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Research Article

Induction of Apoptosis in Mouse Thymocytes by Cyclospori: in Vivo Study

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Pages 359-388 | Published online: 27 Sep 2008

References

  • White D. J., Caine R. Y. The use of cyclosporin A. Immunosuppression in organ grafting. Immunol.Rev. 1982; 65: 115
  • Kaufman Y., Chang A. E., Robb R. J., Rosenberg S. A., Miller S. D. Mechanism of cyclosporin A: inhibition of lymphokine secretion studied with antigen stimulated T cell hybridomas. J. Immunol. 1984; 133: 3107
  • Gelfand E., Cheung R. K., Mills G. B. The cyclosporins inhibit lymphocyte activation at more than on site. J. Immunol. 1987; 138: 1115
  • Stutman O. Intrathymic and extrathymic T cell maturation. Immunol. Rev. 1978; 42: 138
  • Sprent J., Lo D., Gao E., Ron R. T cell selection in the thymus. Immunol. Rev. 1988; 101: 173
  • Hiramine C., Hojo K., Matsumoto H., Koseto M., Itoh M. Differential effect of cyclosporine in vivo on the distribution of T cell subsets in the thymus, spleen, and lymph nodes. Transplantation 1989; 47: 499
  • Beschorner W. E., Di Gennaro K. A., Hess A. D., Santos G. W. Cyclosporin and the thymus: influence of irradiation and age on thymic immunopathology and recovery. Cell. Immunol. 1987; 110: 350
  • Beschorner W. E., Nammoun J. D., Hess A. D., Shinn C. A., Santos G. W. Cyclosporin A and the thymus. Immunopathology. Am. J. Pathol. 1987; 126: 487
  • Beschorner W. E., Olson J. L., Hess A. D., Di Gennaro K. A., Santos G. W. Cyclosporin-induced cell-mediated injury of the thymic medullary epithelium. Transplantation 1988; 45: 797
  • Fabien N. H., Auger C., Moreira A., Monier J. C. Effects of cyclosporin A on mouse thymus: immunochemical and ultrastructural studies. Thymus. 1992; 20: 153
  • Jenkins M. K., Schwartz R. H., Pardoll D. M. Effect of cyclosporin A on T cell developpemnt and clonal deletion. Science 1988; 241: 1655
  • Shi Y., Sahai B. M., Green D. R. Cyclosporin A inhibits activation-induced cell death in T cell hybridomas and thymocytes. Nature 1989; 339: 625
  • Shi Y., Szalay M. G., Paskar L., Boyer M., Singh B., Green D. R. Activation-induced cell death in T-cell hybridomas is due to apoptosis. Morphologic aspects and DNA fragmentation. J. Immunol. 1990; 144: 3326
  • Yasutomi D., Odaka C., Saito S., Niizeki H., Kizaki H., Tadakuma T. Inhibition of programmed cell death by cyclosporin A; preferential blocking of cell death induced by signals via TCR/CD3 complex and its mode of action. Immunology. 1992; 77: 68
  • Kerr J. F.R., Wyllie A. H., Currie A. R. Abasic biological phenomenon with wide ranging implications in tissue kinetics. Cancer. 1972; 26: 239
  • Wyllie A. H. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 1980; 284: 555
  • Arends M., Morris R., Wyllie A. H. Apoptosis: the role of the endonuclease. Am. J. Pathol. 1990; 136: 593
  • Shi Y., Bissonnette R. P., Parfray N., Zcalay M., Kubo R. T., Green D. R. In vivo administration of monoclonal antibodies to the CD3/T-cell receptor complex induces cell death (apoptosis) in immature thymocytes. J. Immunol. 1991; 146: 3340
  • Hiramine C., Hojo K., Matsumoto H. Abnormal distribution of T cell subsets in the thymus of cyclosporin A (CsA) treated mice. Thymus 1943; 1, 1988
  • Lundberg K. Dexamethasone and 2,3,7,8-tetrachlorodibenzo-p-dioxin can induce thymic atrophy by different mecanisms in mice. Biochemical and biophysical research communications 1991; 178: 16
  • Auger C., Monier J. C., Savino W., Dardenne M. Localization of thymulin (FTS-Zn) in mouse thymus. Comparative data using monoclonal antibodies following different plastic embedding procedures. Biol. Cell. 1984; 52: 139
  • Nicoletti I., Migliorati G., Pagliacci M. C., Grignani F., Riccardi C. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide stainingand flow cytometry. J. Immunol. Methods. 1991; 139: 271
  • Takeuchi A., Habu S., Okumura K., Suzuki G. Cyclosporin A and anti-Ia antibody cause a maturation defect of CD4±CD8- cells in organcultured fetal thymus. Immunology. 1989; 66: 362
  • Tanaka M., Shinohara K., Fukumoto T., Tanaka H., Kaneko T. Effect of cyclosporin A on rat thymus: time course analysis by immunoperoxidase technique and flow cytofluorometry. Clin. Exp. Immunol. 1988; 72216
  • Mc Carthy S. A., Cacchione R. N., Mainwaring M. S., Walker J. A., Cairns J. S. The effects of immunosuppressive drugs on the regulation of activation-induced apoptotic cell death in thymocytes. Tmnsplantation 1992; 54: 543
  • Me Conkey D. J., Hartzell P., Nicotera P., Orrenius S. Calcium activated DNA fragmentation kills immature thymocytes. FASEB J. 1989b; 3: 1843
  • Iseki R., Mukai M., Iwata M. Regulation of T lymphocyte apoptosis. Signals for the antagonism between activation and glucocorticoid-induced death. J. Immunol. 1991; 147: 4286
  • Mc Conkey D. J., Hartzell P., Jondal M., Orrenius S. Inhibition of DNA fragmentation in thymocytes and isolated thymocyte nuclei by agents that stimulate protein kinase C. J. Biol. Chem. 1989a; 264: 13399
  • Kisaki H., Tadakuma T., Odaka C., Muramatsu J., Ishimura Y. Activation of a suicide process of thpocytes through DNA fragmentation by calcium ionophores and phorbol esters. J. Immunol. 1989; 143: 1790
  • Boe R., Gjertsen B. T., Vintemyr O. K., Houge G., Lanotte M., Doskeland S O. The protein phosphatase inhibitor okadaic acid induces morphological changes typical of apoptosis in mammalian cells. Exp. Cell. Res. 1991; 195: 237
  • Song Q., Baxter G. D., Kovacs E. M., Findik D., Lavin M. Inhibition of apoptosis in human tumour cells by okadaic acid. J. Cell. Physiol. 1992; 153: 550
  • Duvall E., Wyllie A. H., Morris R. G. Macrophages recognition of cells undergoing programmed cell death (apoptosis). Immunology 1985; 56: 351
  • Zeira M., Gaillv R. Effect of strain and age on in vitro proliferation of murin; thymus-derived macrophazes. Thymus 1990; 15: 1
  • Rothenberg E. V. Death and transfiguration of cortical thymocytes: a reconsideration. Immunol. Today 1990; 11: 116
  • Kosugi A., Sharrow S. O., Shearer G. M. Effect of cyclosporin A on lymphopoiesis. I. Absence of mature T cells in thymus and periphery of bone marrow transplanted mice treated with cyclosporin A. J. Immunol. 1989; 142
  • Gao E. K., Lo D., Cheney R., Kanagawa O., Sprent J. Abnormal differentiation of thymocytes in mice treated with cyclosporin A. Nature 1988; 336: 176
  • Matsuhashi N., Kawase Y., Suzuki G. Effects of cyclosporin A on thymocyte differentiation in fetal thymus organ culture. Cell. Immunol. 1989; 123: 307
  • Kanariou M., Huby R., Ladyman H., Colic M., Sivplapenko G., Lampert I., Ritter M. Immunosuppression with ciclosporin A alters the thymic microenvironment. Clin. Exp. Immunol. 1989; 78: 263
  • Schuurmann H. J., Van Loveren H., Rozing J., Vandijk A., Loeber G., Vos J. G. Cyclosporin and the rat thymus. An immunohistochemical study. Thymus. 1990; 16: 235
  • Swat W., Ignatowicz L., Von Boehmer H., Kisielow P. Clonal deletion of immature CD4±8± thymocytes in suspension culture by extrathymic antigen-presenting cells. Nature 1991; 351: 150
  • Cairns J. S., Mainwaring M. S., Cacchione R. N., Walker J. A., Mc Carthy S. A. Regulation of apoptosis in thymocytes. Thymus. 1993; 21: 177
  • Nakayama K., Nakauchi H. Cyclosporin A inhibits the decrease of CD4/CD8 expression induced by protein kinase C activation. Int. Immunol. 1993; 5: 419
  • Mc Duffie M., Born W., Marrack P., Kappler J. The role of the T-cell receptor in thymocyte maturation. Proc. Natl. Acad. Sci. USA. 1986; 83: 8728
  • Shortman K., Vremec D., Egerton M. The kinetics of T cell antigen receptor expression by subgroups of CD4±CD8± thymocytes: Delineation of CD4±CD8±CD3±± thymocytes as post selection intermediates leading to mature T-cells. J. Exp. Med. 1991; 173: 323
  • Nakashima I., Zhang Y. H., Rahrnan S. M.J., Yooshida Y., Isobe K. I., Ding L. N., Iwamoto T., Hamaguchi M., Ikezawa H., Taguchi R. Evidence of synergiy between Thy-1 and CD3/TCR complex in sisignal delivery to murine thymocytes for cell death. J. Immunol. 1991; 147: 1153
  • Smith C. A., Williams G. T., Kingston R., Jenkinson E. J., Owen J. J.T. Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T-cells in thymic cultures. Nature 1989; 337: 181

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