178
Views
11
CrossRef citations to date
0
Altmetric
Research Article

Immunomodulatory effects of rosuvastatin on hepatic ischemia/reperfusion induced injury

&
Pages 555-561 | Received 13 Nov 2009, Accepted 21 Dec 2009, Published online: 02 Feb 2010

References

  • Han, J.Y., Fan, J.Y., Horie, Y., Miura, S., Cui, D.H., Ishii, H., Hibi, T., Tsuneki, H., Kimura, I. Ameliorating effects of compounds derived from Salvia miltiorrhiza root extract on microcirculatory disturbance and target organ injury by ischemia and reperfusion. Pharmacol. Ther. 2008, 117, 280–295.
  • Jiang, H., Meng, F., Li, W., Tong, L., Qiao, H., Sun, X. Splenectomy ameliorates acute multiple organ damage induced by liver warm ischemia reperfusion in rats. Surgery 2007, 141, 32–40.
  • Shin, T., Kuboki, S., Huber, N., Eismann, T., Galloway, E., Schuster, R., Blanchard, J., Pritts, T.A., Lentsch, A.B. Activation of peroxisome proliferator-activated receptor-gamma during hepatic ischemia is age-dependent. J. Surg. Res. 2008, 147, 200–205.
  • van Gulik, T.M., de Graaf, W., Dinant, S., Busch, O.R., Gouma, D.J. Vascular occlusion techniques during liver resection. Dig. Surg. 2007, 24, 274–281.
  • He, X.S., Ma, Y., Wu, L.W., Wu, J.L., Hu, R.D., Chen, G.H., Huang, J.F. Dynamical changing patterns of glycogen and enzyme histochemical activities in rat liver graft undergoing warm ischemia injury. World J. Gastroenterol. 2005, 11, 2662–2665.
  • Lentsch, A.B., Kato, A., Yoshidome, H., McMasters, K.M., Edwards, M.J. Inflammatory mechanisms and therapeutic strategies for warm hepatic ischemia/reperfusion injury. Hepatology 2000, 32, 169–173.
  • Liu, T.Z., Lee, K.T., Chern, C.L., Cheng, J.T., Stern, A., Tsai, L.Y. Free radical-triggered hepatic injury of experimental obstructive jaundice of rats involves overproduction of proinflammatory cytokines and enhanced activation of nuclear factor kappaB. Ann. Clin. Lab. Sci. 2001, 31, 383–390.
  • Jaeschke, H. Reactive oxygen and mechanisms of inflammatory liver injury. J. Gastroenterol. Hepatol. 2000, 15, 718–724.
  • Weiss, S.J. Tissue destruction by neutrophils. N. Engl. J. Med. 1989, 320, 365–376.
  • Shao, H., Shen, Y., Liu, H., Dong, G., Qiang, J., Jing, H. Simvastatin suppresses lung inflammatory response in a rat cardiopulmonary bypass model. Ann. Thorac. Surg. 2007, 84, 2011–2018.
  • Manzoni, M., Rollini, M. Biosynthesis and biotechnological production of statins by filamentous fungi and application of these cholesterol-lowering drugs. Appl. Microbiol. Biotechnol. 2002, 58, 555–564.
  • Kwak, B., Mulhaupt, F., Myit, S., Mach, F. Statins as a newly recognized type of immunomodulator. Nat. Med. 2000, 6, 1399–1402.
  • Case, C.C., Ballantyne, C.M. Statins and inflammatory markers. Curr. Atheroscler. Rep. 2002, 4, 42–47.
  • Ikeda, Y., Young, L.H., Lefer, A.M. Rosuvastatin, a new HMG-CoA reductase inhibitor, protects ischemic reperfused myocardium in normocholesterolemic rats. J. Cardiovasc. Pharmacol. 2003, 41, 649–656.
  • Bulhak, A., Sjoquist, P., Pernow, J. Rosuvastatin protects the myocardium against ischaemia-reperfusion injury via inhibition of GGPP synthesis. Cardiovasc. J. S. Afr. 2004, 15, S11.
  • Weinberg, E.O., Scherrer-Crosbie, M., Picard, M.H., Nasseri, B.A., MacGillivray, C., Gannon, J., Lian, Q., Bloch, K.D., Lee, R.T. Rosuvastatin reduces experimental left ventricular infarct size after ischemia-reperfusion injury but not total coronary occlusion. Am. J. Physiol. Heart Circ. Physiol. 2005, 288, H1802–H1809.
  • Bulhak, A.A., Gourine, A.V., Gonon, A.T., Sjöquist, P.O., Valen, G., Pernow, J. Oral pre-treatment with rosuvastatin protects porcine myocardium from ischaemia/reperfusion injury via a mechanism related to nitric oxide but not to serum cholesterol level. Acta Physiol. Scand. 2005, 183, 151–159.
  • Di Napoli, P., Taccardi, A.A., Grilli, A., De Lutiis, M.A., Barsotti, A., Felaco, M., De Caterina, R. Chronic treatment with rosuvastatin modulates nitric oxide synthase expression and reduces ischemia-reperfusion injury in rat hearts. Cardiovasc. Res. 2005, 66, 462–471.
  • Dibazar, F., Hajipour, B., Hosseinian, M.M., Hemmati, M.R., Ghandiha, A. Simvastatin decreases hepatic ischaemia/reperfusion-induced liver and lung injury in rats. Folia Morphol. (Warsz) 2008, 67, 231–235.
  • Bouali, S., Evrard, A., Chastanet, M., Lesch, K.P., Hamon, M., Adrien, J. Sex hormone-dependent desensitization of 5-HT1A autoreceptors in knockout mice deficient in the 5-HT transporter. Eur. J. Neurosci. 2003, 18, 2203–2212.
  • Lukivskaya, O., Knas, M., Dudzik, D., Borzym-Kluczyk, M., Lis, R., Buko, V., Zwierz, K. Effects of statins on liver fibrosis reversibility and activities of lysosomal exoglycosidases E&C. Hepatology 2007, 3, 14–17.
  • Jaeschke, H., Farhood, A. Neutrophil and Kupffer cell-induced oxidant stress and ischemia-reperfusion injury in rat liver. Am. J. Physiol. 1991, 260, G355–G362.
  • McGown, C.C., Brookes, Z.L. Beneficial effects of statins on the microcirculation during sepsis: the role of nitric oxide. Br. J. Anaesth. 2007, 98, 163–175.
  • Locksley, R.M., Killeen, N., Lenardo, M.J. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell 2001, 104, 487–501.
  • Ishihara, K., Hirano, T. IL-6 in autoimmune disease and chronic inflammatory proliferative disease. Cytokine Growth Factor Rev. 2003, 13, 357–368.
  • Chello, M., Patti, G., Candura, D., Mastrobuoni, S., Di Sciascio, G., Agrò, F., Carassiti, M., Covino, E. Effects of atorvastatin on systemic inflammatory response after coronary bypass surgery. Crit. Care Med. 2006, 34, 660–667.
  • Souza Neto, J.L., Araújo Filho, I., Rego, A.C., Dominici, V.A., Azevedo, I.M., Egito, E.S., Brandão-Neto, J., Medeiros, A.C. Effects of simvastatin in abdominal sepsis in rats. Acta Cir. Bras. 2006, 21(Suppl. 4), 8–12.
  • Almeida, J.L., Sampietre, S.N., Mendonça Coelho, A.M., Trindade Molan, N.A., Machado, M.C., Monteiro da Cunha, J.E., Jukemura, J. Statin pretreatment in experimental acute pancreatitis. JOP 2008, 9, 431–439.
  • Li, W., Asagami, T., Matsushita, H., Lee, K.H., Tsao, P.S. Rosuvastatin attenuates monocyte-endothelial cell interactions and vascular free radical production in hypercholesterolemic mice. J. Pharmacol. Exp. Ther. 2005, 313, 557–562.
  • Weber, C., Schober, A., Zernecke, A. Chemokines: key regulators of mononuclear cell recruitment in atherosclerotic vascular disease. Arterioscler. Thromb. Vasc. Biol. 2004, 24, 1997–2008.
  • Sironi, L., Gianazza, E., Gelosa, P., Guerrini, U., Nobili, E., Gianella, A., Cremonesi, B., Paoletti, R., Tremoli, E. Rosuvastatin, but not simvastatin, provides end-organ protection in stroke-prone rats by antiinflammatory effects. Arterioscler. Thromb. Vasc. Biol. 2005, 25, 598–603.
  • de Mendonça-Filho, H.T., Pereira, K.C., Fontes, M., Vieira, D.A., de Mendonça, M.L., Campos, L.A., Castro-Faria-Neto, H.C. Circulating inflammatory mediators and organ dysfunction after cardiovascular surgery with cardiopulmonary bypass: a prospective observational study. Crit. Care 2006, 10, R46.
  • Eskdale, J., Kube, D., Tesch, H., Gallagher, G. Mapping of the human IL10 gene and further characterization of the 5′ flanking sequence. Immunogenetics 1997, 46, 120–128.
  • Wang, Q., Fang, C.H., Hasselgren, P.O. Intestinal permeability is reduced and IL-10 levels are increased in septic IL-6 knockout mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2001, 281, R1013–R1023.
  • Grimbaldeston, M.A., Nakae, S., Kalesnikoff, J., Tsai, M., Galli, S.J. Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B. Nat. Immunol. 2007, 8, 1095–1104.
  • Zhang, J., Cheng, X., Liao, Y., Lu, B., Yang, B., Ge, H., Wang, M., Liu, Y., Guo, Z., Zhang, L. Simvastatin regulates myocardial cytokine expression and improves ventricular remodeling in rats after acute myocardial infarction. Cardiovasc. Drugs Ther. 2005, 19, 13–21.
  • Karupiah, C. Cytokines and chemokines in infectious diseases handbook [Book Reviews]. Immunol. Cell Biol. 2003, 81, 496–498.
  • Palinski, W., Tsimikas, S. Immunomodulatory effects of statins: mechanisms and potential impact on arteriosclerosis. J. Am. Soc. Nephrol. 2002, 13, 1673–1681.
  • Van Laethem, J.L., Eskinazi, R., Louis, H., Rickaert, F., Robberecht, P., Devière, J. Multisystemic production of interleukin 10 limits the severity of acute pancreatitis in mice. Gut 1998, 43, 408–413.
  • Steffens, S., Mach, F. Drug insight: immunomodulatory effects of statins—potential benefits for renal patients? Nat. Clin. Pract. Nephrol. 2006, 2, 378–387.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.