Chlorogenic acid and luteolin synergistically inhibit the proliferation of interleukin-1β-induced fibroblast-like synoviocytes through regulating the activation of NF-κB and JAK/STAT-signaling pathways

References

• Bartok B, Firestein GS. Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis. Immunol Rev 2010;233:233–255
   PubMed Web of Science ®Google Scholar
• Fan L, Wang Q, Liu R, et al. Citrullinated fibronectin inhibits apoptosis and promotes the secretion of pro-inflammatory cytokines in fibroblast-like synoviocytes in rheumatoid arthritis. Arthritis Res Ther 2012;14:R266
   PubMed Web of Science ®Google Scholar
• Huber LC, Distler O, Tarner I, et al. Synovial fibroblasts: key players in rheumatoid arthritis. Rheumatology (Oxford) 2006;45:669–675
   PubMed Web of Science ®Google Scholar
• Baeuerle PA, Henkel T. Function and activation of NF-kappa B in the immune system. Annu Rev Immunol 1994;12:141–179
   PubMed Web of Science ®Google Scholar
• Bresnihan B, Cobby M. Clinical and radiological effects of anakinra in patients with rheumatoid arthritis. Rheumatology (Oxford) 2003;42:ii22–28
   PubMed Web of Science ®Google Scholar
• Fujisawa K, Aono H, Hasunuma T, et al. Activation of transcription factor NF-kappa B in human synovial cells in response to tumor necrosis factor alpha. Arthritis Rheum 1996;39:197–203
   PubMed Web of Science ®Google Scholar
• Handel ML, McMorrow LB, Gravallese EM. Nuclear factor-kappa B in rheumatoid synovium. Localization of p50 and p65. Arthritis Rheum 1995;38:1762–1770
   PubMed Web of Science ®Google Scholar
• Bond M, Baker AH, Newby AC. Nuclear factor κB activity is essential for matrix metalloproteinase-1 and -3 upregulation in rabbit dermal fibroblasts. Biochem Biophys Res Commun 1999;264:561–567
   PubMed Web of Science ®Google Scholar
• Georganas C, Liu H, Perlman H, et al. Regulation of IL-6 and IL-8 expression in rheumatoid arthritis synovial fibroblasts: the dominant role for NF-kappa B but not C/EBP beta or c-Jun. J Immunol 2000;165:7199–7206
   PubMed Web of Science ®Google Scholar
• Morel JC, Park CC, Kumar P, Koch AE. Interleukin-18 induces rheumatoid arthritis synovial fibroblast CXC chemokine production through NFkappaB activation. Lab Invest 2001;81:1371–1383
   PubMed Web of Science ®Google Scholar
• Youn J, Kim HY, Park JH, et al. Regulation of TNF-α-mediated hyperplasia through TNF receptors, TRAFs, and NF-κB in synoviocytes obtained from patients with rheumatoid arthritis. Immunol Lett 2002;83:85–93
   PubMed Web of Science ®Google Scholar
• Choe JY, Park KY, Park SH, et al. Regulatory effect of calcineurin inhibitor, tacrolimus, on IL-6/sIL-6R-mediated RANKL expression through JAK2-STAT3-SOCS3 signaling pathway in fibroblast-like synoviocytes. Arthritis Res Ther 2013;15:R26
   PubMed Web of Science ®Google Scholar
• Hirano T, Ishihara K, Hibi M. Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors. Oncogene 2000;19:2548–2556
   PubMed Web of Science ®Google Scholar
• Moncada-Pazos A, Obaya AJ, Viloria CG, et al. The nutraceutical flavonoid luteolin inhibits ADAMTS-4 and ADAMTS-5 aggrecanase activities. J Mol Med 2011;89:611–619
   PubMed Web of Science ®Google Scholar
• Shouda T, Yoshida T, Hanada T, et al. Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis. J Clin Invest 2001;108:1781–1788
   PubMed Web of Science ®Google Scholar
• Suzuki A, Yamamoto N, Jokura H, et al. Chlorogenic acid attenuates hypertension and improves endothelial function in spontaneously hypertensive rats. J Hypertens 2006;24:1065–1073
   PubMed Web of Science ®Google Scholar
• Sonoda M, Nishiyama T, Matsukawa Y, Moriyasu M. Cytotoxic activities of flavonoids from two Scutellaria plants in Chinese medicine. J Ethnopharmacol 2004;91:65–68
   PubMed Web of Science ®Google Scholar
• Wu C, Luan H, Zhang X, et al. Chlorogenic acid protects against atherosclerosis in ApoE-/- mice and promotes cholesterol efflux from RAW264.7 macrophages. PLoS One 2014;9:e95452
   PubMed Web of Science ®Google Scholar
• Sato Y, Itagaki S, Kurokawa T, et al. In vitro and in vivo antioxidant properties of chlorogenic acid and caffeic acid. Int J Pharm 2011;403:136–138
   PubMed Web of Science ®Google Scholar
• Xu JG, Hu QP, Liu Y. Antioxidant and DNA-protective activities of chlorogenic acid isomers. J Agric Food Chem 2012;60:11625–11630
   PubMed Web of Science ®Google Scholar
• dos Santos MD, Almeida MC, Lopes NP, de Souza GE. Evaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acid. Biol Pharm Bull 2006;29:2236–2240
   PubMed Web of Science ®Google Scholar
• Liu YJ, Zhou CY, Qiu CH, et al. Chlorogenic acid induced apoptosis and inhibition of proliferation in human acute promyelocytic leukemia HL60 cells. Mol Med Rep 2013;8:1106–1110
   PubMed Web of Science ®Google Scholar
• Jung HA, Jin SE, Min BS, et al. Anti-inflammatory activity of Korean thistle Cirsium maackii and its major flavonoid, luteolin 5-O-glucoside. Food Chem Toxicol 2012;50:2171–2179
   PubMed Web of Science ®Google Scholar
• Sun GB, Sun X, Wang M, et al. Oxidative stress suppression by luteolin-induced heme oxygenase-1 expression. Toxicol Appl Pharmacol 2012;265:229–240
   PubMed Web of Science ®Google Scholar
• Manju V, Nalini N. Protective role of luteolin in 1,2-dimethylhydrazine induced experimental colon carcinogenesis. Cell Biochem Funct 2007;25:189–194
   PubMed Web of Science ®Google Scholar
• Lee JH, Han Y. Antiarthritic effect of lonicerin on Candida albicans arthritis in mice. Arch Pharm Res 2011;34:853–859
   PubMed Web of Science ®Google Scholar
• Hou Y, Wu J, Huang Q, Guo L. Luteolin inhibits proliferation and affects the function of stimulated rat synovial fibroblasts. Cell Biol Int 2009;33:135–147
   PubMed Web of Science ®Google Scholar
• Kang BJ, Ryu J, Lee CJ, Hwang SC. Luteolin inhibits the activity, secretion and gene expression of MMP-3 in cultured articular chondrocytes and production of MMP-3 in the rat knee. Biomol Ther 2014;22:239–245
   PubMed Web of Science ®Google Scholar
• Mori T, Miyamoto T, Yoshida H, et al. IL-1β and TNFα-initiated IL-6-STAT3 pathway is critical in mediating inflammatory cytokines and RANKL expression in inflammatory arthritis. Int Immunol 2011;23:701–712
   PubMed Web of Science ®Google Scholar
• Guo HF, Liu SX, Zhang YJ, et al. High mobility group box 1 induces synoviocyte proliferation in rheumatoid arthritis by activating the signal transducer and activator transcription signal pathway. Clin Exp Med 2011;11:65–74
   PubMed Web of Science ®Google Scholar
• Wang J, Ma J, Dong L, et al. Effect of anatase TiO2 nanoparticles on the growth of RSC-364 rat synovial cell. J Nanosci Nanotechnol 2013;13:3874–3879
   PubMed Web of Science ®Google Scholar
• Aupperle K, Bennett B, Han Z, et al. NF-kappa B regulation by I kappa B kinase-2 in rheumatoid arthritis synoviocytes. J Immunol 2001;166:2705–2711
   PubMed Web of Science ®Google Scholar
• Firestein GS. NF-kappaB: holy grail for rheumatoid arthritis? Arthritis Rheum 2004;50:2381–2386
   PubMed Web of Science ®Google Scholar
• Simmonds RE, Foxwell BM. Signalling, inflammation and arthritis: NF-kappaB and its relevance to arthritis and inflammation. Rheumatology (Oxford) 2008;47:584–590
   PubMed Web of Science ®Google Scholar
• Miyazawa K, Mori A, Yamamoto K, Okudaira H. Constitutive transcription of the human interleukin-6 gene by rheumatoid synoviocytes: spontaneous activation of NF-kappaB and CBF1. Am J Pathol 1998;152:793–803
   PubMed Web of Science ®Google Scholar
• Okamoto H, Yamamura M, Morita Y, et al. The synovial expression and serum levels of interleukin-6, interleukin-11, leukemia inhibitory factor, and oncostatin M in rheumatoid arthritis. Arthritis Rheum 1997;40:1096–1105
   PubMed Web of Science ®Google Scholar
• Ospelt C, Neidhart M, Gay RE, Gay S. Synovial activation in rheumatoid arthritis. Front Biosci 2004;9:2323–2334
   PubMed Web of Science ®Google Scholar
• Valencia X, Higgins JM, Kiener HP, et al. Cadherin-11 provides specific cellular adhesion between fibroblast-like synoviocytes. J Exp Med 2004;200:1673–1679
   PubMed Web of Science ®Google Scholar
• Konttinen YT, Ainola M, Valleala H, et al. Analysis of 16 different matrix metalloproteinases (MMP-1 to MMP-20) in the synovial membrane: different profiles in trauma and rheumatoid arthritis. Ann Rheum Dis 1999;58:691–697
   PubMed Web of Science ®Google Scholar
• Pap T, Shigeyama Y, Kuchen S, et al. Differential expression pattern of membrane-type matrix metalloproteinases in rheumatoid arthritis. Arthritis Rheum 2000;43:1226–1232
   PubMed Web of Science ®Google Scholar
• Yamanaka H, Makino K, Takizawa M, et al. Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in rheumatoid synovium. Lab Invest 2000;80:677–687
   PubMed Web of Science ®Google Scholar
• Alghasham A, Rasheed Z. Therapeutic targets for rheumatoid arthritis: progress and promises. Autoimmunity 2014;47:77–94
   PubMed Web of Science ®Google Scholar
• O'Brien CA, Gubrij I, Lin SC, et al. STAT3 activation in stromal/osteoblastic cells is required for induction of the receptor activator of NF-κB ligand and stimulation of osteoclastogenesis by gp130-utilizing cytokines or interleukin-1 but not 1,25-dihydroxyvitamin D3 or parathyroid hormone. J Biol Chem 1999;274:19301–19308
   PubMed Web of Science ®Google Scholar
• Fonseca JE, Santos MJ, Canhão H, Choy E. Interleukin-6 as a key player in systemic inflammation and joint destruction. Autoimmun Rev 2009;8:538–542
   PubMed Web of Science ®Google Scholar
• Neurath MF, Finotto S. IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer. Cytokine Growth Factor Rev 2011;22:83–89
   PubMed Web of Science ®Google Scholar
• Rose-John S, Waetzig GH, Scheller J, et al. The IL-6/sIL-6R complex as a novel target for therapeutic approaches. Expert Opin Ther Targets 2007;11:613–624
   PubMed Web of Science ®Google Scholar