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ORIGINAL RESEARCH

Treatment with Chlorhexidine Modifies the Healing of Colon Anastomosis in Rats

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Pages 8-12 | Received 04 Mar 2010, Accepted 25 Aug 2010, Published online: 22 Oct 2010

REFERENCES

  • Brook I. Microbiology and management of abdominal infections. Dig Dis Sci. 2007;53:2585–2591.
  • Orlando MD, Chendrasekhar A, Bundz S, The effect of peritoneal contamination on wound strength of small bowel and colonic anastomoses. Am Surg. 1999;65:673–676.
  • Platell C, Papadimitriou JM, Hall JC. The influence of lavage on peritonitis. J Am Coll Surg. 2000;191:672–680.
  • Platt J, Jones RA, Bucknall RA. Intraperitoneal antiseptics in experimental bacterial peritonitis. Br J Surg. 1984;71: 626–628.
  • Edmiston-Junior CE, Goheen MP, Kornhall S, Fecal peritonitis: microbial adherence to serosal mesothelium and resistance to peritoneal lavage. World J Surg. 1990;14:176–183.
  • Celdran UA, Inãrrea LP, Marijuan MJL, Effect of povidone iodine and chlorhexidine on the mortality and bacterial clearance in the abdominal cavity of peritonitis rats. Eur J Surg. 1991;157:393–395.
  • Ablan CJ, Olen RN, Dobrin PB, et al.Efficacy of intraperitoneal antibiotics in the treatment of severe fecal peritonitis. Am J Surg. 1991;162:453–456.
  • Rosman C, Westerveld GJ, Kooi K, Local treatment of generalised peritonitis in rats; effects on bacteria, endotoxin and mortality. Eur J Surg. 1999;165:1072–1079.
  • Akkus AK, Gülmen M, Çevik A, Effect of peritoneal lavage with taurolidine on primary colonic anastomosis in a rat model of secondary peritonitis. Surg Today. 2006;36:436–440.
  • Bondar VM, Rago BSC, Cottone FJ, Chlorhexidine lavage in the treatment of experimental intra-abdominal infection. Arch Surg. 2000;135:309–314.
  • Brocco MC, Salomão PDN, Baptista JFA, Efeito da lavagem peritoneal com bupivacaína na sobrevida de ratos com peritonite fecal. Rev Bras Anestesiol. 2008;58:470–479.
  • Lelynov AD, Sergienko VI, Ivliev NV. Effects of sodium hypochlorite and ozone on healing of intestinal anastomosis in simulated strangulation colorectal obstruction. Bull Exp Biol Med. 2004;137:103–105.
  • Lores ME, Ortíz JR, Rosselló PJ. Peritoneal lavage with povidone-iodine solution in experimentally induced peritonitis. Surg Gynecol Obstet. 1981;153:33–38.
  • Teke Z, Aytekin FO, Kabay B, Pyrrolidine dithiocarbamate prevents deleterious effects of remote ischemia/ reperfusion injury on healing of colonic anastomoses in rats. World J Surg. 2007;31:1835–1842.
  • Maleckas A, Daubaras V, Vaitkus V, Increased postoperative peritoneal adhesion formation after the treatment of experimental peritonitis with chlorhexidine. Langenbecks Arch Surg. 2004;389:256–260.
  • Vallance S, Waldron R. Antiseptic vs. saline lavage in purulent and faecal peritonitis. J Hosp Infect. 1985;6:87–91.
  • Puryan K, Karadayi K, Topcu O, Chlorhexidine gluconate: an ideal scolicidal agent in the treatment of intraperitoneal hydatidosis? World J Surg. 2005;29:227–230.
  • Sortini D, Feo CV, Maravegias K, Role of peritoneal lavage in adhesion formation and survival rate in rats: an experimental study. J Invest Surg. 2006;19:291–297.
  • Kreimer F, Aguiar JCA, Castro CMMB, Resposta terapêutica e inflamatória de ratos com peritonite secundária submetidos ao uso tópico de ampicilina/ sulbactan. Acta Cir Bras. 2005;20:31–39.
  • Schein M, Gecelter G, Freinkel W, Peritoneal lavage in abdominal sepsis. A controlled clinical study. Arch Surg. 1990;125:1132–1135.
  • Milagres LC, Araújo ID, Barral SM, Efeito do uso de povidine-iodine na cicatrização de anastomoses de cólon direito de ratos. Arq Gastroenterol. 2005;42:95–98.
  • Dunn DL, Barke RA, Ahrenholz DH, The adjuvant effect of peritoneal fluid in experimental peritonitis. Mechanism and clinical implications. Ann Surg. 1984;199:37–43.
  • Yao V, Platell C, Hall JC. Lavage enhances the production of proinflammatory mediators by peritoneal mesothelial cells in an experimental model. Dis Colon Rectum. 2005;48:560–566.
  • Lineaweaver W, Howard R, Soucy D, Topical antimicrobial toxicity. Arch Surg. 1985;120:267–270.
  • Sido B, Teklote JR, Hartel M, Inflammatory response after abdominal surgery. Best Pract Res Clin Anaesthesiol. 2004;18:439–454.
  • Bicalho PRR, Lima LB, Alvarenga DG, Clinical and histological responses to laparoscopically-induced peritonitis in rats. Acta Cir Bras. 2008;23:456–461.
  • Thornton FJ, Barbull A. Healing in the gastrointestinal tract. Surg Clin North Am. 1997;77:549–573.
  • Singhal R, Hull P, Budhoo M. Management of left sided colorectal emergencies. Results of a postal questionnaire. Minerva Chir. 2007;62:437–441.
  • Conrad JK, Ferry KM, Foreman ML, Changing management trends in penetrating colon trauma. Dis Colon Rectum. 2000;43:466–471.
  • Torres OJM, Macedo EL, Melo TCM, Peritonite fecal em ratos: eficácia da lavagem da cavidade peritoneal com solução de cloreto de sódio a 0.9% por cento. Acta Cir Bras. 1999;14:65–68.
  • Rittirsch LD, Hoesel M, Ward PA. The disconnect between animal models of sepsis and human sepsis. J Leukoc Biol. 2007;81:137–143.
  • Wichterman KA, Baue AE, Chaudry IH. Sepsis and septic shock—a review of laboratory models and a proposal. J Surg Res. 1980;29:189–201.
  • Ahrendt GM, Tantry US, Barbul A. Intra-abdominal sepsis impairs colonic reparative collagen synthesis. Am J Surg. 1996;171:102–108.
  • Aytekin FO, Teke Z, Aydin C, Effects of a membrane-permeable radical scavenger, Tempol, on healing of colonic anastomoses in the cecal ligation and puncture model of polymicrobial sepsis in rats. Am J Surg. 2007;193:723–729.
  • Ballantyne G. The experimental basis of intestinal suturing. Dis Colon Rectum. 1984;27:61–72.
  • Braskén P, Lehto M, Renvall S. Changes in the connective tissue composition of the submucosal layer of colonic anastomosis. Acta Chir Scand. 1989;155:413–419.

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