2009

References

  • Gupta M. K. Thyrotropin receptor antibodies: Advances and importance of detection techniques in thyroid disease. Clin Biochem 1992; 25: 193–199
  • Weetman A. P., McGregor A. M. Autoimmune thyroid disease: further developments in our understanding. Endocrine Revs 1994; 15: 788–830
  • Rees Smith B., McLachlan S. M., Furmaniak J. Autoantibodies to the thyrotropin receptor. Endocr Rev 1988; 9: 106–100
  • Konishi J., Iida Y., Kasagi K., Misaki T., Nakashima T., Endo K., Mori T., Shinpo S., Nohara Y., Matsuura N., Torizuka K. Primary myxoedema with thyrotropin-binding inhibitor immunoglobulin; clinical and laboratory findings in 15 patients. Ann Intern Med 1985; 103: 26–31
  • DiCerbo A., Paola R. D., Bonati M., Zingrillo M., Fil-Ippis V. D., Corda D. Subgroups of Graves' patients identified on the basis of the biochemical activities of their immunoglobulins. J Clin Endocrinol Metab 1995; 80: 2785–2790
  • Kosugi S., Ban T., Akamizu T., Kohn L. D. Identification of separate determinants on the thyrotropin receptor reactive with Graves' thyroid stimulating antibodies and with thyroid-stimulating blocking antibodies in idiopathic myxoedema: These determinants have no homologous sequences on gonadotropin receptors. Mol Endocrinol 1992; 6: 168–180
  • Nagayama Y., Wadsworth H. L., Russo D., Chazen-Balk G. D., Rapoport B. Binding domain of stimulatory and inhibitory thyrotropin (TSH) receptor autoantibodies determined with chimeric TSH-lutropin/choriogonadotropin receptors. J Clin Invest 1991; 88: 336–340
  • Costagliola S., Alcade L., Tonacchera M., Ruf J., Vas-Sart G., Ludgate M. Induction of thyrotropin receptor (TSH-R) autoantibodies and thyroiditis in mice immunised with the recombinant TSH-R. Biochem Biophx Res Commun 1994; 199: 1027–1034
  • Wagle N. M., Dallas J. S., Seetharamaiah G. S., Fan I.-J., Desai R. K., Memar O., Rajaraman S., Prab-Hakar B. S. Induction of hyperthyroxinemia in BALB/c but not in several other strains of mice. Autoim-mun 1994; 18: 103–112
  • Costagliola S., Alcade L., Ruf J., Vassart G., Ludgate M. Overexpression of the cellular domain of the thyrotropin receptor in bacteria; production of thyrotropin binding inhibiting immunoglobulins. J Mol Endocrinol 1994; 13: 11–21
  • Dallas J. S., Desai R. K., Cunningham S. J., Morris J. C, Seetharamaiah G. S., Wagle N., Goldblum R. M., Prabhakar B. S. Thyrotropin (TSH) interacts with multiple discrete regions of the TSH receptor: Polyclonal rabbit antibodies to one or more of these regions can inhibit TSH binding and function. Endocrinol 1994; 134: 1437–1445
  • Harfst E., Ross M. S., Nussey S. S., Johnstone A. P. Production of antibodies to the human thyrotropin receptor and their use in characterising eukaryotically expressed functional receptor. Mol Cell Endocrinol 1994; 102: 77–84
  • Carayanniotis G., Huang G. C, Nicholson L. B., Scott T., Allain P., McGregor A. M., Banga J. P. Unaltered thyroid function in mice responding to a highly immunogenic thyrotropin receptor: implications for the establishment of a mouse model for Graves' disease. Clin Expt Immunol 1995; 99: 294–302
  • Banga J. P. Immunopathogenicity of thyrotropin receptor-ability to induce autoimmune thyroid disease in an experimental animal model. A Commentary. Expt Clin Endocrinol Metab 1996; 104: 32–34
  • Shimojo N., Kohno Y., Yamaguchi K., Kikuoka S., Hoshioka A., Niimi H., Hirai A., Tamura Y., Saito Y., Kohn L. D., Tahara K. Induction of Graves-like disease in mice by immunisation with fibroblasts transfected with the thyrotropin receptor and a class II molecule. Proc Natl Acad Sci 1996; 93: 11074–11079
  • Huang G. C, Page M. J., Nicholson L. B., Collison K. S., McGregor A. M., Banga J. P. The thyrotropin hormone receptor of Graves' disease: overexpression of the extracellular domain in insect cells using recombinant baculovirus and analysis of the autoantibody response. J Mol Endocrinol 1993; 10: 127–142
  • Nicholson L. B., Vlase H., Graves P., Nilsson M., Mol-Ne J., Huang G. C., Morgenthaler N. G., Davies T. F., McGregor A. M., Banga J. P. Monoclonal antibodies to the human thyrotropin receptor: epitope mapping and binding to the native receptor on the basolateral plasma membrane of thyroid follicular cells. J Mol Endocrinol 1996; 16: 159–170
  • Morris J. C, Gibson J. L., Haas E. J., Bergert E. R., Dallas J. S., Prabhakar B. S. Identification of epitopes and affinity purification of thyroid stimulating autoantibodies using synthetic human TSH receptor peptides. Autoimmun 1994; 17: 287–299
  • Gupta M. K., McBride N., Secic M., Sheeler L., Koh-Se L., Licata A., Schumacher P., Hoogworf B. TSH receptor antibodies in Graves' ophthalmology: high association and predictive role of thyroid stimulating but not TSH binding inhibitory antibodies. Endocrine J 1994; 2: 305–310
  • Morgenthaler N. G., Kim M. R., Tremble J., Huang G. C., Richter W., Gupta M., Scherbaum W. A., McGregor A. M., Banga J. P. Human IgG autoantibodies to the thyrotropin receptor from Epstein Barr Virus transformed B lymphocytes: characterisation by immuno-precipitation with recombinant antigen and biological activity. J Clin Endocrinol Metab 1996; 81: 3155–3161
  • Perret J., Ludgate M., Libert F., Gerard C., Dumont E.-J., Vassart G., Parmentier M. Stable expression of the human TSH receptor in CHO cells and characterization of differently expressing clones. Biochem BiophysRes Comm 1990; 171: 1044–1050
  • Morgenthaler N. G., Tremble J., Huang G. C, Scherbaum W. A., McGregor A. M., Banga J. P. Binding of anti-thyrotropin receptor autoantibodies in Graves' disease serum to nascent, in vitro, translated thyrotropin receptor; ability to map epitopes recognised by antibodies. J Clin Endocrinol Metab 1996; 81: 700–706
  • Xie Y. B., Wang H., Segaloff D. L. Extracellular domain of lutropin-choriogonadotropin receptor expressed in transfected cells binds choriogonadotropin with high affinity. J Biol Chem 1990; 265: 21411–21414
  • Pajot-Augy E., Couture L., Bozon V., Remy J. J., Biac-He G., Severini M., Huet J. C, Pernollet J. C., Salesse R. High level expression of recombinant porcine LH receptor in baculovirus infected insect cells or caterpillars. J Mol Endocrinol 1995; 14: 51–66
  • Nagayama Y., Takeshita A., Luo W., Ashizawa K., Tokoyama N., Nagataki S. High affinity binding of thyrotropin (TSH) and thyroid stimulating autoantibody for the TSH receptor extracellular domain. Thyroid 1994; 4: 155–159
  • Seetharamaiah G. S., Kurosky A., Desai R. K., Dallas J. S., Prabakar B. S. A recombinant extracellular domain of the thyrotropin receptor binds TSH in the absence of membranes. Endocrinol 1994; 134: 549–554
  • Harfst E., Johnstone A. P., Nussey S. S. Characterization of the extracellular region of the human thyrotropin receptor expressed as a recombinant protein. J Mol Endocrinol 1992; 9: 227–236
  • Huang G. C, Collison K. S., McGregor A. M., Banga J. P. Expression of a human thyrotropin receptor fragment in Escherichia coli, and its interaction with the hormone and autoantibodies from patients with Graves' disease. J Mol Endocrinol 1992; 8: 137–144
  • Rowley M. J., Maeda T., Mackay I. R., Loveland B. E., McMullen G. L., Tribbick G., Bernard C. C. A. Differing epitope selection of experimentally induced and natural antibodies to a disease specific autoantigen, the E2 subunit of pyruvate dehydrogenase complex (PDC-E2). Int Immunol 1992; 4: 1245–1253
  • Vlase H., Nakashima M., Graves P. N., Tomer Y., Morris J. C., Davies T. F. Defining the major antibody epitopes on the human thyrotropin receptor in immunised mice: evidence for intramolecular epitope spreading. Endocrinol 1995; 136: 4415–4423
  • Desai R. K., Dallas J. S., Gupta M., Seetharamaiah S.-G., Fan J. L., Tahara K., Kohn L. D., Prabakar S.-B. Dual mechanism of perturbation of thyrotropin mediated activation of thyroid cells by antibodies to the thyrotropin receptor (TSHR) and TSHR derived peptides. Endocrinol 1993; 77: 658–663
  • Dallas J. S., Cunningham S. J., Patibanda S. A., Seetharamaiah G. S., Morris J. C, Tahara K., Kohn L. D., Prabhakar B. S. Thyrotropin (TSH) receptor antibodies (TSHrAb) can inhibit TSH-mediated cyclic adenosine 3',5'-monophosphate production in thyroid cells by either blocking TSH binding or affecting a step subsequent to TSH binding. Endocrinol 1996; 137: 3329–3339
  • Kim W. B., Cho B. Y., Park H. Y., Lee H. K., Kohn D.-L., Tahara K., Koh C. S. Epitopes for thyroid stimulating antibodies in Graves' sera: a possible link of heterogeneity to differences in response to antithyroid drug treatment. J Clin Endocrinol Metab 1996; 81: 1758–1767

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