References
- Larson AM, Polson J, Fontana RJ, et al. Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study. Hepatology 2005;42:1364–72
- Ramaiah SK. A toxicologist guide to the diagnostic interpretation of hepatic biochemical parameters. Food Chem Toxicol 2007;45:1551–7
- Russo MW, Galanko JA, Shrestha R, et al. Liver transplantation for acute liver failure from drug induced liver injury in the United States. Liver Transplant 2004;10:1018–23
- Shinohara M, Ybanez MD, Win S, et al. Silencing glycogen synthase kinase-3beta inhibits acetaminophen hepatotoxicity and attenuates JNK activation and loss of glutamate cysteine ligase and myeloid cell leukemia sequence 1. J Biol Chem 2010;285:8244–55
- Bronstein AC, Spyker DA, Cantilena Jr LR, et al. 2008 Annual report of the American association of poison control centers' National Poison Data System (NPDS): 26th annual report. Clin Toxicol 2009;47:911–1084
- Hung OL, Nelson LS. Acetaminophen. In: Tintinalli JE, Kelen GD, Stapczynski JS, eds. Tintinalli's emergency medicine: a comprehensive study guide. 6th ed. New York: McGraw-Hill; 2004:1088–94
- Corcoran GB, Mitchell JR, Vaishnav YN, Horning EC. Evidence that acetaminophen and N-hydroxyacetaminophen form a common arylating intermediate, N-acetyl-p-benzoquinoneimine. Mol Pharmacol 1980;18:536–42
- Bessems JG, Vermeulen NP. Paracetamol (acetaminophen)-induced toxicity: molecular and biochemical mechanisms, analogues and protective approaches. Crit Rev Toxicol 2001;31:55–138
- Jaeschke H, Bajt ML. Intracellular signaling mechanisms of acetaminophen-induced liver cell death. Toxicol Sci 2006;89:31–41
- Lauterburg BH, Corcoran GB, Mitchell JR. Mechanism of action of N-acetylcysteine in the protection against the hepatotoxicity of acetaminophen in rats in vivo. J Clin Invest 1983;71:980–91
- Lardizabal MN, Nocito AL, Daniele SM, et al. Reference genes for real-time PCR quantification of microRNAs and messenger RNAs in rat models of hepatotoxicity. PLoS one 2012;7:e36323–36
- Gul H, Uysal B, Cakir E, et al. The protective effects of ozone therapy in a rat model of acetaminophen-induced liver injury. Environ Toxicol Pharmacol 2012;34:81–6
- Ezzat T, Dhar DK, Malago M, Olde Damink SW. Dynamic tracking of stem cells in an acute liver failure model. World J Gastroenterol 2012;18:507–16
- Singhal R, Ganey PE, Roth RA. Complement activation in acetaminophen-induced liver injury in mice. J Pharm Exp Ther 2012;341:377–85
- Rajasekaran A, Periyasamy M. Hepatoprotective effect of ethanolic extract of Trichosanthes lobata on paracetamol-induced liver toxicity in rats. Chinese Med 2012;7:12–18
- Eesha BR, Mohanbabu Amberkar V, Meena Kumari K, et al. Hepatoprotective activity of Terminalia paniculata against paracetamol induced hepatocellular damage in Wistar albino rats. Asian Pac J Trop Med 2011;4:466–9
- Jain NK, Singhai AK. Protective effects of Phyllanthus acidus (L.) Skeels leaf extracts on acetaminophen and thioacetamide induced hepatic injuries in Wistar rats. Asian Pac J Trop Med 2011;4:470–4
- Luster MI, Simeonova PP, Gallucci R, Matheson J. Tumor necrosis factor alpha and toxicology. Crit Rev Toxicol 1999;29:491–511
- Edwards CK, Borcherding SM, Zhang J, Borcherding DB. Chapter No. 13. In: Schook LB, Laskin DL, eds. Xenobiotics and inflammation. New York: Academic Press; 1994:301–12
- Laskin DL, Pilaro AM. Potential role of activated macrophages in acetaminophen hepatotoxicity. I. Isolation and characterization of activated macrophages from rat liver. Toxicol Appl Pharmacol 1986;86:204–15
- Laskin DL, Pilaro AM, Ji S. Potential role of activated macrophages in acetaminophen hepatotoxicity. II. Mechanism of macrophage accumulation and activation. Toxicol Appl Pharmacol 1986;86:216–26
- Laskin DL, Gardner CR, Price VF, Jollow DJ. Modulation of macrophage functioning abrogates the acute hepatotoxicity of acetaminophen. Hepatology 1995;21:1045–50
- Wallach D, Varfolomeev EE, Malinin NL, et al. Tumor necrosis factor receptor and Fas signaling mechanisms. Annu Rev Immunol 1999;17:331–67
- Gardner C, Laskin D. Sinusoidal cells in liver injury and repair. In: Sahu S, ed. Hepatotoxicity: from genomics to in vitro and in vivo models. West Sussex: John Wiley & Sons; 2007:341–70
- Laskin D, Gardner C. Nonparenchymal cells, inflammatory macrophages, and hepatotoxicity. In: Kaplowitz N, DeLeve L, eds. Drug-induced liver disease. New York: Informa Heatlthcare; 2007:159–84
- Laskin DL. Macrophages and inflammatory mediators in chemical toxicity: a battle of forces. Chem Res Toxicol 2009;22:1376–85
- Wullaert A, van Loo G, Heyninck K, Beyaert R. Hepatic tumor necrosis factor signaling and nuclear factor-kappaB: effects on liver homeostasis and beyond. Endocrine Rev 2007;28:365–86
- Leist M, Gantner F, Bohlinger I, et al. Tumor necrosis factor-induced hepatocyte apoptosis precedes liver failure in experimental murine shock models. Am J Clin Pathol 1995;146:1220–34
- Czaja MJ, Xu J, Alt E. Prevention of carbon tetrachloride-induced rat liver injury by soluble tumor necrosis factor receptor. Gastroenterology 1995;108:1849–54
- Blazka ME, Wilmer JL, Holladay SD, et al. Role of proinflammatory cytokines in acetaminophen hepatotoxicity. Toxicol Appl Pharmacol 1995;133:43–52
- Blazka ME, Elwell MR, Holladay SD, et al. Histopathology of acetaminophen-induced liver changes: role of interleukin 1 alpha and tumor necrosis factor alpha. Toxicol Pathol 1996;24:181–9
- Simpson KJ, Lukacs NW, McGregor AH, et al. Inhibition of tumour necrosis factor alpha does not prevent experimental paracetamol-induced hepatic necrosis. J Pathol 2000;190:489–94
- Boess F, Bopst M, Althaus R, et al. Acetaminophen hepatotoxicity in tumor necrosis factor/lymphotoxin-alpha gene knockout mice. Hepatology 1998;27:1021–9
- Ishida Y, Kondo T, Tsuneyama K, et al. The pathogenic roles of tumor necrosis factor receptor p55 in acetaminophen-induced liver injury in mice. J Leukoc Biol 2004;75:59–67
- Nikolaus S, Raedler A, Kuhbacker T, et al. Mechanisms in failure of infliximab for Crohn's disease. Lancet 2000;356:1475–9
- Ajith TA, Hema U, Aswathy MS. Zingiber officinale Roscoe prevents acetaminophen-induced acute hepatotoxicity by enhancing hepatic antioxidant status. Food Chem Toxicol 2007;45:2267–72
- Kuvandik G, Duru M, Nacar A, et al. Effects of erdosteine on acetaminophen-induced hepatotoxicity in rats. Toxicol Pathol 2008;36:714–19
- Ozer JS, Chetty R, Kenna G, et al. Enhancing the utility of alanine aminotransferase as a reference standard biomarker for drug-induced liver injury. Regul Toxicol Pharmacol 2010;56:237–46
- Liu WX, Jia FL, He YY, Zhang BX. Protective effects of 5-methoxypsoralen against acetaminophen-induced hepatotoxicity in mice. World J Gastroenterol 2012;18:2197–202
- Karakus E, Halici Z, Albayrak A, et al. Agomelatine: an antidepressant with new potent hepatoprotective effects on paracetamol induced liver damage in rats. Hum Exp Toxicol 2012; DOI: 10.1177/096032712472994
- Younes M, Cornelius S, Siegers CP. Ferrous ion supported in vivo lipid peroxidation induced by paracetamol – its relation to hepatotoxicity. Res Commun Chem Pathol Pharmacol 1986;51:89–99
- Muriel P, Garciapina T, Perez-Alvarez V, Mourelle M. Silymarin protects against paracetamol-induced lipid peroxidation and liver damage. J Appl Toxicol 1992;12:439–42
- Saoudi M, El Feki A. Protective role of Ficus carica stem extract against hepatic oxidative damage induced by methanol in male wistar rats. Evid Based Complement Alternat Med 2012;2012:1–8
- Lee DM, Hoffman WH, Carl GF, et al. Lipid peroxidation and antioxidant vitamins prior to, during, after correction of diabetic ketoacidosis. J Diabetes Complications 2002;16:294–300
- Curtis SJ, Moritz M, Snodgrass PJ. Serum enzymes derived from liver cell fractions. I. The response to carbon tetrachloride intoxication in rats. Gastroenterology 1972;62:84–92
- Hwang HJ, Kim IH, Nam TJ. Effect of a glycoprotein from Hizikia fusiformis on acetaminophen-induced liver injury. Food Chem Toxicol 2008;46:3475–81
- Vane JR, Mitchell JA, Appleton I, et al. Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation. Proc Nat Acad Sci USA 1994;91:2046–50
- Choi EY, Hwang HJ, Kim IH, Nam TJ. Protective effects of a polysaccharide from Hizikia fusiformis against ethanol toxicity in rats. Food Chem Toxicol 2009;47:134–9
- Hsu CC, Lin KY, Wang ZH, et al. Preventive effect of Ganoderma amboinense on acetaminophen-induced acute liver injury. Phytomedicine 2008;15:946–50
- Drapier JC, Wietzerbin J, Hibbs Jr JB. Interferon-gamma and tumor necrosis factor induce the L-arginine-dependent cytotoxic effector mechanism in murine macrophages. Eur J Immunol 1988;18:1587–92
- Ding AH, Nathan CF, Stuehr DJ. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production. J Immunol 1988;141:2407–12
- Yamauchi N, Watanabe N, Kuriyama H, et al. Suppressive effects of intracellular glutathione on hydroxyl radical production induced by tumor necrosis factor. Int J Cancer 1990;46:884–8
- Bautista AP, Schuler A, Spolarics Z, Spitzer JJ. Tumor necrosis factor-alpha stimulates superoxide anion generation by perfused rat liver and Kupffer cells. Am J Physiol 1991;261:G891–5
- Adamson GM, Billings RE. Tumor necrosis factor induced oxidative stress in isolated mouse hepatocytes. Arch Biochem Biophys 1992;294:223–9
- Essid E, Dernawi Y, Petzinger E. Apoptosis induction by OTA and TNF-alpha in cultured primary rat hepatocytes and prevention by silibinin. Toxins 2012;4:1139–56
- Pierce RH, Campbell JS, Stephenson AB, et al. Disruption of redox homeostasis in tumor necrosis factor-induced apoptosis in a murine hepatocyte cell line. Am J Pathol 2000;157:221–36
- Albano E. Oxidative mechanisms in the pathogenesis of alcoholic liver disease. Mol Aspects Med 2008;29:9–16
- Schwabe RF, Brenner DA. Mechanisms of liver injury. I. TNF-alpha-induced liver injury: role of IKK, JNK: ROS pathways. Am J Physiol Gastrointest Liver Physiol 2006;290:G583–9
- Baud V, Karin M. Signal transduction by tumor necrosis factor and its relatives. Trends Cell Biol 2001;11:372–7
- Jaeschke H, Gores GJ, Cederbaum AI, et al. Mechanisms of hepatotoxicity. Toxicol Sci 2002;65:166–76
- James LP, Mayeux PR, Hinson JA. Acetaminophen-induced hepatotoxicity. Drug Metab Dispos 2003;31:1499–506
- Yang BS, Ma YJ, Wang Y, et al. Protective effect and mechanism of stronger neo-minophagen C against fulminant hepatic failure. World J Gastroenterol 2007;13:462–6
- Thorburn A. Death receptor-induced cell killing. Cell Signal 2004;16:139–44
- Sun WY, Wei W, Gui SY, et al. Protective effect of extract from Paeonia lactiflora, Astragalus membranaceus against liver injury induced by bacillus Calmette-Guerin and lipopolysaccharide in mice. Basic Clin Pharmacol Toxicol 2008;103:143–9
- Yang R, Zhang S, Kajander H, et al. Ringer's lactate improves liver recovery in a murine model of acetaminophen toxicity. BMC Gastroenterol 2011;11:125–35
- Das J, Ghosh J, Manna P, Sil PC. Taurine protects acetaminophen-induced oxidative damage in mice kidney through APAP urinary excretion and CYP2E1 inactivation. Toxicology 2010;269:24–34
- Uzkeser M, Karakus E, Albayrak A, et al. Protective effect of Panax ginseng against N-acetyl-p-aminophenol-induced hepatotoxicity in rats. Afr J Pharm Pharmacol 2012;6:2634–42
- Pech T, Finger T, Fujishiro J, et al. Perioperative infliximab application ameliorates acute rejection associated inflammation after intestinal transplantation. Am J Transplant 2010;10:2431–41
- Couriel DR, Saliba R, de Lima M, et al. A phase III study of infliximab and corticosteroids for the initial treatment of acute graft-versus-host disease. Biol Blood Marrow Transplant 2009;15:1555–62
- Mitchell JR, Jollow DJ, Potter WZ, et al. Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism. J Pharm Exp Ther 1973;187:185–94