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Research Article

Protective effect of astragaloside IV on lipopolysaccharide-induced cardiac dysfunction via downregulation of inflammatory signaling in mice

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Pages 428-433 | Received 27 May 2015, Accepted 03 Jul 2015, Published online: 16 Sep 2015

References

  • Merx MW, Weber C. Sepsis and the heart. Circulation 2007;116:793–802
  • Bone R, Balk R, Cerra F, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Chest 1992;101:1644–1655
  • Watanabe Y, Shibata R, Ouchi N, et al. Adiponectin ameliorates endotoxin-induced acute cardiac injury. Biomed Res Int 2014;2014:382035
  • Zanotti-Cavazzoni SL, Hollenberg SM. Cardiac dysfunction in severe sepsis and septic shock. Curr Opin Crit Care 2009;15:392–397
  • Kang-Woo L, So Young J, Sun-Mi C, Eun Jin Y. Effects of ginsenoside Re on LPS-induced inflammatory mediators in BV2 microglial cells. BMC Comp Alt Med 2012;12:196
  • Avlas O, Fallach R, Shainberg A, et al. Toll-like receptor 4 stimulation initiates an inflammatory response that decreases cardiomyocyte contractility. Antioxid Redox Signal 2011;15:1895–1909
  • Sun B, Xiao J, Sun XB, Wu Y. Notoginsenoside R1 attenuates cardiac dysfunction in endotoxemic mice: an insight into oestrogen receptor activation and PI3K/Akt signalling. Br J Pharmacol 2013;168:1758–1770
  • Liu CJ, Lo JF, Kuo CH, et al. Akt mediates 17beta-estradiol and/or estrogen receptor-alpha inhibition of LPS-induced tumor necrosis factor-alpha expression and myocardial cell apoptosis by suppressing the JNK1/2-NFkappaB pathway. J Cell Mol Med 2009;13:3655–3667
  • Dong M, Hu N, Hua Y, et al. Chronic Akt activation attenuated lipopolysaccharide-induced cardiac dysfunction via Akt/GSK3beta-dependent inhibition of apoptosis and ER stress. Biochim Biophys Acta 2013;1832:848–863
  • Kwon HJ, Park YD. Determination of astragalin and astragaloside content in Radix Astragali using high-performance liquid chromatography coupled with pulsed amperometric detection. J Chromatogr A 2012;1232:212–217
  • Tohda C, Tamura T, Matsuyama S, Komatsu K. Promotion of axonal maturation and prevention of memory loss in mice by extracts of Astragalus mongholicus. Br J Pharmacol 2006;149:532–541
  • Zhao Y, Li Q, Zhao W, et al. Astragaloside IV and cycloastragenol are equally effective in inhibition of endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation in the endothelium. J Ethnopharmacol 2015;169:210–218
  • Ji K, Chen J, Hu J, et al. The protective effect of astragaloside IV against benzo[a]pyrene induced endothelial progenitor cell dysfunction. Life Sci 2015;132:13–19
  • He CL, Yi PF, Fan QJ, et al. Xiang-Qi-Tang and its active components exhibit anti-inflammatory and anticoagulant properties by inhibiting MAPK and NF-kappaB signaling pathways in LPS-treated rat cardiac microvascular endothelial cells. Immunopharmacol Immunotoxicol 2013;35:215–224
  • Wang S-G, Xu Y, Xie H, et al. Astragaloside IV prevents lipopolysaccharide-induced injury in H9C2 cardiomyocytes. Chin J Nat Med 2015;13:127–132
  • Hessel MH, Atsma DE, van der Valk EJ, et al. Release of cardiac troponin I from viable cardiomyocytes is mediated by integrin stimulation. Pflugers Arch 2008;455:979–986
  • Ha T, Lu C, Liu L, et al. TLR2 ligands attenuate cardiac dysfunction in polymicrobial sepsis via a phosphoinositide 3-kinase-dependent mechanism. Am J Physiol Heart Circ Physiol 2010;298:H984–H991
  • Landesberg G, Gilon D, Meroz Y, et al. Diastolic dysfunction and mortality in severe sepsis and septic shock. Eur Heart J 2012;33:895–903
  • Luan A, Tang F, Yang Y, et al. Astragalus polysaccharide attenuates isoproterenol-induced cardiac hypertrophy by regulating TNF-alpha/PGC-1alpha signaling mediated energy biosynthesis. Environ Toxicol Pharmacol 2015;39:1081–1090
  • Xiang Li, Lijing Jiang, Shenghui Lin, et al. Inhibition of mTORC1 renders cardiac protection against lipopolysaccharide. Int J Clin Exp Pathol 2014;7:8432–8442
  • Flierl MA, Rittirsch D, Huber-Lang MS, et al. Molecular events in the cardiomyopathy of sepsis. Mol Med 2008;14:327–336
  • Horton J, Maass D, White J, Sanders B. Nitric oxide modulation of TNF-alpha-induced cardiac contractile dysfunction is concentration dependent. Am J Physiol Heart Circ Physiol 2000;278:H1955–H1965
  • Kolattukudy PE, Quach T, Bergese S, et al. Myocarditis induced by targeted expression of the MCP-1 gene in murine cardiac muscle. Am J Pathol 1998;152:101–111
  • Kawai T, Akira S. Signaling to NF-κB by Toll-like receptors. Trends Mol Med 2007;13:460–469
  • Jiang S, Zhu W, Li C, et al. alpha-Lipoic acid attenuates LPS-induced cardiac dysfunction through a PI3K/Akt-dependent mechanism. Int Immunopharmacol 2013;16:100–107

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